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Journal Articles

Abstract 1250: Aberrant polyunsaturated fatty acids desaturation impairs survival and anti-tumor immunity of tumor resident memory CD8+ T cell in hepatocellular carcinoma

Tao Ding, Li Pang, Runying Long, Shinuan Zeng, Kevin TP Ng, Qingmei Zhang, Zhiwei Chen, Kwan Man
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1250.
https://doi.org/10.1158/1538-7445.AM2023-1250
Published: 04 April 2023
View article titled, Abstract 1250: Aberrant polyunsaturated fatty acids desaturation impairs survival and anti-tumor immunity of tumor resident memory CD8<sup>+</sup> T cell in hepatocellular carcinoma
Journal Articles

Abstract 617: Oncogenic CXCL10 triggers CD8+ T cell exhaustion in ovarian cancer

Runying Long, Tao Ding, Michelle K.L Siu, David W Chan, Jiangnan He, Annie NY Cheung, Kwan Man, Hextan YS NGAN, Karen KL Chan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 617.
https://doi.org/10.1158/1538-7445.AM2023-617
Published: 04 April 2023
View article titled, Abstract 617: Oncogenic CXCL10 triggers CD8<sup>+</sup> T cell exhaustion in ovarian cancer
Journal Articles

Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence

Li Pang, Oscar W.H. Yeung, Kevin T.P. Ng, Hui Liu, Jiye Zhu, Jiang Liu, Xinxiang Yang, Tao Ding, Wenqi Qiu, Yuewen Wang, T.L. Shirley Chiu, Zhiwei Chen, Chung-Mau Lo, Kwan Man
Journal: Cancer Research
Cancer Res (2022) 82 (22): 4206–4218.
https://doi.org/10.1158/0008-5472.CAN-22-1199
Published: 15 November 2022
View article titled, Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence
Open the PDF for Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence in another window
Includes: Supplementary data
Journal Articles

FSTL1 Secreted by Activated Fibroblasts Promotes Hepatocellular Carcinoma Metastasis and Stemness

Jia-Jian Loh, Tsz-Wai Li, Lei Zhou, Tin-Lok Wong, Xue Liu, Victor W.S. Ma, Chung-Mau Lo, Kwan Man, Terence K. Lee, Wen Ning, Man Tong, Stephanie Ma
Journal: Cancer Research
Cancer Res (2021) 81 (22): 5692–5705.
https://doi.org/10.1158/0008-5472.CAN-20-4226
Published: 15 November 2021
View article titled, FSTL1 Secreted by Activated Fibroblasts Promotes Hepatocellular Carcinoma Metastasis and Stemness
Open the PDF for FSTL1 Secreted by Activated Fibroblasts Promotes Hepatocellular Carcinoma Metastasis and Stemness in another window
Includes: Supplementary data
Journal Articles

Abstract 4496: Myofibroblast-secreted follistatin-like 1 promotes hepatocellular carcinoma formation and metastasis

Natalie Tsz Wai Li, Man Tong, Lei Zhou, Wen Ning, Chung-Mau Lo, Kwan Man, Terence Kin-Wah Lee, Stephanie Kwai-Yee Ma
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4496.
https://doi.org/10.1158/1538-7445.AM2018-4496
Published: 01 July 2018
View article titled, Abstract 4496: Myofibroblast-secreted follistatin-like 1 promotes hepatocellular carcinoma formation and metastasis
Journal Articles

Abstract LB-139: PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer

Lok Hei Chan, Lei Zhou, Kai Yu Ng, Tin Lok Wong, Stella Chai, Terence K Lee, Xin Yuan Guan, Yick Pang Ching, Chung Mau Lo, Kwan Man, Benedetta Artegiani, Hans Clevers, Helen H Yan, Suet Yi Leung, Stèphane Richard, Michael SY Huen, Stephanie Ma
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-139.
https://doi.org/10.1158/1538-7445.AM2017-LB-139
Published: 01 July 2017
View article titled, Abstract LB-139: PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer
Journal Articles

Abstract 2895: Octamer-4/microRNA-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells

Stella Chai, Kai-Yu Ng, Man Tong, Eunice Y. Lau, Terence K. Lee, Kwok Wah Chan, Yun Fei Yuan, Tan To Cheung, Siu Tim Cheung, Xiao Qi Wang, Nathalie Wong, Chung Mau Lo, Kwan Man, Xin Yuan Guan, Stephanie K. Ma
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2895.
https://doi.org/10.1158/1538-7445.AM2017-2895
Published: 01 July 2017
View article titled, Abstract 2895: Octamer-4/microRNA-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells
Journal Articles

Mechanisms through Which Hypoxia-Induced Caveolin-1 Drives Tumorigenesis and Metastasis in Hepatocellular Carcinoma

Xiaowen Mao, Sivia Yuen Sze Wong, Edith Yuk Ting Tse, Frankie Chi Fat Ko, Sze Keong Tey, Yin Shan Yeung, Kwan Man, Regina Cheuk-Lam Lo, Irene Oi-Lin Ng, Judy Wai Ping Yam
Journal: Cancer Research
Cancer Res (2016) 76 (24): 7242–7253.
https://doi.org/10.1158/0008-5472.CAN-16-1031
Published: 15 December 2016
View article titled, Mechanisms through Which Hypoxia-Induced Caveolin-1 Drives Tumorigenesis and Metastasis in Hepatocellular Carcinoma
Open the PDF for Mechanisms through Which Hypoxia-Induced Caveolin-1 Drives Tumorigenesis and Metastasis in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 5032: Acute phase liver graft injury mobilizes regulating B cells after transplantation for HCC patients through TLR4/CXCL10/CXCR3 signaling

Kwan Man, Yan Shao, Chang Xian Li, Chung Mau Lo
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5032.
https://doi.org/10.1158/1538-7445.AM2015-5032
Published: 01 August 2015
View article titled, Abstract 5032: Acute phase liver graft injury mobilizes regulating B cells after transplantation for HCC patients through TLR4/CXCL10/CXCR3 signaling
Journal Articles

Vaccine-Elicited CD8+ T Cells Cure Mesothelioma by Overcoming Tumor-Induced Immunosuppressive Environment

Zhiwu Tan, Jingying Zhou, Allen K.L. Cheung, Zhe Yu, Ka-Wai Cheung, Jianguo Liang, Haibo Wang, Boon Kiat Lee, Kwan Man, Li Liu, Kwok-Yung Yuen, Zhiwei Chen
Journal: Cancer Research
Cancer Res (2014) 74 (21): 6010–6021.
https://doi.org/10.1158/0008-5472.CAN-14-0473
Published: 30 October 2014
View article titled, Vaccine-Elicited CD8<sup>+</sup> T Cells Cure Mesothelioma by Overcoming Tumor-Induced Immunosuppressive Environment
Open the PDF for Vaccine-Elicited CD8<sup>+</sup> T Cells Cure Mesothelioma by Overcoming Tumor-Induced Immunosuppressive Environment in another window
Includes: Supplementary data
Journal Articles

Abstract 4389: Hypoxia-inducible HIF1α-miR-210 signaling axis enhances chemoresistance in human hepatocellular carcinoma

Alan K. Kai, Regina CL Lo, Joyce MF Lee, Kwan Man, Carmen CL Wong, Jack CM Wong, Irene OL Ng
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4389.
https://doi.org/10.1158/1538-7445.AM2014-4389
Published: 01 October 2014
View article titled, Abstract 4389: Hypoxia-inducible HIF1α-miR-210 signaling axis enhances chemoresistance in human hepatocellular carcinoma
Journal Articles

Abstract 3936: A hemoglobin-based oxygen carrier enhances chemotherapy in a rat orthotopic HCC model

Xiaobing Liu, Kwan Man
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3936.
https://doi.org/10.1158/1538-7445.AM2012-3936
Published: 15 April 2012
View article titled, Abstract 3936: A hemoglobin-based oxygen carrier enhances chemotherapy in a rat orthotopic HCC model
Journal Articles

Abstract 471: M2 macrophages promotes tumor growth and invasion in hepatocellular carcinoma

