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Journal Articles

Abstract 5714: Targeting serine metabolism impairs tumor growth in preclinical models of Ewing sarcoma

Sameer Issaq, Arnulfo Mendoza, Tracy Rosales, Christine Heske, Craig Thomas, Ralph DeBerardinis, Lee Helman
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5714.
https://doi.org/10.1158/1538-7445.AM2020-5714
Published: 15 August 2020
View article titled, Abstract 5714: Targeting serine metabolism impairs tumor growth in preclinical models of Ewing sarcoma
Journal Articles

Abstract 3892: Targeting Hippo-dependent and Hippo-independent regulation of the YAP1 oncoprotein in childhood rhabdomyosarcoma

Katherine Slemmons, Choh Yeung, Josh Baumgart, Jhazeel Martinez Juarez, Amy McCalla, Lee Helman
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3892.
https://doi.org/10.1158/1538-7445.AM2020-3892
Published: 15 August 2020
View article titled, Abstract 3892: Targeting Hippo-dependent and Hippo-independent regulation of the YAP1 oncoprotein in childhood rhabdomyosarcoma
Journal Articles

Abstract 4126: DNA methyltransferase inhibitors target a YES1-YAP1 signaling axis in childhood rhabdomyosarcoma

Katherine Slemmons, Choh Yeung, Josh Baumgart, Amy McCalla-Martin, Lee Helman
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4126.
https://doi.org/10.1158/1538-7445.AM2018-4126
Published: 01 July 2018
View article titled, Abstract 4126: DNA methyltransferase inhibitors target a YES1-YAP1 signaling axis in childhood rhabdomyosarcoma
Journal Articles

Abstract 1632: Suppression of EWS-FLI1 transcription using a combination therapy of mithramycin and cyclin-dependent kinase 9 inhibition

Guillermo Flores, Joel Everett, Brandon Oswald, Natasha Caplen, Lee Helman, Zachary Madaj, Patrick Grohar
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1632.
https://doi.org/10.1158/1538-7445.AM2018-1632
Published: 01 July 2018
View article titled, Abstract 1632: Suppression of EWS-FLI1 transcription using a combination therapy of mithramycin and cyclin-dependent kinase 9 inhibition
Journal Articles

Abstract 434: Characterizing the role of serine metabolism in pediatric sarcomas

Sameer Issaq, Ria Kidner, Jason Rohde, Matthew Boxer, Lee Helman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 434.
https://doi.org/10.1158/1538-7445.AM2017-434
Published: 01 July 2017
View article titled, Abstract 434: Characterizing the role of serine metabolism in pediatric sarcomas
Journal Articles

Abstract 1032: Characterizing the metabolic dependencies of rhabdomyosarcoma and Ewing's sarcoma cells

Sameer Issaq, Lee Helman
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1032.
https://doi.org/10.1158/1538-7445.AM2016-1032
Published: 15 July 2016
View article titled, Abstract 1032: Characterizing the metabolic dependencies of rhabdomyosarcoma and Ewing's sarcoma cells
Journal Articles

Abstract A46: HSP-90 inhibition in pediatric sarcomas

Fernanda I. Arnaldez, Toby Terwilliger, Choh Yeung, Len Neckers, Lee Helman
Journal: Cancer Research
Cancer Res (2014) 74 (20_Supplement): A46.
https://doi.org/10.1158/1538-7445.PEDCAN-A46
Published: 09 October 2014
View article titled, Abstract A46: HSP-90 inhibition in pediatric sarcomas
Journal Articles

Abstract 1719: Down-regulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma

Zhigang Kang, Yunkai Yu, Yuelin J. Zhu, Lee Helman, Paul Meltzer, Liang Cao
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1719.
https://doi.org/10.1158/1538-7445.AM2014-1719
Published: 01 October 2014
View article titled, Abstract 1719: Down-regulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma
Journal Articles

Abstract 4449: Resistance to insulin-like growth factor 1 receptor antibody associated with downregulated IGFBP2.

Yunkai Yu, Zhigang Kang, Lee Helman, Paul Meltzer, Liang Cao
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4449.
https://doi.org/10.1158/1538-7445.AM2013-4449
Published: 15 April 2013
View article titled, Abstract 4449: Resistance to insulin-like growth factor 1 receptor antibody associated with downregulated IGFBP2.
Journal Articles

Abstract 4593: Genome-wide association study identifies novel loci associated with osteosarcoma.

Sharon A. Savage, Lisa Mirabello, Zhaoming Wang, Julie Gastier-Foster, Richard Gorlick, Chand Khanna, Adrienne M. Flanagan, Roberto Tirabosco, Irene L. Andrulis, Jay Wunder, Nalan Gokgoz, Ana Patino-Garcia, Luis Sierrasesumaga, Fernando Lecanda, Nilgun Kurucu, Inci Ergurhan Ilhan, Neriman Sari, Massimo Serra, Claudia Hattinger, Piero Picci, Logan Spector, Donald A. Barkauskas, Neyssa Marina, Siliva Caminada de Toledo, Sergio Petrilli, Maria Fernanda Amary, Dina Halai, David Thomas, Chester Douglass, Paul Meltzer, Kevin Jacobs, Charles C. Chung, Sonja I. Berndt, Mark P. Purdue, Neil E. Caporaso, Margaret Tucker, Nathaniel Rothman, Maria Teresa Landi, Debra T. Silverman, Peter Kraft, David J. Hunter, Nuria Malats, Manolis Kogevinas, Sholom Wacholder, Rebecca Troisi, Lee Helman, Joseph F. Fraumeni, Jr., Meredith Yeager, Robert Hoover, Stephen J. Chanock
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4593.
https://doi.org/10.1158/1538-7445.AM2013-4593
Published: 15 April 2013
View article titled, Abstract 4593: Genome-wide association study identifies novel loci associated with osteosarcoma.
Journal Articles

Abstract 2963: Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor.

