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Lawrence D. True
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Journal Articles

Abstract PR005: Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3’ untranslated region mutations

Samantha L. Schuster, Sonali Arora, Cynthia L. Wladyka, Lukas Corey, Bethany L. Stackhouse, Lori Kollath, Eva Corey, Lawrence D. True, Dave Young, Patrick J. Paddison, Andrew C. Hsieh
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): PR005.
https://doi.org/10.1158/1538-7445.PRCA2023-PR005
Published: 02 June 2023
View article titled, Abstract PR005: Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3’ untranslated region mutations
Journal Articles

Abstract B050: Human interpretation of 3D histopathology image datasets of whole prostate biopsies reveals more cribriform pattern (Gleason pattern 4) carcinoma than is seen in standard 2D histology images

Lawrence D. True, Peter A. Humphrey, Vanessa Roybal, Suet-Ling Sarah Chow, Weisi Xie, Jonathan T. C. Liu
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B050.
https://doi.org/10.1158/1538-7445.PRCA2023-B050
Published: 02 June 2023
View article titled, Abstract B050: Human interpretation of 3D histopathology image datasets of whole prostate biopsies reveals more cribriform pattern (Gleason pattern 4) carcinoma than is seen in standard 2D histology images
Journal Articles

Abstract 6617: Gleason score 6 often coexists with Gleason score 7 adenocarcinoma within 3D z-levels of a prostate biopsy

Xavier Farré, Vanessa Roybal, Can Koyuncu, Sarah Chow, Hongyi Huang, Alan Aberdeen, Andrew Janowczyk, Anant Madabhushi, Lawrence D. True, Jonathan T. Liu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6617.
https://doi.org/10.1158/1538-7445.AM2023-6617
Published: 04 April 2023
View article titled, Abstract 6617: Gleason score 6 often coexists with Gleason score 7 adenocarcinoma within 3D z-levels of a prostate biopsy
Journal Articles

Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning–Assisted Gland Analysis

Weisi Xie, Nicholas P. Reder, Can Koyuncu, Patrick Leo, Sarah Hawley, Hongyi Huang, Chenyi Mao, Nadia Postupna, Soyoung Kang, Robert Serafin, Gan Gao, Qinghua Han, Kevin W. Bishop, Lindsey A. Barner, Pingfu Fu, Jonathan L. Wright, C. Dirk Keene, Joshua C. Vaughan, Andrew Janowczyk, Adam K. Glaser, Anant Madabhushi, Lawrence D. True, Jonathan T.C. Liu
Journal: Cancer Research
Cancer Res (2022) 82 (2): 334–345.
https://doi.org/10.1158/0008-5472.CAN-21-2843
Published: 15 January 2022
View article titled, Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning–Assisted Gland Analysis
Open the PDF for Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning–Assisted Gland Analysis in another window
Includes: Multimedia, Supplementary data
Journal Articles

RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer

Mark P. Labrecque, Lisha G. Brown, Ilsa M. Coleman, Bryce Lakely, Nicholas J. Brady, John K. Lee, Holly M. Nguyen, Dapei Li, Brian Hanratty, Michael C. Haffner, David S. Rickman, Lawrence D. True, Daniel W. Lin, Hung-Ming Lam, Joshi J. Alumkal, Eva Corey, Peter S. Nelson, Colm Morrissey
Journal: Cancer Research
Cancer Res (2021) 81 (18): 4736–4750.
https://doi.org/10.1158/0008-5472.CAN-21-0307
Published: 15 September 2021
View article titled, RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer
Open the PDF for RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4392: Pre-mRNA splicing factors promote cellular plasticity in castration-resistant prostate cancer

Mark P. Labrecque, Ilsa M. Coleman, Lisha G. Brown, Bryce Lakely, Lori Kollath, Daniel W. Lin, Lawrence D. True, Eva Corey, Peter S. Nelson, Colm Morrissey
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4392.
https://doi.org/10.1158/1538-7445.AM2019-4392
Published: 01 July 2019
View article titled, Abstract 4392: Pre-mRNA splicing factors promote cellular plasticity in castration-resistant prostate cancer
Journal Articles

Abstract IA21: AR is ablated: Now what? Targeting the double-negative phenotype

Colm Morrissey, Eric G. Bluemn, Ilsa M. Coleman, Jared M. Lucas, Roger T. Coleman, Robin Tharakan, Daniella Bianchi-Frias, Ruth F. Dumpit, Arja Kaipainen, Alexandra N. Corella, Yu Chi Yang, Michael D. Nyquist, Elahe Mostaghel, Xiaotun Zhang, Eva Corey, Lisha G. Brown, Holly M. Nguyen, Michael Schweizer, Lawrence D. True, Paul S. Rennie, Robert L. Vessella, Peter S. Nelson
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): IA21.
https://doi.org/10.1158/1538-7445.PRCA2017-IA21
Published: 14 August 2018
View article titled, Abstract IA21: AR is ablated: Now what? Targeting the double-negative phenotype
Journal Articles

