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Kurt W. Kohn
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Journal Articles

The NCI-60 Methylome and Its Integration into CellMiner

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William C. Reinhold, Sudhir Varma, Margot Sunshine, Vinodh Rajapakse, Augustin Luna, Kurt W. Kohn, Holly Stevenson, Yonghong Wang, Holger Heyn, Vanesa Nogales, Sebastian Moran, David J. Goldstein, James H. Doroshow, Paul S. Meltzer, Manel Esteller, Yves Pommier
Journal: Cancer Research
Cancer Res (2017) 77 (3): 601–612.
https://doi.org/10.1158/0008-5472.CAN-16-0655
Published: 31 January 2017
View articletitled, The NCI-60 Methylome and Its Integration into CellMiner
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Includes: Supplementary data
Journal Articles

Abstract 4104: LIX1L, an EMT-correlated gene that behaves as if it inhibits the EMT

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Mihoko Yamade, Yves Pommier, Kurt W. Kohn
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4104.
https://doi.org/10.1158/1538-7445.AM2015-4104
Published: 01 August 2015
View articletitled, Abstract 4104: LIX1L, an EMT-correlated gene that behaves as if it inhibits the EMT
Journal Articles

Transcription Poisoning by Topoisomerase I Is Controlled by Gene Length, Splice Sites, and miR-142-3p

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Stéphanie Solier, Michael C. Ryan, Scott E. Martin, Sudhir Varma, Kurt W. Kohn, Hongfang Liu, Barry R. Zeeberg, Yves Pommier
Journal: Cancer Research
Cancer Res (2013) 73 (15): 4830–4839.
https://doi.org/10.1158/0008-5472.CAN-12-3504
Published: 31 July 2013
View articletitled, Transcription Poisoning by Topoisomerase I Is Controlled by Gene Length, Splice Sites, and miR-142-3p
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Includes: Supplementary data
Journal Articles

Abstract 5219: Molecular phenotype of an epithelial-like subset of the NCI-60 human tumor cell lines and relevance to gene expression patterns in TCGA normal breast and breast cancer tissue samples.

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Kurt W. Kohn, Barry R. Zeeberg, William C. Reinhold, Ari Kahn, Yves Pommier
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5219.
https://doi.org/10.1158/1538-7445.AM2013-5219
Published: 15 April 2013
View articletitled, Abstract 5219: Molecular phenotype of an epithelial-like subset of the NCI-60 human tumor cell lines and relevance to gene expression patterns in TCGA normal breast and breast cancer tissue samples.
Journal Articles

CellMiner: A Web-Based Suite of Genomic and Pharmacologic Tools to Explore Transcript and Drug Patterns in the NCI-60 Cell Line Set

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William C. Reinhold, Margot Sunshine, Hongfang Liu, Sudhir Varma, Kurt W. Kohn, Joel Morris, James Doroshow, Yves Pommier
Journal: Cancer Research
Cancer Res (2012) 72 (14): 3499–3511.
https://doi.org/10.1158/0008-5472.CAN-12-1370
Published: 15 July 2012
View articletitled, CellMiner: A Web-Based Suite of Genomic and Pharmacologic Tools to Explore Transcript and Drug Patterns in the NCI-60 Cell Line Set
Open the PDF for CellMiner: A Web-Based Suite of Genomic and Pharmacologic Tools to Explore Transcript and Drug Patterns in the NCI-60 Cell Line Set in another window
Journal Articles

Genome-wide Analysis of Novel Splice Variants Induced by Topoisomerase I Poisoning Shows Preferential Occurrence in Genes Encoding Splicing Factors

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Stéphanie Solier, Jennifer Barb, Barry R. Zeeberg, Sudhir Varma, Mike C. Ryan, Kurt W. Kohn, John N. Weinstein, Peter J. Munson, Yves Pommier
Journal: Cancer Research
Cancer Res (2010) 70 (20): 8055–8065.
https://doi.org/10.1158/0008-5472.CAN-10-2491
Published: 13 October 2010
View articletitled, Genome-wide Analysis of Novel Splice Variants Induced by Topoisomerase I Poisoning Shows Preferential Occurrence in Genes Encoding Splicing Factors
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Includes: Supplementary data
Journal Articles

Abstract 1103: Linkage between endogenous Chk2 activation and p14ARF expression in p53-mutated cells revealed by proteomic and genomic analyses of the NCI60

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Gabriele M. Zoppoli, William C. Reinhold, Stephanie Solier, Anne Monks, John W. Connelly, Hongfang Liu, Kurt W. Kohn, Robert Shoemaker, Yves Pommier
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1103.
https://doi.org/10.1158/1538-7445.AM10-1103
Published: 15 April 2010
View articletitled, Abstract 1103: Linkage between endogenous Chk2 activation and p14ARF expression in p53-mutated cells revealed by proteomic and genomic analyses of the NCI60
Journal Articles

