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Journal Articles

Abstract B073: Stat5a/b blockade sensitizes prostate cancer to radiation through inhibition of Rad51 and DNA repair

Free
Cristina Maranto, Vindhya Udhane, Ayush Dagvadorj, David T. Hoang, Lei Gu, Vitali Alexeev, Kareem Malas, Karmel Cardenas, Mateusz Koptyra, Jonathan R. Brody, Ulrich Rodeck, Carmen Bergom, Ken A. Iczkowski, Ken Jacobsohn, William See, Sara M. Schmitt, Marja T. Nevalainen
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): B073.
https://doi.org/10.1158/1538-7445.PRCA2017-B073
Published: 14 August 2018
View articletitled, Abstract B073: Stat5a/b blockade sensitizes prostate cancer to radiation through inhibition of Rad51 and DNA repair
Journal Articles

Abstract 3362: Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex and promote the Warburg effect

Free
Jun Fan, Ting-Lei Gu, Titus Boggon, Sumin Kang, Jing Chen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3362.
https://doi.org/10.1158/1538-7445.AM2014-3362
Published: 01 October 2014
View articletitled, Abstract 3362: Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex and promote the Warburg effect
Journal Articles

Abstract 961: 6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling

Free
Changliang Shan, Shannon E. Elf, Ting-Lei Gu, Hanna J. Khoury, Titus Boggon, Sumin Kang, Jing Chen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 961.
https://doi.org/10.1158/1538-7445.AM2014-961
Published: 01 October 2014
View articletitled, Abstract 961: 6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling
Journal Articles

Abstract B42: An integrated view on genetic and epigenetic mechanisms revealed aberrant DNA methylation as an important source for miRNA deregulation in prostate cancer

Free
Olga Bogatyrova, Daniela Wuttig, Lei Gu, Yassen Assenov, Ruprecht Kuner, Constance Baer, Lars Feuerbach, Clarissa Gerhäuser, Dieter Weichenhan, Thorsten Schlomm, Ronald Simon, Guido Sauter, Holger Sültmann
Journal: Cancer Research
Cancer Res (2013) 73 (13_Supplement): B42.
https://doi.org/10.1158/1538-7445.CEC13-B42
Published: 13 May 2014
View articletitled, Abstract B42: An integrated view on genetic and epigenetic mechanisms revealed aberrant DNA methylation as an important source for miRNA deregulation in prostate cancer
Journal Articles

Abstract 2925: p90RSK2 coordinates pro-apoptotic and anti-apoptotic signaling pathways to protect cancer cells from anoikis.

Free
Lingtao Jin, Dan Li, Jongseok Lee, Gina N. Alesi, Jun Fan, Hee-Bum Kang, Dongsheng Wang, Haian Fu, Jack Taunton, Titus J. Boggon, Meghan Tucker, Ting-Lei Gu, Zhuo G. Chen, Dong M. Shin, Fadlo R. Khuri, Sumin Kang
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2925.
https://doi.org/10.1158/1538-7445.AM2013-2925
Published: 15 April 2013
View articletitled, Abstract 2925: p90RSK2 coordinates pro-apoptotic and anti-apoptotic signaling pathways to protect cancer cells from anoikis.
Journal Articles

Abstract B10: Genome-wide profiling reveals hyper- and hypomethylation at microRNA promoters in chronic lymphocytic leukemia

Free
Constance Baer, Michael Rehli, John C. Byrd, Clemens-Martin Wendtner, Christoph Plass, Rainer Claus, Lukas Frenzel, Manuela Zucknick, Yoon Jung Park, Lei Gu, Dieter Weichenhan, Martina Fischer, Christian Pallasch
Journal: Cancer Research
Cancer Res (2012) 72 (2_Supplement): B10.
https://doi.org/10.1158/1538-7445.NONRNA12-B10
Published: 03 April 2013
View articletitled, Abstract B10: Genome-wide profiling reveals hyper- and hypomethylation at microRNA promoters in chronic lymphocytic leukemia
Journal Articles

Extensive Promoter DNA Hypermethylation and Hypomethylation Is Associated with Aberrant MicroRNA Expression in Chronic Lymphocytic Leukemia

