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Journal Articles

Editor’s Note: Truncated Glioma-Associated Oncogene Homolog 1 (tGLI1) Mediates Mesenchymal Glioblastoma via Transcriptional Activation of CD44

Tadas K. Rimkus, Richard L. Carpenter, Sherona Sirkisoon, Dongqin Zhu, Boris C. Pasche, Michael D. Chan, Glenn J. Lesser, Stephen B. Tatter, Kounosuke Watabe, Waldemar Debinski, Hui-Wen Lo
Journal: Cancer Research
Cancer Res (2024) 84 (19): 3310.
https://doi.org/10.1158/0008-5472.CAN-24-2889
Published: 01 October 2024
View articletitled, Editor’s Note: Truncated Glioma-Associated Oncogene Homolog 1 (tGLI1) Mediates Mesenchymal Glioblastoma via Transcriptional Activation of CD44
Open the PDF for Editor’s Note: Truncated Glioma-Associated Oncogene Homolog 1 (tGLI1) Mediates Mesenchymal Glioblastoma via Transcriptional Activation of CD44 in another window
Journal Articles

Abstract 7514: Tumor intrinsic CDC42BPB confers resistance to anti-PD-1 immune checkpoint blockade in breast cancer

Ravindra Pramod Deshpande, Kerui Wu, Shih-Ying Wu, Abhishek Tyagi, John Hunting, Jimmy Ruiz, Wencheng Li, Kounosuke Watabe
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7514.
https://doi.org/10.1158/1538-7445.AM2024-7514
Published: 22 March 2024
View articletitled, Abstract 7514: Tumor intrinsic CDC42BPB confers resistance to anti-PD-1 immune checkpoint blockade in breast cancer
Journal Articles

Abstract 5521: Nicotine promotes perineural brain metastasis of lung cancer by activating GABAergic neurons

Shih-Ying Wu, Abhishek Tyagi, Ravindra Pramod Deshpande, Kerui Wu, Eleanor Cecile Smith, Kounosuke Watabe
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5521.
https://doi.org/10.1158/1538-7445.AM2024-5521
Published: 22 March 2024
View articletitled, Abstract 5521: Nicotine promotes perineural brain metastasis of lung cancer by activating GABAergic neurons
Journal Articles

Abstract 5080: Antibody drug conjugate trastuzumab deruxtecan suppresses leptomeningeal brain metastasis cells and is potentiated by addition of immune check point inhibitor

Eleanor C. Smith, Shih-Ying Wu, Ravindra P. Deshpande, Abhishek Tyagi, Kounosuke Watabe
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5080.
https://doi.org/10.1158/1538-7445.AM2024-5080
Published: 22 March 2024
View articletitled, Abstract 5080: Antibody drug conjugate trastuzumab deruxtecan suppresses leptomeningeal brain metastasis cells and is potentiated by addition of immune check point inhibitor
Journal Articles

Abstract 5515: Low body mass index (BMI) induces neuronal NPY and promotes brain metastasis of lung cancer

Abhishek Tyagi, Shih-Ying Wu, Ravindra Deshpande, Kerui Wu, Liang Liu, Kounosuke Watabe
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5515.
https://doi.org/10.1158/1538-7445.AM2024-5515
Published: 22 March 2024
View articletitled, Abstract 5515: Low body mass index (BMI) induces neuronal NPY and promotes brain metastasis of lung cancer
Journal Articles

Abstract P3-07-21: Therapeutic efficacy of NGY-091 against triple negative breast cancer is mediated by direct cell killing and activation of antitumor immunity

Sambad Sharma, Sanath Wijerathna, Kerui Wu, Abhishek Tyagi, Shih-Ying Wu, Kounosuke Watabe, Nelly Kuklin, Jaime Escobedo, Vincent Sandanayaka
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P3-07-21.
https://doi.org/10.1158/1538-7445.SABCS22-P3-07-21
Published: 01 March 2023
View articletitled, Abstract P3-07-21: Therapeutic efficacy of NGY-091 against triple negative breast cancer is mediated by direct cell killing and activation of antitumor immunity
Journal Articles

Abstract 2354: Astrocytes activated by tGLI1-expressing breast cancer brain metastases upregulate CNTF to activate astrocytes and promote breast cancer stem cells

Grace L. Wong, Sherona R. Sirkisoon, Noah R. Aguayo, Daniel L. Doheny, Dongqin Zhu, Angelina T. Regua, Austin Arrigo, Sara G. Manore, Calvin J. Wagner, Alexandra Thomas, Ravi Singh, Fei Xing, Guangxu Jin, Kounosuke Watabe, Hui-Wen Lo
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2354.
https://doi.org/10.1158/1538-7445.AM2022-2354
Published: 15 June 2022
View articletitled, Abstract 2354: Astrocytes activated by tGLI1-expressing breast cancer brain metastases upregulate CNTF to activate astrocytes and promote breast cancer stem cells
Journal Articles

