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Kumiko Koyama
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Journal Articles

Abstract LB042: Targeting ATR enhances the antitumor efficacy of patritumab deruxtecan (HER3-DXd)in tamoxifen-resistant ER+ breast cancer cells by inducing DNA damage and apoptosis

Xuemei Xie, Jangsoon Lee, Jon A. Fuson, Huey Liu, Young J. Gi, Thanasis Poullikkas, Pang-Dian Fan, Kumiko Koyama, Debu Tripathy, Naoto T. Ueno
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB042.
https://doi.org/10.1158/1538-7445.AM2023-LB042
Published: 14 April 2023
View article titled, Abstract LB042: Targeting ATR enhances the antitumor efficacy of patritumab deruxtecan (HER3-DXd)in tamoxifen-resistant ER<sup>+</sup> breast cancer cells by inducing DNA damage and apoptosis
Journal Articles

Abstract 3405: Changes in HER3 expression associated with chemotherapy for pancreatic cancer

Tomoyuki Satake, Chigusa Morizane, Mao Okada, Mariko Nishioka, Nobuyoshi Hiraoka, Satoshi Nara, Tomoya Kakegawa, Maki Kobayashi, Kumiko Koyama, Minoru Esaki, Takuji Okusaka
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3405.
https://doi.org/10.1158/1538-7445.AM2023-3405
Published: 04 April 2023
View article titled, Abstract 3405: Changes in HER3 expression associated with chemotherapy for pancreatic cancer
Journal Articles

Abstract 3996: The impact of HER3 dynamics on the efficacy of HER3-DXd, a novel HER3 directed antibody-drug conjugate

Nagiho Komatsu, Saori Sato, Sumie Muramatsu, Ryuichi Nakamura, Kumiko Koyama
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3996.
https://doi.org/10.1158/1538-7445.AM2023-3996
Published: 04 April 2023
View article titled, Abstract 3996: The impact of HER3 dynamics on the efficacy of HER3-DXd, a novel HER3 directed antibody-drug conjugate
Journal Articles

Abstract 4484: HER3 expression after systemic therapy and clinical characteristics in patients with hepatocellular carcinoma

Mao Okada, Chigusa Morizane, Tomoyuki Satake, Mariko Nishioka, Nobuyoshi Hiraoka, Satoshi Nara, Tomoya Kakegawa, Maki Kobayashi, Kumiko Koyama, Minoru Esaki, Takuji Okusaka
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4484.
https://doi.org/10.1158/1538-7445.AM2023-4484
Published: 04 April 2023
View article titled, Abstract 4484: HER3 expression after systemic therapy and clinical characteristics in patients with hepatocellular carcinoma
Journal Articles

Abstract LB088: Targeting ATR enhances the antitumor efficacy of patritumab deruxtecan (HER3-DXd) in tamoxifen-resistant ER+ breast cancer cells by reprogramming cell cycle progression

Xuemei Xie, Jangsoon Lee, Jon A. Fuson, Huey Liu, Young Jin Gi, Pang-Dian Fan, Kumiko Koyama, Debu Tripathy, Naoto T. Ueno
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB088.
https://doi.org/10.1158/1538-7445.AM2022-LB088
Published: 15 June 2022
View article titled, Abstract LB088: Targeting ATR enhances the antitumor efficacy of patritumab deruxtecan (HER3-DXd) in tamoxifen-resistant ER<sup>+</sup> breast cancer cells by reprogramming cell cycle progression
Journal Articles

Abstract 5083: Changes in HER3 expression profiles between initial diagnosis and recurrence in gynecologic cancers

Yuki Kojima, Kazuki Sudo, Hiroshi Yoshida, Shu Yazaki, Momoko Tokura, Shosuke Kita, Kasumi Yamamoto, Chiharu Mizoguchi, Hitomi S Okuma, Tadaaki Nishikawa, Emi Noguchi, Tatsunori Shimoi, Yasuhito Tanase, Masaya Uno, Mitsuya Ishikawa, Tomoyasu Kato, Kumiko Koyama, Maki Kobayashi, Tomoya Kakegawa, Yasuhiro Fujiwara, Kan Yonemori
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5083.
https://doi.org/10.1158/1538-7445.AM2022-5083
Published: 15 June 2022
View article titled, Abstract 5083: Changes in HER3 expression profiles between initial diagnosis and recurrence in gynecologic cancers
Journal Articles

Abstract P5-13-14: Antitumor activity of patritumab deruxtecan (HER3-DXd), a HER3-directed antibody drug conjugate (ADC) across a diverse panel of breast cancer (BC) patient-derived xenografts (PDXs)

Andreu Òdena, Laia Monserrat, Fara Brasó-Maristany, Marta Guzmán, Judit Grueso, Olga Rodríguez, Maurizio Scaltriti, Sarat Chandarlapaty, Yang Qiu, Kumiko Koyama, Mafalda Oliveira, Aleix Prat, Violeta Serra
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-13-14.
https://doi.org/10.1158/1538-7445.SABCS21-P5-13-14
Published: 15 February 2022
View article titled, Abstract P5-13-14: Antitumor activity of patritumab deruxtecan (HER3-DXd), a HER3-directed antibody drug conjugate (ADC) across a diverse panel of breast cancer (BC) patient-derived xenografts (PDXs)
Journal Articles

