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Journal Articles

Abstract ND07: BBO-8520, a first-in-class, direct inhibitor of KRASG12C (ON), locks GTP-bound KRASG12C in the state 1 conformation resulting in rapid and complete blockade of effector binding

Anna E. Maciag, James Stice, Bin Wang, Alok Sharma, Albert Chan, Ken Lin, Devansh Singh, Marcin Dyba, Yue Yang, Saman Setoodeh, Brian P. Smith, Dana Rabara, Zuhui Zhang, Erik K. Larsen, Dom Esposito, John Paul Denson, Michela Ranieri, Mary Meynardie, Sadaf Mehdizadeh, Patrick Alexander, Maria Abreu Blanco, David Turner, Rui Xu, Felice C. Lightstone, Kwok Kin Wong, Dhirendra Simanshu, Keshi Wang, Andrew G. Stephen, Kerstin Sinkevicius, Dwight V. Nissley, Eli Wallace, Frank McCormick, Pedro J. Beltran
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): ND07.
https://doi.org/10.1158/1538-7445.AM2024-ND07
Published: 05 April 2024
View article titled, Abstract ND07: BBO-8520, a first-in-class, direct inhibitor of KRASG12C (ON), locks GTP-bound KRASG12C in the state 1 conformation resulting in rapid and complete blockade of effector binding
Journal Articles

Abstract 3916: TNG260, a small molecule CoREST inhibitor, sensitizes STK11-mutant NSCLC to anti-PD1 immunotherapy

Ayushi Patel, Soumyadip Sahu, Ke Geng, Salman Punekar, Janaye Stephens, Jiehui Deng, Ting Chen, Leanne Ahronian, Minjie Zhang, Jannik Andersen, Brian Haines, Kwok-Kin Wong
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3916.
https://doi.org/10.1158/1538-7445.AM2024-3916
Published: 22 March 2024
View article titled, Abstract 3916: TNG260, a small molecule CoREST inhibitor, sensitizes STK11-mutant NSCLC to anti-PD1 immunotherapy
Journal Articles

Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy

Suman Mukhopadhyay, Hsin-Yi Huang, Ziyan Lin, Michela Ranieri, Shuai Li, Soumyadip Sahu, Yingzhuo Liu, Yi Ban, Kayla Guidry, Hai Hu, Alfonso Lopez, Fiona Sherman, Yi Jer Tan, Yeuan Ting Lee, Amanda P. Armstrong, Igor Dolgalev, Priyanka Sahu, Tinghu Zhang, Wenchao Lu, Nathanael S. Gray, James G. Christensen, Tracy T. Tang, Vamsidhar Velcheti, Alireza Khodadadi-Jamayran, Kwok-Kin Wong, Benjamin G. Neel
Journal: Cancer Research
Cancer Res (2023) 83 (24): 4095–4111.
https://doi.org/10.1158/0008-5472.CAN-23-2729
Published: 15 December 2023
View article titled, Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRAS<sup>G12C</sup> Inhibitor Efficacy
Open the PDF for Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRAS<sup>G12C</sup> Inhibitor Efficacy in another window
Includes: Supplementary data
Journal Articles

Abstract 5766: Prospective evaluation of cell-free DNA fragmentomes for lung cancer detection

Peter J. Mazzone, Kwok-Kin Wong, Jun-Chieh J. Tsay, Harvey I. Pass, Anil Vachani, Allison Ryan, Jacob Carey, Debbie Jakubowski, Tony Wu, Yuhua Zong, Carter Portwood, Keith Lumbard, Joseph Catallini, Nicholas C. Dracopoli, Tara Maddala, Peter B. Bach, Robert B. Scharpf, Victor E. Velculescu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5766.
https://doi.org/10.1158/1538-7445.AM2023-5766
Published: 04 April 2023
View article titled, Abstract 5766: Prospective evaluation of cell-free DNA fragmentomes for lung cancer detection
Journal Articles

Abstract 3441: A multivalent peptoid conjugate that inhibits therapy-resistant prostate cancer cell proliferation by modulating androgen receptor transcriptional activity

