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Journal Articles

Abstract 5822: Targeting an immortalization mutation to control glioblastoma

Jayashree S. Iyer, Nanyun Tang, Shayesteh R. Ferdosi, Vijay Gokhale, Laurence H. Hurley, Harshil D. Dhruv, Michael E. Berens

Cancer Res (2020) 80 (16_Supplement): 5822.

https://doi.org/10.1158/1538-7445.AM2020-5822

Published: 15 August 2020

View article titled, Abstract 5822: Targeting an immortalization mutation to control glioblastoma

Journal Articles

Abstract B04: Direct downregulation of MYC in AML cells using promoter G-quadruplex interacting small molecules

Megan A. Turnidge, Daniel H. Wai, Apurvi Patel, Justin J. Montoya, David W. Lee, Laurence H. Hurley, Vijay Gokhale, Robert J. Arceci, David O. Azorsa

Cancer Res (2018) 78 (19_Supplement): B04.

https://doi.org/10.1158/1538-7445.PEDCA17-B04

Published: 01 October 2018

View article titled, Abstract B04: Direct downregulation of MYC in AML cells using promoter G-quadruplex interacting small molecules

Journal Articles

Abstract 4841: Prostate cancer cell death triggered by a small molecule interacting with the hTERT G-quadruplex

Jin H. Song, Libia A. Luevano, Hyunjin Kang, Vijay Gokhale, Laurence H. Hurley, Andrew S. Kraft

Cancer Res (2018) 78 (13_Supplement): 4841.

https://doi.org/10.1158/1538-7445.AM2018-4841

Published: 01 July 2018

View article titled, Abstract 4841: Prostate cancer cell death triggered by a small molecule interacting with the hTERT G-quadruplex

Journal Articles

Abstract 3389: Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma

Cancer Res (2017) 77 (13_Supplement): 3389.

https://doi.org/10.1158/1538-7445.AM2017-3389

Published: 01 July 2017

View article titled, Abstract 3389: Integrated genomic analyses reveal frequent <em>TERT</em> aberrations in acral melanoma

Journal Articles

Abstract 5230: Targeting two unique end-insertion G-quadruplexes formed in the 3′-end of the PDGFR-β core promoter nuclease hypersensitive element with ellipticine analog

Buket Onel, Prashansa Agrawal, Megan Carver, Laurence H. Hurley, Danzhou Yang

Cancer Res (2017) 77 (13_Supplement): 5230.

https://doi.org/10.1158/1538-7445.AM2017-5230

Published: 01 July 2017

View article titled, Abstract 5230: Targeting two unique end-insertion G-quadruplexes formed in the 3′-end of the PDGFR-β core promoter nuclease hypersensitive element with ellipticine analog

Journal Articles

Abstract 3766: Targeting promoter regions of c-Myc and Bcl-2 in AML cells using G-quadruplex interacting drugs

Megan Turnidge, Justin J. Montoya, Apurvi Patel, David W. Lee, Eiman Aleem, Daniel H. Wai, Laurence H. Hurley, Vijay Gokhale, Robert J. Arceci, David O. Azorsa

Cancer Res (2016) 76 (14_Supplement): 3766.

https://doi.org/10.1158/1538-7445.AM2016-3766

Published: 15 July 2016

View article titled, Abstract 3766: Targeting promoter regions of c-Myc and Bcl-2 in AML cells using G-quadruplex interacting drugs

Journal Articles

Abstract 1829: Small molecule stabilization of the kRAS promoter G-quadruplex as a target for novel pancreatic cancer therapeutics

Christine E. Kaiser, Vanessa C. Gaerig, Laurence H. Hurley, Tracy A. Brooks

Cancer Res (2012) 72 (8_Supplement): 1829.

https://doi.org/10.1158/1538-7445.AM2012-1829

Published: 15 April 2012

View article titled, Abstract 1829: Small molecule stabilization of the kRAS promoter G-quadruplex as a target for novel pancreatic cancer therapeutics

Journal Articles

Abstract 4422: Direct demonstration of c-MYC G-quadruplex stabilization in vitro: elucidating the CA46 system

Robert V. Brown, Laurence H. Hurley, Tracy A. Brooks

Cancer Res (2011) 71 (8_Supplement): 4422.

https://doi.org/10.1158/1538-7445.AM2011-4422

Published: 15 April 2011

View article titled, Abstract 4422: Direct demonstration of c-MYC G-quadruplex stabilization in vitro: elucidating the CA46 system

Journal Articles

Abstract #5467: Identification of a small molecule selectively lethal for SMAD4-/- cells using TRAP technology

Carolyn Ustach, Yu Zhao, Paul Beroza, Komath Damodaran, Seungchan Kim, Robert Dorr, Laurence H. Hurley, Daniel Von Hoff, Haiyong Han

Cancer Res (2009) 69 (9_Supplement): 5467.

