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Larry Witte
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Journal Articles

Abstract 572: A novel anti-PDL1 x anti-VEGFR2 bispecific antibody for enhanced antitumor immunity

Dan Lu, Zhanna Polonskaya, Haifan Zhang, Xenia Luna, Stella Martomo, Zhikai Zhang, Zhaojing Zhong, Yan Wu, Jeegar Patel, James Tonra, Larry Witte, Sam Waksal, Zhenping Zhu
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 572.
https://doi.org/10.1158/1538-7445.AM2016-572
Published: 15 July 2016
View article titled, Abstract 572: A novel anti-PDL1 x anti-VEGFR2 bispecific antibody for enhanced antitumor immunity
Journal Articles

Abstract 4997: Novel anti-PD-L1/IL-15 bifunctional immunotherapeutics potentiates antitumor immunity

Yan Wu, Zhaojing Zhong, Stella Martomo, Dan Lu, Haifan Zhang, Zhanna Polonskaya, Xenia Luna, Zhikai Zhang, Zhun Wang, Leo Liu, Jeegar Patel, James Tonra, Henry Li, Larry Witte, Sam Waksal, Zhenping Zhu
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4997.
https://doi.org/10.1158/1538-7445.AM2016-4997
Published: 15 July 2016
View article titled, Abstract 4997: Novel anti-PD-L1/IL-15 bifunctional immunotherapeutics potentiates antitumor immunity
Journal Articles

Abstract 2590: KD019: Blood brain barrier penetrant HER2/neu, Src, and EGFR inhibitor

James R. Tonra, Masha Poyurovsky, Kevin G. Liu, Jeegar Patel, Nishta Rao, Robert Tilton, John L. Ryan, Mark S. Berger, Larry Witte, Ji-In Kim, Samuel D. Waksal
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2590.
https://doi.org/10.1158/1538-7445.AM2015-2590
Published: 01 August 2015
View article titled, Abstract 2590: KD019: Blood brain barrier penetrant HER2/neu, Src, and EGFR inhibitor
Journal Articles

Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice

David Surguladze, Dhanvanthri Deevi, Nidia Claros, Erik Corcoran, Su Wang, Mary Jane Plym, Yan Wu, Jacqueline Doody, David J. Mauro, Larry Witte, Klaus J. Busam, Bronek Pytowski, Ulrich Rodeck, James R. Tonra
Journal: Cancer Research
Cancer Res (2009) 69 (14): 5643–5647.
https://doi.org/10.1158/0008-5472.CAN-09-0487
Published: 15 July 2009
View article titled, Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice
Open the PDF for Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice in another window
Includes: Supplementary data
Journal Articles

Abstract #5659: Anti-TGF beta receptor II antibody abrogates FoxP3+/TGF \#946; RII + Treg cells and enhances antitumor immunity against tumor growth and metastasis

Kyla Carroll, Zhaojing Zhong, Desiree Policarpio, Michael Gregory, Rajiv Bassi, Xenia Jimenez, Kris Persaud, Paul Balderes, Dale Ludwig, Larry Witte, Zhenping Zhu, Yan Wu
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5659.
Published: 01 May 2009
View article titled, Abstract #5659: Anti-TGF beta receptor II antibody abrogates FoxP3+/TGF \#946; RII + Treg cells and enhances antitumor immunity against tumor growth and metastasis
Journal Articles

Abstract #844: Anti-TGF beta receptor II antibody suppresses tumor growth and metastasis through inhibiting TGF beta autocrine stimulation of tumor cells and myeloid cells

Zhaojing Zhong, Desiree Policarpio, Kyla Carroll, Michael Gregory, Rajiv Bassi, Marie Prewette, Su Wang, Jim Tonra, Xenia Jimenez, Jackie Doody, Kris Persaud, Paul Balderes, Dale Ludwig, Larry Witte, Zhenping Zhu, Yan Wu
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 844.
Published: 01 May 2009
View article titled, Abstract #844: Anti-TGF beta receptor II antibody suppresses tumor growth and metastasis through inhibiting TGF beta autocrine stimulation of tumor cells and myeloid cells
Journal Articles

Abstract #2811: Ability of EGFR and IGF-IR antibodies to reduce HIF-1\#945; activity and VEGF production in tumors does not correlate with monotherapy efficacy, but may prevent escape from VEGFR2 targeted therapy

Dhanvanthri Deevi, Huiling Li, Erik Corcoran, Dale Ludwig, Zhenping Zhu, David Surguladze, Larry Witte, James Tonra
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2811.
Published: 01 May 2009
View article titled, Abstract #2811: Ability of EGFR and IGF-IR antibodies to reduce HIF-1\#945; activity and VEGF production in tumors does not correlate with monotherapy efficacy, but may prevent escape from VEGFR2 targeted therapy
Journal Articles

