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Journal Articles

Abstract 4338: The role of IMPACT in survival of cancer cells during tryptophan deprivation by immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO1)

Petr Tomek, Ariane Hallermayr, Michael Kilian, Cristin Gregor Print, Lai-Ming Ching

Cancer Res (2017) 77 (13_Supplement): 4338.

https://doi.org/10.1158/1538-7445.AM2017-4338

Published: 01 July 2017

View article titled, Abstract 4338: The role of IMPACT in survival of cancer cells during tryptophan deprivation by immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO1)

Journal Articles

Abstract 4691: Polarization of macrophages with STING agonists

Kimiora L. Henare, Sofian M. Tijono, Lai-Ming Ching

Cancer Res (2017) 77 (13_Supplement): 4691.

https://doi.org/10.1158/1538-7445.AM2017-4691

Published: 01 July 2017

View article titled, Abstract 4691: Polarization of macrophages with STING agonists

Journal Articles

Abstract 4138: In vitro and in vivo models for evaluation of inhibitors of tryptophan dioxygenases

Lai-Ming Ching, Petr Tomek, Brian D. Palmer, Sofian Tijono, Kimiora Henare, Lukas M. Braun

Cancer Res (2017) 77 (13_Supplement): 4138.

https://doi.org/10.1158/1538-7445.AM2017-4138

Published: 01 July 2017

View article titled, Abstract 4138: In vitro and in vivo models for evaluation of inhibitors of tryptophan dioxygenases

Journal Articles

Abstract 4469: A novel class of inhibitors of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1) with potential for the treatment of cancer

Lai-Ming Ching, Brian D. Palmer, Petr Tomek, Jack U. Flanagan, Kimiora Henare

Cancer Res (2015) 75 (15_Supplement): 4469.

https://doi.org/10.1158/1538-7445.AM2015-4469

Published: 01 August 2015

View article titled, Abstract 4469: A novel class of inhibitors of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1) with potential for the treatment of cancer

Journal Articles

Abstract A19: Characterizing the tumor stroma of B16 melanoma at different sites

Kimiora Henare, Raymond Yung, P. Rod Dunbar, Cristin G. Print, Lai-Ming Ching

Cancer Res (2015) 75 (1_Supplement): A19.

https://doi.org/10.1158/1538-7445.CHTME14-A19

Published: 12 January 2015

View article titled, Abstract A19: Characterizing the tumor stroma of B16 melanoma at different sites

Journal Articles

Abstract 5372: A molecular docking strategy for identifying fragment inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1)

Simon Fung, Jack U. Flanagan, Christopher J. Squire, Brian D. Palmer, Lai-Ming Ching

Cancer Res (2014) 74 (19_Supplement): 5372.

https://doi.org/10.1158/1538-7445.AM2014-5372

Published: 01 October 2014

View article titled, Abstract 5372: A molecular docking strategy for identifying fragment inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1)

Journal Articles

Abstract 24: Labeling of oxidizable proteins with a photoactivatable analog of the antitumor agent DMXAA and evidence for redox signaling in its mode of action

Lai-Ming Ching, Liang-Chuan S. Wang, Romy Brauer, David J.A Bridewell, Kimiora Henare, Brian D. Palmer

Cancer Res (2010) 70 (8_Supplement): 24.

https://doi.org/10.1158/1538-7445.AM10-24

Published: 15 April 2010

View article titled, Abstract 24: Labeling of oxidizable proteins with a photoactivatable analog of the antitumor agent DMXAA and evidence for redox signaling in its mode of action

Journal Articles

Abstract 1555: In vitro and in vivo evaluation of analogs of N-(o-carboxybenzoyl)glutamic acid imide, an active thalidomide metabolite

Kaveshree Pather, Nuala A. Helsby, Brian D. Palmer, Lai-Ming Ching

Cancer Res (2010) 70 (8_Supplement): 1555.

https://doi.org/10.1158/1538-7445.AM10-1555

Published: 15 April 2010

View article titled, Abstract 1555: In vitro and in vivo evaluation of analogs of N-(o-carboxybenzoyl)glutamic acid imide, an active thalidomide metabolite

Journal Articles

Abstract #4421: Protein degradation via the ubiquitin-proteasome system is disrupted in ovarian cancer cell lines expressing mutant p53

In Young Hwang, Bruce Baguley, Lai-Ming Ching, Catherine Gilchrist

Cancer Res (2009) 69 (9_Supplement): 4421.

Published: 01 May 2009

View article titled, Abstract #4421: Protein degradation via the ubiquitin-proteasome system is disrupted in ovarian cancer cell lines expressing mutant p53

Journal Articles

Abstract #4623: The anti-tumor agent, DMXAA, activates p38 MAP kinase which is involved in proinflammatory cytokine production in murine macrophages

Jing Sun, Zvi Fridlender, Luana Pereira, Guanjun Cheng, Lai-Ming Ching, Steven Albelda

Cancer Res (2009) 69 (9_Supplement): 4623.