Justine Habault, Jeffrey A. Schneider, Susan Ha, Rachel Ruoff, Joseph Puccini, Dafna Bar-Sagi, Kwok-Kin Wong, Amina Zoubeidi, Frank Claessens, David R. Wise, Susan K. Logan, Kent Kirshenbaum, Michael J. Garabedian
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3441.
https://doi.org/10.1158/1538-7445.AM2023-3441
Published: 04 April 2023
View article titled, Abstract 3441: A multivalent peptoid conjugate that inhibits therapy-resistant prostate cancer cell proliferation by modulating androgen receptor transcriptional activity
Journal Articles

Abstract 4859: Bi-steric mTORC1 inhibitors are superior to rapamycin and induce apoptotic cell death in tumor models with hyperactivated mTORC1

Heng Du, Yu Chi Yang, Heng-Jia Liu, Min Yuan, John Asara, Kwok-Kin Wong, Mallika Singh, David Kwiatkowski
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4859.
https://doi.org/10.1158/1538-7445.AM2023-4859
Published: 04 April 2023
View article titled, Abstract 4859: Bi-steric mTORC1 inhibitors are superior to rapamycin and induce apoptotic cell death in tumor models with hyperactivated mTORC1
Journal Articles

Abstract 2297: Profound anti-tumor efficacy of dual CDK7 and PD1 blockade in novel syngeneic prostate cancer models

David Wise, Luiza Doro Pereira, Jiansheng Wu, Victor R. Adorno Febles, Jonathan Melamed, Fang-Ming Deng, Hua Zhang, Kwok-Kin Wong
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2297.
https://doi.org/10.1158/1538-7445.AM2022-2297
Published: 15 June 2022
View article titled, Abstract 2297: Profound anti-tumor efficacy of dual CDK7 and PD1 blockade in novel syngeneic prostate cancer models
Journal Articles

Targeting HER2 Exon 20 Insertion–Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib

Han Han, Shuai Li, Ting Chen, Michael Fitzgerald, Shengwu Liu, Chengwei Peng, Kwan Ho Tang, Shougen Cao, Johara Chouitar, Jiansheng Wu, David Peng, Jiehui Deng, Zhendong Gao, Theresa E. Baker, Fei Li, Hua Zhang, Yuanwang Pan, Hailin Ding, Hai Hu, Val Pyon, Cassandra Thakurdin, Eleni Papadopoulos, Sittinon Tang, Francois Gonzalvez, Haiquan Chen, Victor M. Rivera, Rachael Brake, Sylvie Vincent, Kwok-Kin Wong
Journal: Cancer Research
Cancer Res (2021) 81 (20): 5311–5324.
https://doi.org/10.1158/0008-5472.CAN-21-1526
Published: 15 October 2021
View article titled, Targeting <em>HER2</em> Exon 20 Insertion–Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib
Open the PDF for Targeting <em>HER2</em> Exon 20 Insertion–Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib in another window
Includes: Supplementary data
Journal Articles

BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency

Manav Gupta, Carla P. Concepcion, Caroline G. Fahey, Hasmik Keshishian, Arjun Bhutkar, Christine F. Brainson, Francisco J. Sanchez-Rivera, Patrizia Pessina, Jonathan Y. Kim, Antoine Simoneau, Margherita Paschini, Mary C. Beytagh, Caroline R. Stanclift, Monica Schenone, D.R. Mani, Chendi Li, Audris Oh, Fei Li, Hai Hu, Angeliki Karatza, Roderick T. Bronson, Alice T. Shaw, Aaron N. Hata, Kwok-Kin Wong, Lee Zou, Steven A. Carr, Tyler Jacks, Carla F. Kim
Journal: Cancer Research
Cancer Res (2020) 80 (18): 3841–3854.
https://doi.org/10.1158/0008-5472.CAN-20-1744
Published: 15 September 2020
View article titled, BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency
Open the PDF for BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency in another window
Includes: Supplementary data
Journal Articles

Epigenetic CRISPR Screens Identify Npm1 as a Therapeutic Vulnerability in Non–Small Cell Lung Cancer