Published: 01 May 2009

View article titled, Abstract #5467: Identification of a small molecule selectively lethal for SMAD4-/- cells using TRAP technology

Journal Articles

Dietary Administration of the Proapoptotic Vitamin E Analogue α-Tocopheryloxyacetic Acid Inhibits Metastatic Murine Breast Cancer

Tobias Hahn, Lajos Szabo, Mikhal Gold, Lalitha Ramanathapuram, Laurence H. Hurley, Emmanuel T. Akporiaye

Cancer Res (2006) 66 (19): 9374–9378.

https://doi.org/10.1158/0008-5472.CAN-06-2403

Published: 03 October 2006

View article titled, Dietary Administration of the Proapoptotic Vitamin E Analogue α-Tocopheryloxyacetic Acid Inhibits Metastatic Murine Breast Cancer

Journal Articles

Molecular cloning of the human PDGFR-β promoter and targeting the G-quadruplex-forming region to control gene expression

Yong Qin, Mary Guzman, Laurence H. Hurley

Cancer Res (2006) 66 (8_Supplement): 206.

Published: 15 April 2006

View article titled, Molecular cloning of the human PDGFR-β promoter and targeting the G-quadruplex-forming region to control gene expression

Journal Articles

In vitro footprinting of the promoter region of the human c-MYC proto-oncogene is consistent with the formation of i-motif and G-quadruplex structures in the coding and noncoding strands of the nuclease hypersensitivity element (NHE) III1 of the c-MYC promoter, respectively

Daekyu Sun, Jadrian Rusche, Laurence H. Hurley

Cancer Res (2006) 66 (8_Supplement): 211.

Published: 15 April 2006

View article titled, In vitro footprinting of the promoter region of the human c-MYC proto-oncogene is consistent with the formation of i-motif and G-quadruplex structures in the coding and noncoding strands of the nuclease hypersensitivity element (NHE) III1 of the c-MYC promoter, respectively

Journal Articles

The comparison of aurora A and aurora B as therapeutic targets using antisense oligonucleotides

Steven L. Warner, Ruben M. Munoz, Erich Koller, Laurence H. Hurley, Daniel D. Von Hoff, Haiyong Han

Cancer Res (2005) 65 (9_Supplement): 139.

Published: 01 May 2005

View article titled, The comparison of aurora A and aurora B as therapeutic targets using antisense oligonucleotides

Journal Articles

In vitro and in vivo footprinting of the promoter region of the human vascular endothelial growth factor gene is consistent with G-quadruplex formation

Kexiao Guo, Daekyu Sun, Jadrian J. Rusche, Laurence H. Hurley

Cancer Res (2005) 65 (9_Supplement): 1439.

Published: 01 May 2005

View article titled, In vitro and in vivo footprinting of the promoter region of the human vascular endothelial growth factor gene is consistent with G-quadruplex formation

Journal Articles

The dynamic secondary DNA structures in the G- and C-rich strands of the NHE III1 in the c-Myc promoter

Tiffanie J. Bialis, Denise Tye, Jeyaprakashnarayanan Seenisamy, Evonne M. Rezler, Jack Griffith, Vijay Gokhale, Daekyu Sun, Laurence H. Hurley

Cancer Res (2005) 65 (9_Supplement): 1141.

Published: 01 May 2005

View article titled, The dynamic secondary DNA structures in the G- and C-rich strands of the NHE III1 in the c-Myc promoter

Journal Articles

Design of CX-3543, a novel multi-targeting antitumor agent

William G. Rice, John K. C. Lim, Michael K. Schwaebe, Adam Siddiqui-Jain, Nicole H. Streiner, Katharine B. Trent, Jeffrey P. Whitten, Laurence H. Hurley, Daniel D. Von Hoff

Cancer Res (2005) 65 (9_Supplement): 594.

