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Kyle A. Furge
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Journal Articles

CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma

Aikseng Ooi, Karl Dykema, Asif Ansari, David Petillo, John Snider, Richard Kahnoski, John Anema, David Craig, John Carpten, Bin-Tean Teh, Kyle A. Furge
Journal: Cancer Research
Cancer Res (2013) 73 (7): 2044–2051.
https://doi.org/10.1158/0008-5472.CAN-12-3227
Published: 02 April 2013
View article titled, <em>CUL3</em> and <em>NRF2</em> Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma
Open the PDF for <em>CUL3</em> and <em>NRF2</em> Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Expression of the PTTG1 Oncogene Is Associated with Aggressive Clear Cell Renal Cell Carcinoma

Bill Wondergem, Zhongfa Zhang, Dachuan Huang, Choon Kiat Ong, Julie Koeman, David Van't Hof, David Petillo, Aikseng Ooi, John Anema, Brian Lane, Richard J. Kahnoski, Kyle A. Furge, Bin Tean Teh
Journal: Cancer Research
Cancer Res (2012) 72 (17): 4361–4371.
https://doi.org/10.1158/0008-5472.CAN-11-2330
Published: 30 August 2012
View article titled, Expression of the PTTG1 Oncogene Is Associated with Aggressive Clear Cell Renal Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Abstract 1134: Fumarate activates NRF2 in tissues with fumarate hydratase mutation

Aikseng Ooi, Douglas Whitten, Ximing J. Yang, Ming Zhou, Stéphane Richard, Bin Tean Teh, Kyle A. Furge
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1134.
https://doi.org/10.1158/1538-7445.AM2012-1134
Published: 15 April 2012
View article titled, Abstract 1134: Fumarate activates NRF2 in tissues with fumarate hydratase mutation
Journal Articles

Combined Gene Expression Profiling and RNAi Screening in Clear Cell Renal Cell Carcinoma Identify PLK1 and Other Therapeutic Kinase Targets

Yan Ding, Dan Huang, Zhongfa Zhang, Josh Smith, David Petillo, Brendan D. Looyenga, Kristin Feenstra, Jeffrey P. MacKeigan, Kyle A. Furge, Bin T. Teh
Journal: Cancer Research
Cancer Res (2011) 71 (15): 5225–5234.
https://doi.org/10.1158/0008-5472.CAN-11-0076
Published: 28 July 2011
View article titled, Combined Gene Expression Profiling and RNAi Screening in Clear Cell Renal Cell Carcinoma Identify PLK1 and Other Therapeutic Kinase Targets
Open the PDF for Combined Gene Expression Profiling and RNAi Screening in Clear Cell Renal Cell Carcinoma Identify PLK1 and Other Therapeutic Kinase Targets in another window
Includes: Supplementary data
Journal Articles

Abstract 4036: Chromosomal amplification of LRRK2 is required for oncogenic MET signaling in papillary renal and thyroid carcinomas

Brendan D. Looyenga, Kyle A. Furge, Karl J. Dykema, Julie Koeman, Pamela J. Swiatek, Thomas J. Giordano, Andrew B. West, James H. Resau, Bin T. Teh, Jeffrey P. MacKeigan
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4036.
https://doi.org/10.1158/1538-7445.AM2011-4036
Published: 15 April 2011
View article titled, Abstract 4036: Chromosomal amplification of LRRK2 is required for oncogenic MET signaling in papillary renal and thyroid carcinomas
Journal Articles

Abstract 2805: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

Ignacio Varela, Patrick Tarpey, Keiran Raine, Dachuan Huang, Choon Kiat Ong, Philip Stephens, Helen Davies, David Jones, Meng-Lay Lin, Jon Teague, Graham Bignell, Adam Butler, Juok Cho, Gillian L. Dalgliesh, Danushka Galappaththige, Chris Greenman, Claire Hardy, Mingming Jia, Calli Latimer, King Wai Lau, John Marshall, Stuart McLaren, Andrew Menzies, Laura Mudie, Lucy Stebbings, David A. Largaespada, L.F.A. Wessels, Stéphane Richard, Richard J. Kahnoski, John Anema, David Tuveson, Pedro Perez-Mancera, Ville Mustonen, Andrej Fischer, David J. Adams, Alistair Rust, Waraporn Chan-on, Chutima Subimerb, Karl Dykema, Kyle A. Furge, Peter J. Campbell, Bin Tean Teh, Michael R. Stratton, P. Andrew Futreal
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2805.
https://doi.org/10.1158/1538-7445.AM2011-2805
Published: 15 April 2011
View article titled, Abstract 2805: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene <em>PBRM1</em> in renal carcinoma
Journal Articles