Paul S. Meltzer, J. Keith Killian, Su Young Kim, Markku Miettinen, Carly Smith, Maria Tsokos, Martha Quezado, William I. Smith, Mona S. Jahromi, Robert L. Walker, Jerzy Lasota, Brandy Klotzle, Zengfeng Wang, Laura Jones, Yuelin Zhu, Yonghong Wang, Joshua J. Waterfall, Marina Bibikova, Maureen J. O'Sullivan, Constantine A. Stratakis, Joshua D. Schiffman, Jian-Bing Fan, Lee Helman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2963.
https://doi.org/10.1158/1538-7445.AM2013-2963
Published: 15 April 2013
View article titled, Abstract 2963: Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor.
Journal Articles

Abstract 651: Insulin-like growth factor 1 receptor antibody induces rhabdomyosarcoma cell death via a process involving AKT and Bcl-xL

Linnia Mayeenuddin, Yunkai Yu, Zhigang Kang, Lee Helman, Liang Cao
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 651.
https://doi.org/10.1158/1538-7445.AM2011-651
Published: 15 April 2011
View article titled, Abstract 651: Insulin-like growth factor 1 receptor antibody induces rhabdomyosarcoma cell death via a process involving AKT and Bcl-xL
Journal Articles

Abstract 2211: Quantitative analysis of IGF-1R expression and signaling pathway activation in FFPE xenograft and human tumor tissues

Sheeno Thyparambil, Todd Hembrough, Liang Cao, David Krizman, Marlene Darfler, Jon Burrows, Lee Helman
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2211.
https://doi.org/10.1158/1538-7445.AM2011-2211
Published: 15 April 2011
View article titled, Abstract 2211: Quantitative analysis of IGF-1R expression and signaling pathway activation in FFPE xenograft and human tumor tissues
Journal Articles

Abstract #3805: Identification of transcription factor inhibitors: A method used to identify small molecules that block EWS-Fli1 transcription factor activity

Patrick Grohar, Girma Woldemichael, Laurie Griffin, Choh Yeung, Qingrong Chen, Chand Khanna, Javed Khan, James McMahon, Lee Helman
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3805.
Published: 01 May 2009
View article titled, Abstract #3805: Identification of transcription factor inhibitors: A method used to identify small molecules that block EWS-Fli1 transcription factor activity
Journal Articles

Abstract #5682: Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin

Xiaolin Wan, Su Young Kim, Arnulfo Mendoza, Joseph Briggs, Choh Yeung, Hua Zhang, Crystal Mackall, Wan-Ju Li, Rocky Tuan, Andrea Deyrup, Chand Khanna, Lee Helman
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5682.
Published: 01 May 2009
View article titled, Abstract #5682: Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin
Journal Articles

Abstract #1501: ET-743 modulates EWS-FLi1 activity in Ewing\#8217;s sarcoma cells

Laurie Griffin, Patrick Grohar, Yves Pommier, Chand Khanna, Javed Khan, Lee Helman
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1501.
Published: 01 May 2009
View article titled, Abstract #1501: ET-743 modulates EWS-FLi1 activity in Ewing\#8217;s sarcoma cells
Journal Articles

Abstract #3398: Investigation of MET modulation in osteosarcoma

Lillian Guenther, Xiaolin Wan, Chand Khanna, Lee Helman, Su Young Kim
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3398.
Published: 01 May 2009
View article titled, Abstract #3398: Investigation of MET modulation in osteosarcoma
Journal Articles

Abstract #5683: Loss of function screen in rhabdomyosarcoma uncovers CRKL: Biological assessment confirms a role in tumor progression in vitro and in vivo

Choh Yeung, Vu Ngo, Xiao Wan, Su Young Kim, Patrick Grohar, Chand Khanna, Louis Staudt, Lee Helman
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5683.
Published: 01 May 2009
View article titled, Abstract #5683: Loss of function screen in rhabdomyosarcoma uncovers CRKL: Biological assessment confirms a role in tumor progression <em>in vitro</em> and<em> in vivo</em>
Journal Articles

The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors

Fei Huang, Ann Greer, Warren Hurlburt, Xia Han, Rameh Hafezi, Gayle M. Wittenberg, Karen Reeves, Jiwen Chen, Douglas Robinson, Aixin Li, Francis Y. Lee, Marco M. Gottardis, Edwin Clark, Lee Helman, Ricardo M. Attar, Ashok Dongre, Joan M. Carboni
Journal: Cancer Research
Cancer Res (2009) 69 (1): 161–170.
https://doi.org/10.1158/0008-5472.CAN-08-0835
Published: 31 December 2008
View article titled, The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors
Open the PDF for The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors in another window
Includes: Supplementary data
Journal Articles

The anti-proliferative activity of an IGF1R antibody is correlated with IGF1R level and associated with the inhibition of AKT pathway in rhabdomyosarcoma

Liang Cao, Yunkai Yu, Isaac Darko, Duane Currier, Chand Khanna, Lee Helman
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1507.
Published: 01 May 2008
View article titled, The anti-proliferative activity of an IGF1R antibody is correlated with IGF1R level and associated with the inhibition of AKT pathway in rhabdomyosarcoma