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Kwong Y. Tsang
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Journal Articles

Abstract 4783: Development and characterization of an antibody-drug conjugate (ADC) utilizing PB-223, a novel monoclonal antibody (mAb) specifically targeting core 2 O-glycans on human carcinomas

Free
Kwong Y. Tsang, Massimo Fantini, Anjum Zaki, Sharon A. Mavroukakis, Philip M. Arlen
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4783.
https://doi.org/10.1158/1538-7445.AM2025-4783
Published: 21 April 2025
View articletitled, Abstract 4783: Development and characterization of an antibody-drug conjugate (ADC) utilizing PB-223, a novel monoclonal antibody (mAb) specifically targeting core 2 O-glycans on human carcinomas
Journal Articles

Abstract 2716: The O-glycan epitope targeting anti-human carcinoma monoclonal antibody (mAb) NEO-201 can also target human regulatory T cells (Tregs)

Free
Atsushi Tanaka, Massimo Fantini, Philip M. Arlen, Christina M. Annunziata, Kwong Y. Tsang, Shimon Sakaguchi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2716.
https://doi.org/10.1158/1538-7445.AM2024-2716
Published: 22 March 2024
View articletitled, Abstract 2716: The O-glycan epitope targeting anti-human carcinoma monoclonal antibody (mAb) NEO-201 can also target human regulatory T cells (Tregs)
Journal Articles

Abstract 5654: A therapeutic humanized anti-carcinoma monoclonal antibody (mAb) NEO-201 can also target human granulocytic myeloid-derived suppressor cells (gMDSCs) and regulatory T (Tregs) cells

Free
Massimo Fantini, Christina M. Annunziata, Philip M. Arlen, Kwong Y. Tsang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5654.
https://doi.org/10.1158/1538-7445.AM2023-5654
Published: 04 April 2023
View articletitled, Abstract 5654: A therapeutic humanized anti-carcinoma monoclonal antibody (mAb) NEO-201 can also target human granulocytic myeloid-derived suppressor cells (gMDSCs) and regulatory T (Tregs) cells
Journal Articles

Abstract 4185: Targeting variant of CEACAM5 and CEACAM6 using NEO-201 and IL-15 in gynecologic cancers

Free
Maria Pia Morelli, Massimo Fantini, Kwong Y. Tsang, Phillip Arlen, Paulette Fauceglia, Lidia Hernandez, Soumya Korrapati, Elijah Edmonson, Christopher Cole, Christina M. Annunziata
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4185.
https://doi.org/10.1158/1538-7445.AM2022-4185
Published: 15 June 2022
View articletitled, Abstract 4185: Targeting variant of CEACAM5 and CEACAM6 using NEO-201 and IL-15 in gynecologic cancers
Journal Articles

Abstract 4534: A therapeutic humanized anti-carcinoma monoclonal antibody (mAb) can enhance NK activity and target immunosuppressive regulatory T cells

Free
Massimo Fantini, Maria Pia Morelli, Christina M. Annunziata, Philip M. Arlen, Kwong Y. Tsang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4534.
https://doi.org/10.1158/1538-7445.AM2020-4534
Published: 15 August 2020
View articletitled, Abstract 4534: A therapeutic humanized anti-carcinoma monoclonal antibody (mAb) can enhance NK activity and target immunosuppressive regulatory T cells
Journal Articles

Abstract 3947: Mechanisms of action of a neoantigen-targeting antibody NEO-201

Free
Philip Martin Arlen, Massimo Fantini, Justin David, Christina M. Annunziata, Kwong Y. Tsang, Pia Morelli
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3947.
https://doi.org/10.1158/1538-7445.AM2019-3947
Published: 01 July 2019
View articletitled, Abstract 3947: Mechanisms of action of a neoantigen-targeting antibody NEO-201
Journal Articles

Abstract 3821: The neoantigen-targeting antibody NEO-201 enhances NK cell-dependent killing of tumor cells through blockade of the inhibitory CEACAM5/CEACAM1 immune checkpoint pathway

Free
Justin M. David, Massimo Fantini, Christina M. Annunziata, Philip M. Arlen, Kwong Y. Tsang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3821.
https://doi.org/10.1158/1538-7445.AM2018-3821
Published: 01 July 2018
View articletitled, Abstract 3821: The neoantigen-targeting antibody NEO-201 enhances NK cell-dependent killing of tumor cells through blockade of the inhibitory CEACAM5/CEACAM1 immune checkpoint pathway
Journal Articles