Abstract 5201: U3-1402, a novel HER3-targeting antibody-drug conjugate, exhibits in vitro antitumor activity against breast cancer cells expressing HER3 mutations without dependence on HER2 overexpression

Kumiko Koyama, Hirokazu Ishikawa, Manabu Abe, Yoshinobu Shiose, Suguru Ueno, Kenji Nakamaru, Masato Murakami
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5201.
https://doi.org/10.1158/1538-7445.AM2020-5201
Published: 15 August 2020
View article titled, Abstract 5201: U3-1402, a novel HER3-targeting antibody-drug conjugate, exhibits <em>in vitro</em> antitumor activity against breast cancer cells expressing HER3 mutations without dependence on HER2 overexpression
Journal Articles

Abstract 5880: Pan-cancer gene expression analysis of tissue microarray using EdgeSeq Oncology Biomarker Panel and a cross-comparison with ERBB3 immunohistochemical analysis

Koichiro Inaki, Naoyuki Maeda, Tomoko Shibutani, Serenella Eppenberger-Castori, Stefan Nicolet, Kumiko Koyama, Yui Tanaka, Yuki Kaneda, Kenichi Wakita, Yoshinobu Shiose, Masato Murakami
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5880.
https://doi.org/10.1158/1538-7445.AM2020-5880
Published: 15 August 2020
View article titled, Abstract 5880: Pan-cancer gene expression analysis of tissue microarray using EdgeSeq Oncology Biomarker Panel and a cross-comparison with ERBB3 immunohistochemical analysis
Journal Articles

Abstract LB-264: Autophagy modulates intracellular dynamics of [fam-] trastuzumab deruxtecan (DS-8201a), a novel HER2 antibody-drug conjugate (HER2-ADC)

Manabu Abe, Motoko Nagata, Kumiko Koyama, Satoru Yasuda, Tsuyoshi Hirata, Yusuke Kuwahara, Koichiro Inaki, Naomi Kasanuki, Megumi Minami, Katsunobu Hagihara, Kenichi Wakita, Eric Slosberg, Masato Murakami
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-264.
https://doi.org/10.1158/1538-7445.AM2019-LB-264
Published: 01 July 2019
View article titled, Abstract LB-264: Autophagy modulates intracellular dynamics of [fam-] trastuzumab deruxtecan (DS-8201a), a novel HER2 antibody-drug conjugate (HER2-ADC)
Journal Articles

Abstract LB-275: U3-1402, a novel HER3-targeting antibody-drug conjugate, exhibits its antitumor activity through increased payload intracellular delivery via highly efficient drug internalization

Kumiko Koyama, Yuuri Hashimoto, Yasuki Kamai, Yoshinobu Shiose, Manabu Abe, Yuki Kaneda, Naoyuki Maeda, Kenji Hirotani, Yusuke Ogitani, Tsuyoshi Karibe, Takashi Kagari, Kenichi Wakita, Suguru Ueno, Toshinori Agatsuma, Masato Murakami
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-275.
https://doi.org/10.1158/1538-7445.AM2019-LB-275
Published: 01 July 2019
View article titled, Abstract LB-275: U3-1402, a novel HER3-targeting antibody-drug conjugate, exhibits its antitumor activity through increased payload intracellular delivery via highly efficient drug internalization
Journal Articles

Abstract 1311: Disposition and biotransformation of [14C]-radiolabeled CS-7017 in healthy male subjects

Mohinder Bathala, Minoru Uchiyama, Hiroko Koda, Ling He, Fraser Pickersgill, Kumiko Koyama, Hamim Zahir, Haruo Iwabuchi, Takashi Izumi, Taro Tokui
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1311.
https://doi.org/10.1158/1538-7445.AM2011-1311
Published: 15 April 2011
View article titled, Abstract 1311: Disposition and biotransformation of [<sup>14</sup>C]-radiolabeled CS-7017 in healthy male subjects
Journal Articles

APCL, a Central Nervous System-specific Homologue of Adenomatous Polyposis Coli Tumor Suppressor, Binds to p53-binding Protein 2 and Translocates it to the Perinucleus

Hidewaki Nakagawa, Kumiko Koyama, Yoji Murata, Monden Morito, Tetsu Akiyama, Yusuke Nakamura
Journal: Cancer Research
Cancer Res (2000) 60 (1): 101–105.
Published: 01 January 2000
View article titled, APCL, a Central Nervous System-specific Homologue of Adenomatous Polyposis Coli Tumor Suppressor, Binds to p53-binding Protein 2 and Translocates it to the Perinucleus
Open the PDF for APCL, a Central Nervous System-specific Homologue of Adenomatous Polyposis Coli Tumor Suppressor, Binds to p53-binding Protein 2 and Translocates it to the Perinucleus in another window
Journal Articles

Identification of a Brain-specific APC Homologue, APCL, and Its Interaction with β-Catenin

Hidewaki Nakagawa, Yoji Murata, Kumiko Koyama, Asao Fujiyama, Yasuo Miyoshi, Morito Monden, Tetsu Akiyama, Yusuke Nakamura
Journal: Cancer Research
Cancer Res (1998) 58 (22): 5176–5181.
Published: 01 November 1998
View article titled, Identification of a Brain-specific <em>APC</em> Homologue, <em>APCL</em>, and Its Interaction with β-Catenin
Open the PDF for Identification of a Brain-specific <em>APC</em> Homologue, <em>APCL</em>, and Its Interaction with β-Catenin in another window