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Lawrence Fong
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Journal Articles

Abstract 2179: Multiomic co-detection of proteins, mRNA and protein-protein interactions reveal PD1-PDL1 interactions in the tumor microenvironment of bladder cancer patients treated with anti-PD-L1

Free
Ge-Ah Kim, Sonali A. Deshpande, Li-Chong Wang, Julia Yu, Hamidreza Sepasizangabadi, Ji Zhang, Jason Au, Kathryn Allaire, Junyan He, Maithreyan Srinivasan, David Y. Oh, Lawrence Fong
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2179.
https://doi.org/10.1158/1538-7445.AM2025-2179
Published: 21 April 2025
View articletitled, Abstract 2179: Multiomic co-detection of proteins, mRNA and protein-protein interactions reveal PD1-PDL1 interactions in the tumor microenvironment of bladder cancer patients treated with anti-PD-L1
Journal Articles

Abstract 4325: FXYD5 plays diverse roles in immune evasion and tumor progression in prostate cancer

Free
Ru Wen, G Edward W. Marti, Neeladrisingha Das, Zhengyuan Qiu, Nathan Lam, Eric E. Peterson, Zenghua Fan, Aram Lyu, Fernando Jose Garcia Marques, Abel Bermudez, Hongjuan Zhao, Lawrence Fong, Guillem Pratx, Donna M. Peehl, Sharon J. Pitteri, James D. Brooks
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4325.
https://doi.org/10.1158/1538-7445.AM2025-4325
Published: 21 April 2025
View articletitled, Abstract 4325: FXYD5 plays diverse roles in immune evasion and tumor progression in prostate cancer
Journal Articles

Abstract LB237: PVRL2 suppresses antitumor immune responses through PVRIG- and TIGIT-independent pathways

Free
Jiuling Yang, Li Wang, James Byrnes, Lisa Kirkemo, Hannah Driks, Cassandra Belair, Oscar Aguilar, Lewis Lanier, Jim Wells, Lawrence Fong, Robert Blelloch
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB237.
https://doi.org/10.1158/1538-7445.AM2024-LB237
Published: 05 April 2024
View articletitled, Abstract LB237: PVRL2 suppresses antitumor immune responses through PVRIG- and TIGIT-independent pathways
Journal Articles

Abstract 6725: NTX-470, a novel multispecific T cell engager expressed from mRNA targets PSMA and STEAP1 prostate cancer antigens to generate enhanced functional activity

Free
Chris Rae, Sudha Adusumilli, Srinivasa Bandi, Shruti Lal, Pragyesh Dhungel, Kimmy Ferry, Shima Gholizadeh, Anushtha Sharma, Adrienne Sallets, Weiqun Liu, Evan McCartney-Melstad, Pei-Ken Hsu, Ray Low, Colin McKinlay, Meredith Leong, David Y. Oh, Lawrence Fong, Guna Kannan, Samuel Deutsch, Ole Haabeth
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6725.
https://doi.org/10.1158/1538-7445.AM2024-6725
Published: 22 March 2024
View articletitled, Abstract 6725: NTX-470, a novel multispecific T cell engager expressed from mRNA targets PSMA and STEAP1 prostate cancer antigens to generate enhanced functional activity
Journal Articles

Abstract 6857: Evolution of myeloid-mediated mechanisms of immunotherapy resistance at single-cell resolution with prostate cancer progression

Free
Aram Lyu, Zenghua Fan, Diamond Luong, Ali Setayesh, Alec Starzinski, Laura Valderrábano, Eliezer Van Allen, Lawrence Fong
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6857.
https://doi.org/10.1158/1538-7445.AM2024-6857
Published: 22 March 2024
View articletitled, Abstract 6857: Evolution of myeloid-mediated mechanisms of immunotherapy resistance at single-cell resolution with prostate cancer progression
Journal Articles

Abstract 4988: Responders to combination radiation and PD-1 blockade demonstrate reduced myeloid immunosuppression and enhanced interferon signaling in oligometastatic prostate cancer patients

