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Kouji Matsushima
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Journal Articles

Abstract 607: CD8+ T cell clones maintain a pool of memory-like Ly108+ cells in the tumor during their contraction phase

Munetomo Takahashi, Mikiya Tsunoda, Hiroyasu Aoki, Haru Ogiwara, Shigeyuki Shichino, Kouji Matsushima, Satoshi Ueha
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 607.
https://doi.org/10.1158/1538-7445.AM2023-607
Published: 04 April 2023
View article titled, Abstract 607: CD8+ T cell clones maintain a pool of memory-like Ly108+ cells in the tumor during their contraction phase
Journal Articles

Abstract 5180: T cell receptor repertoire analysis revealed tissue tropism of tumor-reactive T-cell clones in cell cycle reporter mice

Mikiya Tsunoda, Hiroyasu Aoki, Munetomo Takahashi, Haruka Shimizu, Haru Ogiwara, Shigeyuki Shichino, Kouji Matsushima, Satoshi Ueha
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5180.
https://doi.org/10.1158/1538-7445.AM2023-5180
Published: 04 April 2023
View article titled, Abstract 5180: T cell receptor repertoire analysis revealed tissue tropism of tumor-reactive T-cell clones in cell cycle reporter mice
Journal Articles

Abstract 5630: Intratumoral regulatory T cell clones originate from the draining lymph nodes regulatory T cells

Hiroyasu Aoki, Haruka Shimizu, Shigeyuki Shichino, Mikiya Tsunoda, Haru Ogiwara, Shohei Hori, Kouji Matsushima, Satoshi Ueha
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5630.
https://doi.org/10.1158/1538-7445.AM2022-5630
Published: 15 June 2022
View article titled, Abstract 5630: Intratumoral regulatory T cell clones originate from the draining lymph nodes regulatory T cells
Journal Articles

Abstract LB-019: Anti-CD4 monoclonal antibody immunotherapy exerts an antitumor effect by replacing the T cell receptor repertoire in patients with gastrointestinal cancer

Hiroyasu Aoki, SATOSHI UEHA, Shigeyuki Shichino, Haru Ogiwara, Kohei Shitara, Tetsuya Nakatsura, Toshihiro Suzuki, Manami Shimomura, Toshiaki Yoshikawa, Kayoko Shoda, Shigehisa Kitano, Makiko Yamashita, Takayuki Nakayama, Akihiro Sato, Sakiko Kuroda, Masashi Wakabayashi, Shogo Nomura, Shoji Yokochi, Satoru Ito, Toshihiko Doi, Kouji Matsushima
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-019.
https://doi.org/10.1158/1538-7445.AM2019-LB-019
Published: 01 July 2019
View article titled, Abstract LB-019: Anti-CD4 monoclonal antibody immunotherapy exerts an antitumor effect by replacing the T cell receptor repertoire in patients with gastrointestinal cancer
Journal Articles

Abstract 3663: An anti-CD4 depleting antibody reverses regulatory T-cell-induced suppression of dendritic cells while preventing nonspecific CD4+ T cell responses in tumor-bearing mice

Satoshi Ueha, Haru Ogiwara, Shoji Yokochi, Yoshiro Ishiwata, Francis Shand, Shohei Hori, Kazuhiro Kakimi, Satoru Ito, Kouji Matsushima
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3663.
https://doi.org/10.1158/1538-7445.AM2017-3663
Published: 01 July 2017
View article titled, Abstract 3663: An anti-CD4 depleting antibody reverses regulatory T-cell-induced suppression of dendritic cells while preventing nonspecific CD4<sup>+</sup> T cell responses in tumor-bearing mice
Journal Articles

Abstract 4126: An anti-CD4 antibody protects mice from anti-PD-1/PDL-1 antibody-induced fatal anaphylaxis and shows potent anti-metastatic activity in the 4T1 spontaneous metastasis model

Satoru Ito, Shoji Yokochi, Yoshiro Ishiwata, Satoshi Ueha, Francis Shand, Kouji Matsushima
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4126.
https://doi.org/10.1158/1538-7445.AM2016-4126
Published: 15 July 2016
View article titled, Abstract 4126: An anti-CD4 antibody protects mice from anti-PD-1/PDL-1 antibody-induced fatal anaphylaxis and shows potent anti-metastatic activity in the 4T1 spontaneous metastasis model
Journal Articles

Abstract 265: Robust anti-tumor effects of combined anti-CD4 depleting antibody and anti-PD-1/PD-L1 immune checkpoint antibody treatment in mice

