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Journal Articles

Comprehensive Analysis of Metabolic Isozyme Targets in Cancer

Michal Marczyk, Vignesh Gunasekharan, David Casadevall, Tao Qing, Julia Foldi, Raghav Sehgal, Naing Lin Shan, Kim R.M. Blenman, Tess A. O'Meara, Sheila Umlauf, Yulia V. Surovtseva, Viswanathan Muthusamy, Jesse Rinehart, Rachel J. Perry, Richard Kibbey, Christos Hatzis, Lajos Pusztai
Journal: Cancer Research
Cancer Res (2022) 82 (9): 1698–1711.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-3983
Published: 03 May 2022
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Includes: Supplementary data
Journal Articles

Abstract P3-07-01: Young women with breast cancer and high risk family history but no high penetrance germline mutations have a higher load of rare high functional impact germline variants in cancer relevant genes

Mariya Rozenblit, Tao Qing, Yixuan Ye, Hongyu Zhao, Erin Hofstatter, Vinit Singh, Emily Reisenbichler, Michael Murray, Lajos Pusztai
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-07-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-07-01
Published: 15 February 2022
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Journal Articles

Abstract P5-08-16: MTAP deletion and synthetic lethality-based drug development for metastatic breast cancer (MBC)

Lajos Pusztai, Natalie Danziger, Ethan S Sokol, Dean C Pavlick, Ryon Graf, Shakti Ramkissoon, Richard SP Huang, Brennan J Decker, Jeffrey S Ross
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-08-16.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P5-08-16
Published: 15 February 2022
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Journal Articles

Abstract P5-17-01: Targeting Acetyl-CoA carboxylase in pre-clinical breast cancer models

Julia Foldi, Michal Marczyk, Vignesh Gunasekharan, Tao Qing, Raghav Sehgal, Naing Lin Shan, Viswanathan Muthusamy, Sheila Umlau, Yulia V. Surovtseva, Richard Kibbey, Lajos Pusztai
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-17-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P5-17-01
Published: 15 February 2022
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Journal Articles

Abstract PD10-07: Chemokine12 (CK12) tertiary lymphoid gene expression signature as a predictor of response in 3 immunotherapy arms of the neoadjuvant ISPY 2 TRIAL - pembrolizumab with and without SD101, and durvalumab combined with olaparib - and in 9 other arms of the trial including platinum-based and dual-anti-HER2 therapies

Hatem Soliman, Denise Wolf, Jo Chien, Christina Yau, Michael Campbell, Mark Magbanua, Ruixiao Lu, Nicholas O'Grady, Lamorna Brown-Swigart, Gillian Hirst, Beverly Parker, Laura Sit, Smita Asare, Doug Yee, Angie DeMichele, Rita Nanda, Lajos Pusztai, Don Berry, Laura Esserman, Laura Van't Veer
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD10-07.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD10-07
Published: 15 February 2022
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Journal Articles

Abstract GS4-02: Analysis of clinical outcomes and expression-based immune signatures by race in the I-SPY 2 trial

Beverly Kyalwazi, Christina Yau, Olufunmilayo Olopade, A. Jo Chien, Anne Wallace, Andres Forero-Torres, Lajos Pusztai, Erin Ellis, Kathy Albain, Anne Blaes, Barbara Haley, Judy Boughey, Anthony Elias, Amy Clark, Claudine Isaacs, Rita Nanda, Hyo Han, Rachel Yung, Debu Tripathy, Kristen Edmiston, Rebecca Viscusi, Donald Northfelt, Qamar Khan, Ashish Sanil, Scott Berry, Smita Asare, Amy Wilson, Gillian Hirst, Nola Hylton, Michelle Melisko, Jane Perlmutter, Hope Rugo, Fraser Symmans, Laura van ‘t Veer, Donald Berry, Laura Esserman
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): GS4-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-GS4-02
Published: 15 February 2022
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Journal Articles

Abstract GS2-07: Updated results from a phase 3 randomized clinical trial in participants (pts) with 1-3 positive lymph nodes (LN), hormone receptor-positive (HR+) and HER2-negative (HER2-) breast cancer (BC) with recurrence score (RS) ≤ 25 randomized to endocrine therapy (ET) +/- chemotherapy (CT): SWOG S1007 (RxPONDER)