Abstract 4726: Inhibitors of histone deacetylase 1 reverse the immune evasion phenotype to enhance T-cell-mediated lysis of prostate and breast carcinoma cells

Free
Sofia R. Gameiro, Anthony S. Malamas, Massimo Fantini, Kwong Y. Tsang, Soldano Ferrone, James W. Hodge
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4726.
https://doi.org/10.1158/1538-7445.AM2016-4726
Published: 15 July 2016
View articletitled, Abstract 4726: Inhibitors of histone deacetylase 1 reverse the immune evasion phenotype to enhance T-cell-mediated lysis of prostate and breast carcinoma cells
Journal Articles

Abstract 1406: Analysis of immune responses as a consequence of androgen deprivation therapy in patients with biochemical progression of prostate cancer

Free
Caroline Jochems, Ravi A. Madan, Romaine I. Fernando, James L. Gulley, Kwong Y. Tsang, Jeffrey Schlom
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1406.
https://doi.org/10.1158/1538-7445.AM2016-1406
Published: 15 July 2016
View articletitled, Abstract 1406: Analysis of immune responses as a consequence of androgen deprivation therapy in patients with biochemical progression of prostate cancer
Journal Articles

Abstract 632: Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing

Free
Sofia R. Gameiro, Momodou L. Jammeh, Max M. Wattenberg, Kwong Y. Tsang, Soldano Ferrone, James W. Hodge
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 632.
https://doi.org/10.1158/1538-7445.AM2014-632
Published: 01 October 2014
View articletitled, Abstract 632: Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing
Journal Articles

Abstract 628: Pan-Bcl-2 inhibitor, GX15-070 (Obatoclax), decreases human T regulatory lymphocytes while preserving effector T Lymphocytes: A rationale for its use in combination immunotherapy

Free
Peter S. Kim, Caroline Jochems, Italia Grenga, Renee N. Donahue, Kwong Y. Tsang, James L. Gulley, Jeffrey Schlom, Benedetto Farsaci
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 628.
https://doi.org/10.1158/1538-7445.AM2014-628
Published: 01 October 2014
View articletitled, Abstract 628: Pan-Bcl-2 inhibitor, GX15-070 (Obatoclax), decreases human T regulatory lymphocytes while preserving effector T Lymphocytes: A rationale for its use in combination immunotherapy
Journal Articles

Abstract 2561: Yeast vector-encoding multiple MUC1 agonist epitopes (yeast-MUC1) can induce MUC1-specific T-cell immune responses

Free
Kwong Y. Tsang, Benjamin Boyerinas, Caroline Jochems, Tim Rodell, Thomas King, Jeffey Schlom
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2561.
https://doi.org/10.1158/1538-7445.AM2014-2561
Published: 01 October 2014
View articletitled, Abstract 2561: Yeast vector-encoding multiple MUC1 agonist epitopes (yeast-MUC1) can induce MUC1-specific T-cell immune responses
Journal Articles

Abstract IA13: Phase I trial of targeted therapy with PSA-TRICOM vaccine (V) and ipilimumab (ipi) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC).

Free
James L. Gulley, Ravi A. Madan, Kwong Y. Tsang, Caroline Jochems, William L. Dahut, Jeffrey Schlom
Journal: Cancer Research
Cancer Res (2013) 73 (1_Supplement): IA13.
https://doi.org/10.1158/1538-7445.TUMIMM2012-IA13
Published: 02 April 2014
View articletitled, Abstract IA13: Phase I trial of targeted therapy with PSA-TRICOM vaccine (V) and ipilimumab (ipi) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC).
Journal Articles

Abstract 1260: Generation of human T cells directed against an agonist epitope of a transcription factor involved in epithelial to mesenchymal transition (EMT).