Published: 01 May 2009

View article titled, Abstract #4623: The anti-tumor agent, DMXAA, activates p38 MAP kinase which is involved in proinflammatory cytokine production in murine macrophages

Journal Articles

DMXAA (AS1404) activates macrophages and B-lymphocytes within tumors to produce chemokines leading to an influx of immune cells

Liang-Chuan Wang, Lotte Thomsen, Lai-Ming Ching

Cancer Res (2008) 68 (9_Supplement): 3349.

Published: 01 May 2008

View article titled, DMXAA (AS1404) activates macrophages and B-lymphocytes within tumors to produce chemokines leading to an influx of immune cells

Journal Articles

The Vascular Disrupting Agent, DMXAA, Directly Activates Dendritic Cells through a MyD88-Independent Mechanism and Generates Antitumor Cytotoxic T Lymphocytes

Africa Wallace, David F. LaRosa, Veena Kapoor, Jing Sun, Guanjun Cheng, Arminder Jassar, Aaron Blouin, Lai-Ming Ching, Steven M. Albelda

Cancer Res (2007) 67 (14): 7011–7019.

https://doi.org/10.1158/0008-5472.CAN-06-3757

Published: 17 July 2007

View article titled, The Vascular Disrupting Agent, DMXAA, Directly Activates Dendritic Cells through a MyD88-Independent Mechanism and Generates Antitumor Cytotoxic T Lymphocytes

Journal Articles

Activation of Tumor-Associated Macrophages by the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid Induces an Effective CD8⁺ T-Cell–Mediated Antitumor Immune Response in Murine Models of Lung Cancer and Mesothelioma

Arminder S. Jassar, Eiji Suzuki, Veena Kapoor, Jing Sun, Michael B. Silverberg, Lumei Cheung, Marie D. Burdick, Robert M. Strieter, Lai-Ming Ching, Larry R. Kaiser, Steven M. Albelda

Cancer Res (2005) 65 (24): 11752–11761.

https://doi.org/10.1158/0008-5472.CAN-05-1658

Published: 15 December 2005

View article titled, Activation of Tumor-Associated Macrophages by the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid Induces an Effective CD8+ T-Cell–Mediated Antitumor Immune Response in Murine Models of Lung Cancer and Mesothelioma

Journal Articles

The antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) markedly augments immunotherapy in murine models of lung cancer

Arminder S. Jassar, Andrew H. Haas, Eiji Suzuki, Jing Sun, Lumei Cheung, Veena Kapoor, Michael B. Silverberg, Lai-Ming Ching, Larry R. Kaiser, Steven M. Albelda

Cancer Res (2005) 65 (9_Supplement): 172.

Published: 01 May 2005

View article titled, The antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) markedly augments immunotherapy in murine models of lung cancer

Journal Articles

Vascular Attack by 5,6-Dimethylxanthenone-4-acetic Acid Combined with B7.1 (CD80)-mediated Immunotherapy Overcomes Immune Resistance and Leads to the Eradication of Large Tumors and Multiple Tumor Foci

Jagat R. Kanwar, Rupinder K. Kanwar, Sushil Pandey, Lai-Ming Ching, Geoffrey W. Krissansen

Cancer Res (2001) 61 (5): 1948–1956.

Published: 01 March 2001

View article titled, Vascular Attack by 5,6-Dimethylxanthenone-4-acetic Acid Combined with B7.1 (CD80)-mediated Immunotherapy Overcomes Immune Resistance and Leads to the Eradication of Large Tumors and Multiple Tumor Foci

Journal Articles

Interferon-inducible Protein 10 Induction and Inhibition of Angiogenesis in Vivo by the Antitumor Agent 5,6-Dimethylxanthenone-4-acetic Acid (DMXAA)

Zhihui Cao, Bruce C Baguley, Lai-Ming Ching

Cancer Res (2001) 61 (4): 1517–1521.

Published: 02 February 2001

View article titled, Interferon-inducible Protein 10 Induction and Inhibition of Angiogenesis in Vivo by the Antitumor Agent 5,6-Dimethylxanthenone-4-acetic Acid (DMXAA)

Journal Articles

Induction of Intratumoral Tumor Necrosis Factor (TNF) Synthesis and Hemorrhagic Necrosis by 5,6-Dimethylxanthenone-4-Acetic Acid (DMXAA) in TNF Knockout Mice

Lai-Ming Ching, David Goldsmith, Wayne R. Joseph, Heinrich Körner, Jonathon D. Sedgwick, Bruce C. Baguley

Cancer Res (1999) 59 (14): 3304–3307.

