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Koichi Takayama
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Journal Articles

Abstract 1941: AXL activation promotes adaptive resistance to KRAS-G12C inhibitors in KRAS-G12C-mutated non-small cell lung cancer

Kenji Morimoto, Tadaaki Yamada, Soichi Hirai, Yuki Katayama, Kei Kunimasa, Takaaki Sasaki, Makoto Nishida, Satoshi Watanabe, Shinsuke Shiotsu, Hisanori Uehara, Koichi Takayama
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1941.
https://doi.org/10.1158/1538-7445.AM2024-1941
Published: 22 March 2024
View article titled, Abstract 1941: AXL activation promotes adaptive resistance to KRAS-G12C inhibitors in KRAS-G12C-mutated non-small cell lung cancer
Journal Articles

Abstract 3730: Impact of proton pump inhibitor on ICI with or without chemotherapy for NSCLC with high PD-L1 TPS

Ryo Sawada, Hayato Kawachi, Tadaaki Yamada, Motohiro Tamiya, Yoshiki Negi, Yasuhiro Goto, Akira Nakao, Shinsuke Shiotsu, Takayuki Takeda, Asuka Okada, Taishi Harada, Koji Date, Yusuke Chihara, Isao Hasegawa, Takashi Kijima, Koichi Takayama
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3730.
https://doi.org/10.1158/1538-7445.AM2024-3730
Published: 22 March 2024
View article titled, Abstract 3730: Impact of proton pump inhibitor on ICI with or without chemotherapy for NSCLC with high PD-L1 TPS
Journal Articles

Abstract 3729: Association between clinical characteristics and treatment outcome of immune checkpoint inhibitor with or without chemotherapy in elderly non-small cell lung cancer patients with high PD-L1 expression

Hayato Kawachi, Shota Takei, Tadaaki Yamada, Motohiro Tamiya, Yoshiki Negi, Yasuhiro Goto, Akira Nakao, Shinsuke Shiotsu, Takayuki Takeda, Asuka Okada, Taishi Harada, Koji Date, Yusuke Chihara, Isao Hasegawa, Nobuyo Tamiya, Takashi Kijima, Koichi Takayama
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3729.
https://doi.org/10.1158/1538-7445.AM2024-3729
Published: 22 March 2024
View article titled, Abstract 3729: Association between clinical characteristics and treatment outcome of immune checkpoint inhibitor with or without chemotherapy in elderly non-small cell lung cancer patients with high PD-L1 expression
Journal Articles

Abstract 7194: Targeting AXL and MCL-1 to eradicate lazertinib tolerance in EGFR-mutated NSCLC cells

Tadaaki Yamada, Yohei Matsui, Koichi Takayama
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7194.
https://doi.org/10.1158/1538-7445.AM2024-7194
Published: 22 March 2024
View article titled, Abstract 7194: Targeting AXL and MCL-1 to eradicate lazertinib tolerance in EGFR-mutated NSCLC cells
Journal Articles

Abstract 935: The real-world data of the cancer genome profiling testing for pancreatic ductal adenocarcinoma from a nationwide database in Japan

Toshifumi Doi, Takeshi Ishikawa, Tomoki Sakakida, Ryuichi Morita, Daiki Sone, Junichiro Itani, Seita Kataoka, Hayato Miyake, Masahiro Iwasaku, Yoshio Sogame, Hideyuki Konishi, Koichi Takayama, Yoshito Itoh
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 935.
https://doi.org/10.1158/1538-7445.AM2023-935
Published: 04 April 2023
View article titled, Abstract 935: The real-world data of the cancer genome profiling testing for pancreatic ductal adenocarcinoma from a nationwide database in Japan
Journal Articles

Abstract 594: Effects of interstitial pressure on lung cancer cells

Shinsaku Tokuda, Keisuke Onoi, Tadaaki Yamada, Koichi Takayama
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 594.
https://doi.org/10.1158/1538-7445.AM2023-594
Published: 04 April 2023
View article titled, Abstract 594: Effects of interstitial pressure on lung cancer cells
Journal Articles

Abstract 4015: EGFR activation via c-Jun axis promotes adaptive resistance to third generation ALK-TKI lorlatinib in ALK-rearranged non-small cell lung cancer cells