Abstract #833: TNF \#945; and IL-1 antagonists alleviate inflammatory skin changes associated with EGFR antibody therapy in mice

David Surguladze, Dhanvanthri Deevi, Su Wang, Nidia Claros, Mary Plym, Yan Wu, Jacqueline Doody, David Mauro, Larry Witte, Klaus Busam, Bronek Pytowski, Ulrich Rodeck, James Tonra
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 833.
Published: 01 May 2009
View article titled, Abstract #833: TNF \#945; and IL-1 antagonists alleviate inflammatory skin changes associated with EGFR antibody therapy in mice
Journal Articles

Vascular endothelial growth factor receptor 3 (VEGFR-3) is involved in tumor angiogenesis and growth

Pirjo Laakkonen, Marika Waltari, Tanja Holopainen, Bronislaw Pytowski, Philipp Steiner, Daniel Hicklin, Kris Persaud, James Tonra, Larry Witte, Kari Alitalo
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5740.
Published: 01 May 2007
View article titled, Vascular endothelial growth factor receptor 3 (VEGFR-3) is involved in tumor angiogenesis and growth
Journal Articles

Vascular Endothelial Growth Factor Receptor 3 Is Involved in Tumor Angiogenesis and Growth

Pirjo Laakkonen, Marika Waltari, Tanja Holopainen, Takashi Takahashi, Bronislaw Pytowski, Philipp Steiner, Daniel Hicklin, Kris Persaud, James R. Tonra, Larry Witte, Kari Alitalo
Journal: Cancer Research
Cancer Res (2007) 67 (2): 593–599.
https://doi.org/10.1158/0008-5472.CAN-06-3567
Published: 18 January 2007
View article titled, Vascular Endothelial Growth Factor Receptor 3 Is Involved in Tumor Angiogenesis and Growth
Open the PDF for Vascular Endothelial Growth Factor Receptor 3 Is Involved in Tumor Angiogenesis and Growth in another window
Includes: Supplementary data
Journal Articles

IMC-EB10, an Anti-FLT3 Monoclonal Antibody, Prolongs Survival and Reduces Nonobese Diabetic/Severe Combined Immunodeficient Engraftment of Some Acute Lymphoblastic Leukemia Cell Lines and Primary Leukemic Samples

Obdulio Piloto, Bao Nguyen, David Huso, Kyu-Tae Kim, Yiwen Li, Larry Witte, Daniel J. Hicklin, Patrick Brown, Donald Small
Journal: Cancer Research
Cancer Res (2006) 66 (9): 4843–4851.
https://doi.org/10.1158/0008-5472.CAN-06-0018
Published: 01 May 2006
View article titled, IMC-EB10, an Anti-FLT3 Monoclonal Antibody, Prolongs Survival and Reduces Nonobese Diabetic/Severe Combined Immunodeficient Engraftment of Some Acute Lymphoblastic Leukemia Cell Lines and Primary Leukemic Samples
Open the PDF for IMC-EB10, an Anti-FLT3 Monoclonal Antibody, Prolongs Survival and Reduces Nonobese Diabetic/Severe Combined Immunodeficient Engraftment of Some Acute Lymphoblastic Leukemia Cell Lines and Primary Leukemic Samples in another window
Journal Articles

Therapeutic implications of a human neutralizing antibody to the Macrophage-Stimulating Protein receptor tyrosine kinase (RON) that inhibits cancer cell signaling, migration and tumorigenesis

Jennifer M. O’Toole, Karen E. Rabenau, Kerri Burns, Yuan Cheng, Dan Lu, Venkat R. M. Mangalampalli, Paul Balderes, Marie C. Prewett, Zhenping Zhu, Dale L. Ludwig, Larry Witte, Daniel S. Pereira
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 876.
Published: 15 April 2006
View article titled, Therapeutic implications of a human neutralizing antibody to the Macrophage-Stimulating Protein receptor tyrosine kinase (RON) that inhibits cancer cell signaling, migration and tumorigenesis
Journal Articles

Suppression of leukemia growth in vivo by a novel anti-FLT3 antibody-auristatin conjugate

Yiwen Li, Hongli Li, Mei-Nai Wang, Rajiv Bassi, Venkat Mangalampalli, Dale L. Ludwig, Paul Balderes, Larry Witte, Zhenping Zhu, Damon Meyer, Angelyn Larkin, Peter Senter, Peter Bohlen, Daniel J. Hicklin
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1455.
Published: 01 May 2005
View article titled, Suppression of leukemia growth in vivo by a novel anti-FLT3 antibody-auristatin conjugate
Journal Articles

Enhanced anti-tumor activity with cetuximab (ERBITUX®) in combination with oxaliplatin in human colon carcinoma xenografts