Free
Constance Baer, Rainer Claus, Lukas P. Frenzel, Manuela Zucknick, Yoon Jung Park, Lei Gu, Dieter Weichenhan, Martina Fischer, Christian Philipp Pallasch, Esther Herpel, Michael Rehli, John C. Byrd, Clemens-Martin Wendtner, Christoph Plass
Journal: Cancer Research
Cancer Res (2012) 72 (15): 3775–3785.
https://doi.org/10.1158/0008-5472.CAN-12-0803
Published: 31 July 2012
View articletitled, Extensive Promoter DNA Hypermethylation and Hypomethylation Is Associated with Aberrant MicroRNA Expression in Chronic Lymphocytic Leukemia
Open the PDF for Extensive Promoter DNA Hypermethylation and Hypomethylation Is Associated with Aberrant MicroRNA Expression in Chronic Lymphocytic Leukemia in another window
Includes: Supplementary data
Journal Articles

Identification of Anaplastic Lymphoma Kinase as a Potential Therapeutic Target in Ovarian Cancer

Free
Hong Ren, Zhi-Ping Tan, Xin Zhu, Katherine Crosby, Herbert Haack, Jian-Min Ren, Sean Beausoleil, Albrecht Moritz, Gregory Innocenti, John Rush, Yi Zhang, Xin-Min Zhou, Ting-Lei Gu, Yi-Feng Yang, Michael J. Comb
Journal: Cancer Research
Cancer Res (2012) 72 (13): 3312–3323.
https://doi.org/10.1158/0008-5472.CAN-11-3931
Published: 01 July 2012
View articletitled, Identification of Anaplastic Lymphoma Kinase as a Potential Therapeutic Target in Ovarian Cancer
Open the PDF for Identification of Anaplastic Lymphoma Kinase as a Potential Therapeutic Target in Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 997: Oncogenic tyrosine kinases are localized to mitochondria and regulate cancer metabolism by phosphorylating key components of pyruvate dehydrogenase kinase complex

Free
Jing Chen, Taro Hitosugi, Jun Fan, Sumin Kang, Ting-Lei Gu, Titus Boggon
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 997.
https://doi.org/10.1158/1538-7445.AM2012-997
Published: 15 April 2012
View articletitled, Abstract 997: Oncogenic tyrosine kinases are localized to mitochondria and regulate cancer metabolism by phosphorylating key components of pyruvate dehydrogenase kinase complex
Journal Articles

Abstract 1257: Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism

Free
Tae-Wook Chung, Taro Hitosugi, Jun Fan, Xu Wang, Ting-Lei Gu, Johannes L. Roesel, Titus Boggon, Zhuo (Georgia) Chen, Fadlo R. Khuri, Sumin Kang, Jing Chen
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1257.
https://doi.org/10.1158/1538-7445.AM2011-1257
Published: 15 April 2011
View articletitled, Abstract 1257: Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism
Journal Articles

Abstract 2798: Tyrosine phosphorylation of LDH-A is important for cancer cell redox homeostasis and tumor growth

Free
Jun Fan, Taro Hitosugi, Tae-Wook Chung, Xu Wang, Ting-Lei Gu, Johannes L. Roesel, Zhuo (Georgia) Chen, Titus Boggon, Fadlo R. Khuri, Sumin Kang, Jing Chen
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2798.
https://doi.org/10.1158/1538-7445.AM2011-2798
Published: 15 April 2011
View articletitled, Abstract 2798: Tyrosine phosphorylation of LDH-A is important for cancer cell redox homeostasis and tumor growth
Journal Articles

Abstract LB-399: Chronic inhibition of mutant EGFR in NSCLC leads to EGFR TKI resistance by TGF-β1 mediated epithelial to mesenchymal transition

Free
Takeshi Shimamura, Julian Carretero, Chunxiao Xu, Marzia Capelletti, Klarisa Rikova, Ting-Lei Gu, Susumu Kobayashi, Andrew Rogers, Pasi A. Janne, Kwok-Kin Wong, Geoffrey I. Shapiro
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-399.
https://doi.org/10.1158/1538-7445.AM2011-LB-399
Published: 15 April 2011
View articletitled, Abstract LB-399: Chronic inhibition of mutant EGFR in NSCLC leads to EGFR TKI resistance by TGF-β1 mediated epithelial to mesenchymal transition
Journal Articles

Abstract LB-309: EML4-ALK signaling is required for the maintenance of neoplastic phenotype of non-small cell lung cancer cells: Novel strategy for lung cancer-tailored therapies

