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Leena Gandhi
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Journal Articles

Abstract CT244: A phase 1a/1b study of STK-012, an α/β IL-2 receptor selective partial agonist as monotherapy and in combination with pembrolizumab in advanced solid tumors (NCT05098132)

David Spigel, Alexander Spira, Dmitriy Zamarin, David F. McDermott, Jason Luke, John V. Heymach, Rebecca Previs, Ryan Sullivan, Leena Gandhi, Alex Azrilevich, Naiyer Rizvi, Martin Oft, Natalie Busby, Benjamin Izar
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT244.
https://doi.org/10.1158/1538-7445.AM2022-CT244
Published: 15 June 2022
View article titled, Abstract CT244: A phase 1a/1b study of STK-012, an α/β IL-2 receptor selective partial agonist as monotherapy and in combination with pembrolizumab in advanced solid tumors (NCT05098132)
Journal Articles

Abstract CT075: KEYNOTE-189: Randomized, double-blind, phase 3 study of pembrolizumab (pembro) or placebo plus pemetrexed (pem) and platinum as first-line therapy for metastatic NSCLC

Leena Gandhi, Delvys Rodgríguez-Abreu, Shirish Gadgeel, Emilio Esteban, Enriqueta Felip, Flávia De Angelis, Manuel Domine, Philip Clingan, Maximilian J Hochmair, Steven Powell, Susanna Yee-Shan Cheng, Helge G Bischoff, Nir Peled, Francesco Grossi, Ross R Jennens, Martin Reck, Rina Hui, Edward B Garon, Michael Boyer, Belén Rubio-Viqueira, Silvia Novello, Takayasu Kurata, Jhanelle E Gray, John J Vida, Ziwen Wei, Jing Yang, Harry Raftopoulos, M. Catherine Pietanza, Marina C Garassino
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): CT075.
https://doi.org/10.1158/1538-7445.AM2018-CT075
Published: 01 July 2018
View article titled, Abstract CT075: KEYNOTE-189: Randomized, double-blind, phase 3 study of pembrolizumab (pembro) or placebo plus pemetrexed (pem) and platinum as first-line therapy for metastatic NSCLC
Journal Articles

Abstract CT155: Phase 2 study of sacituzumab govitecan (IMMU-132), an anti-Trop-2/SN-38 antibody-drug conjugate (ADC), in patients with pretreated metastatic small-cell lung cancer (mSCLC)

Jhanelle E. Gray, Rebecca S. Heist, Alexander N. Starodub, D. Ross Camidge, Ebenezer Kio, Gregory Masters, W. Thomas Purcell, Michael J. Guarino, Jamal Misleh, Charles J. Schneider, Bryan J. Schneider, Allyson J. Ocean, Tirrell Johnson, Leena Gandhi, Kevin Kalinsky, Serengulam V. Govindan, Pius Maliakal, Boyd Mudenda, William A. Wegener, Robert M. Sharkey, David M. Goldenberg
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT155.
https://doi.org/10.1158/1538-7445.AM2017-CT155
Published: 01 July 2017
View article titled, Abstract CT155: Phase 2 study of sacituzumab govitecan (IMMU-132), an anti-Trop-2/SN-38 antibody-drug conjugate (ADC), in patients with pretreated metastatic small-cell lung cancer (mSCLC)
Journal Articles

Abstract 2340: Thymidine kinase activity as a response marker for CDK 4/6 inhibition

Geoffrey Shapiro, Magnus Neumuller, Sara Lööf, Smaranda Bacanu, Takahiro Seki, John Hilton, Khan Do, Nicole Chau, Leena Gandhi, Joseph W. Gibson, Robert Distel, Pawel Niekrasz, Edward M. Suh, Mattias Bergqvist
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2340.
https://doi.org/10.1158/1538-7445.AM2017-2340
Published: 01 July 2017
View article titled, Abstract 2340: Thymidine kinase activity as a response marker for CDK 4/6 inhibition
Journal Articles

Abstract 3157: Serial droplet digital PCR (ddPCR) of plasma cell-free DNA (cfDNA) as pharmacodynamic (PD) biomarker in Phase 1 clinical trials for patients (pts) with KRAS mutant non-small cell lung cancer (NSCLC)