Marie Prewett, James R. Tonra, Rajiv Bassi, Francine Carrick, Genevieve Makhoul, Bridget Finnerty, Larry Witte, Peter Bohlen, Daniel J. Hicklin
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1192.
Published: 01 May 2005
View article titled, Enhanced anti-tumor activity with cetuximab (ERBITUX®) in combination with oxaliplatin in human colon carcinoma xenografts
Journal Articles

Activity of small molecule inhibitors of the epidermal growth factor receptor (EGFR) kinase, on EGFR kinase domain mutants

Jacqueline Doody, Robin Rolser, Sheetal Patel, Cindy Wang, Cindy Chiang, Kun Hu, Leon Smith, Sabina Burdzovic-Wizmann, Larry Witte, Peter Bohlen, Daniel J. Hicklin, Paul Kussie, Yaron R. Hadari
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1250.
Published: 01 May 2005
View article titled, Activity of small molecule inhibitors of the epidermal growth factor receptor (EGFR) kinase, on EGFR kinase domain mutants
Journal Articles

Antibody against mouse platelet-derived growth factor β receptor suppresses growth of human ovarian tumor xenografts

Juqun Shen, Marie Vil, James Tonra, Haifan Zhang, Dhanvanthri Deevi, Bridget Finnerty, Paul Balderes, Venkat Mangalampalli, Anthony Kayas, Xenia Jimenez, Michelle Iacolina, Julie Yuen, Heather Griffith, Nick Loizos, Dale Ludwig, Larry Witte, Zhenping Zhu
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 127.
Published: 01 May 2005
View article titled, Antibody against mouse platelet-derived growth factor β receptor suppresses growth of human ovarian tumor xenografts
Journal Articles

Cell-based selection of internalizing antagonistic fully human antibodies directed against FLT3 for suppression of leukemia cell growth

Brent R. Williams, Amanda Atkins, Haifan Zhang, Dan Lu, Xenia Jimenez, Hongli Li, Mei-Nai Wang, Dale Ludwig, Paul Balderes, Larry Witte, Yiwen Li, Zhenping Zhu
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 129.
Published: 01 May 2005
View article titled, Cell-based selection of internalizing antagonistic fully human antibodies directed against FLT3 for suppression of leukemia cell growth
Journal Articles

Therapeutic implications of an antibody to the human macrophage-stimulating protein receptor tyrosine kinase (RON)

Daniel S. Pereira, Jennifer M. O’Toole, Karen E. Rabenau, Dan Lu, Venkat Mangalampalli, Henry Koo, Anthony Kayas, Julie P. Yuen, Paul Balderes, Nicole Covino, Rajiv Bassi, Andrea Hooper, Philipp Steiner, Xenia Jimenez, Zhenping Zhu, Dale L. Ludwig, Daniel J. Hicklin, Larry Witte
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 130–131.
Published: 01 May 2005
View article titled, Therapeutic implications of an antibody to the human macrophage-stimulating protein receptor tyrosine kinase (RON)
Journal Articles

Inhibitory activity of the anti-epidermal growth factor receptor (EGFR) antibody Erbitux® on EGFR kinase domain mutants

Jacqueline Doody, Cindy Wang, Sheetal Patel, Robin Rolser, Cindy Chiang, Kun Hu, Michelle Iacolina, Larry Witte, Peter Bohlen, Daniel J. Hicklin, Paul Kussie, Yaron R. Hadari
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1191–1192.
Published: 01 May 2005
View article titled, Inhibitory activity of the anti-epidermal growth factor receptor (EGFR) antibody Erbitux® on EGFR kinase domain mutants
Journal Articles

Inhibitory Anti-FLT3 Antibodies Are Capable of Mediating Antibody-Dependent Cell-Mediated Cytotoxicity and Reducing Engraftment of Acute Myelogenous Leukemia Blasts in Nonobese Diabetic/Severe Combined Immunodeficient Mice

Obdulio Piloto, Mark Levis, David Huso, Yiwen Li, Hongli Li, Mei-Nai Wang, Rajiv Bassi, Paul Balderes, Dale L. Ludwig, Larry Witte, Zhenping Zhu, Daniel J. Hicklin, Donald Small
Journal: Cancer Research
Cancer Res (2005) 65 (4): 1514–1522.
https://doi.org/10.1158/0008-5472.CAN-04-3081
Published: 25 February 2005
View article titled, Inhibitory Anti-FLT3 Antibodies Are Capable of Mediating Antibody-Dependent Cell-Mediated Cytotoxicity and Reducing Engraftment of Acute Myelogenous Leukemia Blasts in Nonobese Diabetic/Severe Combined Immunodeficient Mice
Open the PDF for Inhibitory Anti-FLT3 Antibodies Are Capable of Mediating Antibody-Dependent Cell-Mediated Cytotoxicity and Reducing Engraftment of Acute Myelogenous Leukemia Blasts in Nonobese Diabetic/Severe Combined Immunodeficient Mice in another window