Cancers as wounds that do not heal: Differences and similarities between renal regeneration/repair and renal cell carcinoma

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Joseph Riss, Chand Khanna, Gadisetti V.R. Chandramouli, David E. Kleiner, Andreas Rosenwald, Carl F. Schaefer, Olga Aprelikova, Kurt W. Kohn, Ken H. Buetow, W. Marston Linehan, John N. Weinstein, Maxwell P. Lee, Glenn Merlino, Richard D. Klausner, J. Carl Barrett
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): LB-115.
Published: 01 May 2008
View articletitled, Cancers as wounds that do not heal: Differences and similarities between renal regeneration/repair and renal cell carcinoma
Journal Articles

Cancers as Wounds that Do Not Heal: Differences and Similarities between Renal Regeneration/Repair and Renal Cell Carcinoma

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Joseph Riss, Chand Khanna, Seongjoon Koo, Gadisetti V.R. Chandramouli, Howard H. Yang, Ying Hu, David E. Kleiner, Andreas Rosenwald, Carl F. Schaefer, Shmuel A. Ben-Sasson, Liming Yang, John Powell, David W. Kane, Robert A. Star, Olga Aprelikova, Kristin Bauer, James R. Vasselli, Jodi K. Maranchie, Kurt W. Kohn, Ken H. Buetow, W. Marston Linehan, John N. Weinstein, Maxwell P. Lee, Richard D. Klausner, J. Carl Barrett
Journal: Cancer Research
Cancer Res (2006) 66 (14): 7216–7224.
https://doi.org/10.1158/0008-5472.CAN-06-0040
Published: 18 July 2006
View articletitled, Cancers as Wounds that Do Not Heal: Differences and Similarities between Renal Regeneration/Repair and Renal Cell Carcinoma
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Includes: Supplementary data
Journal Articles

4-Nitroquinoline-1-Oxide Induces the Formation of Cellular Topoisomerase I-DNA Cleavage Complexes

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Ze-Hong Miao, V. Ashutosh Rao, Keli Agama, Smitha Antony, Kurt W. Kohn, Yves Pommier
Journal: Cancer Research
Cancer Res (2006) 66 (13): 6540–6545.
https://doi.org/10.1158/0008-5472.CAN-05-4471
Published: 03 July 2006
View articletitled, 4-Nitroquinoline-1-Oxide Induces the Formation of Cellular Topoisomerase I-DNA Cleavage Complexes
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Journal Articles

Towards a standard notation for bioregulatory network diagrams: The EGFR signaling network

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Kurt W. Kohn, Mirit I. Aladjem, John N. Weinstein, Yves Pommier
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 307.
Published: 15 April 2006
View articletitled, Towards a standard notation for bioregulatory network diagrams: The EGFR signaling network
Journal Articles

Cancers as wounds that do not heal: Similarities and differences between renal regeneration and repair and renal cell carcinoma

Free
Joseph Riss, Chand Khanna, Seongjoon Koo, Gadisetti V R Chandramouli, Howard H. Yang, Ying Hu, David E. Kleiner, Andreas Rosenwald, Carl F. Schaefer, Shmuel A. Ben-Sasson, John Powell, David W. Kane, Robert A. Star, Olga Aprelikova, Kristin Bauer, James R. Vasselli, Jodi K. Maranchie, Kurt W. Kohn, Barry R. Zeeberg, Ken H. Buetow, W. Marston Linehan, John N. Weinstein, Maxwell P. Lee, Richard D. Klausner, J. Carl Barrett
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 196.
Published: 15 April 2006
View articletitled, Cancers as wounds that do not heal: Similarities and differences between renal regeneration and repair and renal cell carcinoma
Journal Articles

Microarray analysis of acquired resistance to apoptosis: Improved Gene Ontology analysis through customization of categories in the GoMiner program package

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William C. Reinhold, Barry R. Zeeberg, Uma T. Shankavaram, Kurt W. Kohn, Sudarshan Narasimhan, Yves Pommier, John N. Weinstein
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 585–586.
Published: 15 April 2006
View articletitled, Microarray analysis of acquired resistance to apoptosis: Improved Gene Ontology analysis through customization of categories in the GoMiner program package
Journal Articles

Comprehensive molecular profiling of the NCI-60 cancer cell panel: A Human Cancer Cell Line Integromics Project (HCLIP)

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John N. Weinstein, David W. Kane, Barry R. Zeeberg, Mark Reimers, Satoshi Nishizuka, Satoshi Nishizuka, Uma Shankavaram, Kimberly J. Bussey, Philip Lorenzi, Ogechi Ikediobi, Kurt W. Kohn, Mirit Aladjem, Yves Pommier, Dominic Scudiero, Susan Holbeck, William C. Reinhold
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 37.
Published: 15 April 2006
View articletitled, Comprehensive molecular profiling of the NCI-60 cancer cell panel: A Human Cancer Cell Line Integromics Project (HCLIP)
Journal Articles