Published: 15 July 1999

View article titled, Induction of Intratumoral Tumor Necrosis Factor (TNF) Synthesis and Hemorrhagic Necrosis by 5,6-Dimethylxanthenone-4-Acetic Acid (DMXAA) in TNF Knockout Mice

Journal Articles

Stimulation of Tumors to Synthesize Tumor Necrosis Factor-α in Situ Using 5,6-Dimethylxanthenone-4-acetic Acid: A Novel Approach to Cancer Therapy

Wayne R. Joseph, Zhihui Cao, Kathleen G. Mountjoy, Elaine S. Marshall, Bruce C. Baguley, Lai-Ming Ching

Cancer Res (1999) 59 (3): 633–638.

Published: 01 February 1999

View article titled, Stimulation of Tumors to Synthesize Tumor Necrosis Factor-α in Situ Using 5,6-Dimethylxanthenone-4-acetic Acid: <subtitle>A Novel Approach to Cancer Therapy</subtitle>

Journal Articles

Induction of Tumor Necrosis Factor-β Messenger RNA in Human and Murine Cells by the Flavone Acetic Acid Analogue 5,6-Dimethylxanthenone-4-acetic Acid (NSC 640488)

Lai-Ming Ching, Wayne R. Joseph, Kathryn E. Crosier, Bruce C. Baguley

Cancer Res (1994) 54 (4): 870–872.

Published: 01 February 1994

View article titled, Induction of Tumor Necrosis Factor-β Messenger RNA in Human and Murine Cells by the Flavone Acetic Acid Analogue 5,6-Dimethylxanthenone-4-acetic Acid (NSC 640488)

Journal Articles

Tumor-dependent Increased Plasma Nitrate Concentrations as an Indication of the Antitumor Effect of Flavone-8-acetic Acid and Analogues in Mice

Lindy L. Thomsen, Lai-Ming Ching, Li Zhuang, John B. Gavin, Bruce C. Baguley

Cancer Res (1991) 51 (1): 77–81.

Published: 01 January 1991

View article titled, Tumor-dependent Increased Plasma Nitrate Concentrations as an Indication of the Antitumor Effect of Flavone-8-acetic Acid and Analogues in Mice

NARROW

Abstract 4338: The role of IMPACT in survival of cancer cells during tryptophan deprivation by immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO1)

Abstract 4691: Polarization of macrophages with STING agonists

Abstract 4138: In vitro and in vivo models for evaluation of inhibitors of tryptophan dioxygenases

Abstract 4469: A novel class of inhibitors of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1) with potential for the treatment of cancer

Abstract A19: Characterizing the tumor stroma of B16 melanoma at different sites

Abstract 5372: A molecular docking strategy for identifying fragment inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1)

Abstract 24: Labeling of oxidizable proteins with a photoactivatable analog of the antitumor agent DMXAA and evidence for redox signaling in its mode of action

Abstract 1555: In vitro and in vivo evaluation of analogs of N-(o-carboxybenzoyl)glutamic acid imide, an active thalidomide metabolite

Abstract #4421: Protein degradation via the ubiquitin-proteasome system is disrupted in ovarian cancer cell lines expressing mutant p53

Abstract #4623: The anti-tumor agent, DMXAA, activates p38 MAP kinase which is involved in proinflammatory cytokine production in murine macrophages

DMXAA (AS1404) activates macrophages and B-lymphocytes within tumors to produce chemokines leading to an influx of immune cells

The Vascular Disrupting Agent, DMXAA, Directly Activates Dendritic Cells through a MyD88-Independent Mechanism and Generates Antitumor Cytotoxic T Lymphocytes

Activation of Tumor-Associated Macrophages by the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid Induces an Effective CD8⁺ T-Cell–Mediated Antitumor Immune Response in Murine Models of Lung Cancer and Mesothelioma

The antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) markedly augments immunotherapy in murine models of lung cancer

Vascular Attack by 5,6-Dimethylxanthenone-4-acetic Acid Combined with B7.1 (CD80)-mediated Immunotherapy Overcomes Immune Resistance and Leads to the Eradication of Large Tumors and Multiple Tumor Foci

Interferon-inducible Protein 10 Induction and Inhibition of Angiogenesis in Vivo by the Antitumor Agent 5,6-Dimethylxanthenone-4-acetic Acid (DMXAA)

Induction of Intratumoral Tumor Necrosis Factor (TNF) Synthesis and Hemorrhagic Necrosis by 5,6-Dimethylxanthenone-4-Acetic Acid (DMXAA) in TNF Knockout Mice

Stimulation of Tumors to Synthesize Tumor Necrosis Factor-α in Situ Using 5,6-Dimethylxanthenone-4-acetic Acid: A Novel Approach to Cancer Therapy

Induction of Tumor Necrosis Factor-β Messenger RNA in Human and Murine Cells by the Flavone Acetic Acid Analogue 5,6-Dimethylxanthenone-4-acetic Acid (NSC 640488)

Tumor-dependent Increased Plasma Nitrate Concentrations as an Indication of the Antitumor Effect of Flavone-8-acetic Acid and Analogues in Mice

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