1-20 of 67
Larry H. Matherly
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Abstract 3785: ME-344, a novel isoflavone mitochondrial inhibitor, in combination with venetoclax constitutes a new metabolism-targeted approach to overcome resistance to Bcl-2 inhibition and standard of care treatment in AML

Katie H. Hurrish, Yongwei Su, Shraddha Patel, Sandra E. Wiley, Zhanjun Hou, Jenna Carter, Hasini Kalpage, Maik Hüttemann, Connie Weng, Holly Edwards, Lisa Polin, Jing Li, Jay Yang, Larry H. Matherly, Sergej Naumovich Konoplev, Jeffrey W. Taub, Marina Konopleva, Yubin Ge, Natalia Baran
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3785.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3785
Published: 15 June 2022
View article
Journal Articles

Abstract 2348: Targeting mitochondrial and cytosolic one-carbon metabolism in epithelial ovarian cancer via folate receptor alpha

Adrianne C. Wallace-Povirk, Carrie O'Connor, Xun Bao, Jade Katinas, Jennifer Wong-Roushar, Aamod Dekhne, Zhanjun Hou, Md. Junayed Nayeen, Khushbu Shah, Jose Cardiel Nunez, Jing Li, Seongho Kim, Lisa Polin, Charles E. Dann, Aleem Gangjee, Larry H. Matherly
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2348.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2348
Published: 01 July 2021
View article
Journal Articles

Abstract 811: Multi-targeted inhibitors of mitochondrial one-carbon metabolism and cytosolic de novo purine synthesis enzymes as anti-tumor agents

Md Junayed Nayeen, Khushbu Shah, Aamod Dekhne, Changwon Ning, Carrie O'Connor, Jade M. Katinas, Jennifer Wong, Zhanjun Hou, Charles E. Dann, III, Larry H. Matherly, Aleem Gangjee
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 811.
DOI: https://doi.org/10.1158/1538-7445.AM2019-811
Published: 01 July 2019
View article
Journal Articles

Abstract 789: Multi-targeted novel 5-substituted pyrrolo[3,2-d]pyrimidines with tumor-selective targeting and inhibition of cytosolic de novo purine biosynthesis and mitochondrial one-carbon metabolism

Nian Tong, Khushbu Shah, Aleem Gangjee, Carrie O’Connor, Adrianne W. Porvirk, Aamod Dekhne, Zhanjun Hou, Larry H. Matherly
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 789.
DOI: https://doi.org/10.1158/1538-7445.AM2019-789
Published: 01 July 2019
View article
Journal Articles

Abstract 4794: Targeting mitochondrial and cytosolic one carbon metabolism of pancreatic adenocarcinoma via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-d]pyrimidine analogs

Changwen Ning, Aamod Dekhne, Md. Junayed Nayeen, Jade M. Katinas, Jennifer Wong, Josephine Frühauf, Xun Bao, Carrie O’Connor, Adrianne Wallace-Povirk, Jing Li, Charles E. Dann, Aleem Gangjee, Larry H. Matherly, Zhanjun Hou
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4794.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4794
Published: 01 July 2019
View article
Journal Articles

Abstract 4791: Impact of folate transport redundancies on the therapy with tumor-targeted and untargeted antifolates

Zhanjun Hou, Carrie O’Connor, Changwen Ning, Adrianne Wallace-Povirk, Josephine Frühauf, Md. Junayed Nayeen, Aleem Gangjee, Larry H. Matherly
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4791.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4791
Published: 01 July 2019
View article
Journal Articles

Abstract 1656: First-in-class, fluorinated folate receptor specific agents that target tumor cells via inhibition of serine hydroxymethyltransferase 2 (SHMT2) and 5-aminoimidazole-4-carboxamide formyltransferase (AICARFTase)

Md Junayed Nayeen, Khushbu Shah, Aleem Gangjee, Aamod Dekhne, Zhanjun Hou, Larry H. Matherly
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1656.
DOI: https://doi.org/10.1158/1538-7445.AM2018-1656
Published: 01 July 2018
View article
Journal Articles

Abstract 3980: Dual targeting mitochondrial and cytosolic one-carbon metabolism via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-d]pyrimidine antifolates

Aamod S. Dekhne, Gregory S. Ducker, Josephine Frühauf, Khushbu Shah, Md. Junayed Nayeen, Adrianne Wallace-Povirk, Carrie O'Connor, Zhanjun Hou, Lisa Polin, Aleem Gangjee, Joshua D. Rabinowitz, Larry H. Matherly
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3980.
DOI: https://doi.org/10.1158/1538-7445.AM2018-3980
Published: 01 July 2018
View article
Journal Articles

Abstract 5123: Targeted thieno[2,3-d]pyrimidines with fluorinated phenyl side chains as antitumor agents

Nian Tong, Aleem Gangjee, Adrianne Wallace Povrik, Carrie O’Connor, Aamod Aamod Dekhneb, Zhanjun Hou, Larry H. Matherly
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5123.
DOI: https://doi.org/10.1158/1538-7445.AM2017-5123
Published: 01 July 2017
View article
Journal Articles