Yuki Katayama, Tadaaki Yamada, Kenji Morimoto, Hiroaki Ozasa, Shinsaku Tokuda, Koichi Takayama
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4015.
https://doi.org/10.1158/1538-7445.AM2023-4015
Published: 04 April 2023
View article titled, Abstract 4015: EGFR activation via c-Jun axis promotes adaptive resistance to third generation ALK-TKI lorlatinib in ALK-rearranged non-small cell lung cancer cells
Journal Articles

Abstract 410: Tumor heterogeneity via AXL activation on primary resistance to EGFR tyrosine kinase inhibitors in EGFR mutated lung cancer

Tadaaki Yamada, Ryota Nakamura, Hiroyuki Fujii, Takeshi Yaoi, Kyoko Itoh, Shinsaku Tokuda, Koichi Takayama
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 410.
https://doi.org/10.1158/1538-7445.AM2023-410
Published: 04 April 2023
View article titled, Abstract 410: Tumor heterogeneity via AXL activation on primary resistance to EGFR tyrosine kinase inhibitors in EGFR mutated lung cancer
Journal Articles

Abstract 6222: Clinical impact of p53 and AXL immunostaining on the efficacy of immune checkpoint inhibitor-based therapy after osimertinib treatment in patients with epidermal growth factor mutant non-small cell lung cancer

Kenji Morimoto, Tadaaki Yamada, Shinsaku Tokuda, Koichi Takayama
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6222.
https://doi.org/10.1158/1538-7445.AM2023-6222
Published: 04 April 2023
View article titled, Abstract 6222: Clinical impact of p53 and AXL immunostaining on the efficacy of immune checkpoint inhibitor-based therapy after osimertinib treatment in patients with epidermal growth factor mutant non-small cell lung cancer
Journal Articles

Abstract 1986: Mutation analysis in cell-free DNA upon development of resistance to afatinib

Nanao Terada, Hideharu Kimura, Mako Miyakawa, Hayato Koba, Taro Yoneda, Takayuki Takeda, Hiroki Shirasaki, Kazuhiko Shibata, Koichi Nishi, Koichi Takayama, Kazuo Kasahara
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1986.
https://doi.org/10.1158/1538-7445.AM2020-1986
Published: 15 August 2020
View article titled, Abstract 1986: Mutation analysis in cell-free DNA upon development of resistance to afatinib
Journal Articles

Abstract 4306: Retrospective analysis of docetaxel in combination with ramucirumab for previously treated non-small cell lung cancer patients

Rui Kitadai, Akihiro Yoshimura, Tadaaki Yamada, Yusuke Okuma, Takayuki Takeda, Takanori Kanematsu, Junji Uchino, Yasuhiko Nishioka, Koichi Takayama
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4306.
https://doi.org/10.1158/1538-7445.AM2020-4306
Published: 15 August 2020
View article titled, Abstract 4306: Retrospective analysis of docetaxel in combination with ramucirumab for previously treated non-small cell lung cancer patients
Journal Articles

Abstract 3996: Search for prognosis prediction factors in treatment selection for elderly patients with EGFR negative advanced stage non-small cell lung cancer patients

Yoshiko Kaneko, Takako Mouri, Nobuyo Tamiya, Tadaaki Yamada, Junji Uchino, Koichi Takayama
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3996.
https://doi.org/10.1158/1538-7445.AM2019-3996
Published: 01 July 2019
View article titled, Abstract 3996: Search for prognosis prediction factors in treatment selection for elderly patients with EGFR negative advanced stage non-small cell lung cancer patients
Journal Articles

Abstract 4036: The efficacy of immune checkpoint inhibitors in patients with EGFR mutated non small cell lung cancer in retrospective analysis

Tadaaki Yamada, Soichi Hirai, Akihiro Yoshimura, Satoshi Watanabe, Junji Uchino, Koichi Takayama
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4036.
https://doi.org/10.1158/1538-7445.AM2019-4036
Published: 01 July 2019
View article titled, Abstract 4036: The efficacy of immune checkpoint inhibitors in patients with EGFR mutated non small cell lung cancer in retrospective analysis
Journal Articles

Abstract 4899: The impact of the EGFR-T790M mutation detection by re-biopsy in EGFR mutant NSCLC patients in the retrospective analysis

Akihiro Yoshimura, Tadaaki Yamada, Naoko Okura, Junji Uchino, Koichi Takayama
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4899.
https://doi.org/10.1158/1538-7445.AM2019-4899
Published: 01 July 2019
View article titled, Abstract 4899: The impact of the <em>EGFR</em>-T790M mutation detection by re-biopsy in EGFR mutant NSCLC patients in the retrospective analysis
Journal Articles

