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Klaus Podar
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Journal Articles

Retraction: Insulin-like Growth Factor-1 Induces Adhesion and Migration in Human Multiple Myeloma Cells via Activation of β1-Integrin and Phosphatidylinositol 3′-Kinase/AKT Signaling

Yu-Tzu Tai, Klaus Podar, Laurence Catley, Yu-Hua Tseng, Masaharu Akiyama, Reshma Shringarpure, Renate Burger, Teru Hideshima, Dharminder Chauhan, Nicholas Mitsiades, Paul Richardson, Nikhil C. Munshi, C. Ronald Kahn, Constantine Mitsiades, Kenneth C. Anderson
Journal: Cancer Research
Cancer Res (2024) 84 (6): 938.
https://doi.org/10.1158/0008-5472.CAN-24-0519
Published: 15 March 2024
View article titled, Retraction: Insulin-like Growth Factor-1 Induces Adhesion and Migration in Human Multiple Myeloma Cells via Activation of β1-Integrin and Phosphatidylinositol 3′-Kinase/AKT Signaling
Open the PDF for Retraction: Insulin-like Growth Factor-1 Induces Adhesion and Migration in Human Multiple Myeloma Cells via Activation of β1-Integrin and Phosphatidylinositol 3′-Kinase/AKT Signaling in another window
Journal Articles

Retraction: Mechanisms by which SGN-40, a Humanized Anti-CD40 Antibody, Induces Cytotoxicity in Human Multiple Myeloma Cells: Clinical Implications

Yu-Tzu Tai, Laurence P. Catley, Constantine S. Mitsiades, Renate Burger, Klaus Podar, Reshma Shringpaure, Teru Hideshima, Dharminder Chauhan, Makoto Hamasaki, Kenji Ishitsuka, Paul Richardson, Steven P. Treon, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Cancer Research
Cancer Res (2024) 84 (6): 936.
https://doi.org/10.1158/0008-5472.CAN-24-0520
Published: 15 March 2024
View article titled, Retraction: Mechanisms by which SGN-40, a Humanized Anti-CD40 Antibody, Induces Cytotoxicity in Human Multiple Myeloma Cells: Clinical Implications
Open the PDF for Retraction: Mechanisms by which SGN-40, a Humanized Anti-CD40 Antibody, Induces Cytotoxicity in Human Multiple Myeloma Cells: Clinical Implications in another window
Journal Articles

Abstract 2912: The AP-1 transcription factor JunB promotes multiple myeloma cell proliferation, survival and drug resistance in the bone marrow microenvironment

Fengjuan Fan, Sonia Vallet, Muhammad Hasan Bashari, Mostafa Jarahian, Eugenio Morelli, Dirk Hose, Latifa Bakiri, Claudia Ball, Hanno Glimm, Martin Sattler, Hartmut Goldschmidt, Giovanni Tonon, Pierfrancesco Tassone, Erwin F. Wagner, Dirk Jäger, Klaus Podar
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2912.
https://doi.org/10.1158/1538-7445.AM2016-2912
Published: 15 July 2016
View article titled, Abstract 2912: The AP-1 transcription factor JunB promotes multiple myeloma cell proliferation, survival and drug resistance in the bone marrow microenvironment
Journal Articles

Prolyl Hydroxylase 3 Attenuates MCL-1–Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells

Praveenkumar Radhakrishnan, Nadine Ruh, Jonathan M. Harnoss, Judit Kiss, Martin Mollenhauer, Anna-Lena Scherr, Lisa K. Platzer, Thomas Schmidt, Klaus Podar, Joseph T. Opferman, Juergen Weitz, Henning Schulze-Bergkamen, Bruno C. Koehler, Alexis Ulrich, Martin Schneider
Journal: Cancer Research
Cancer Res (2016) 76 (8): 2219–2230.
https://doi.org/10.1158/0008-5472.CAN-15-1474
Published: 14 April 2016
View article titled, Prolyl Hydroxylase 3 Attenuates MCL-1–Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells
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Journal Articles

Abstract 3383: JunB/AP-1 controls MM cell proliferation, survival and drug resistance in the bone marrow microenvironment

Fengjuan Fan, Sonia Vallet, Martin Sattler, Giovanni Tonon, Muhammad Hasan Bashari, Latifa Bakiri, Hartmut Goldschmidt, Erwin F. Wagner, Dirk Jaeger, Klaus Podar
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3383.
https://doi.org/10.1158/1538-7445.AM2014-3383
Published: 01 October 2014
View article titled, Abstract 3383: JunB/AP-1 controls MM cell proliferation, survival and drug resistance in the bone marrow microenvironment
Journal Articles

Abstract 1734: Drug- induced generation of Mcl-1128-350 fragment triggers apoptosis in multiple myeloma cells through upregulation of c-Jun.