Abstract 5491: Identification of transcriptional controls responsible for differential gene expression of the proton-coupled folate transporter in human solid tumors

Zhanjun Hou, Carrie O'Connor, Steve Orr, Larry H. Matherly
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5491.
DOI: https://doi.org/10.1158/1538-7445.AM2017-5491
Published: 01 July 2017
View article
Journal Articles

Abstract 3239: Selective tumor targeting with 5-substituted pyrrolo[2,3-d]pyrimidines with heteroatom bridge substitution

Aleem Gangjee, Rishabh Mohan, Manasa Ravindra, Adrianne Wallace-Povirk, Carrie O’Connor, Aamod Dekhne, Zhanjun Hou, Larry H. Matherly
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3239.
DOI: https://doi.org/10.1158/1538-7445.AM2017-3239
Published: 01 July 2017
View article
Journal Articles

Abstract 1362: Novel proton coupled folate transporter (PCFT) and reduced folate carrier (RFC) pharmacophore models for development of transporter-selective antifolates

Sudhir Raghavan, Aleem Gangjee, Larry H. Matherly
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1362.
DOI: https://doi.org/10.1158/1538-7445.AM2016-1362
Published: 15 July 2016
View article
Journal Articles

Abstract 1359: Design, synthesis and evaluation of fluorinated antifolates for improved selectivity and potency against tumor cells

Aleem Gangjee, Manasa P. Ravindra, Mike R. Wilson, Adrianne W. Povrik, Lisa P. Hou, Carrie O’Connor, Zhanjun Hou, Larry H. Matherly
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1359.
DOI: https://doi.org/10.1158/1538-7445.AM2016-1359
Published: 15 July 2016
View article
Journal Articles

Abstract 1365: Pseudo-cis and pseudo-trans amide conformations lead to potent targeted antifolates that are selectively transported by FR over RFC

Aleem Gangjee, Weiguo Xiang, Aamod Dehkne, Mike R. Wilson, Adrianne Wallace-Povrik, Carrie O’Connor, Zhanjun Hou, Larry H. Matherly
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1365.
DOI: https://doi.org/10.1158/1538-7445.AM2016-1365
Published: 15 July 2016
View article
Journal Articles

Abstract 4836: Targeted antifolates with thienoyl regioisomers in the side chain result in improved selectivity and potency against KB human tumor cells

Aleem Gangjee, Nian Tong, Adrianne Wallace Povrik, Zhanjun Hou, Larry H. Matherly
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4836.
DOI: https://doi.org/10.1158/1538-7445.AM2016-4836
Published: 15 July 2016
View article
Journal Articles

Abstract 4791: Targeting ovarian cancer with novel 6-substituted pyrrolo [2,3-d] pyrimidine fluorinated antifolates via cellular uptake by folate receptor á and the proton-coupled folate transporter

Mike R. Wilson, Manasa P. Ravindraa, Adrianne Wallace-Povirk, Lisa Polin, Zhanjun Hou, Aleem Gangjee, Larry H. Matherly
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4791.
DOI: https://doi.org/10.1158/1538-7445.AM2016-4791
Published: 15 July 2016
View article
Journal Articles

Abstract 4393: Design and synthesis of novel conjugates for targeting the folate receptor: Exploiting cytotoxic GARFTase inhibitors for delivering additional chemotherapeutic payloads to cancer cells

Iontcho R. Vlahov, Fei You, Hanna F. Klein, Paul J. Kleindl, Melissa Nelson, Marilynn Vetzel, Joseph A. Reddy, Christopher P. Leamon, Larry H. Matherly, Aleem Gangjee
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4393.
DOI: https://doi.org/10.1158/1538-7445.AM2015-4393
Published: 01 August 2015
View article
Journal Articles

Abstract 4488: Folate receptor targeted therapy using small molecule drug conjugates constructed with high affinity antifolate ligands

Christopher P. Leamon, Joseph A. Reddy, Iontcho R. Vlahov, Fei You, Hanna F. Klein, Paul J. Kleindl, Melissa Nelson, Marilynn Vetzel, Patrick J. Klein, Larry H. Matherly, Aleem Gangjee
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4488.
DOI: https://doi.org/10.1158/1538-7445.AM2015-4488
Published: 01 August 2015
View article
Journal Articles

Abstract 4483: Impact of loss of folate receptor alpha on antitumor effects of novel 6-substituted pyrrolo[2,3-d]pyrimidine antifolates with substrate activities for both folate receptors and the proton-coupled folate transporter

Zhanjun Hou, Steve Orr, Christina George, Adrianne Wallace, Larry H. Matherly, Lei Wang, Si Yang, Aleem Gandjee
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4483.
DOI: https://doi.org/10.1158/1538-7445.AM2015-4483
Published: 01 August 2015
View article
Journal Articles

Abstract 4481: Tumor-targeting with novel 6-substituted thienoyl[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α, and inhibition of de novo purine nucleotide biosynthesis

Larry H. Matherly, Xin Zhang, Adrianne Wallace, Zhanjun Hou, Christina George, Xilin Zhou, Aleem Gangjee
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4481.
DOI: https://doi.org/10.1158/1538-7445.AM2015-4481
Published: 01 August 2015
View article