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Laura Sepp-Lorenzino
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Journal Articles

Abstract 2888: Lipid nanoparticle-mediated delivery of siRNA to extrahepatic tumors

Joseph P. Davide, Bruce Ng, Xianzhi Mao, Manishkumar Patel, Bin Shi, Jerome Hochman, James J. Cunningham, Laura Sepp-Lorenzino, Weikang Tao
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2888.
https://doi.org/10.1158/1538-7445.AM2012-2888
Published: 15 April 2012
View article titled, Abstract 2888: Lipid nanoparticle-mediated delivery of siRNA to extrahepatic tumors
Journal Articles

Abstract #4600: Chk1 inhibitors override the DNA damage checkpoint and enhance anti-tumor activity of irinotecan in p53-deficient tumor xenografts in mice

Joe Davide, Ron Diehl, Vicki South, Rob Lobell, Rob Garbaccio, Vadim Dudkin, Mark Fraley, Laura Sepp-Lorenzino, Weikang Tao
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4600.
Published: 01 May 2009
View article titled, Abstract #4600: Chk1 inhibitors override the DNA damage checkpoint and enhance anti-tumor activity of irinotecan in p53-deficient tumor xenografts in mice
Journal Articles

Inhibitors of the kinesin spindle protein induce senescence in primary epithelial cells while triggering apoptosis in primary hematopoietic progenitor cells

Yun Zhang, Vicki South, Rob Lobell, Nancy Kohl, Laura Sepp-Lorenzino, Mark Fraley, Kenneth Arrington, Weikang Tao
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2570.
Published: 01 May 2008
View article titled, Inhibitors of the kinesin spindle protein induce senescence in primary epithelial cells while triggering apoptosis in primary hematopoietic progenitor cells
Journal Articles

The tumor context-dependent mitotic catastrophe induced by a combination of doxorubicin and a Chk1 inhibitor exhibits features of apoptosis and does not engage the spindle checkpoint

Weikang Tao, Ron Diehl, Joe Davide, Laura Sepp-Lorenzino, Rob Garbaccio, Mark Fraley, Rob Lobell
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5384.
Published: 01 May 2007
View article titled, The tumor context-dependent mitotic catastrophe induced by a combination of doxorubicin and a Chk1 inhibitor exhibits features of apoptosis and does not engage the spindle checkpoint
Journal Articles

The induction of apoptosis by a KSP inhibitor is independent of p53

Weikang Tao, Vicki South, Laura Sepp-Lorenzino, Rob Lobell
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 487–488.
Published: 15 April 2006
View article titled, The induction of apoptosis by a KSP inhibitor is independent of p53
Journal Articles

The spindle assembly checkpoint in the induction of apoptosis by KSP inhibitors

Weikang Tao, Vicki South, Yun Zhang, Joe Davide, Nancy Kohl, Laura Sepp-Lorenzino, Rob Lobell
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 535.
Published: 01 May 2005
View article titled, The spindle assembly checkpoint in the induction of apoptosis by KSP inhibitors
Journal Articles

Pharmacodynamic evaluation of an indolyl quinolinone KDR/Flt-3 kinase inhibitor in normal healthy volunteers.

Stephen Beck, Aimee Dallob, Lenora Davis, Mary Flynn, Wesley Tanaka, Yih Lee, Yang Xu, Chau Thach, Kathryn Mazina, Inge De Lepeleire, Kristien Van Dyck, Anne Johnson, Qinwen Zeng, Bo-Sheng Pan, Kenneth Thomas, Jackson Gibbs, Howard Greenberg, Pierre Zachee, Steven Ramael, Keith Gottesdiener, Paul Deutsch, Nancy Kohl, Marian Iwamoto, Laura Sepp-Lorenzino
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 490.
Published: 01 April 2004
View article titled, Pharmacodynamic evaluation of an indolyl quinolinone KDR/Flt-3 kinase inhibitor in normal healthy volunteers.
Journal Articles

Anti-tumor and anti-metastatic effects of novel oral bioavailable KDR inhibitors in rat tumor models

Bin Shi, Susan Hill, Laura Schina, Rosemary McFall, Xianzhi Mao, Noelle P. Dahl, Cindy Spencer Bauer, Sandra Veggian, Ryan Desautels, Brad Smith, Jeannine Manzella, Jim Destefano, Totoe Kuffuor, Alan Savitz, Patricia Rebbeck, Lenora Davis, Jennifer Shipman, Yi Yang, James Hardwick, Seth Clark, Varaporn Treemaneekarn, Kenneth Thomas, Jackson Gibbs, Nancy Kohl, Laura Sepp-Lorenzino
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1053.
Published: 01 April 2004
View article titled, Anti-tumor and anti-metastatic effects of novel oral bioavailable KDR inhibitors in rat tumor models
Journal Articles

Identification of gene expression biomarkers to assess tumor endothelial cell proliferation.