Abstract 1092: Defining the molecular phenotypes of metastatic castration-resistant prostate cancer sensitive to FGF pathway inhibition

Mark P. Labrecque, Lisha G. Brown, Ilsa M. Coleman, Lawrence D. True, Lori Kollath, Bryce Lakely, Yu C. Yang, Holly M. Nguyen, Eva Corey, Peter S. Nelson, Colm Morrissey
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1092.
https://doi.org/10.1158/1538-7445.AM2018-1092
Published: 01 July 2018
View article titled, Abstract 1092: Defining the molecular phenotypes of metastatic castration-resistant prostate cancer sensitive to FGF pathway inhibition
Journal Articles

Abstract 1718: The importance of clinically relevant rapid autopsy specimens and LuCaP patient-derived xenograft models to interrogate the heterogeneous and evolving treatment resistance of castration-resistant prostate cancer

Colm Morrissey, Ming H. Lam, Tia S. Higano, Lawrence D. True, Martine Roudier, Robert B. Montgomery, Peter S. Nelson, Paul H. Lange, Evan Y. Yu, Robert L. Vessella, Eva Corey
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1718.
https://doi.org/10.1158/1538-7445.AM2015-1718
Published: 01 August 2015
View article titled, Abstract 1718: The importance of clinically relevant rapid autopsy specimens and LuCaP patient-derived xenograft models to interrogate the heterogeneous and evolving treatment resistance of castration-resistant prostate cancer
Journal Articles

Abstract 5122: Characterizing the molecular features of ERG positive tumors in primary and castration resistant prostate cancer.

Martine Roudier, Ilsa Coleman, Xiaotun Zhang, Roger Coleman, Lisly Chéry, Lisha Brown, Bryce Lakely, Celestia Higano, Lawrence D. True, Paul H. Lange, Shiv Srivistava, Aykut Üren, Eva Corey, Robert L. Vessella, Peter S. Nelson, Colm Morrissey
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5122.
https://doi.org/10.1158/1538-7445.AM2013-5122
Published: 15 April 2013
View article titled, Abstract 5122: Characterizing the molecular features of ERG positive tumors in primary and castration resistant prostate cancer.
Journal Articles

Abstract 406: Characterizing the molecular features of the neuroendocrine phenotype in castration resistant prostate cancer.

Xiaotun Zhang, Ilsa Coleman, Roger Coleman, Khanhthy Doan, Martine Roudier, Lisly Chéry, Jennifer Noteboom, Celestia Higano, Lawrence D. True, Paul H. Lange, Peter S. Nelson, Robert L. Vessella, Colm Morrissey
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 406.
https://doi.org/10.1158/1538-7445.AM2013-406
Published: 15 April 2013
View article titled, Abstract 406: Characterizing the molecular features of the neuroendocrine phenotype in castration resistant prostate cancer.
Journal Articles

Abstract 5059: Exome and targeted sequencing to discover and validate candidate genes in advanced and lethal prostate cancer

Akash Kumar, Alexandra P. MacKenzie, Brian J. O'Roak, Ilsa Coleman, Colm Morrissey, Choli Lee, Thomas A. White, Ruth F. Dumpit, Lawrence D. True, Eva Corey, Robert L. Vessella, Peter S. Nelson, Jay Shendure
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5059.
https://doi.org/10.1158/1538-7445.AM2012-5059
Published: 15 April 2012
View article titled, Abstract 5059: Exome and targeted sequencing to discover and validate candidate genes in advanced and lethal prostate cancer
Journal Articles

Abstract 5249: LuCaP prostate cancer xenografts: Models that allow clinically relevant investigation of prostate cancer in a preclinical setting

Holly M. Nguyen, Colm M. Morrissey, Peter S. Nelson, Xiaotun Zhang, Stephen R. Plymate, Celestia S. Higano, Paul H. Lange, Lawrence D. True, Martine PM Roudier, Robert L. Vessella, Eva Corey
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5249.
https://doi.org/10.1158/1538-7445.AM2012-5249
Published: 15 April 2012
View article titled, Abstract 5249: LuCaP prostate cancer xenografts: Models that allow clinically relevant investigation of prostate cancer in a preclinical setting
Journal Articles

Abstract 1532: The identification of osteoblastic and osteolytic factors in prostate cancer bone metastases

Xiaotun Zhang, Sandy Larson, Ruth Dumpit, Ilsa Coleman, Bryce Lakely, Martine Roudier, Celestia Higano, Lawrence D. True, Paul H. Lange, Peter S. Nelson, Eva Corey, Robert L. Vessella, Colm Morrissey
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1532.
https://doi.org/10.1158/1538-7445.AM2012-1532
Published: 15 April 2012
View article titled, Abstract 1532: The identification of osteoblastic and osteolytic factors in prostate cancer bone metastases
Journal Articles

Abstract 1583: The biological and molecular characterization of 24 unique prostate cancer xenograft lines, including responses to therapy