Free
Zenghua Fan, David Y. Oh, Anthony Wong, Katsuto Shinohara, Hao Nguyen, Caleb Hwang, Hewitt Chang, Alec Starzinski, Tony Li, Christopher De Leon, Marissa Gin, Eliezer Van Allen, Li Zhang, Rahaul R. Aggarwal, Terence W. Friedlander, Eric J. Small, Felix Y. Feng, Lawrence Fong
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4988.
https://doi.org/10.1158/1538-7445.AM2024-4988
Published: 22 March 2024
View articletitled, Abstract 4988: Responders to combination radiation and PD-1 blockade demonstrate reduced myeloid immunosuppression and enhanced interferon signaling in oligometastatic prostate cancer patients
Journal Articles

Abstract 3617: Expansion and persistence of anti-BCMA CAR T cells correlates with durability of responses in multiple myeloma patients

Free
Kai Wu, Karen Law, Guy Ledergor, Chang Liu, Zenghua Fan, Vibha Gurunathan, Averey Lea, Matthew Clark, Serena Kwek, Alexander Cheung, Jeffrey Wolf, Ajai Chari, Anupuma Kumar, Justin Eyquem, Thomas Martin, Lawrence Fong
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3617.
https://doi.org/10.1158/1538-7445.AM2024-3617
Published: 22 March 2024
View articletitled, Abstract 3617: Expansion and persistence of anti-BCMA CAR T cells correlates with durability of responses in multiple myeloma patients
Journal Articles

Abstract LB346: Mapping of shared tumor antigen reactivity with nanoparticle encapsulated mRNA in prostate cancer patients

Free
Elena Montauti, Ole Haabeth, Chris Rae, Samuel Deutsch, Lawrence Fong, David Oh
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB346.
https://doi.org/10.1158/1538-7445.AM2023-LB346
Published: 14 April 2023
View articletitled, Abstract LB346: Mapping of shared tumor antigen reactivity with nanoparticle encapsulated mRNA in prostate cancer patients
Journal Articles

Abstract 1120: Dissecting tumor cell programs through group biology estimation in clinical single-cell transcriptomics

Free
Shreya Johri, Kevin Bi, Breanna M. Titchen, Jingxin Fu, Jake Conway, Jett Crowdis, Natalie I. Volkes, Zenghua Fan, Lawrence Fong, Jihye Park, David Liu, Meng Xiao He, Eliezer M. Van Allen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1120.
https://doi.org/10.1158/1538-7445.AM2023-1120
Published: 04 April 2023
View articletitled, Abstract 1120: Dissecting tumor cell programs through group biology estimation in clinical single-cell transcriptomics
Journal Articles

Abstract 6420: Harnessing immune responses in prostate MMRd tumors treated with immune checkpoint blockade

Free
Marcel Arias Badia, Zenghua Fan, Yee May Lwin, PeiXi Chen, Aahir Srinath, Lawrence Fong
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6420.
https://doi.org/10.1158/1538-7445.AM2023-6420
Published: 04 April 2023
View articletitled, Abstract 6420: Harnessing immune responses in prostate MMRd tumors treated with immune checkpoint blockade
Journal Articles