Cloud P. Paweletz, Geoffrey R. Oxnard, Nora Feeney, John F. Hilton, Leena Gandhi, Khanh T. Do, Adrienne Anderson, Andrew Wolanski, Alexander Tejeda, Jessie M. English, Paul T. Kirschmeier, Pasi A. Jänne, Geoffrey I. Shapiro
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3157.
https://doi.org/10.1158/1538-7445.AM2016-3157
Published: 15 July 2016
View article titled, Abstract 3157: Serial droplet digital PCR (ddPCR) of plasma cell-free DNA (cfDNA) as pharmacodynamic (PD) biomarker in Phase 1 clinical trials for patients (pts) with KRAS mutant non-small cell lung cancer (NSCLC)
Journal Articles

Abstract CT024: First-in-human phase 1 dose-escalation study of DS-6051b, an oral ROS1 and NTRK inhibitor, in subjects with advanced solid tumors

Kyriakos P. Papadopoulos, Erkut Borazanci, Daniel Von Hoff, Leena Gandhi, Amita Patnaik, Masaya Tachibana, Hamim Zahir, Roohi Gajee, Terri Goldberg, Giorgio Senaldi, Sai-Hong Ou
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): CT024.
https://doi.org/10.1158/1538-7445.AM2016-CT024
Published: 15 July 2016
View article titled, Abstract CT024: First-in-human phase 1 dose-escalation study of DS-6051b, an oral ROS1 and NTRK inhibitor, in subjects with advanced solid tumors
Journal Articles

Abstract CT104: Efficacy of pembrolizumab (MK-3475) and relationship with PD-L1 expression in patients with non-small cell lung cancer: Findings from KEYNOTE-001)

Edward B. Garon, Naiyer Rizvi, Rina Hui, Natasha B. Leighl, Ani S. Balmanoukian, Joseph P. Eder, Amita Patnaik, Charu Aggarwal, Matthew A. Gubens, Leora Horn, Enric Carcereny, Myung-Ju Ahn, Enriqueta Felip, Jong-Seok Lee, Jin Zhang, Reshma A. Rangwala, Gregory M. Lubiniecki, Charlotte M. Roach, Kenneth Emancipator, Leena Gandhi
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): CT104.
https://doi.org/10.1158/1538-7445.AM2015-CT104
Published: 01 August 2015
View article titled, Abstract CT104: Efficacy of pembrolizumab (MK-3475) and relationship with PD-L1 expression in patients with non-small cell lung cancer: Findings from KEYNOTE-001)
Journal Articles

Abstract P5-19-13: Clinical activity of abemaciclib, an oral cell cycle inhibitor, in metastatic breast cancer

Sara M Tolaney, Lee S Rosen, Muralidhar Beeram, Jonathan W Goldman, Leena Gandhi, Anthony W Tolcher, Kyriakos P Papadopoulos, Drew W Rasco, Scott P Myrand, Palaniappan Kulanthaivel, Joan M Andrews, Martin Frenzel, Damien M Cronier, Edward M Chan, Keith T Flaherty, Patrick Y Wen, Geoffrey I Shapiro, Amita Patnaik
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P5-19-13.
https://doi.org/10.1158/1538-7445.SABCS14-P5-19-13
Published: 01 May 2015
View article titled, Abstract P5-19-13: Clinical activity of abemaciclib, an oral cell cycle inhibitor, in metastatic breast cancer
Journal Articles

Abstract CT105: MK-3475 (anti-PD-1 monoclonal antibody) for non-small cell lung cancer (NSCLC): Antitumor activity and association with tumor PD-L1 expression

Leena Gandhi, Ani Balmanoukian, Rina Hui, Omid Hamid, Naiyer A. Rizvi, Natasha Leighl, Matthew Gubens, Jonathan W. Goldman, Gregory M. Lubiniecki, Kenneth Emancipator, Marisa Dolled-Filhart, Jared K. Lunceford, Michelle Niewood, Kevin Gergich, Edward B. Garon
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): CT105.
https://doi.org/10.1158/1538-7445.AM2014-CT105
Published: 01 October 2014
View article titled, Abstract CT105: MK-3475 (anti-PD-1 monoclonal antibody) for non-small cell lung cancer (NSCLC): Antitumor activity and association with tumor PD-L1 expression
Journal Articles

Abstract CT232: Clinical activity of LY2835219, a novel cell cycle inhibitor selective for CDK4 and CDK6, in patients with metastatic breast cancer