Practical bioinformatic tools you can use for biomarker and molecular target research: integrating genomics, proteomics, and pharmacology

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John N. Weinstein, William C. Reinhold, Satoshi Nishizuka, Kimberly Bussey, Kurt W. Kohn, Mirit Aladjem, Yves Pommier, Barry Zeeberg, Uma Shankavaram, Sohyoung Kim, Lorraine Tanabe, Joseph Riss, J. Carl Barrett, Paul Blower, Jr., Margot Sunshine, Sudarshan Narasimhan, Hong Cao, Ari Kahn, Robert Sfeir, David Kane
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 384.
Published: 01 May 2005
View articletitled, Practical bioinformatic tools you can use for biomarker and molecular target research: integrating genomics, proteomics, and pharmacology
Journal Articles

The hypoxia response system: A theoretical investigation of a bioregulatory network

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Kurt W. Kohn, Joseph Riss, John N. Weinstein, Yves Pommier, Carl Barrett
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1001.
Published: 01 April 2004
View articletitled, The hypoxia response system: A theoretical investigation of a bioregulatory network
Journal Articles

Developing bioinformatic tools for integrating DNA, RNA, protein, and pharmacological data: The “integromic” enterprise.

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John N. Weinstein, William C. Reinhold, Satoshi Nishizuka, Sylvia M. Major, Uma Shankavaram, Kimberly Bussey, Joseph Ludwig, Kurt W. Kohn, Yves Pommier, Barry Zeeberg, Sohyoung Kim, Samir Lababidi, Paul Blower, Margot Sunshine, Sudarshan Narasimhan, Hong Cao, Ike Nnabugwu, J. Carl Barrett, David Kane Kane
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 754.
Published: 01 April 2004
View articletitled, Developing bioinformatic tools for integrating DNA, RNA, protein, and pharmacological data: The “integromic” enterprise.
Journal Articles

Differential Induction of Topoisomerase I-DNA Cleavage Complexes by the Indenoisoquinoline MJ-III-65 (NSC 706744) and Camptothecin: Base Sequence Analysis and Activity against Camptothecin- Resistant Topoisomerases I

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Smitha Antony, Muthusamy Jayaraman, Gary Laco, Glenda Kohlhagen, Kurt W. Kohn, Mark Cushman, Yves Pommier
Journal: Cancer Research
Cancer Res (2003) 63 (21): 7428–7435.
Published: 11 November 2003
View articletitled, Differential Induction of Topoisomerase I-DNA Cleavage Complexes by the Indenoisoquinoline MJ-III-65 (NSC 706744) and Camptothecin: Base Sequence Analysis and Activity against Camptothecin- Resistant Topoisomerases I
Open the PDF for Differential Induction of Topoisomerase I-DNA Cleavage Complexes by the Indenoisoquinoline MJ-III-65 (NSC 706744) and Camptothecin: Base Sequence Analysis and Activity against Camptothecin- Resistant Topoisomerases I in another window
Journal Articles

Impact of p53 Knockout and Topotecan Treatment on Gene Expression Profiles in Human Colon Carcinoma Cells: A Pharmacogenomic Study

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Sayed S. Daoud, Peter J. Munson, William Reinhold, Lynn Young, Vinay V. Prabhu, Qiang Yu, Jihyun LaRose, Kurt W. Kohn, John N. Weinstein, Yves Pommier
Journal: Cancer Research
Cancer Res (2003) 63 (11): 2782–2793.
Published: 01 June 2003
View articletitled, Impact of p53 Knockout and Topotecan Treatment on Gene Expression Profiles in Human Colon Carcinoma Cells: A Pharmacogenomic Study
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Journal Articles

Apoptotic Susceptibility of Cancer Cells Selected for Camptothecin Resistance: Gene Expression Profiling, Functional Analysis, and Molecular Interaction Mapping

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William C. Reinhold, Hosein Kouros-Mehr, Kurt W. Kohn, Alika K. Maunakea, Samir Lababidi, Anna Roschke, Kristen Stover, Jes Alexander, Panayotis Pantazis, Lance Miller, Edison Liu, Ilan R. Kirsch, Yoshimasa Urasaki, Yves Pommier, John N. Weinstein
Journal: Cancer Research
Cancer Res (2003) 63 (5): 1000–1011.
Published: 01 March 2003
View articletitled, Apoptotic Susceptibility of Cancer Cells Selected for Camptothecin Resistance: Gene Expression Profiling, Functional Analysis, and Molecular Interaction Mapping
Open the PDF for Apoptotic Susceptibility of Cancer Cells Selected for Camptothecin Resistance: Gene Expression Profiling, Functional Analysis, and Molecular Interaction Mapping in another window
Includes: Supplementary data