Abstract 6153: MyD88-mediated chimeric antigen receptor macrophage suppresses brain metastasis by target-specific phagocytosis and bystander effect through TNF-α

Shih-Ying Wu, Kerui Wu, Abhishek Tyagi, Fei Xing, Dan Zhao, Ravindra Pramod Deshpande, Yin Liu Liu, Kounosuke Watabe
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6153.
https://doi.org/10.1158/1538-7445.AM2022-6153
Published: 15 June 2022
View articletitled, Abstract 6153: MyD88-mediated chimeric antigen receptor macrophage suppresses brain metastasis by target-specific phagocytosis and bystander effect through TNF-α
Journal Articles

Abstract 5817: Exosomal miR-4466 from nicotine-activated neutrophils promotes tumor cell stemness & metabolism in brain metastasis

Abhishek Tyagi, Shih-Ying Wu, Sambad Sharma, Kerui Wu, Dan Zhao, Ravindra Deshpande, Kounosuke Watabe
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5817.
https://doi.org/10.1158/1538-7445.AM2022-5817
Published: 15 June 2022
View articletitled, Abstract 5817: Exosomal miR-4466 from nicotine-activated neutrophils promotes tumor cell stemness & metabolism in brain metastasis
Journal Articles

Abstract 2652: Efficacy of a small molecule MCT1 and MCT4 transporter inhibitor in cancer

Sambad Sharma, Gregory Goreczny, Nicole Bowman, Jennifer Duffy, Daliya Banerjee, Sanath Wijerathna, John Dzuris, Kerui Wu, Shih-Ying Wu, Abhishek Tyagi, Kounosuke Watabe, Jaime Escobedo, Vincent Sandanayaka
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2652.
https://doi.org/10.1158/1538-7445.AM2022-2652
Published: 15 June 2022
View articletitled, Abstract 2652: Efficacy of a small molecule MCT1 and MCT4 transporter inhibitor in cancer
Journal Articles

Correction: Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis

Fei Xing, Yin Liu, Shih-Ying Wu, Kerui Wu, Sambad Sharma, Yin-Yuan Mo, Jiamei Feng, Stephanie Sanders, Guangxu Jin, Ravi Singh, Pierre-Alexandre Vidi, Abhishek Tyagi, Michael D. Chan, Jimmy Ruiz, Waldemar Debinski, Boris C. Pasche, Hui-Wen Lo, Linda J. Metheny-Barlow, Ralph B. D'Agostino, Jr, Kounosuke Watabe
Journal: Cancer Research
Cancer Res (2021) 81 (21): 5582.
https://doi.org/10.1158/0008-5472.CAN-21-3056
Published: 01 November 2021
View articletitled, Correction: Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis
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Journal Articles

Abstract 2866: Truncated glioma-associated oncogene homolog 1 (tGLI1) is an actionable therapeutic target in breast cancer brain metastases

Daniel L. Doheny, Sherona R. Sirkisoon, Tadas Rimkus, Dongqin Zhu, Noah R. Aguayo, Marlyn Anguelov, Sara Manore, Fei Xing, Linda Metheny-Barlow, Kounosuke Watabe, Alexandra Thomas, Adrianna Henson Masters, Roy E. Strowd, Hui-Wen Lo
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2866.
https://doi.org/10.1158/1538-7445.AM2021-2866
Published: 01 July 2021
View articletitled, Abstract 2866: Truncated glioma-associated oncogene homolog 1 (tGLI1) is an actionable therapeutic target in breast cancer brain metastases
Journal Articles

Abstract 3181: Nicotine promotes pre-metastatic niche formation in hormone receptor negative breast cancer through paracrine signaling in the tumor microenvironment

Abhishek Tyagi, Sambad Sharma, Kerui Wu, Shih-Ying Wu, Dan Zhao, Ravindra Deshpande, Kounosuke Watabe
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3181.
https://doi.org/10.1158/1538-7445.AM2021-3181
Published: 01 July 2021
View articletitled, Abstract 3181: Nicotine promotes pre-metastatic niche formation in hormone receptor negative breast cancer through paracrine signaling in the tumor microenvironment
Journal Articles

Epigenetic and Posttranscriptional Modulation of SOS1 Can Promote Breast Cancer Metastasis through Obesity-Activated c-Met Signaling in African-American Women

Fei Xing, Dan Zhao, Shih-Ying Wu, Abhishek Tyagi, Kerui Wu, Sambad Sharma, Yin Liu, Ravindra Deshpande, Yuezhu Wang, Jacob Cleary, Lance D. Miller, Amar G. Chittiboyina, Chinni Yalamanchili, Yin-Yuan Mo, Kounosuke Watabe
Journal: Cancer Research
Cancer Res (2021) 81 (11): 3008–3021.
https://doi.org/10.1158/0008-5472.CAN-19-4031
Published: 01 June 2021
View articletitled, Epigenetic and Posttranscriptional Modulation of SOS1 Can Promote Breast Cancer Metastasis through Obesity-Activated c-Met Signaling in African-American Women
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Includes: Supplementary data
Journal Articles