James S. Hardwick, Yi Yang, Chunsheng Zhang, Bin Shi, Rosemary C. McFall, Elizabeth J. Koury, Susan L. Hill, Hongyue Dai, Robert Wasserman, Robert L. Phillips, Edward J. Weinstein, Nancy E. Kohl, Michael E. Severino, John R. Lamb, Laura Sepp-Lorenzino
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 751.
Published: 01 April 2004
View article titled, Identification of gene expression biomarkers to assess tumor endothelial cell proliferation.
Journal Articles

Novel Flt-3/KDR inhibitor is effective against activated Flt-3 and is cytotoxic against Flt-3-driven leukemias in vitro and in vivo

Stephen Beck, Lenora Davis, Jennifer Shipman, Laura Schina, Bin Shi, Kathleen Coll, Keith Rickert, Anne Johnson, Qinwen Zeng, Bo-Sheng Pan, Kenneth Thomas, Aimee Dallob, Mary Flynn, Wesley Tanaka, Maricel Torrent, Yih Lee, Kathryn Mazina, Sarah Liou, Dale Schaar, Malgorzata Wojtowicz, Paul Deutsch, Marian Iwamoto, Jackson Gibbs, Nancy Kohl, Laura Sepp-Lorenzino
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1301.
Published: 01 April 2004
View article titled, Novel Flt-3/KDR inhibitor is effective against activated Flt-3 and is cytotoxic against Flt-3-driven leukemias <em>in vitro</em> and <em>in vivo</em>
Journal Articles

A Novel Orally Bioavailable Inhibitor of Kinase Insert Domain-Containing Receptor Induces Antiangiogenic Effects and Prevents Tumor Growth in Vivo

Laura Sepp-Lorenzino, Elaine Rands, Xianzhi Mao, Brett Connolly, Jennifer Shipman, Joanne Antanavage, Susan Hill, Lenora Davis, Stephen Beck, Keith Rickert, Kathleen Coll, Patrice Ciecko, Mark Fraley, William Hoffman, George Hartman, David Heimbrook, Jackson Gibbs, Nancy Kohl, Kenneth Thomas
Journal: Cancer Research
Cancer Res (2004) 64 (2): 751–756.
https://doi.org/10.1158/0008-5472.CAN-03-2871
Published: 26 January 2004
View article titled, A Novel Orally Bioavailable Inhibitor of Kinase Insert Domain-Containing Receptor Induces Antiangiogenic Effects and Prevents Tumor Growth <em>in Vivo</em>
Open the PDF for A Novel Orally Bioavailable Inhibitor of Kinase Insert Domain-Containing Receptor Induces Antiangiogenic Effects and Prevents Tumor Growth <em>in Vivo</em> in another window
Journal Articles

Identification of a Geldanamycin Dimer That Induces the Selective Degradation of HER-Family Tyrosine Kinases

Fuzhong F. Zheng, Scott D. Kuduk, Gabriela Chiosis, Pamela N. Münster, Laura Sepp-Lorenzino, Samuel J. Danishefsky, Neal Rosen
Journal: Cancer Research
Cancer Res (2000) 60 (8): 2090–2094.
Published: 01 April 2000
View article titled, Identification of a Geldanamycin Dimer That Induces the Selective Degradation of HER-Family Tyrosine Kinases
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Journal Articles

A Peptidomimetic Inhibitor of Farnesyl:Protein Transferase Blocks the Anchorage-dependent and -independent Growth of Human Tumor Cell Lines

Laura Sepp-Lorenzino, Zhenping Ma, Elaine Rands, Nancy E. Kohl, Jackson B. Gibbs, Allen Oliff, Neal Rosen
Journal: Cancer Research
Cancer Res (1995) 55 (22): 5302–5309.
Published: 01 November 1995
View article titled, A Peptidomimetic Inhibitor of Farnesyl:Protein Transferase Blocks the Anchorage-dependent and -independent Growth of Human Tumor Cell Lines
Open the PDF for A Peptidomimetic Inhibitor of Farnesyl:Protein Transferase Blocks the Anchorage-dependent and -independent Growth of Human Tumor Cell Lines in another window