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Journal Articles

Abstract 2922: Stoichiometric depletion of glutathione by anticancer agent JS-K.

Ryan J. Holland, Anna E. Maciag, Robert Y.-S. Cheng, Luis G. Rodriguez, Joseph E. Saavedra, Lucy M. Anderson, Larry K. Keefer

Cancer Res (2013) 73 (8_Supplement): 2922.

https://doi.org/10.1158/1538-7445.AM2013-2922

Published: 15 April 2013

View articletitled, Abstract 2922: Stoichiometric depletion of glutathione by anticancer agent JS-K.

Journal Articles

Abstract 3334: GSTP1-activated nitric oxide-releasing/PARP inhibitor hybrid prodrugs induce cancer cell death through ROS/RNS, DNA damage, ER stress, and apoptosis.

Anna E. Maciag, Joseph E. Saavedra, Ryan J. Holland, Youseung Kim, Vandana Kumari, Christina E. Luthers, Waheed S. Sehareen, Xinhua Ji, Lucy M. Anderson, Larry K. Keefer

Cancer Res (2013) 73 (8_Supplement): 3334.

https://doi.org/10.1158/1538-7445.AM2013-3334

Published: 15 April 2013

View articletitled, Abstract 3334: GSTP1-activated nitric oxide-releasing/PARP inhibitor hybrid prodrugs induce cancer cell death through ROS/RNS, DNA damage, ER stress, and apoptosis.

Journal Articles

Urinary Estrogens and Estrogen Metabolites and Subsequent Risk of Breast Cancer among Premenopausal Women

A. Heather Eliassen, Donna Spiegelman, Xia Xu, Larry K. Keefer, Timothy D. Veenstra, Robert L. Barbieri, Walter C. Willett, Susan E. Hankinson, Regina G. Ziegler

Cancer Res (2012) 72 (3): 696–706.

https://doi.org/10.1158/0008-5472.CAN-11-2507

Published: 31 January 2012

View articletitled, Urinary Estrogens and Estrogen Metabolites and Subsequent Risk of Breast Cancer among Premenopausal Women

Includes: Supplementary data

Journal Articles

Abstract 4392: Protein Interaction and Binding Studies of the Nitric Oxide-Generating Antineoplastic Agent JS-K

Imit Kaur, Ken M. Kosak, John C. Sweeley, Moises Terrazas, Joseph E. Saavedra, Larry K. Keefer, James N. Herron, Paul J. Shami

Cancer Res (2011) 71 (8_Supplement): 4392.

https://doi.org/10.1158/1538-7445.AM2011-4392

Published: 15 April 2011

View articletitled, Abstract 4392: Protein Interaction and Binding Studies of the Nitric Oxide-Generating Antineoplastic Agent JS-K

Journal Articles

Abstract 4547: Diazeniumdiolate-based nitric oxide-releasing prodrugs kill lung adenocarcinoma cells in culture and in vivo through alterations in cellular redox balance leading to mitochondrially-mediated apoptosis

Anna E. Maciag, Harinath Chakrapani, Ryan J. Holland, Nicole L. Morris, Paul J. Shami, Joseph E. Saavedra, Lucy M. Anderson, Larry K. Keefer

Cancer Res (2010) 70 (8_Supplement): 4547.

https://doi.org/10.1158/1538-7445.AM10-4547

Published: 15 April 2010

View articletitled, Abstract 4547: Diazeniumdiolate-based nitric oxide-releasing prodrugs kill lung adenocarcinoma cells in culture and in vivo through alterations in cellular redox balance leading to mitochondrially-mediated apoptosis

Journal Articles

Abstract 2662: Pharmacokinetics, metabolism and tissue distribution of the nitric oxide-donating prodrug JS-K following administration in liposomes

Sarah A. Buhrow, Joel M. Reid, Chad A. Walden, Lee Jia, Myrtle Davis, Larry K. Keefer, Heba Barazi, Matthew M. Ames

Cancer Res (2010) 70 (8_Supplement): 2662.

https://doi.org/10.1158/1538-7445.AM10-2662

Published: 15 April 2010

View articletitled, Abstract 2662: Pharmacokinetics, metabolism and tissue distribution of the nitric oxide-donating prodrug JS-K following administration in liposomes

Journal Articles

Abstract 2651: Cellular uptake and stability studies of the nitric oxide-generating pro-drug JS-K

Imit Kaur, Ken M. Kosak, Joseph E. Saavedra, Larry K. Keefer, Steven E. Kern, Paul J. Shami

Cancer Res (2010) 70 (8_Supplement): 2651.