Abstract 5025: Antifungal ketoconazole inhibits tumor-specific transcription factor tGLI1 leading to suppression of breast cancer stem cells and brain metastasis

Daniel L. Doheny, Sherona R. Sirkisoon, Tadas Rimkus, Dongqin Zhu, Noah R. Aguayo, Alexandria Harrison, Marlyn Anguelov, Sara Manore, Fei Xing, Linda J. Metheny-Barlow, Kounosuke Watabe, Alexandra Thomas, Adrianna Henson Masters, Roy Strowd, Hui-Wen Lo
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5025.
https://doi.org/10.1158/1538-7445.AM2020-5025
Published: 15 August 2020
View articletitled, Abstract 5025: Antifungal ketoconazole inhibits tumor-specific transcription factor tGLI1 leading to suppression of breast cancer stem cells and brain metastasis
Journal Articles

Abstract 3689: Tumor-specific gain-of-function tGLI1 transcription factor is a novel mediator of breast cancer stem cells and a novel transcriptional activator of cancer stemness genes

Sherona R. Sirkisoon, Richard L. Carpenter, Tadas Rimkus, Daniel Doheny, Dongqin Zhu, Noah R. Aguayo, Marlyn Anguelov, Austin Arrigo, Fei Xing, Michael Chan, Jimmy Ruiz, Linda J. Metheny-Barlow, Roy Strowd, Jiayuh Lin, Boris C. Pasche, Waldemar Debinski, Kounosuke Watabe, Hui-Wen Lo
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3689.
https://doi.org/10.1158/1538-7445.AM2019-3689
Published: 01 July 2019
View articletitled, Abstract 3689: Tumor-specific gain-of-function tGLI1 transcription factor is a novel mediator of breast cancer stem cells and a novel transcriptional activator of cancer stemness genes
Journal Articles

Abstract 434: Breast cancer bone metastasis mediated by the exosomal miR-19a and secreted IBSP

Kerui Wu, Jiamei Feng, Fei Xing, Sambad Sharma, Yin Liu, Shih-Ying Wu, Abhishek Tyagi, Ravi Singh, Kounosuke Watabe
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 434.
https://doi.org/10.1158/1538-7445.AM2019-434
Published: 01 July 2019
View articletitled, Abstract 434: Breast cancer bone metastasis mediated by the exosomal miR-19a and secreted IBSP
Journal Articles

Abstract 1512: Nicotine promotes brain metastasis of lung cancer by inducing M1/M2 conversion and suppressing the innate immune response of microglia

Shih-Ying Wu, Fei Xing, Sambad Sharma, Abhishek Tyagi, Kerui Wu, Yin Liu, Dan Zhao, Ravindra Deshpande, Yusuke Shiozawa, Kounosuke Watabe
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1512.
https://doi.org/10.1158/1538-7445.AM2019-1512
Published: 01 July 2019
View articletitled, Abstract 1512: Nicotine promotes brain metastasis of lung cancer by inducing M1/M2 conversion and suppressing the innate immune response of microglia
Journal Articles

Abstract 3391: Dissecting intratumoral cell-cell interactions in myeloid reprogramming by single cell RNA-seq

Qianqian Song, Gregory A. Hawkins, Leonard Wudel, Ping-Chieh Chou, Elizabeth Forbes, Ashok K. Pullikuth, Liang Liu, Guangxu Jin, Lou Craddock, Umit Topaloglu, Gregory Kucera, Stacey O’Neill, Edward A. Levine, Peiqing Sun, Kounosuke Watabe, Yong Lu, Martha A. Alexander-Miller, Boris Pasche, Lance D. Miller, Wei Zhang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3391.
https://doi.org/10.1158/1538-7445.AM2019-3391
Published: 01 July 2019
View articletitled, Abstract 3391: Dissecting intratumoral cell-cell interactions in myeloid reprogramming by single cell RNA-seq
Journal Articles

Abstract 2025: Nicotine promotes lung metastasis in triple negative breast cancer through paracrine signaling in the tumor microenvironment

Abhishek Tyagi, Sambad Sharma, Kerui Wu, Shih-Ying Wu, Fei Xing, Yin Liu, Dan Zhao, Ravindra Pramod Deshpande, Yin-Yuan MO, Kounosuke Watabe
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2025.
https://doi.org/10.1158/1538-7445.AM2019-2025
Published: 01 July 2019
View articletitled, Abstract 2025: Nicotine promotes lung metastasis in triple negative breast cancer through paracrine signaling in the tumor microenvironment