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Lawrence A. Loeb
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Journal Articles

Abstract 1776: Loss of estrogen receptor alters drug responsiveness and supports a basal-like phenotype in endocrine-resistant HER2+/ER+ breast cancer

Shaymaa Bahnassy, Hillary Stires, Lu Jin, Stanley Tam, Yasmin J. Dunn, Brendan F. Kohrn, Lawrence A. Loeb, Manasi Balachandran, Mircea Podar, Matthew D. McCoy, Robert A. Beckman, Rebecca B. Riggins
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1776.
https://doi.org/10.1158/1538-7445.AM2022-1776
Published: 15 June 2022
View article titled, Abstract 1776: Loss of estrogen receptor alters drug responsiveness and supports a basal-like phenotype in endocrine-resistant HER2+/ER+ breast cancer
Journal Articles

Abstract 3770: Unexpectedly high subclonal mutational diversity in human colorectal cancer and its significance

Robert A. Beckman, Brendan Kohrn, Kaitlyn Loubet-Senear, Jasmin Dunn, Jacintha OSullivan, Mary Bronner, Lawrence A. Loeb
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3770.
https://doi.org/10.1158/1538-7445.AM2019-3770
Published: 01 July 2019
View article titled, Abstract 3770: Unexpectedly high subclonal mutational diversity in human colorectal cancer and its significance
Journal Articles

Abstract 3377: Extensive subclonal mutations in human colorectal cancers detected by duplex sequencing

Lawrence A. Loeb, Kaitlyn J. Loubet-Senear, Brendan F. Kohrn, Michael W. Schmitt, Mary P. Bronner, Robert A. Beckman
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3377.
https://doi.org/10.1158/1538-7445.AM2018-3377
Published: 01 July 2018
View article titled, Abstract 3377: Extensive subclonal mutations in human colorectal cancers detected by duplex sequencing
Journal Articles

Abstract 2071: Sub-clonal heterogeneity and risk of treatment failure in Philadelphia-positive leukemias

Michael W. Schmitt, Justin R. Pritchard, Lan Beppu, J. Graeme Hodgson, Victor M. Rivera, Lawrence A. Loeb, Jerald P. Radich
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2071.
https://doi.org/10.1158/1538-7445.AM2017-2071
Published: 01 July 2017
View article titled, Abstract 2071: Sub-clonal heterogeneity and risk of treatment failure in Philadelphia-positive leukemias
Journal Articles

Abstract 3041: Duplex Sequencing detects cancer-associated mutations arising during normal aging: Clonal evolution over a century of human lifetime

Jesse J. Salk, Elisabeth Maritschnegg, Paul Speiser, Robert Zeillinger, Rosana Risques, Lawrence A. Loeb
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3041.
https://doi.org/10.1158/1538-7445.AM2017-3041
Published: 01 July 2017
View article titled, Abstract 3041: Duplex Sequencing detects cancer-associated mutations arising during normal aging: Clonal evolution over a century of human lifetime
Journal Articles

Abstract A08: Extensive subclonal mutations in human colorectal cancers detected by Duplex Sequencing

Edward John Paul Fox, Michael W. Schmitt, Kate S. Reid-Bayliss, Robert A. Beckman, Lawrence A. Loeb
Journal: Cancer Research
Cancer Res (2017) 77 (3_Supplement): A08.
https://doi.org/10.1158/1538-7445.CRC16-A08
Published: 31 January 2017
View article titled, Abstract A08: Extensive subclonal mutations in human colorectal cancers detected by Duplex Sequencing
Journal Articles

Richmond T. Prehn: In Memoriam (1922–2016)

Lawrence A. Loeb
Journal: Cancer Research
Cancer Res (2017) 77 (3): 593–594.
https://doi.org/10.1158/0008-5472.CAN-16-3328
Published: 31 January 2017
View article titled, Richmond T. Prehn: In Memoriam (1922–2016)
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Journal Articles

Decreased Mitochondrial Mutagenesis during Transformation of Human Breast Stem Cells into Tumorigenic Cells

Eun Hyun Ahn, Seung Hyuk Lee, Joon Yup Kim, Chia-Cheng Chang, Lawrence A. Loeb
Journal: Cancer Research
Cancer Res (2016) 76 (15): 4569–4578.
https://doi.org/10.1158/0008-5472.CAN-15-3462
Published: 31 July 2016
View article titled, Decreased Mitochondrial Mutagenesis during Transformation of Human Breast Stem Cells into Tumorigenic Cells
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Includes: Supplementary data
Journal Articles

Abstract LB-338: Extensive subclonal mutations in human colorectal cancers detected by duplex sequencing

Edward J.P. Fox, Michael W. Schmitt, Kate S. Reid-Bayliss, Robert A. Beckman, Lawrence A. Loeb
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-338.
https://doi.org/10.1158/1538-7445.AM2016-LB-338
Published: 15 July 2016
View article titled, Abstract LB-338: Extensive subclonal mutations in human colorectal cancers detected by duplex sequencing
Journal Articles

Abstract 2395: Direct assessment of sequence heterogeneity in human cancers by Duplex Sequencing