The 5-Hydroxymethylcytosine Landscape of Prostate Cancer

Open Access
Martin Sjöström, Shuang G. Zhao, Samuel Levy, Meng Zhang, Yuhong Ning, Raunak Shrestha, Arian Lundberg, Cameron Herberts, Adam Foye, Rahul Aggarwal, Junjie T. Hua, Haolong Li, Anna Bergamaschi, Corinne Maurice-Dror, Ashutosh Maheshwari, Sujun Chen, Sarah W.S. Ng, Wenbin Ye, Jessica Petricca, Michael Fraser, Lisa Chesner, Marc D. Perry, Thaidy Moreno-Rodriguez, William S. Chen, Joshi J. Alumkal, Jonathan Chou, Alicia K. Morgans, Tomasz M. Beer, George V. Thomas, Martin Gleave, Paul Lloyd, Tierney Phillips, Erin McCarthy, Michael C. Haffner, Amina Zoubeidi, Matti Annala, Robert E. Reiter, Matthew B. Rettig, Owen N. Witte, Lawrence Fong, Rohit Bose, Franklin W. Huang, Jianhua Luo, Anders Bjartell, Joshua M. Lang, Nupam P. Mahajan, Primo N. Lara, Christopher P. Evans, Phuoc T. Tran, Edwin M. Posadas, Chuan He, Xiao-Long Cui, Jiaoti Huang, Wilbert Zwart, Luke A. Gilbert, Christopher A. Maher, Paul C. Boutros, Kim N. Chi, Alan Ashworth, Eric J. Small, Housheng H. He, Alexander W. Wyatt, David A. Quigley, Felix Y. Feng
Journal: Cancer Research
Cancer Res (2022) 82 (21): 3888–3902.
https://doi.org/10.1158/0008-5472.CAN-22-1123
Published: 02 November 2022
View articletitled, The 5-Hydroxymethylcytosine Landscape of Prostate Cancer
Open the PDF for The 5-Hydroxymethylcytosine Landscape of Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract CT301: A phase Ib study to evaluate RO7198457, an individualized Neoantigen Specific immunoTherapy (iNeST), in combination with atezolizumab in patients with locally advanced or metastatic solid tumors

Free
Juanita S. Lopez, Ross Camidge, Marco Iafolla, Sylvie Rottey, Martin Schuler, Matthew Hellmann, Ani Balmanoukian, Luc Dirix, Michael Gordon, Ryan Sullivan, Brian S. Henick, Charles Drake, Kit Wong, Patricia LoRusso, Patrick Ott, Lawrence Fong, Aglaia Schiza, Jeffery Yachnin, Christian Ottensmeier, Fadi Braiteh, Johanna Bendell, Rom Leidner, George Fisher, Guy Jerusalem, Laura Molenaar-Kuijsten, Marcus Schmidt, Scott A. Laurie, Raid Aljumaily, Achim Rittmeyer, Eelke Gort, Ignacio Melero, Lars Mueller, Rachel Sabado, Patrick Twomey, Jack Huang, Manesh Yadav, Jingbin Zhang, Felicitas Mueller, Evelyna Derhovanessian, Ugur Sahin, Özlem Türeci, Thomas Powles
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT301.
https://doi.org/10.1158/1538-7445.AM2020-CT301
Published: 15 August 2020
View articletitled, Abstract CT301: A phase Ib study to evaluate RO7198457, an individualized Neoantigen Specific immunoTherapy (iNeST), in combination with atezolizumab in patients with locally advanced or metastatic solid tumors
Journal Articles

Abstract 5672: Pharmacodynamics and potential predictive biomarkers of ABBV-428, a first-in-class mesothelin (MSLN)-CD40 bispecific, in patients with advanced solid tumors

Free
Hua Fang, Shiming Ye, Anita Reddy, Tolga Turan, Andrew Woolley, Debra T. Chao, Cyril Ramathal, William R. Henner, Kinjal Hew, Michael McDevitt, Joel Hayflick, Frances Fan, Kathryn Allaire, Lawrence Fong
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5672.
https://doi.org/10.1158/1538-7445.AM2020-5672
Published: 15 August 2020
View articletitled, Abstract 5672: Pharmacodynamics and potential predictive biomarkers of ABBV-428, a first-in-class mesothelin (MSLN)-CD40 bispecific, in patients with advanced solid tumors
Journal Articles

Abstract 5512: Identification of circulating myeloid cells induced in advanced biliary cancer patients responding to anti-PD1 through combined single cell RNA sequencing and protein expression analysis

Free
Bridget P. Keenan, Elizabeth E. McCarthy, Arielle Ilano, David S. Lee, Yang Sun, Brenna Sheldon, Alexander Cheung, Chun Jimmie Ye, Robin Kate Kelley, Lawrence Fong
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5512.
https://doi.org/10.1158/1538-7445.AM2020-5512
Published: 15 August 2020
View articletitled, Abstract 5512: Identification of circulating myeloid cells induced in advanced biliary cancer patients responding to anti-PD1 through combined single cell RNA sequencing and protein expression analysis
Journal Articles