https://doi.org/10.1158/1538-7445.AM10-2651

Published: 15 April 2010

View articletitled, Abstract 2651: Cellular uptake and stability studies of the nitric oxide-generating pro-drug JS-K

Journal Articles

JS-K, a GST-activated nitric oxide generator, induces DNA double strand breaks, activates DNA damage response pathways and induces apoptosis in human multiple myeloma cells

Tanyel Kiziltepe, Teru Hideshima, Kenji Ishitsuka, Noopur Raje, Chun-Qi Li, Laura J. Trudel, Hiroshi Yasui, Laurence Catley, Enrique M. Ocio, Yu-Tzu Tai, Dharminder Chauhan, Joseph E. Saavedra, Gerald N. Wogan, Larry K. Keefer, Paul J. Shami, Kenneth C. Anderson

Cancer Res (2006) 66 (8_Supplement): 579.

Published: 15 April 2006

View articletitled, JS-K, a GST-activated nitric oxide generator, induces DNA double strand breaks, activates DNA damage response pathways and induces apoptosis in human multiple myeloma cells

Journal Articles

Drug mediated oxidative or nitrosative stress induces glutathionylation of cellular proteins

Danyelle M. Townsend, Victoria J. Findlay, Laurent Gate, Joseph E. Saavedra, Larry K. Keefer, Kenneth D. Tew

Cancer Res (2005) 65 (9_Supplement): 1197.

Published: 01 May 2005

View articletitled, Drug mediated oxidative or nitrosative stress induces glutathionylation of cellular proteins

Journal Articles

PABA-NO, a nitric oxide releasing prodrug, is a potent inducer of protein glutathionylation

Danyelle M. Townsend, Farit Fazliyev, Victoria J. Findlay, Joseph E. Saavedra, Larry K. Keefer, Kenneth D. Tew

Cancer Res (2004) 64 (7_Supplement): 1226.

Published: 01 April 2004

View articletitled, PABA-NO, a nitric oxide releasing prodrug, is a potent inducer of protein glutathionylation

Journal Articles

In Vivo Radiation Protection by Nitric Oxide Modulation

James Liebmann, Anne Marie DeLuca, Deborah Coffin, Larry K. Keefer, David Venzon, David A. Wink, James B. Mitchell

Cancer Res (1994) 54 (13): 3365–3368.

Published: 01 July 1994

View articletitled, In Vivo Radiation Protection by Nitric Oxide Modulation

Journal Articles

Hypoxic Mammalian Cell Radiosensitization by Nitric Oxide

James B. Mitchell, David A. Wink, William DeGraff, Janet Gamson, Larry K. Keefer, Murali C. Krishna

Cancer Res (1993) 53 (24): 5845–5848.

Published: 01 December 1993

View articletitled, Hypoxic Mammalian Cell Radiosensitization by Nitric Oxide

Journal Articles

Nitric Oxide/Nucleophile Complexes Inhibit the in Vitro Proliferation of A375 Melanoma Cells via Nitric Oxide Release

Chris M. Maragos, Ji Ming Wang, Joseph A. Hrabie, Joost J. Oppenheim, Larry K. Keefer

Cancer Res (1993) 53 (3): 564–568.

Published: 01 February 1993

View articletitled, Nitric Oxide/Nucleophile Complexes Inhibit the in Vitro Proliferation of A375 Melanoma Cells via Nitric Oxide Release

Journal Articles

Metabolic Denitrosation of N-Nitrosodimethylamine in Vivo in the Rat

Anthony J. Streeter, Raymond W. Nims, Pamela R. Sheffels, Young-Hun Heur, Chung S. Yang, Bruce A. Mico, Charles T. Gombar, Larry K. Keefer

Cancer Res (1990) 50 (4): 1144–1150.

Published: 01 February 1990

View articletitled, Metabolic Denitrosation of N-Nitrosodimethylamine in Vivo in the Rat

Journal Articles

Sex Differences in the Single-Dose Toxicokinetics of N-Nitrosomethyl(2-hydroxyethyl)amine in the Rat

Anthony J. Streeter, Raymond W. Nims, Joseph A. Hrabie, Young-Hun Heur, Larry K. Keefer

Cancer Res (1989) 49 (7): 1783–1789.

Published: 01 April 1989

View articletitled, Sex Differences in the Single-Dose Toxicokinetics of N-Nitrosomethyl(2-hydroxyethyl)amine in the Rat

Journal Articles

Carcinogenicity of Deuterium-labeled 1,2-Dimethylhydrazine in Mice

Vladimir S. Turusov, Natalya S. Lanko, Yuri D. Parfenov, W. Perry Gordon, Sidney D. Nelson, Paul S. Hillery, Larry K. Keefer

Cancer Res (1988) 48 (8): 2162–2167.

