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Laura Soucek
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Journal Articles

Abstract 6386: Omomyc synergizes with PARP inhibition (PARPi) and reverts resistance to therapy in multiple PARPi-resistant triple-negative breast cancer models

Free
Fabio Giuntini, Andrea Herencia-Ropero, Íñigo González-Larreategui, Silvia Casacuberta-Serra, Sandra Martínez-Martín, Mariano F. Zacarías-Fluck, Hugo Thabussot, Laia Foradada, Erika Serrano, Judit Grueso, Sergio López-Estévez, Flaminia Pedretti, Olga Rodríguez, Marta Guzmán, Marie-Eve Beaulieu, Lara Nonell, Violeta Serra, Jonathan Richard Whitfield, Daniel Massó-Vallés, Laura Soucek
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6386.
https://doi.org/10.1158/1538-7445.AM2025-6386
Published: 21 April 2025
View articletitled, Abstract 6386: Omomyc synergizes with PARP inhibition (PARPi) and reverts resistance to therapy in multiple PARPi-resistant triple-negative breast cancer models
Journal Articles

Abstract 1487: MYC inhibition modulates DNA damage response and is capable of enhancing PARPi therapeutic impact

Free
Fabio Giuntini, Andrea Herencia-Ropero, Íñigo González-Larreategui, Silvia Casacuberta-Serra, Sandra Martínez-Martín, Mariano F. Zacarías-Fluck, Hugo Thabussot, Flaminia Pedretti, Laia Foradada, Erika Serrano, Judit Grueso, Sergio López-Estévez, Olga Rodríguez, Marta Guzmán, Adela Rodríguez-Hernández, Fara Brasó-Maristany, Marie-Eve Beaulieu, Lara Nonell, Violeta Serra, Aleix Prat, Jonathan Richard Whitfield, Daniel Massó-Vallés, Laura Soucek
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1487.
https://doi.org/10.1158/1538-7445.AM2025-1487
Published: 21 April 2025
View articletitled, Abstract 1487: MYC inhibition modulates DNA damage response and is capable of enhancing PARPi therapeutic impact
Journal Articles

Abstract 519: Targeting MYC as a novel therapeutic strategy for an epigenetic-driven cancer: NUT Carcinoma

Free
Carmen Escudero-Iriarte, Joel Castro, Iker Beniavides-Puy, Natalia S. Tissera, Jessica Querol-Paños, Irene Agustí, Jonathan R. Whitfield, Maria Vieito, Lara Nonell, Teresa Macarulla, Irene Braña, Laura Soucek, Tian V. Tian
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 519.
https://doi.org/10.1158/1538-7445.AM2024-519
Published: 22 March 2024
View articletitled, Abstract 519: Targeting MYC as a novel therapeutic strategy for an epigenetic-driven cancer: NUT Carcinoma
Journal Articles

Abstract 7166: Pharmacokinetic analysis of omomyc therapeutic protein in preclinical and human tumor tissue using targeted mass spectrometry

Free
Marie-Eve Beaulieu, Sandra Martinez-Martin, Maik Mueller, Yuehan Feng, Jakob Vowinckel, Antoine Amaury Lachaud, Laura Soucek
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7166.
https://doi.org/10.1158/1538-7445.AM2024-7166
Published: 22 March 2024
View articletitled, Abstract 7166: Pharmacokinetic analysis of omomyc therapeutic protein in preclinical and human tumor tissue using targeted mass spectrometry
Journal Articles

Abstract 3435: Identification of potential biomarkers of response to OMO-103, a first-in-modality pan-MYC inhibitor, in patients with advanced solid tumors

Free
Marie-Eve Beaulieu, Elena Garralda, Sílvia Casacuberta-Serra, Sandra Sandra Martínez-Martín, Emiliano Calvo, Víctor Moreno, Sergio López-Estévez, Laia Foradada, Guzman Alonso, Elena Corral, Bernard Doger, Tatiana Hernández, Judit Grueso, Íñigo Íñigo González-Larreategui, Erika Serrano del Pozo, Hugo Thabussot, Virginia Castillo Cano, Mariano F. Mariano F. Zacarías-Fluck, Jastrinjan Kaur, Fabio Giuntini, Jonathan R. Whitfield, Josefa Morales, Manuela Niewel, Laura Soucek
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3435.
https://doi.org/10.1158/1538-7445.AM2023-3435
Published: 04 April 2023
View articletitled, Abstract 3435: Identification of potential biomarkers of response to OMO-103, a first-in-modality pan-MYC inhibitor, in patients with advanced solid tumors
Journal Articles