Satoru Ito, Kouji Matsushima, Satoshi Ueha, Shoji Yokochi, Yoshiro Ishiwata, Kosuke Hachiga, Haru Ogiwara, Krishant Chand, Takumi Nakajima
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 265.
https://doi.org/10.1158/1538-7445.AM2015-265
Published: 01 August 2015
View article titled, Abstract 265: Robust anti-tumor effects of combined anti-CD4 depleting antibody and anti-PD-1/PD-L1 immune checkpoint antibody treatment in mice
Journal Articles

Macrophage Inflammatory Protein Derivative ECI301 Enhances the Alarmin-Associated Abscopal Benefits of Tumor Radiotherapy

Shiro Kanegasaki, Kouji Matsushima, Kenshiro Shiraishi, Keiichi Nakagawa, Tomoko Tsuchiya
Journal: Cancer Research
Cancer Res (2014) 74 (18): 5070–5078.
https://doi.org/10.1158/0008-5472.CAN-14-0551
Published: 14 September 2014
View article titled, Macrophage Inflammatory Protein Derivative ECI301 Enhances the Alarmin-Associated Abscopal Benefits of Tumor Radiotherapy
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Includes: Supplementary data
Journal Articles

Abstract 5617: Enhancement of antitumor radiation efficacy and the abscopal effect by ECI301 mediated TLR4 dependent innate immunity in mice

Kenshiro Shiraishi, Shoji Yokochi, Yoshiro Ishiwata, Mariko Ishihara, Keiichi Nakagawa, Kouji Matsushima
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5617.
https://doi.org/10.1158/1538-7445.AM10-5617
Published: 15 April 2010
View article titled, Abstract 5617: Enhancement of antitumor radiation efficacy and the abscopal effect by ECI301 mediated TLR4 dependent innate immunity in mice
Journal Articles

Enhancement of antitumor radiation efficacy and consistent induction of the abscopal effect in mice by novel immunotherapy with ECI301, an active variant of MIP-1α

Kenshiro Shiraishi, Shoji Yokochi, Keiichi Nakagawa, Chiho Taruki, Teruo Akuta, Kuni Ohtomo, Kouji Matsushima, Shiro Kanegasaki
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4829.
Published: 01 May 2008
View article titled, Enhancement of antitumor radiation efficacy and consistent induction of the abscopal effect in mice by novel immunotherapy with ECI301, an active variant of MIP-1α
Journal Articles

ECI301, a derivative of MIP-1α enhances the efficacy of radiation and induces an abscopal effect in tumor-bearing mice

Ishiwata Yoshiro, Kenshiro Shiraishi, Keiichi Nakagawa, Shoji Yokochi, Chiho Taruki, Teruo Akuta, Mariko Ishihara, Takuya Tamatani, Shiro Kanegasaki, Kouji Matsushima
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 757.
Published: 01 May 2007
View article titled, ECI301, a derivative of MIP-1α enhances the efficacy of radiation and induces an abscopal effect in tumor-bearing mice
Journal Articles

Defucosylated chimeric anti-CCR4 IGG1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T cell leukemia and lymphoma.

Kenya Shitara, Rinpei Niwa, Kazuyasu Nakamura, Shiro Akinaga, Nobuo Hanai, Kouji Matsushima, Ryuzo Ueda
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 572.
Published: 01 April 2004
View article titled, Defucosylated chimeric anti-CCR4 IGG1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T cell leukemia and lymphoma.
Journal Articles

Defucosylated Chimeric Anti-CC Chemokine Receptor 4 IgG1 with Enhanced Antibody-Dependent Cellular Cytotoxicity Shows Potent Therapeutic Activity to T-Cell Leukemia and Lymphoma

Rinpei Niwa, Emi Shoji-Hosaka, Mikiko Sakurada, Toyohide Shinkawa, Kazuhisa Uchida, Kazuyasu Nakamura, Kouji Matsushima, Ryuzo Ueda, Nobuo Hanai, Kenya Shitara
Journal: Cancer Research
Cancer Res (2004) 64 (6): 2127–2133.
https://doi.org/10.1158/0008-5472.CAN-03-2068
Published: 16 March 2004
View article titled, Defucosylated Chimeric Anti-CC Chemokine Receptor 4 IgG1 with Enhanced Antibody-Dependent Cellular Cytotoxicity Shows Potent Therapeutic Activity to T-Cell Leukemia and Lymphoma
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Journal Articles

A Pivotal Role for CC Chemokine Receptor 5 in T-Cell Migration to Tumor Sites Induced by Interleukin 12 Treatment in Tumor-bearing Mice