Fei Li, Wai-Lung Ng, Troy A. Luster, Hai Hu, Vladislav O. Sviderskiy, Catríona M. Dowling, Kate E.R. Hollinshead, Paula Zouitine, Hua Zhang, Qingyuan Huang, Michela Ranieri, Wei Wang, Zhaoyuan Fang, Ting Chen, Jiehui Deng, Kai Zhao, Hon-Cheong So, Alireza Khodadadi-Jamayran, Mousheng Xu, Angeliki Karatza, Val Pyon, Shuai Li, Yuanwang Pan, Kristen Labbe, Christina Almonte, John T. Poirier, George Miller, Richard Possemato, Jun Qi, Kwok-Kin Wong
Journal: Cancer Research
Cancer Res (2020) 80 (17): 3556–3567.
https://doi.org/10.1158/0008-5472.CAN-19-3782
Published: 02 September 2020
View article titled, Epigenetic CRISPR Screens Identify <em>Npm1</em> as a Therapeutic Vulnerability in Non–Small Cell Lung Cancer
Open the PDF for Epigenetic CRISPR Screens Identify <em>Npm1</em> as a Therapeutic Vulnerability in Non–Small Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 923: Pulsatile MEK inhibition improves anti-tumor immunity and T cell function in Kras mutant lung cancer

Hyejin Choi, Jiehui Deng, Shuai Li, Tarik Silk, Lauren Dong, Elliott J. Brea, Sean Houghton, David Redmond, Hong Zhong, Jonathan Boiarsky, Esra A. Akbay, Paul D. Smith, Taha Merghoub, Kwok-Kin Wong, Jedd D. Wolchok
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 923.
https://doi.org/10.1158/1538-7445.AM2020-923
Published: 15 August 2020
View article titled, Abstract 923: Pulsatile MEK inhibition improves anti-tumor immunity and T cell function in Kras mutant lung cancer
Journal Articles

CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC

Jeffrey H. Becker, Yandi Gao, Margaret Soucheray, Ines Pulido, Eiki Kikuchi, María L. Rodríguez, Rutu Gandhi, Aranzazu Lafuente-Sanchis, Miguel Aupí, Javier Alcácer Fernández-Coronado, Paloma Martín-Martorell, Antonio Cremades, José M. Galbis-Caravajal, Javier Alcácer, Camilla L. Christensen, Patricia Simms, Ashley Hess, Hajime Asahina, Michael P. Kahle, Fatima Al-Shahrour, Jeffrey A. Borgia, Agustín Lahoz, Amelia Insa, Oscar Juan, Pasi A. Jänne, Kwok-Kin Wong, Julian Carretero, Takeshi Shimamura
Journal: Cancer Research
Cancer Res (2019) 79 (17): 4439–4452.
https://doi.org/10.1158/0008-5472.CAN-19-0024
Published: 03 September 2019
View article titled, CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC
Open the PDF for CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC in another window
Includes: Supplementary data
Journal Articles

Abstract 4563: Profiling the tumor immune microenvironment of adenocarcinoma and squamous cell NSCLC

Kayla Harmeyer, Jiehui Deng, Suhagi Shah, Ece Bagdatlioglu, Aarif Ahsan, Christopher Reid, Aatish Thennavan, Charles Perou, Kwok-Kin Wong, Harvey Pass
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4563.
https://doi.org/10.1158/1538-7445.AM2019-4563
Published: 01 July 2019
View article titled, Abstract 4563: Profiling the tumor immune microenvironment of adenocarcinoma and squamous cell NSCLC
Journal Articles

Abstract 4044: The immune phenotype in serial biopsies from metastatic TNBC undergoing chemo-immunotherapy

Jiehui Deng, Suhagi Shah, Aatish Thennavan, Michelle Krogsgaard, Charles M. Perou, Kwok-Kin Wong, Sylvia Adams
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4044.
https://doi.org/10.1158/1538-7445.AM2019-4044
Published: 01 July 2019
View article titled, Abstract 4044: The immune phenotype in serial biopsies from metastatic TNBC undergoing chemo-immunotherapy
Journal Articles