Abstract 1823: Translating Myc inhibition to the clinic in metastatic breast cancer

Free
Daniel Massó-Vallés, Marie-Eve Beaulieu, Toni Jauset, Erika Serrano, Sandra Martínez-Martín, Laia Foradada, Virginia Castillo, Francisco Castillo, Génesis Martín, Sílvia Casacuberta-Serra, Mariano F. Zacarias-Fluck, Antonio Luque-García, Marta Escorihuela, Jonathan R. Whitfield, Joaquín Arribas, Laura Soucek
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1823.
https://doi.org/10.1158/1538-7445.AM2020-1823
Published: 15 August 2020
View articletitled, Abstract 1823: Translating Myc inhibition to the clinic in metastatic breast cancer
Journal Articles

Abstract 1685: The EurOPDX Research Infrastructure: Supporting European and worldwide cancer research with patient-derived xenografts

Free
Emilie Vinolo, Joaquin Arribas, Andrea Bertotti, Alejandra Bruna, Annette T. Byrne, Robert B. Clarke, Nathalie Conte, Steven de Jong, Didier Decaudin, Zdenka Dudova, Jos Jonkers, Daniela Krasser, Ales Krenek, Luisa Lanfrancone, Eleonora Leucci, Elisabetta Marangoni, Gunhild Mari Maelandsmo, Michaela Th. Mayrhofer, Terrence F. Meehan, Jens Henrik Norum, Hector G. Palmer, Alejandro Piris Gimenez, Leo Price, Sergio Roman-Roman, Francesca Sarno, Violeta Serra, Laura Soucek, Livio Trusolino, Marieke van de Ven, Luca Vezzadini, Alberto Villanueva, Andrea Wutte, Enzo Medico, on behalf of the EurOPDX Research Infrastructure
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1685.
https://doi.org/10.1158/1538-7445.AM2020-1685
Published: 15 August 2020
View articletitled, Abstract 1685: The EurOPDX Research Infrastructure: Supporting European and worldwide cancer research with patient-derived xenografts
Journal Articles

Epigenetic SMAD3 Repression in Tumor-Associated Fibroblasts Impairs Fibrosis and Response to the Antifibrotic Drug Nintedanib in Lung Squamous Cell Carcinoma

Available to Purchase
Rafael Ikemori, Marta Gabasa, Paula Duch, Miguel Vizoso, Paloma Bragado, Marselina Arshakyan, Iuliana-Cristiana Luis, Albert Marín, Sebastian Morán, Manuel Castro, Gemma Fuster, Sabrina Gea-Sorli, Toni Jauset, Laura Soucek, Luis M. Montuenga, Manel Esteller, Eduard Monsó, Victor Ivo Peinado, Pere Gascon, Cristina Fillat, Frank Hilberg, Noemí Reguart, Jordi Alcaraz
Journal: Cancer Research
Cancer Res (2020) 80 (2): 276–290.
https://doi.org/10.1158/0008-5472.CAN-19-0637
Published: 15 January 2020
View articletitled, Epigenetic SMAD3 Repression in Tumor-Associated Fibroblasts Impairs Fibrosis and Response to the Antifibrotic Drug Nintedanib in Lung Squamous Cell Carcinoma
Open the PDF for Epigenetic SMAD3 Repression in Tumor-Associated Fibroblasts Impairs Fibrosis and Response to the Antifibrotic Drug Nintedanib in Lung Squamous Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract LB-034: Myc instructs and maintains pancreatic adenocarcinoma phenotype