Published: 01 May 2005

View article titled, Design of CX-3543, a novel multi-targeting antitumor agent

Journal Articles

Evidence for G-quadruplex formation in the promoter region of the bcl-2 gene

Thomas S. Dexheimer, Laurence H. Hurley

Cancer Res (2005) 65 (9_Supplement): 353.

Published: 01 May 2005

View article titled, Evidence for G-quadruplex formation in the promoter region of the bcl-2 gene

Journal Articles

Formation of G-quadruplexes in the PDGF-A promoter and mechanism for silencing by the 5` silencer element

Yong Qin, Evonne M. Rezler, Daekyu Sun, Laurence H. Hurley

Cancer Res (2005) 65 (9_Supplement): 1087.

Published: 01 May 2005

View article titled, Formation of G-quadruplexes in the PDGF-A promoter and mechanism for silencing by the 5` silencer element

Journal Articles

Identification and development of novel inhibitors of urokinase type plasminogen activator (uPA).

Ming Zhu, Vijay Gokhale, Lajos Szabo, Hyoungee Baek, Sridevi Bashyam, Ruben Munoz, Laurence H. Hurley, Daniel D. Von Hoff, Haiyong Han

Cancer Res (2005) 65 (9_Supplement): 65.

Published: 01 May 2005

View article titled, Identification and development of novel inhibitors of urokinase type plasminogen activator (uPA).

Journal Articles

Characterization of the G-quadruplex structures formed by the G-rich strand of the proximal promoter region of the vascular endothelial growth factor gene

Daekyu Sun, Kexiao Guo, Jadrian J. Rusche, Laurence H. Hurley

Cancer Res (2005) 65 (9_Supplement): 882.

Published: 01 May 2005

View article titled, Characterization of the G-quadruplex structures formed by the G-rich strand of the proximal promoter region of the vascular endothelial growth factor gene

NARROW

Abstract 5822: Targeting an immortalization mutation to control glioblastoma

Abstract B04: Direct downregulation of MYC in AML cells using promoter G-quadruplex interacting small molecules

Abstract 4841: Prostate cancer cell death triggered by a small molecule interacting with the hTERT G-quadruplex

Abstract 3389: Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma

Abstract 5230: Targeting two unique end-insertion G-quadruplexes formed in the 3′-end of the PDGFR-β core promoter nuclease hypersensitive element with ellipticine analog

Abstract 3766: Targeting promoter regions of c-Myc and Bcl-2 in AML cells using G-quadruplex interacting drugs

Abstract 1829: Small molecule stabilization of the kRAS promoter G-quadruplex as a target for novel pancreatic cancer therapeutics

Abstract 4422: Direct demonstration of c-MYC G-quadruplex stabilization in vitro: elucidating the CA46 system

Abstract #5467: Identification of a small molecule selectively lethal for SMAD4-/- cells using TRAP technology

Dietary Administration of the Proapoptotic Vitamin E Analogue α-Tocopheryloxyacetic Acid Inhibits Metastatic Murine Breast Cancer

Molecular cloning of the human PDGFR-β promoter and targeting the G-quadruplex-forming region to control gene expression

In vitro footprinting of the promoter region of the human c-MYC proto-oncogene is consistent with the formation of i-motif and G-quadruplex structures in the coding and noncoding strands of the nuclease hypersensitivity element (NHE) III1 of the c-MYC promoter, respectively

The comparison of aurora A and aurora B as therapeutic targets using antisense oligonucleotides

In vitro and in vivo footprinting of the promoter region of the human vascular endothelial growth factor gene is consistent with G-quadruplex formation

The dynamic secondary DNA structures in the G- and C-rich strands of the NHE III1 in the c-Myc promoter

Design of CX-3543, a novel multi-targeting antitumor agent

Evidence for G-quadruplex formation in the promoter region of the bcl-2 gene

Formation of G-quadruplexes in the PDGF-A promoter and mechanism for silencing by the 5` silencer element

Identification and development of novel inhibitors of urokinase type plasminogen activator (uPA).

Characterization of the G-quadruplex structures formed by the G-rich strand of the proximal promoter region of the vascular endothelial growth factor gene

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