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Claudia Voena, Elena Panizza, Lucia D'Amico, Chiara Ambrogio, Martinengo Cinzia, Francesco Boccalatte, Ludovica Riera, Lisa Bonello, Roberta Pulito, Jorg Hamm, Mangeng Cheng, Bruce Ruggeri, Ting-Lei Gu, Roberto D. Polakiewicz, Enzo Medico, Roberto Chiarle, Giorgio Inghirami
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-309.
https://doi.org/10.1158/1538-7445.AM10-LB-309
Published: 15 April 2010
View articletitled, Abstract LB-309: EML4-ALK signaling is required for the maintenance of neoplastic phenotype of non-small cell lung cancer cells: Novel strategy for lung cancer-tailored therapies
Journal Articles

Abstract 34: Oncogenic tyrosine kinases phosphorylate and inhibit PKM2 to provide a metabolic advantage to tumor growth

Free
Taro Hitosugi, Sumin Kang, Matthew G. Vander Heiden, Tae-Wook Chung, Sagar Lonial, Xu Wang, Georgia Z. Chen, Jianxin Xie, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes L. Roesel, Titus Boggon, Fadlo Khuri, D. Gary Gilliland, Lewis C. Cantley, Jonathan Kaufman, Jing Chen
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 34.
https://doi.org/10.1158/1538-7445.AM10-34
Published: 15 April 2010
View articletitled, Abstract 34: Oncogenic tyrosine kinases phosphorylate and inhibit PKM2 to provide a metabolic advantage to tumor growth
Journal Articles

EGF stimulates RSK2 activation through activation of the MEK/ERK pathway and Src-dependent tyrosine phosphorylation of RSK2 at Y529

Free
Sumin Kang, Shaozhong Dong, Ailan Guo, Hong Ruan, Sagar Lonial, Hanna Khoury, Ting-Lei Gu, Jing Chen
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3486.
Published: 01 May 2008
View articletitled, EGF stimulates RSK2 activation through activation of the MEK/ERK pathway and Src-dependent tyrosine phosphorylation of RSK2 at Y529
Journal Articles

Transcription Factor Stat5 Synergizes with Androgen Receptor in Prostate Cancer Cells

Free
Shyh-Han Tan, Ayush Dagvadorj, Feng Shen, Lei Gu, Zhiyong Liao, Junaid Abdulghani, Ying Zhang, Edward P. Gelmann, Tobias Zellweger, Zoran Culig, Tapio Visakorpi, Lukas Bubendorf, Robert A. Kirken, James Karras, Marja T. Nevalainen
Journal: Cancer Research
Cancer Res (2008) 68 (1): 236–248.
https://doi.org/10.1158/0008-5472.CAN-07-2972
Published: 02 January 2008
View articletitled, Transcription Factor Stat5 Synergizes with Androgen Receptor in Prostate Cancer Cells
Open the PDF for Transcription Factor Stat5 Synergizes with Androgen Receptor in Prostate Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Phosphoproteome of activated FLT3 in leukemia

Free
Ting-Lei Gu, Julie Nardone, Marc Loriaux, Kim Lee, Judit Villen, Steven Gygi, John Rush, Michael Comb, Brian Druker, Michael Heinrich, Roberto Polakiewicz
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3134.
Published: 01 May 2007
View articletitled, Phosphoproteome of activated FLT3 in leukemia
Journal Articles

PhosphoScan® analysis reveals insights into the mechanisms responsible for disruption of cell-cell adhesion mediated by activation of the CSF-1R in mammary epithelial cells

Free
Melodie Knowlton, Carolyn Wrobel, Ting-Lei Gu, Bryan Ballif, Steven Gygi, Roberto Polakiewicz, Joan Brugge
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 408.
Published: 01 May 2007
View articletitled, PhosphoScan® analysis reveals insights into the mechanisms responsible for disruption of cell-cell adhesion mediated by activation of the CSF-1R in mammary epithelial cells
Journal Articles

Core-Binding Factor: A Central Player in Hematopoiesis and Leukemia

Free
Nancy A. Speck, Terry Stacy, Qing Wang, Trista North, Ting-Lei Gu, Janelle Miller, Michael Binder, Miguel Marín-Padilla
Journal: Cancer Research
Cancer Res (1999) 59 (7_Supplement): 1789s–1793s.
Published: 01 April 1999
View articletitled, Core-Binding Factor: A Central Player in Hematopoiesis and Leukemia
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