Free
Nicole M. Sodir, Roderik M. Kortlever, Valentin J.A. Barthet, Luca Pellegrinet, Tania Campos, Steven Kupczak, Laura Soucek, Mark J. Arends, Trevor D. Littlewood, Gerard I. Evan
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-034.
https://doi.org/10.1158/1538-7445.AM2019-LB-034
Published: 01 July 2019
View articletitled, Abstract LB-034: Myc instructs and maintains pancreatic adenocarcinoma phenotype
Journal Articles

Abstract 1225: Aberrant SMAD3 signaling in tumor-associated fibroblasts modulates fibrosis and response to the anti-fibrotic drug nintedanib in non-small cell lung cancer

Free
Rafael Ikemori, Marta Gabasa, Miguel Vizoso, Paula Duch, Sebastian Moran, Sabrina Gea-Sorli, Paloma Bragado, Toni Jauset, Manel Esteller, Laura Soucek, Eduard Monsó, Víctor Peinado, Cristina Fillat, Frank Hilberg, Noemí Reguart, Jordi Alcaraz
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1225.
https://doi.org/10.1158/1538-7445.AM2019-1225
Published: 01 July 2019
View articletitled, Abstract 1225: Aberrant SMAD3 signaling in tumor-associated fibroblasts modulates fibrosis and response to the anti-fibrotic drug nintedanib in non-small cell lung cancer
Journal Articles

Abstract 3351: Myc inhibition by Omomyc impairs melanoma growth and progression through genome-wide gene expression reprogramming

Free
Mariano F. Zacarias-Fluck, Génesis Martín, Daniel Massó-Vallés, Laia Foradada, Jonathan R. Whitfield, Marie-Eve Beaulieu, Laura Soucek
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3351.
https://doi.org/10.1158/1538-7445.AM2018-3351
Published: 01 July 2018
View articletitled, Abstract 3351: Myc inhibition by Omomyc impairs melanoma growth and progression through genome-wide gene expression reprogramming
Journal Articles

Abstract 3956: Omomyc-based cell-penetrating peptides: From proof of concept to a clinically viable anti-Myc therapy

Free
Marie-Eve Beaulieu, Toni Jauset, Daniel Massó-Vallés, Sandra Martínez-Martín, Peter Rahl, Löika Maltais, Mariano F. Zacarias-Fluck, Sílvia Casacuberta-Serra, Erika Serrano del Pozo, Christopher Fiore, Laia Foradada, Virginia Castillo Cano, Matthew Guenther, Eduardo Romero Sanza, Marta Oteo, Cynthia Tremblay Tremblay, Génesis Martín, Danny Letourneau, Martin Montagne, Miguel Ángel Morcillo Alonso, Jonathan R. Whitfield, Pierre Lavigne, Laura Soucek
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3956.
https://doi.org/10.1158/1538-7445.AM2018-3956
Published: 01 July 2018
View articletitled, Abstract 3956: Omomyc-based cell-penetrating peptides: From proof of concept to a clinically viable anti-Myc therapy
Journal Articles

Abstract 2167: Preclinical validation of an Omomyc cell-penetrating peptide as a viable anti-Myc therapy

Free
Marie-eve Beaulieu, Toni Jauset, Daniel Massó-Vallés, Peter Rahl, Sandra Martinez-Martin, Loika Maltais, Mariano F. Zacarias-Fluck, Silvia Casacuberta, Erika Serrano del Pozo, Christopher Fiore, Laia Foradada, Matthew Guenther, Eduardo Romero Sanz, Marta Oteo Vives, Cynthia Tremblay, Martin Montagne, Miguel Ángel Morcillo Alonso, Jonathan R. Whitfield, Pierre Lavigne, Laura Soucek
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2167.
https://doi.org/10.1158/1538-7445.AM2017-2167
Published: 01 July 2017
View articletitled, Abstract 2167: Preclinical validation of an Omomyc cell-penetrating peptide as a viable anti-Myc therapy
Journal Articles

Abstract 2923: Preclinical validation of Omomyc cell-penetrating peptides as a viable in vivo anti-Myc therapy

Free
LAURA SOUCEK.
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2923.
https://doi.org/10.1158/1538-7445.AM2016-2923
Published: 15 July 2016
View articletitled, Abstract 2923: Preclinical validation of Omomyc cell-penetrating peptides as a viable in vivo anti-Myc therapy
Journal Articles