Abstract CT098: KEYNOTE-046: Effects of ADXS-PSA with or without pembrolizumab on survival and antigen spreading in metastatic, castration-resistant prostate cancer patients

Free
Mark Stein, Lawrence Fong, Ronald Tutrone, Anthony Mega, Elaine T. Lam, Surya Vangala, Justin Dennie, Robert Petit, Andres Gutierrez, Sandy Hayes, Naomi Haas
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT098.
https://doi.org/10.1158/1538-7445.AM2019-CT098
Published: 01 July 2019
View articletitled, Abstract CT098: KEYNOTE-046: Effects of ADXS-PSA with or without pembrolizumab on survival and antigen spreading in metastatic, castration-resistant prostate cancer patients
Journal Articles

Abstract CT227: KEYNOTE-495/KeyImPaCT: Phase II biomarker-directed precision oncology study of pembrolizumab-based combination therapy for non-small cell lung cancer

Free
Martin Gutierrez, Matthew D. Hellmann, Matthew Gubens, Charu Aggarwal, Daniel Shao Weng Tan, Enriqueta Felip, Joanne Wing Yan Chiu, Jong-Seok Lee, James Chih-Hsin Yang, Edward Garon, Andrea D. Basso, Hua Ma, Lawrence Fong, Alex Snyder, Jianda Yuan, Roy S. Herbst
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT227.
https://doi.org/10.1158/1538-7445.AM2019-CT227
Published: 01 July 2019
View articletitled, Abstract CT227: KEYNOTE-495/KeyImPaCT: Phase II biomarker-directed precision oncology study of pembrolizumab-based combination therapy for non-small cell lung cancer
Journal Articles

Abstract 518: Hypoxia and high interstitial pressure present within the tumor microenvironment can promote T cell suppression and exhaustion

Free
Chiara Rancan, Rachel Marusinec, James Lim, Lawrence Fong
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 518.
https://doi.org/10.1158/1538-7445.AM2019-518
Published: 01 July 2019
View articletitled, Abstract 518: Hypoxia and high interstitial pressure present within the tumor microenvironment can promote T cell suppression and exhaustion
Journal Articles

Abstract 550: Tumor-conditional anti-CTLA-4 uncouples anti-tumor efficacy from immunotherapy-related toxicity

Free
Steven C. Pai, Donald M. Simons, Xiaoqing Lu, Wendy Ritacco, Michael Evans, Gillian Kingsbury, Lawrence Fong
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 550.
https://doi.org/10.1158/1538-7445.AM2019-550
Published: 01 July 2019
View articletitled, Abstract 550: Tumor-conditional anti-CTLA-4 uncouples anti-tumor efficacy from immunotherapy-related toxicity
Journal Articles

Abstract 4063: Single cell immune profiling of patients with advanced biliary cancers treated with combination checkpoint inhibition and GM-CSF reveals diverse T cell and myeloid cell mechanisms of action

Free
Bridget P. Keenan, Whitney Tamaki, Eric Liu, Brandon Chen, Alexander Cheung, John D. Gordan, Brenna Sheldon, Li Zhang, Robin K. Kelley, Lawrence Fong
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4063.
https://doi.org/10.1158/1538-7445.AM2019-4063
Published: 01 July 2019
View articletitled, Abstract 4063: Single cell immune profiling of patients with advanced biliary cancers treated with combination checkpoint inhibition and GM-CSF reveals diverse T cell and myeloid cell mechanisms of action
Journal Articles

Abstract 4688: Single-cell discrimination of altered human T cell states in the bladder tumor microenvironment

Free
David Yoonsuk Oh, Serena S. Kwek, Serghei Mangul, Siddharth S. Raju, Sasha Targ, Arun Burra, Eric Chow, Dvir Aran, Sima Porten, Maxwell V. Meng, Terence W. Friedlander, Chun Jimmie Ye, Lawrence Fong
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4688.
https://doi.org/10.1158/1538-7445.AM2018-4688
Published: 01 July 2018
View articletitled, Abstract 4688: Single-cell discrimination of altered human T cell states in the bladder tumor microenvironment