Amita Patnaik, Lee S. Rosen, Sara M. Tolaney, Anthony W. Tolcher, Jonathan W. Goldman, Leena Gandhi, Kyriakos P. Papadopoulos, Muralidhar Beeram, Drew W. Rasco, Scott P. Myrand, Palaniappan Kulanthaivel, Lily Li, Martin Frenzel, Damien M. Cronier, Edward M. Chan, Keith T. Flaherty, Patrick Y. Wen, Geoffrey I. Shapiro
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): CT232.
https://doi.org/10.1158/1538-7445.AM2014-CT232
Published: 01 October 2014
View article titled, Abstract CT232: Clinical activity of LY2835219, a novel cell cycle inhibitor selective for CDK4 and CDK6, in patients with metastatic breast cancer
Journal Articles

Abstract 2506: A phase 1 study of ABT-806, a humanized recombinant anti-EGFR monoclonal antibody, in patients with advanced solid tumors

James M. Cleary, Lorrin Kwock-Chong Yee, Nilofer Azad, Michael Carducci, David Cosgrove, Sewanti Limaye, Leena Gandhi, Michelle Pedersen, Peter Ansell, William Ames, Shringi Sharma, Ya-Hui Hsu, Wijith Munasinghe, Edward Reilly, Kyle D. Holen, Rod Humerickhouse
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2506.
https://doi.org/10.1158/1538-7445.AM2012-2506
Published: 15 April 2012
View article titled, Abstract 2506: A phase 1 study of ABT-806, a humanized recombinant anti-EGFR monoclonal antibody, in patients with advanced solid tumors
Journal Articles

Abstract 3738: Exploratory patient (pt) stratification markers associated with sensitivity to ABT-263 in small cell lung cancer (SCLC)

Evelyn McKeegan, Elizabeth M. Litvinovich, Brenda J. Chyla, Philip M. Hemken, Barry Dowell, Sari H. Enschede, Leena Gandhi, Charles M. Rudin, David R. Camidge, Philip D. Bonomi, Divis Khaira, Moacyr Ribeiro de Oliveira, David Gandara, Geoffrey I. Shapiro, Andrew P. Krivoshik, Rod Humerickhouse
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3738.
https://doi.org/10.1158/1538-7445.AM10-3738
Published: 15 April 2010
View article titled, Abstract 3738: Exploratory patient (pt) stratification markers associated with sensitivity to ABT-263 in small cell lung cancer (SCLC)
Journal Articles

Abstract #5407: Exploratory patient stratification markers associated with sensitivity to ABT-263 in small cell lung cancer (SCLC).

Evelyn McKeegan, Elizabeth Litvinovich, Fang Jiang, Philip Hemken, Dimitri Semizarov, Sari Enschede, Leena Gandhi, Charles Rudin, David Camidge, Philip Bonomi, Divis Khaira, Moacyr Ribeiro de Oliveira Ribeiro de Oliveira, David Gandara, Andrew Krivoshik
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5407.
Published: 01 May 2009
View article titled, Abstract #5407: Exploratory patient stratification markers associated with sensitivity to ABT-263 in small cell lung cancer (SCLC).
Journal Articles

Collagen XXIII- a biomarker for lung adenocarcinoma

Kristin Spivey, Lucian Chirieac, Justine Barletta, Scott Rodig, Leena Gandhi, Bruce Zetter
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2157.
Published: 01 May 2008
View article titled, Collagen XXIII- a biomarker for lung adenocarcinoma
Journal Articles

PF00299804, an Irreversible Pan-ERBB Inhibitor, Is Effective in Lung Cancer Models with EGFR and ERBB2 Mutations that Are Resistant to Gefitinib

Jeffrey A. Engelman, Kreshnik Zejnullahu, Christopher-Michael Gale, Eugene Lifshits, Andrea J. Gonzales, Takeshi Shimamura, Feng Zhao, Patrick W. Vincent, George N. Naumov, James E. Bradner, Irene W. Althaus, Leena Gandhi, Geoffrey I. Shapiro, James M. Nelson, John V. Heymach, Matthew Meyerson, Kwok-Kin Wong, Pasi A. Jänne
Journal: Cancer Research
Cancer Res (2007) 67 (24): 11924–11932.
https://doi.org/10.1158/0008-5472.CAN-07-1885
Published: 18 December 2007
View article titled, PF00299804, an Irreversible Pan-ERBB Inhibitor, Is Effective in Lung Cancer Models with <em>EGFR</em> and <em>ERBB2</em> Mutations that Are Resistant to Gefitinib
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Includes: Supplementary data