Abstract 2645: Preclinical validation of Myc inhibition by a new generation of Omomyc-based inhibitors

Free
Marie-Eve Beaulieu, Toni Jauset, Daniel Massó-Vallés, Jonathan Whitfield, Erika Serrano, Martin Montagne, Pierre Lavigne, Antonio Villaverde, Mireia Pesarrodona, Esther Vazquez, Laura Soucek
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2645.
https://doi.org/10.1158/1538-7445.AM2015-2645
Published: 01 August 2015
View articletitled, Abstract 2645: Preclinical validation of Myc inhibition by a new generation of Omomyc-based inhibitors
Journal Articles

Abstract 396: Ibrutinib exerts potent antifibrotic activity in a mouse model of pancreatic adenocarcinoma

Free
Daniel Massó-Vallés, Toni Jauset, Erika Serrano, Nicole M. Sodir, Kim Pedersen, Nesrine I. Affara, Jonathan R. Whitfield, Marie-Eve Beaulieu, Gerard I. Evan, Laurence Elias, Joaquín Arribas, Laura Soucek
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 396.
https://doi.org/10.1158/1538-7445.AM2015-396
Published: 01 August 2015
View articletitled, Abstract 396: Ibrutinib exerts potent antifibrotic activity in a mouse model of pancreatic adenocarcinoma
Journal Articles

Abstract A52: Myc is required for maintenance of KRasG12D-driven pancreatic cancer and its associated microenvironment

Free
Nicole M. Sodir, Laura Soucek, Trevor D. Littlewood, Mark J. Arends, Gerard I. Evan
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): A52.
https://doi.org/10.1158/1538-7445.PANCA2014-A52
Published: 30 June 2015
View articletitled, Abstract A52: Myc is required for maintenance of KRasG12D-driven pancreatic cancer and its associated microenvironment
Journal Articles

Ibrutinib Exerts Potent Antifibrotic and Antitumor Activities in Mouse Models of Pancreatic Adenocarcinoma

Free
Daniel Massó-Vallés, Toni Jauset, Erika Serrano, Nicole M. Sodir, Kim Pedersen, Nesrine I. Affara, Jonathan R. Whitfield, Marie-Eve Beaulieu, Gerard I. Evan, Laurence Elias, Joaquín Arribas, Laura Soucek
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (8): 1675–1681.
https://doi.org/10.1158/0008-5472.CAN-14-2852
Published: 14 April 2015
View articletitled, Ibrutinib Exerts Potent Antifibrotic and Antitumor Activities in Mouse Models of Pancreatic Adenocarcinoma
Open the PDF for Ibrutinib Exerts Potent Antifibrotic and Antitumor Activities in Mouse Models of Pancreatic Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 1085: MYC inhibition is a potent therapy against glioma and induces mitotic crisis in cancer cells.

Free
Daniela Annibali, Jonathan R. Whitfield, Emilia Favuzzi, Toni Jauset, Erika serrano, Gerard Folch, Marta I. Cuartas, Alba Gonzalez, Lamorna Brown Swigart, Sergio Nasi, Gerard I. Evan, Joan Seoane, Laura Soucek
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1085.
https://doi.org/10.1158/1538-7445.AM2013-1085
Published: 15 April 2013
View articletitled, Abstract 1085: MYC inhibition is a potent therapy against glioma and induces mitotic crisis in cancer cells.
Journal Articles

Abstract 4956: Pharmacological inhibition of Bruton's Tyrosine Kinase (BTK) as a therapy for insulinoma and pancreatic ductal adenocarcinoma.

Free
Daniel Massó-Vallés, Erika Serrano, Jonathan R. Whitfield, Joseph J. Buggy, Nicole M. Sodir, Nesrine I. Affara, Lamorna Brown Swigart, Gerard I. Evan, Laura Soucek
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4956.
https://doi.org/10.1158/1538-7445.AM2013-4956
Published: 15 April 2013
View articletitled, Abstract 4956: Pharmacological inhibition of Bruton's Tyrosine Kinase (BTK) as a therapy for insulinoma and pancreatic ductal adenocarcinoma.