Published: 01 April 1988

View articletitled, Carcinogenicity of Deuterium-labeled 1,2-Dimethylhydrazine in Mice

Journal Articles

Decontamination and Disposal of Nitrosoureas and Related N-Nitroso Compounds

George Lunn, Eric B. Sansone, A. W. Andrews, Larry K. Keefer

Cancer Res (1988) 48 (3): 522–526.

Published: 01 February 1988

View articletitled, Decontamination and Disposal of Nitrosoureas and Related N-Nitroso Compounds

Journal Articles

Deuterium Isotope Effect on Denitrosation and Demethylation of N-Nitrosodimethylamine by Rat Liver Microsomes

David Wade, Chung S. Yang, Climaco J. Metral, John M. Roman, Joseph A. Hrabie, Charles W. Riggs, Takako Anjo, Larry K. Keefer, Bruce A. Mico

Cancer Res (1987) 47 (13): 3373–3377.

Published: 01 July 1987

View articletitled, Deuterium Isotope Effect on Denitrosation and Demethylation of N-Nitrosodimethylamine by Rat Liver Microsomes

Journal Articles

Concurrent Generation of Methylamine and Nitrite during Denitrosation of N-Nitrosodimethylamine by Rat Liver Microsomes

Larry K. Keefer, Takako Anjo, David Wade, Tianyuan Wang, Chung S. Yang

Cancer Res (1987) 47 (2): 447–452.

Published: 01 January 1987

View articletitled, Concurrent Generation of Methylamine and Nitrite during Denitrosation of N-Nitrosodimethylamine by Rat Liver Microsomes

Journal Articles

Methylation versus Ethylation of DNA in Target and Nontarget Tissues of Fischer 344 Rats Treated with N-Nitrosomethylethylamine

Eric von Hofe, Friedrich Grahmann, Larry K. Keefer, William Lijinsky, Victor Nelson, Paul Kleihues

Cancer Res (1986) 46 (3): 1038–1042.

Published: 01 March 1986

View articletitled, Methylation versus Ethylation of DNA in Target and Nontarget Tissues of Fischer 344 Rats Treated with N-Nitrosomethylethylamine

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Abstract 2922: Stoichiometric depletion of glutathione by anticancer agent JS-K.

Abstract 3334: GSTP1-activated nitric oxide-releasing/PARP inhibitor hybrid prodrugs induce cancer cell death through ROS/RNS, DNA damage, ER stress, and apoptosis.

Urinary Estrogens and Estrogen Metabolites and Subsequent Risk of Breast Cancer among Premenopausal Women

Abstract 4392: Protein Interaction and Binding Studies of the Nitric Oxide-Generating Antineoplastic Agent JS-K

Abstract 4547: Diazeniumdiolate-based nitric oxide-releasing prodrugs kill lung adenocarcinoma cells in culture and in vivo through alterations in cellular redox balance leading to mitochondrially-mediated apoptosis

Abstract 2662: Pharmacokinetics, metabolism and tissue distribution of the nitric oxide-donating prodrug JS-K following administration in liposomes

Abstract 2651: Cellular uptake and stability studies of the nitric oxide-generating pro-drug JS-K

JS-K, a GST-activated nitric oxide generator, induces DNA double strand breaks, activates DNA damage response pathways and induces apoptosis in human multiple myeloma cells

Drug mediated oxidative or nitrosative stress induces glutathionylation of cellular proteins

PABA-NO, a nitric oxide releasing prodrug, is a potent inducer of protein glutathionylation

In Vivo Radiation Protection by Nitric Oxide Modulation

Hypoxic Mammalian Cell Radiosensitization by Nitric Oxide

Nitric Oxide/Nucleophile Complexes Inhibit the in Vitro Proliferation of A375 Melanoma Cells via Nitric Oxide Release

Metabolic Denitrosation of N-Nitrosodimethylamine in Vivo in the Rat

Sex Differences in the Single-Dose Toxicokinetics of N-Nitrosomethyl(2-hydroxyethyl)amine in the Rat

Carcinogenicity of Deuterium-labeled 1,2-Dimethylhydrazine in Mice

Decontamination and Disposal of Nitrosoureas and Related N-Nitroso Compounds

Deuterium Isotope Effect on Denitrosation and Demethylation of N-Nitrosodimethylamine by Rat Liver Microsomes

Concurrent Generation of Methylamine and Nitrite during Denitrosation of N-Nitrosodimethylamine by Rat Liver Microsomes

Methylation versus Ethylation of DNA in Target and Nontarget Tissues of Fischer 344 Rats Treated with N-Nitrosomethylethylamine

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