Abstract 313: AXL confers intrinsic resistance to osimertinib and the emergence of tolerant cells

Hirokazu Taniguchi, Tadaaki Yamada, Rong Wang, Keiko Tanimura, Akihiro Nishiyama, Azusa Tanimoto, Yuta Adachi, Shinji Takeuchi, Hiroyuki Yamaguchi, Minoru Fukuda, Koichi Takayama, Hiroshi Mukae, Seiji Yano
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 313.
https://doi.org/10.1158/1538-7445.AM2019-313
Published: 01 July 2019
View article titled, Abstract 313: AXL confers intrinsic resistance to osimertinib and the emergence of tolerant cells
Journal Articles

Abstract 1692: The impact of neutrophil/lymphocyte ratio as the predictive marker to anti-PD-1 antibody treatment in NSCLC patients

Keiko Tanimura, Tadaaki Yamada, Nobuyo Tamiya, Yoshiko Kaneko, Takayuki Takeda, Junji Uchino, Yutaka Kubota, Koichi Takayama
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1692.
https://doi.org/10.1158/1538-7445.AM2018-1692
Published: 01 July 2018
View article titled, Abstract 1692: The impact of neutrophil/lymphocyte ratio as the predictive marker to anti-PD-1 antibody treatment in NSCLC patients
Journal Articles

Abstract 5843: The efficacy of a histone deacetylase inhibitor in combination with a MEK inhibitor in lung cancer cells harboring RAS mutations

Tadaaki Yamada, Joseph M. Amann, Azusa Tanimoto, Hirokazu Taniguchi, Takehito Shukuya, Seiji Yano, Koichi Takayama, David P. Carbone
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5843.
https://doi.org/10.1158/1538-7445.AM2018-5843
Published: 01 July 2018
View article titled, Abstract 5843: The efficacy of a histone deacetylase inhibitor in combination with a MEK inhibitor in lung cancer cells harboring RAS mutations
Journal Articles

Abstract 2814: Therapeutic vaccination with GM-CSF gene-transduced iPS cells induces potent T cells-mediated antitumor immunity

Hiroyuki Inoue, Ayumi Watanabe, Megumi Narusawa, Chika Sakamoto, Takafumi Hiramoto, Shohei Miyamoto, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, Tomoki Todo, Kenzaburo Tani
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2814.
https://doi.org/10.1158/1538-7445.AM2014-2814
Published: 01 October 2014
View article titled, Abstract 2814: Therapeutic vaccination with GM-CSF gene-transduced iPS cells induces potent T cells-mediated antitumor immunity
Journal Articles

Coxsackievirus B3 Is an Oncolytic Virus with Immunostimulatory Properties That Is Active against Lung Adenocarcinoma

Shohei Miyamoto, Hiroyuki Inoue, Takafumi Nakamura, Meiko Yamada, Chika Sakamoto, Yasuo Urata, Toshihiko Okazaki, Tomotoshi Marumoto, Atsushi Takahashi, Koichi Takayama, Yoichi Nakanishi, Hiroyuki Shimizu, Kenzaburo Tani
Journal: Cancer Research
Cancer Res (2012) 72 (10): 2609–2621.
https://doi.org/10.1158/0008-5472.CAN-11-3185
Published: 14 May 2012
View article titled, Coxsackievirus B3 Is an Oncolytic Virus with Immunostimulatory Properties That Is Active against Lung Adenocarcinoma
Open the PDF for Coxsackievirus B3 Is an Oncolytic Virus with Immunostimulatory Properties That Is Active against Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract LB-369: Coxsackievirus B3 is an immunostimulatory oncolytic virus active against lung adenocarcinoma

Shohei Miyamoto, Hiroyuki Inoue, Beibei Wang, Keisuke Yasunari, Takafumi Nakamura, Meiko Yamada, Yasuo Urata, Tomotoshi Marumoto, Atsushi Takahashi, Koichi Takayama, Yoichi Nakanishi, Hiroyuki Shimizu, Kenzaburo Tani
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-369.
https://doi.org/10.1158/1538-7445.AM2012-LB-369
Published: 15 April 2012
View article titled, Abstract LB-369: Coxsackievirus B3 is an immunostimulatory oncolytic virus active against lung adenocarcinoma