Abstract 3820: Deregulation of KEAP1-NRF axis in phenotypically type 2 papillary renal cell carcinoma

Aikseng Ooi, Bernice Wong HM, JingChii Wong, Victoria Perrier-Trudova, David Petillo, Douglas Roossien, Zhongfa Zhang, Min-Han Tan, Ming Zhou, Ximing Yang, Stéphane Richard, Bin Tean Teh, Kyle A. Furge
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3820.
https://doi.org/10.1158/1538-7445.AM2011-3820
Published: 15 April 2011
View article titled, Abstract 3820: Deregulation of KEAP1-NRF axis in phenotypically type 2 papillary renal cell carcinoma
Journal Articles

Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

Zhi Jiang Zang, Choon Kiat Ong, Ioana Cutcutache, Willie Yu, Shen Li Zhang, Dachuan Huang, Lian Dee Ler, Karl Dykema, Anna Gan, Jiong Tao, Siyu Lim, Yujing Liu, P. Andrew Futreal, Heike Grabsch, Kyle A. Furge, Liang Kee Goh, Steve Rozen, Bin Tean Teh, Patrick Tan
Journal: Cancer Research
Cancer Res (2011) 71 (1): 29–39.
https://doi.org/10.1158/0008-5472.CAN-10-1749
Published: 02 January 2011
View article titled, Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing
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Includes: Supplementary data
Journal Articles

Abstract 117: jackTom, an algorithm to integrate aCGH and gene expression microarrays to predict activation of oncogenes by DNA amplification in individual tumors

Karl J. Dykema, Zeng Quan Yang, Kyle A. Furge, Stephen P. Ethier, Ramsi Haddad
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 117.
https://doi.org/10.1158/1538-7445.AM10-117
Published: 15 April 2010
View article titled, Abstract 117: jackTom, an algorithm to integrate aCGH and gene expression microarrays to predict activation of oncogenes by DNA amplification in individual tumors
Journal Articles

Abstract 630: Interleukin-8 as a potential mediator for renal cell carcinoma resistance to antiangiogenic sunitinib therapy

Dan Huang, Yan Ding, Ming Zhou, Brian Rini, David Petillo, Chao-Nan Qian, Richard Kahnoski, P. Andrew Futreal, Kyle A. Furge, Bin Tean Teh
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 630.
https://doi.org/10.1158/1538-7445.AM10-630
Published: 15 April 2010
View article titled, Abstract 630: Interleukin-8 as a potential mediator for renal cell carcinoma resistance to antiangiogenic sunitinib therapy
Journal Articles

Abstract 3256: Investigating the intrinsic signaling differences in MET- and ERBB2-driven breast cancers

Carrie R. Graveel, Jack D. DeGroot, Karl Dykema, Robert E. Sigler, Kyle A. Furge, George F. Vande Woude
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3256.
https://doi.org/10.1158/1538-7445.AM10-3256
Published: 15 April 2010
View article titled, Abstract 3256: Investigating the intrinsic signaling differences in MET- and ERBB2-driven breast cancers
Journal Articles

Abstract LB-232: MEK2 signaling pathway alone is sufficient but not necessary for melanoma cell proliferation

Chih-Shia Lee, Karl J. Dykema, Danielle M. Hawkins, Kyle A. Furge, Nicholas S. Duesbery
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-232.
https://doi.org/10.1158/1538-7445.AM10-LB-232
Published: 15 April 2010
View article titled, Abstract LB-232: MEK2 signaling pathway alone is sufficient but not necessary for melanoma cell proliferation
Journal Articles

Interleukin-8 Mediates Resistance to Antiangiogenic Agent Sunitinib in Renal Cell Carcinoma

Dan Huang, Yan Ding, Ming Zhou, Brian I. Rini, David Petillo, Chao-Nan Qian, Richard Kahnoski, P. Andrew Futreal, Kyle A. Furge, Bin Tean Teh
Journal: Cancer Research
Cancer Res (2010) 70 (3): 1063–1071.
https://doi.org/10.1158/0008-5472.CAN-09-3965
Published: 31 January 2010
View article titled, Interleukin-8 Mediates Resistance to Antiangiogenic Agent Sunitinib in Renal Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models