Wai Ho Yeung, Kin Wah Lee, Wei Geng, Chang Xian Li, Tak Pan Ng, Chung Mau Lo, Xin Yuan Guan, Tung Ping Poon, Sheung Tat Fan, Kwan Man
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 471.
https://doi.org/10.1158/1538-7445.AM2011-471
Published: 15 April 2011
View article titled, Abstract 471: M2 macrophages promotes tumor growth and invasion in hepatocellular carcinoma
Journal Articles

Abstract 1336: Inflammatory microenvironment accelerates liver tumor growth and metastasis by mobilizing circulating endothelial progenitor cells and increasing cancer stem like cell populations

Kwan Man, Kevin TP Ng, Xiao Bing Liu, Oscar WH Yeung, Chung-Mau Lo, Sheung-Tat Fan
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1336.
https://doi.org/10.1158/1538-7445.AM10-1336
Published: 15 April 2010
View article titled, Abstract 1336: Inflammatory microenvironment accelerates liver tumor growth and metastasis by mobilizing circulating endothelial progenitor cells and increasing cancer stem like cell populations
Journal Articles

Abstract #4886: CD133+ liver cancer stem cells promote tumor growth and angiogenesis through increased interleukin-8 secretion

Kwan Ho Tang, Stephanie Ma, Terence Lee, Irene Ng, Kwan Man, Ka-Fai To, Bo-Jian Zheng, Xin-Yuan Guan, Kwok Wah Chan
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4886.
Published: 01 May 2009
View article titled, Abstract #4886: CD133<sup>+</sup> liver cancer stem cells promote tumor growth and angiogenesis through increased interleukin-8 secretion
Journal Articles

Abstract #3136: The role of miR-130b in the regulation of CD133+ cancer stem cells-driven hepatocellular carcinoma

Stephanie Ma, Yuen Piu Chan, Terence Lee, Kwan Ho Tang, Irene Ng, Kwan Man, Ka Fai To, Bo-Jian Zheng, Kwok Wah Chan, Xin-Yuan Guan
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3136.
Published: 01 May 2009
View article titled, Abstract #3136: The role of miR-130b in the regulation of CD133<sup>+</sup> cancer stem cells-driven hepatocellular carcinoma
Journal Articles

Abstract #3187: Acute phase inflammatory response promotes liver tumor recurrence and metastasis by mobilization of circulating EPCs and activation of TAMs

Kwan Man, Qiao Cheng, Tung-Tuen Lam, Kevin Ng, Xiao-Bing Liu, Sheung-Tat Fan
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3187.
Published: 01 May 2009
View article titled, Abstract #3187: Acute phase inflammatory response promotes liver tumor recurrence and metastasis by mobilization of circulating EPCs and activation of TAMs
Journal Articles

Angiopoietin-like protein 4 suppresses liver tumor growth and metastases by inhibition of angiogenesis and cell invasion

Kwan Man, Kevin TP Ng, Aimin Xu, Qiao Cheng, Dong-Yong Guo, Zophia Lim, Chung-Mau Lo, Ronnie TP Poon, Sheung-Tat Fan
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1616.
Published: 01 May 2008
View article titled, Angiopoietin-like protein 4 suppresses liver tumor growth and metastases by inhibition of angiogenesis and cell invasion
Journal Articles

Fat-derived hormone adiponetin suppresses liver tumor growth and metastases

Kwan Man, Kevin T Ng, Aimin Xu, Qiao Cheng, Baishun Sun, Chris K Sun, Terence K Lee, Chung-Mau Lo, Ronnie T Poon, Sheung-Tat Fan
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2174.
Published: 01 May 2007
View article titled, Fat-derived hormone adiponetin suppresses liver tumor growth and metastases
Journal Articles

Suppression of tumorigenesis and metastasis of hepatocellular carcinoma by shRNA interference targeting on inhibition of homeoprotein Six1

Tak Pan Ng, Kwan Man, Qiao Cheng, Bai Shun Sun, Terence KW Lee, Ronnie TP Poon, Chung Mau Lo, Sheung Tat Fan
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2184.
Published: 01 May 2007
View article titled, Suppression of tumorigenesis and metastasis of hepatocellular carcinoma by shRNA interference targeting on inhibition of homeoprotein Six1