Yasuhiro Uekusa, Wen-Gong Yu, Takao Mukai, Ping Gao, Nobuya Yamaguchi, Masako Murai, Kouji Matsushima, Satoshi Obika, Takeshi Imanishi, Yuji Higashibata, Shintaro Nomura, Yukihiko Kitamura, Hiromi Fujiwara, Toshiyuki Hamaoka
Journal: Cancer Research
Cancer Res (2002) 62 (13): 3751–3758.
Published: 01 July 2002
View article titled, A Pivotal Role for CC Chemokine Receptor 5 in T-Cell Migration to Tumor Sites Induced by Interleukin 12 Treatment in Tumor-bearing Mice
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Journal Articles

Natural Killer Cell-dependent Suppression of Systemic Spread of Human Lung Adenocarcinoma Cells by Monocyte Chemoattractant Protein-1 Gene Transfection in Severe Combined Immunodeficient Mice

Hiroshi Nokihara, Hiroaki Yanagawa, Yasuhiko Nishioka, Seiji Yano, Naofumi Mukaida, Kouji Matsushima, Saburo Sone
Journal: Cancer Research
Cancer Res (2000) 60 (24): 7002–7007.
Published: 01 December 2000
View article titled, Natural Killer Cell-dependent Suppression of Systemic Spread of Human Lung Adenocarcinoma Cells by Monocyte Chemoattractant Protein-1 Gene Transfection in Severe Combined Immunodeficient Mice
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Journal Articles

CC Chemokine Receptor-7 on Dendritic Cells Is Induced after Interaction with Apoptotic Tumor Cells: Critical Role in Migration from the Tumor Site to Draining Lymph Nodes

Motohiro Hirao, Nobuyuki Onai, Kazumasa Hiroishi, Simon C. Watkins, Kouji Matsushima, Paul D. Robbins, Michael T. Lotze, Hideaki Tahara
Journal: Cancer Research
Cancer Res (2000) 60 (8): 2209–2217.
Published: 01 April 2000
View article titled, CC Chemokine Receptor-7 on Dendritic Cells Is Induced after Interaction with Apoptotic Tumor Cells: Critical Role in Migration from the Tumor Site to Draining Lymph Nodes
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Journal Articles

Hypoxia-induced Elevation in Interleukin-8 Expression by Human Ovarian Carcinoma Cells

Lei Xu, Keping Xie, Naofumi Mukaida, Kouji Matsushima, Isaiah J. Fidler
Journal: Cancer Research
Cancer Res (1999) 59 (22): 5822–5829.
Published: 01 November 1999
View article titled, Hypoxia-induced Elevation in Interleukin-8 Expression by Human Ovarian Carcinoma Cells
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Journal Articles

Human T-Cell Leukemia Virus Type I Tax Transactivates Human Interleukin 8 Gene through Acting Concurrently on AP-1 and Nuclear Factor-κB-like Sites

Naoki Mori, Naofumi Mukaida, Dean W. Ballard, Kouji Matsushima, Naoki Yamamoto
Journal: Cancer Research
Cancer Res (1998) 58 (17): 3993–4000.
Published: 01 September 1998
View article titled, Human T-Cell Leukemia Virus Type I Tax Transactivates Human <em>Interleukin 8</em> Gene through Acting Concurrently on AP-1 and Nuclear Factor-κB-like Sites
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Journal Articles

Prevention of Adenocarcinoma Colon 26-induced Cachexia by Interleukin 10 Gene Transfer

Fujio Fujiki, Naofumi Mukaida, Kunitaka Hirose, Hiroshi Ishida, Akihisa Harada, Shinsuke Ohno, Horst Bluethmann, Masanobu Kawakami, Mariko Akiyama, Saburo Sone, Kouji Matsushima
Journal: Cancer Research
Cancer Res (1997) 57 (1): 94–99.
Published: 01 January 1997
View article titled, Prevention of Adenocarcinoma Colon 26-induced Cachexia by Interleukin 10 Gene Transfer
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Journal Articles

Molecular Analysis of the Cytokine Network Involved in Cachexia in Colon 26 Adenocarcinoma-bearing Mice

Kazuo Yasumoto, Naofumi Mukaida, Akihisa Harada, Kouji Kuno, Mariko Akiyama, Emiko Nakashima, Nakaba Fujioka, Masayoshi Mai, Tadashi Kasahara, Karoi Fujimoto-Ouchi, Kazushige Mori, Yutaka Tanaka, Kouji Matsushima
Journal: Cancer Research
Cancer Res (1995) 55 (4): 921–927.
Published: 01 February 1995
View article titled, Molecular Analysis of the Cytokine Network Involved in Cachexia in Colon 26 Adenocarcinoma-bearing Mice
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