Chao-Nan Qian, Kyle A. Furge, Jared Knol, Dan Huang, Jindong Chen, Karl J. Dykema, Eric J. Kort, Aaron Massie, Sok Kean Khoo, Kristin Vanden Beldt, James H. Resau, John Anema, Richard J. Kahnoski, Hans Morreau, Philippe Camparo, Eva Comperat, Mathilde Sibony, Yves Denoux, Vincent Molinie, Annick Vieillefond, Charis Eng, Bart O. Williams, Bin Tean Teh
Journal: Cancer Research
Cancer Res (2009) 69 (21): 8256–8264.
https://doi.org/10.1158/0008-5472.CAN-09-1689
Published: 28 October 2009
View article titled, Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models
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Includes: Supplementary data
Journal Articles

The E2F3-Oncomir-1 Axis Is Activated in Wilms' Tumor

Eric J. Kort, Leslie Farber, Maria Tretiakova, David Petillo, Kyle A. Furge, Ximing J. Yang, Albert Cornelius, Bin T. Teh
Journal: Cancer Research
Cancer Res (2008) 68 (11): 4034–4038.
https://doi.org/10.1158/0008-5472.CAN-08-0592
Published: 02 June 2008
View article titled, The E2F3-Oncomir-1 Axis Is Activated in Wilms' Tumor
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Journal Articles

Detection of DNA Copy Number Changes and Oncogenic Signaling Abnormalities from Gene Expression Data Reveals MYC Activation in High-Grade Papillary Renal Cell Carcinoma

Kyle A. Furge, Jindong Chen, Julie Koeman, Pamela Swiatek, Karl Dykema, Kseniji Lucin, Richard Kahnoski, Ximing J. Yang, Bin Tean Teh
Journal: Cancer Research
Cancer Res (2007) 67 (7): 3171–3176.
https://doi.org/10.1158/0008-5472.CAN-06-4571
Published: 04 April 2007
View article titled, Detection of DNA Copy Number Changes and Oncogenic Signaling Abnormalities from Gene Expression Data Reveals <em>MYC</em> Activation in High-Grade Papillary Renal Cell Carcinoma
Open the PDF for Detection of DNA Copy Number Changes and Oncogenic Signaling Abnormalities from Gene Expression Data Reveals <em>MYC</em> Activation in High-Grade Papillary Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

A Molecular Classification of Papillary Renal Cell Carcinoma

Ximing J. Yang, Min-Han Tan, Hyung L. Kim, Jonathon A. Ditlev, Mark W. Betten, Carolina E. Png, Eric J. Kort, Kunihiko Futami, Kyle A. Furge, Masayuki Takahashi, Hiro-omi Kanayama, Puay Hoon Tan, Bin Sing Teh, Chunyan Luan, Kim Wang, Michael Pins, Maria Tretiakova, John Anema, Richard Kahnoski, Theresa Nicol, Walter Stadler, Nicholas G. Vogelzang, Robert Amato, David Seligson, Robert Figlin, Arie Belldegrun, Craig G. Rogers, Bin Tean Teh
Journal: Cancer Research
Cancer Res (2005) 65 (13): 5628–5637.
https://doi.org/10.1158/0008-5472.CAN-05-0533
Published: 01 July 2005
View article titled, A Molecular Classification of Papillary Renal Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Robust Classification of Renal Cell Carcinoma Based on Gene Expression Data and Predicted Cytogenetic Profiles

Kyle A. Furge, Kerry A. Lucas, Masayuki Takahashi, Jun Sugimura, Eric J. Kort, Hiro-omi Kanayama, Susumu Kagawa, Philip Hoekstra, John Curry, Ximing J. Yang, Bin T. Teh
Journal: Cancer Research
Cancer Res (2004) 64 (12): 4117–4121.
https://doi.org/10.1158/0008-5472.CAN-04-0534
Published: 17 June 2004
View article titled, Robust Classification of Renal Cell Carcinoma Based on Gene Expression Data and Predicted Cytogenetic Profiles
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Includes: Supplementary data
Journal Articles

Gene Expression Profiling of Favorable Histology Wilms Tumors and Its Correlation with Clinical Features

Masayuki Takahashi, Ximing J. Yang, Todd T. Lavery, Kyle A. Furge, Bart O. Williams, Maria Tretiakova, Anthony Montag, Nicholas J. Vogelzang, Gian G. Re, A. Julian Garvin, Stefan Söderhäll, Susumu Kagawa, Debra Hazel-Martin, Agneta Nordenskjold, Bin Tean Teh
Journal: Cancer Research
Cancer Res (2002) 62 (22): 6598–6605.
Published: 15 November 2002
View article titled, Gene Expression Profiling of Favorable Histology Wilms Tumors and Its Correlation with Clinical Features
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