Kevin M Kalinsky, William E Barlow, Julie R Gralow, Funda Meric-Bernstam, Kathy S Albain, Daniel F Hayes, Nancy U Lin, Edith A Perez, Lori A Goldstein, Stephen KL Chia, Sukhbinder Dhesy-Thind, Priya Rastogi, Emilio Alba, Suzette Delaloge, Miguel Martin, Catherine M Kelly, Manuel Ruiz-Borrego, Miguel Gil-Gil, Claudia H Arce-Salinas, Etienne GC Brain, Eun Sook Lee, Jean-Yves Pierga, Begoña Bermejo, Manuel Ramos-Vasquez, Kyung Hae Jung, Jean-Marc Ferrero, Anne Schott, Steven Shak, Priyanka Sharma, Danika Lew, Jieling Miao, Debasish Tripathy, Lajos Pusztai, Gabriel Hortobagyi
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): GS2-07.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-GS2-07
Published: 15 February 2022
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Journal Articles

Abstract OT1-12-04: A phase 3, open-label trial of neoadjuvant trastuzumab deruxtecan (T-DXd) monotherapy or T-DXd followed by THP compared with ddAC-THP in patients with high-risk HER2-positive early-stage breast cancer (DESTINY-Breast11)

Nadia Harbeck, Jean-François Boileau, Shanu Modi, Catherine M Kelly, Shinji Ohno, Jiong Wu, Mark Brekenridge, Pia Herbolsheimer, Tinghui Yu, Lajos Pusztai
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): OT1-12-04.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-OT1-12-04
Published: 15 February 2022
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Journal Articles

Abstract P1-02-02: Examination of low Her2 expression in breast cancer

Aileen I Fernandez, Matthew Liu, Andrew Bellizzi, Jane Brock, Oluwole Fadare, Krisztina Hanley, Malini Harigopal, Julie M. Jorns, M. Gabriela Kuba, Amy Ly, Mirna Podoll, Kimmie Rabe, Mary Ann Sanders, Kamaljeet Singh, Olivia L Snir, Rinda Soong, Shi Wei, Hannah Wen, Serena Wong, Esther Yoon, Lajos Pusztai, Emily Reisenbichler, David L. Rimm
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P1-02-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P1-02-02
Published: 15 February 2022
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Journal Articles

Abstract P1-05-02: Intratumor molecular tumor heterogeneity in low ER-expressing primary breast tumors

Julia Foldi, Emily Reisenbichler, Liuliu Pan, Krsitina Sorg, Sarah E. Church, Lajos Pusztai
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P1-05-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P1-05-02
Published: 15 February 2022
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Journal Articles

Abstract GS1-01: KEYNOTE-522 study of neoadjuvant pembrolizumab + chemotherapy vs placebo + chemotherapy, followed by adjuvant pembrolizumab vs placebo for early-stage TNBC: Event-free survival sensitivity and subgroup analyses

Peter Schmid, Javier Cortes, Rebecca Dent, Lajos Pusztai, Heather McArthur, Sherko Kümmel, Jonas Bergh, Carsten Denkert, Yeon Hee Park, Rina Hui, Nadia Harbeck, Masato Takahashi, Michael Untch, Peter A. Fasching, Fatima Cardoso, Jay Andersen, Debra Patt, Michael Danso, Marta Ferreira, Marie-Ange Mouret-Reynier, Seock-Ah Im, Jin-Hee Ahn, Maria Gion, Sally Baron-Hay, Jean-Francois Boileau, Yalin Zhu, Wilbur Pan, Konstantinos Tryfonidis, Vassiliki Karantza, Joyce O’Shaughnessy
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): GS1-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-GS1-01
Published: 15 February 2022
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Journal Articles

Abstract PD5-05: Impact of anti-HER2 therapy alone and in association with weekly paclitaxel on the ovarian reserve of young women with HER2-positive early breast cancer: Biomarker analysis of the NeoALTTO trial

Matteo Lambertini, Marcello Ceppi, Richard A. Anderson, David A. Cameron, Marco Bruzzone, Maria Alice Franzoi, Claudia Massarotti, Sarra El-Abed, Yingbo Wang, Christophe Lecocq, Paolo Nuciforo, Rebecca Rolyance, Lajos Pusztai, Joohyuk Sohn, Jacopo Ligato, Maria Maddalena Latocca, Luca Arecco, Barbara Pistilli, Kathryn J. Ruddy, Alberto Ballestrero, Lucia Del Mastro, Fedro A. Peccatori, Ann H. Partridge, Cristina Saura, Michael Untch, Martine Piccart, Serena Di Cosimo, Evandro de Azambuja, Isabelle Demeestere
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD5-05.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD5-05
Published: 15 February 2022
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Journal Articles

Abstract PD9-06: Evaluation of the predicted sensitivity to endocrine therapy (SET2,3 index) and the 21-gene Breast Recurrence Score® assay in node-positive postmenopausal breast cancer: Results from an analysis in the SWOG S8814 trial