Abstract 3223: Overcome LKB1 mutated cancer resistance to anti-PD1 treatment

Jiehui Deng, Aatish Thennavan, Yuanwang Pan, Igor Dolgalev, Ting Chen, Heather Silver, Matthew Harris, Val Pyon, Fei Li, Chelsea Lee, Aristotelis Tsirigos, Eli Rothenberg, Charles M. Perou, Kwok-Kin Wong
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3223.
https://doi.org/10.1158/1538-7445.AM2019-3223
Published: 01 July 2019
View article titled, Abstract 3223: Overcome LKB1 mutated cancer resistance to anti-PD1 treatment
Journal Articles

Abstract 1686: TSC2 enhances antitumor immunity and potentiates PD-1 and CTLA-4 blockade

Heng-Jia Liu, Patrick Lizotte, Heng Du, Maria Speranza, Spencer Vaughan, Nicola Alesi, Kwok-Kin Wong, Gordon Freeman, Arlene Sharpe, Elizabeth Henske
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1686.
https://doi.org/10.1158/1538-7445.AM2018-1686
Published: 01 July 2018
View article titled, Abstract 1686: TSC2 enhances antitumor immunity and potentiates PD-1 and CTLA-4 blockade
Journal Articles

NK Cells Mediate Synergistic Antitumor Effects of Combined Inhibition of HDAC6 and BET in a SCLC Preclinical Model

Yan Liu, Yuyang Li, Shengwu Liu, Dennis O. Adeegbe, Camilla L. Christensen, Max M. Quinn, Ruben Dries, Shiwei Han, Kevin Buczkowski, Xiaoen Wang, Ting Chen, Peng Gao, Hua Zhang, Fei Li, Peter S. Hammerman, James E. Bradner, Steven N. Quayle, Kwok-Kin Wong
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (13): 3709–3717.
https://doi.org/10.1158/0008-5472.CAN-18-0161
Published: 01 July 2018
View article titled, NK Cells Mediate Synergistic Antitumor Effects of Combined Inhibition of HDAC6 and BET in a SCLC Preclinical Model
Open the PDF for NK Cells Mediate Synergistic Antitumor Effects of Combined Inhibition of HDAC6 and BET in a SCLC Preclinical Model in another window
Includes: Supplementary data
Journal Articles

Abstract 5719: RNA-based tumor neoantigens from intron retention

Claire A. Margolis, Alicia C. Smart, Dennis Adeegbe, Diana Miao, Meng Xiao He, Harold Pimentel, Tim Fugmann, Kwok-Kin Wong, Eliezer M. Van Allen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5719.
https://doi.org/10.1158/1538-7445.AM2018-5719
Published: 01 July 2018
View article titled, Abstract 5719: RNA-based tumor neoantigens from intron retention
Journal Articles

Abstract LB-085: A new role for LKB1 to regulate Heat Shock Protein 90 activity

Jeffrey H. Becker, Michael P. Kahle, Margaret Soucheray, Ines Pulido, Fatima Al-Shahrour, Manuel Sanchez del Pino, Kwok-Kin Wong, Julian Carretero, Takeshi Shimamura
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-085.
https://doi.org/10.1158/1538-7445.AM2018-LB-085
Published: 01 July 2018
View article titled, Abstract LB-085: A new role for LKB1 to regulate Heat Shock Protein 90 activity
Journal Articles

Abstract 4778: Assessing efficacy of neratinib in HER2-driven lung cancer

Shuai Li, Shengwu Liu, Ting Chen, Jiehui Deng, Min Wu, Mari Kuraguchi, Cam Anh Tran, Paul T. Kirschmeier, Francesca Avogadri-Connors, Richard E. Cutler, Alshad S. Lalani, Kwok-Kin Wong
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4778.
https://doi.org/10.1158/1538-7445.AM2018-4778
Published: 01 July 2018
View article titled, Abstract 4778: Assessing efficacy of neratinib in HER2-driven lung cancer