Holly M. Nguyen, Eva Corey, Colm Morrissey, Peter S. Nelson, Xiaotun Zhang, Stephen R. Plymate, Celestia S. Higano, Paul H. Lange, Martine P. Roudier, Lawrence D. True, Robert L. Vessella
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1583.
https://doi.org/10.1158/1538-7445.AM2011-1583
Published: 15 April 2011
View article titled, Abstract 1583: The biological and molecular characterization of 24 unique prostate cancer xenograft lines, including responses to therapy
Journal Articles

Variability in the Androgen Response of Prostate Epithelium to 5α-Reductase Inhibition: Implications for Prostate Cancer Chemoprevention

Elahe A. Mostaghel, Linda Geng, Ilona Holcomb, Ilsa M. Coleman, Jared Lucas, Lawrence D. True, Peter S. Nelson
Journal: Cancer Research
Cancer Res (2010) 70 (4): 1286–1295.
https://doi.org/10.1158/0008-5472.CAN-09-2509
Published: 14 February 2010
View article titled, Variability in the Androgen Response of Prostate Epithelium to 5α-Reductase Inhibition: Implications for Prostate Cancer Chemoprevention
Open the PDF for Variability in the Androgen Response of Prostate Epithelium to 5α-Reductase Inhibition: Implications for Prostate Cancer Chemoprevention in another window
Includes: Supplementary data
Journal Articles

Comparative Analyses of Chromosome Alterations in Soft-Tissue Metastases within and across Patients with Castration-Resistant Prostate Cancer

Ilona N. Holcomb, Janet M. Young, Ilsa M. Coleman, Keyan Salari, Douglas I. Grove, Li Hsu, Lawrence D. True, Martine P. Roudier, Colm M. Morrissey, Celestia S. Higano, Peter S. Nelson, Robert L. Vessella, Barbara J. Trask
Journal: Cancer Research
Cancer Res (2009) 69 (19): 7793–7802.
https://doi.org/10.1158/0008-5472.CAN-08-3810
Published: 01 October 2009
View article titled, Comparative Analyses of Chromosome Alterations in Soft-Tissue Metastases within and across Patients with Castration-Resistant Prostate Cancer
Open the PDF for Comparative Analyses of Chromosome Alterations in Soft-Tissue Metastases within and across Patients with Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Oncosome Formation in Prostate Cancer: Association with a Region of Frequent Chromosomal Deletion in Metastatic Disease

Dolores Di Vizio, Jayoung Kim, Martin H. Hager, Matteo Morello, Wei Yang, Christopher J. Lafargue, Lawrence D. True, Mark A. Rubin, Rosalyn M. Adam, Rameen Beroukhim, Francesca Demichelis, Michael R. Freeman
Journal: Cancer Research
Cancer Res (2009) 69 (13): 5601–5609.
https://doi.org/10.1158/0008-5472.CAN-08-3860
Published: 01 July 2009
View article titled, Oncosome Formation in Prostate Cancer: Association with a Region of Frequent Chromosomal Deletion in Metastatic Disease
Open the PDF for Oncosome Formation in Prostate Cancer: Association with a Region of Frequent Chromosomal Deletion in Metastatic Disease in another window
Includes: Multimedia, Supplementary data
Journal Articles

Genomic Alterations Indicate Tumor Origin and Varied Metastatic Potential of Disseminated Cells from Prostate Cancer Patients

Ilona N. Holcomb, Douglas I. Grove, Martin Kinnunen, Cynthia L. Friedman, Ian S. Gallaher, Todd M. Morgan, Cassandra L. Sather, Jeffrey J. Delrow, Peter S. Nelson, Paul H. Lange, William J. Ellis, Lawrence D. True, Janet M. Young, Li Hsu, Barbara J. Trask, Robert L. Vessella
Journal: Cancer Research
Cancer Res (2008) 68 (14): 5599–5608.
https://doi.org/10.1158/0008-5472.CAN-08-0812
Published: 15 July 2008
View article titled, Genomic Alterations Indicate Tumor Origin and Varied Metastatic Potential of Disseminated Cells from Prostate Cancer Patients
Open the PDF for Genomic Alterations Indicate Tumor Origin and Varied Metastatic Potential of Disseminated Cells from Prostate Cancer Patients in another window
Includes: Supplementary data
Journal Articles

Maintenance of Intratumoral Androgens in Metastatic Prostate Cancer: A Mechanism for Castration-Resistant Tumor Growth

R. Bruce Montgomery, Elahe A. Mostaghel, Robert Vessella, David L. Hess, Thomas F. Kalhorn, Celestia S. Higano, Lawrence D. True, Peter S. Nelson
Journal: Cancer Research
Cancer Res (2008) 68 (11): 4447–4454.
https://doi.org/10.1158/0008-5472.CAN-08-0249
Published: 02 June 2008
View article titled, Maintenance of Intratumoral Androgens in Metastatic Prostate Cancer: A Mechanism for Castration-Resistant Tumor Growth
Open the PDF for Maintenance of Intratumoral Androgens in Metastatic Prostate Cancer: A Mechanism for Castration-Resistant Tumor Growth in another window
Includes: Supplementary data