Corey W. Speers, W. Fraser Symmans, William E. Barlow, Alex Trevarton, Stephanie The, Lili Du, James M. Rae, Steven Shak, Frederick L. Baehner, Priyanka Sharma, Lajos Pusztai, Gabriel N. Hortobagyi, Daneil F Hayes, Kathy S. Albain, Andrew Godwin, Alastair Thompson
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD9-06.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD9-06
Published: 15 February 2022
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Journal Articles

Abstract P2-08-03: PD-L1 protein expression in relation to Recurrence Score values in early stage ER+HER2- breast cancer

Kim RM Blenman, Malini Harigopal, Richard Huang, Emily Reisenbichler, Tao Qing, Eiman Ibrahim, Kamaljeet Singh, Shakti Ramkissoon, Roberts Mustimbo, Jeffrey Ross, Lajos Pusztai
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-08-03.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P2-08-03
Published: 15 February 2022
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Journal Articles

Abstract 339: Resistance to trastuzumab is associated with alpha-smooth muscle actin expression in the stroma of patients with HER2+ breast cancer

Ioannis A. Vathiotis, Myrto K. Moutafi, Prajan Divakar, Thazin Nwe Aung, Aileen Fernandez, Vesal Yaghoobi, Saba Shafi, Konstantinos N. Syrigos, George Fountzilas, Lajos Pusztai, Sarah Warren, David L. Rimm
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 339.
DOI: https://doi.org/10.1158/1538-7445.AM2021-339
Published: 01 July 2021
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Journal Articles

Abstract 423: Pooled analysis of matching score and patient outcome in I-PREDICT and WINTHER studies

David Casadevall, Michal Marczyk, Xavier Monzonis, Lajos Pusztai, Joan Albanell
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 423.
DOI: https://doi.org/10.1158/1538-7445.AM2021-423
Published: 01 July 2021
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Journal Articles

Abstract PS2-04: Evaluating serum thymidine kinase 1 in hormone receptor positive metastatic breast cancer patients receiving first line endocrine therapy in the SWOG S0226 trial

Costanza Paoletti, William E. Barlow, Mattias Bergqvist, Rita S. Mehta, Julie R. Gralow, Gabriel N. Hortobagyi, Kathy S. Albain, Lajos Pusztai, Priyanka Sharma, Andrew K. Godwin, Alastair M. Thompson, Daniel F. Hayes, James Rae
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS2-04.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS2-04
Published: 15 February 2021
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Journal Articles

Abstract PS5-08: Comparison of PD-L1 protein expression between primary tumors and metastatic lesions in triple negative breast cancers

Mariya Rozenblit, Richard Huang, Natalie Danziger, Brian Alexander, Shakti Ramkissoon, Kim Blenman, Jeffrey Ross, David Rimm, Lajos Pusztai
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS5-08.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS5-08
Published: 15 February 2021
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Journal Articles

Abstract OT-03-03: SGNLVA-001: A phase 1 open-label dose escalation and expansion study of SGN-LIV1A administered weekly in breast cancer

Heather C Beckwith, Diana C Medgyesy, Jame Abraham, Rita Nanda, Katherine HR Tkaczuk, Ian E Krop, Lajos Pusztai, Shanu Modi, Monica M Mita, Jennifer M Specht, Sara A Hurvitz, Hyo S Han, Kevin Kalinsky, Sharon Wilks, Joyce O’Shaughnessy, Lowell L Hart, Hope S Rugo, Zahi I Mitri, Phillip M Garfin, Howard A Burris, III
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): OT-03-03.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-OT-03-03
Published: 15 February 2021
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Journal Articles

Abstract GS4-07: Assessing prognosis after neoadjuvant therapy: A comparison between anatomic ypAJCC staging, residual cancer burden class and neo-bioscore

Marieke EM van der Noordaa, Christina Yau, Sonal Shad, Marie Osdoit, Tessa G Steenbruggen, Diane de Croze, Anne-Sophie Hamy, Marick Lae, Fabien Reyal, Maria Del Monte-Millán, Miguel Martin, Sara Lopez Tarruella, I-SPY 2 TRIAL Consortium, Judy C Boughey, Matthew Goetz, Tanya Hoskin, Rebecca Gould, Vincent Valero, Gabe Sonke, Maartje van Seijen, Jelle Wesseling, John Bartlett, Stephan Edge, Mi-Ok Kim, Jean Abraham, Carlos Caldas, Helena Earl, Elena Provenzano, Stephen-John Sammut, David Cameron, Ashley Graham, Peter Hall, Lorna MacKintosh, Fang Fan, Andrew K Godwin, Kelsey Schwensen, Priyanka Sharma, Angela DeMichele, Janet Dunn, Louise Hiller, Larry Hayward, Jeremy Thomas, Kimberley Cole, Lajos Pusztai, Laura van 't Veer, Fraser Symmans, Laura Esserman
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): GS4-07.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-GS4-07
Published: 15 February 2021
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