Free
Jo A. Tucker, Diane J. Poole, Claudia Palena, Caroline Jochems, Jeffrey Schlom, Kwong Y. Tsang
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1260.
https://doi.org/10.1158/1538-7445.AM2013-1260
Published: 15 April 2013
View articletitled, Abstract 1260: Generation of human T cells directed against an agonist epitope of a transcription factor involved in epithelial to mesenchymal transition (EMT).
Journal Articles

Abstract 758: Cancer vaccine immunotherapy employing Saccharomyces cerevisiae (yeast) as a vector can modulate the balance between CD4+ T cells and regulatory T cells (Tregs) and enhance the specific antitumor immune response

Free
Matteo Vergati, Vittore Cereda, Chiara Intrivici, Ngar-Yee Huen, Maria Giovanna Di Bari, Caroline Jochems, James L. Gulley, David Apelian, Jeffrey Schlom, Kwong Y. Tsang
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 758.
https://doi.org/10.1158/1538-7445.AM2011-758
Published: 15 April 2011
View articletitled, Abstract 758: Cancer vaccine immunotherapy employing Saccharomyces cerevisiae (yeast) as a vector can modulate the balance between CD4+ T cells and regulatory T cells (Tregs) and enhance the specific antitumor immune response
Journal Articles

Abstract 2405: Treatment of human dendritic cells with Saccharomyces cerevisiae (yeast) reduces number and function of regulatory T cells (Tregs) and enhances the ratio of antigen-specific effectors to Tregs

Free
Vittore Cereda, Matteo Vergati, Ngar-Yee Huen, Maria Giovanna di Bari, James L. Gulley, Alex Franzusoff, Jeffrey Schlom, Kwong Y. Tsang
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2405.
https://doi.org/10.1158/1538-7445.AM10-2405
Published: 15 April 2010
View articletitled, Abstract 2405: Treatment of human dendritic cells with Saccharomyces cerevisiae (yeast) reduces number and function of regulatory T cells (Tregs) and enhances the ratio of antigen-specific effectors to Tregs
Journal Articles

Identification of cytotoxic T-lymphocyte epitope(s) and its agonist epitope(s) of a novel target for vaccine therapy

Free
Junko Yokokawa, Tapan K. Bera, Claudia Palena, Diane J. Poole, Philip Arlen, James Gulley, Ira Pastan, Jeffrey Schlom, Kwong Y. Tsang
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 530–531.
Published: 15 April 2006
View articletitled, Identification of cytotoxic T-lymphocyte epitope(s) and its agonist epitope(s) of a novel target for vaccine therapy
Journal Articles

Identification of novel human cytotoxic T-lymphocyte epitope(s)and its agonist epitope(s) of mesothelin

Free
Junko Yokokawa, Claudia Palena, Philip Arlen, James Gulley, Patricia Beetham, Raffit Hassan, Ira Pastan, Jeffrey Schlom, Kwong Y. Tsang
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1213–1214.
Published: 01 May 2005
View articletitled, Identification of novel human cytotoxic T-lymphocyte epitope(s)and its agonist epitope(s) of mesothelin
Journal Articles

Carcinoembryonic Antigen as a Target for Specific Antitumor Immunotherapy of Head and Neck Cancer

Free
Erik S. Kass, John W. Greiner, Judith A. Kantor, Kwong Y. Tsang, Fiorella Guadagni, Zhong Chen, Bradly Clark, Roberto De Pascalis, Jeffrey Schlom, Carter Van Waes
Journal: Cancer Research
Cancer Res (2002) 62 (17): 5049–5057.
Published: 01 September 2002
View articletitled, Carcinoembryonic Antigen as a Target for Specific Antitumor Immunotherapy of Head and Neck Cancer
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Journal Articles

The Infection of Human Dendritic Cells with Recombinant Avipox Vectors Expressing a Costimulatory Molecule Transgene ( CD80 ) to Enhance the Activation of Antigen-specific Cytolytic T Cells

Free
Kwong Y. Tsang, MingZhu Zhu, Jos Even, James Gulley, Philip Arlen, Jeffrey Schlom
Journal: Cancer Research
Cancer Res (2001) 61 (20): 7568–7576.
Published: 01 October 2001
View articletitled, The Infection of Human Dendritic Cells with Recombinant Avipox Vectors Expressing a Costimulatory Molecule Transgene ( CD80 ) to Enhance the Activation of Antigen-specific Cytolytic T Cells
Open the PDF for The Infection of Human Dendritic Cells with Recombinant Avipox Vectors Expressing a Costimulatory Molecule Transgene ( CD80 ) to Enhance the Activation of Antigen-specific Cytolytic T Cells in another window