Michael W. Schmitt, Jesse J. Salk, Edward J. Fox, Justin R. Pritchard, J Graeme Hodgson, Victor M. Rivera, Pamela S. Becker, Jerald P. Radich, Lawrence A. Loeb
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2395.
https://doi.org/10.1158/1538-7445.AM2016-2395
Published: 15 July 2016
View article titled, Abstract 2395: Direct assessment of sequence heterogeneity in human cancers by Duplex Sequencing
Journal Articles

Human Cancers Express a Mutator Phenotype: Hypothesis, Origin, and Consequences

Lawrence A. Loeb
Journal: Cancer Research
Cancer Res (2016) 76 (8): 2057–2059.
https://doi.org/10.1158/0008-5472.CAN-16-0794
Published: 14 April 2016
View article titled, Human Cancers Express a Mutator Phenotype: Hypothesis, Origin, and Consequences
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Journal Articles

Tobacco Causes Human Cancers—A Concept Founded on Epidemiology and an Insightful Experiment Now Requires Translation Worldwide

Lawrence A. Loeb
Journal: Cancer Research
Cancer Res (2016) 76 (4): 765–766.
https://doi.org/10.1158/0008-5472.CAN-16-0149
Published: 14 February 2016
View article titled, Tobacco Causes Human Cancers—A Concept Founded on Epidemiology and an Insightful Experiment Now Requires Translation Worldwide
Open the PDF for Tobacco Causes Human Cancers—A Concept Founded on Epidemiology and an Insightful Experiment Now Requires Translation Worldwide in another window
Journal Articles

Abstract LB-283: Human cancers harbor extensive subclonal mutations

Michael W. Schmitt, Edward J. Fox, Marc J. Prindle, Kate S. Reid –Bayliss, Pamela S. Becker, Lawrence A. Loeb
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-283.
https://doi.org/10.1158/1538-7445.AM2015-LB-283
Published: 01 August 2015
View article titled, Abstract LB-283: Human cancers harbor extensive subclonal mutations
Journal Articles

Abstract 2846: Ultrasensitive detection of actionable subclones in chronic myeloid leukemia

Michael W. Schmitt, Bella Aminov, Jerald P. Radich, Lawrence A. Loeb
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2846.
https://doi.org/10.1158/1538-7445.AM2015-2846
Published: 01 August 2015
View article titled, Abstract 2846: Ultrasensitive detection of actionable subclones in chronic myeloid leukemia
Journal Articles

Abstract 4890: Duplex sequencing of AML reveals extensive sub clonal heterogeneity

Lawrence A. Loeb, Michael W. Schmitt, Mark J. Prindle, Pamela S. Becker
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4890.
https://doi.org/10.1158/1538-7445.AM2015-4890
Published: 01 August 2015
View article titled, Abstract 4890: Duplex sequencing of AML reveals extensive sub clonal heterogeneity
Journal Articles

Abstract 1789A: Duplex DNA sequencing detects subclonal and ultra-rare mutations in human tumors.

Lawrence A. Loeb, Edward J. Fox, Scott R. Kennedy, Jessica Kuong, Michael W. Schmitt, Jesse J. Salk
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1789A.
https://doi.org/10.1158/1538-7445.AM2013-1789A
Published: 15 April 2013
View article titled, Abstract 1789A: Duplex DNA sequencing detects subclonal and ultra-rare mutations in human tumors.
Journal Articles

Abstract 5493: Lethal mutagenesis of cancer cells by nucleoside analogs

Edward J. Fox, Jiang-Cheng Shen, Lawrence A. Loeb
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5493.
https://doi.org/10.1158/1538-7445.AM2011-5493
Published: 15 April 2011
View article titled, Abstract 5493: Lethal mutagenesis of cancer cells by nucleoside analogs
Journal Articles

Princess Takamatsu Symposium on DNA Repair and Human Cancers

Lawrence A. Loeb, Susumu Nishimura
Journal: Cancer Research
Cancer Res (2010) 70 (11): 4269–4273.
https://doi.org/10.1158/0008-5472.CAN-10-0320
Published: 01 June 2010
View article titled, Princess Takamatsu Symposium on DNA Repair and Human Cancers
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Journal Articles

Abstract 241: A mutant DNA polymerase-delta associated with increased tumor progression causes random deletions in DNA

Lawrence A. Loeb, Michael W. Schmitt, Ranga N. Venkatesan, Marie-Jeanne Pillaire, Jean-Se'bastien Hoffmann
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 241.
https://doi.org/10.1158/1538-7445.AM10-241
Published: 15 April 2010
View article titled, Abstract 241: A mutant DNA polymerase-delta associated with increased tumor progression causes random deletions in DNA
Journal Articles

Cancer Genome Sequencing—An Interim Analysis

Edward J. Fox, Jesse J. Salk, Lawrence A. Loeb
Journal: Cancer Research
Cancer Res (2009) 69 (12): 4948–4950.
https://doi.org/10.1158/0008-5472.CAN-09-1231
Published: 15 June 2009
View article titled, Cancer Genome Sequencing—An Interim Analysis
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