Fengjuan Fan, Giovanni Tonon, Martin Sattler, Hartmut Goldschmidt, Joseph Opferman, Kenneth C. Anderson, Dirk Jäger, Klaus Podar
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1734.
https://doi.org/10.1158/1538-7445.AM2013-1734
Published: 15 April 2013
View article titled, Abstract 1734: Drug- induced generation of Mcl-1<sup>128-350</sup> fragment triggers apoptosis in multiple myeloma cells through upregulation of c-Jun.
Journal Articles

GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth In Vitro and In Vivo

Marc S. Raab, Iris Breitkreutz, Simon Anderhub, Mads H. Rønnest, Blanka Leber, Thomas O. Larsen, Ludmila Weiz, Gleb Konotop, Patrick J. Hayden, Klaus Podar, Johannes Fruehauf, Felix Nissen, Walter Mier, Uwe Haberkorn, Anthony D. Ho, Hartmut Goldschmidt, Kenneth C. Anderson, Mads H. Clausen, Alwin Krämer
Journal: Cancer Research
Cancer Res (2012) 72 (20): 5374–5385.
https://doi.org/10.1158/0008-5472.CAN-12-2026
Published: 14 October 2012
View article titled, GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth <em>In Vitro</em> and <em>In Vivo</em>
Open the PDF for GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth <em>In Vitro</em> and <em>In Vivo</em> in another window
Includes: Supplementary data
Journal Articles

Abstract 660: Inhibition of centrosomal clustering suppresses tumor growth in vivo

Marc S. Raab, Iris Breitkreutz, Blanka Leber, Ludmila Weitz, Patrick J. Hayden, Thomas O. Larsen, Mads H. Cllausen, Johannes Fruehauf, Felix Nissen, Walter Mier, Uwe Haberkorn, Klaus Podar, Anthony D. Ho, Hartmut Goldschmidt, Kenneth C. Anderson, Alwin Kraemer
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 660.
https://doi.org/10.1158/1538-7445.AM2011-660
Published: 15 April 2011
View article titled, Abstract 660: Inhibition of centrosomal clustering suppresses tumor growth <em>in vivo</em>
Journal Articles

Targeting Angiogenesis via a c-Myc/Hypoxia-Inducible Factor-1α–Dependent Pathway in Multiple Myeloma

Jing Zhang, Martin Sattler, Giovanni Tonon, Clemens Grabher, Samir Lababidi, Alexander Zimmerhackl, Marc S. Raab, Sonia Vallet, Yiming Zhou, Marie-Astrid Cartron, Teru Hideshima, Yu-Tzu Tai, Dharminder Chauhan, Kenneth C. Anderson, Klaus Podar
Journal: Cancer Research
Cancer Res (2009) 69 (12): 5082–5090.
https://doi.org/10.1158/0008-5472.CAN-08-4603
Published: 15 June 2009
View article titled, Targeting Angiogenesis via a c-Myc/Hypoxia-Inducible Factor-1α–Dependent Pathway in Multiple Myeloma
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Includes: Supplementary data
Journal Articles

Abstract #325: CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells

Yu-Tzu Tai, Ender Soydan, Mariateresa Fulciniti, Weihua Song, Kihyun Kim, Fangxin Hong, Xian-Feng Li, Peter Burger, Mathew J Rumizen Mathew J Rumizen, Sabikun Nahar, Klaus Podar Klaus Podar, Dharminder Chauhan, Teru Hideshima, Nikhil Munshi, Giovanni Tonon Giovanni Tonon, Ruben Carrasco, Kenneth Anderson
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 325.
Published: 01 May 2009
View article titled, Abstract #325: CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells
Journal Articles

Abstract #2236: Potential therapeutic role of the selective adhesion molecule inhibitor natalizumab (Tysabri) in Multiple Myeloma

Klaus Podar, Alexander Zimmerhackl, Dian Olson, Yu-Tzu Tai, Teru Hideshima, Dharminder Chauhan, Kenneth Anderson
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2236.
Published: 01 May 2009
View article titled, Abstract #2236: Potential therapeutic role of the selective adhesion molecule inhibitor natalizumab (Tysabri) in Multiple Myeloma
Journal Articles

Abstract #3185: Targeting angiogenesis via a c-Myc/ Hif-1\#945;- dependent pathway in MM

Klaus Podar, Jing Zhang, Giovanni Tonon, Martin Sattler, Clemens Grabher, Samir Lababidi, Alexander Zimmerhackl, Marc Raab, Sonia Vallet, Yiming Zhou, Marie-Astrid Cartron, Yu-Tzu Tai, Dharminder Chauhan, Kenneth Anderson
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3185.
Published: 01 May 2009
View article titled, Abstract #3185: Targeting angiogenesis via a c-Myc/ Hif-1\#945;- dependent pathway in MM
Journal Articles

The tyrophostin adaphostin (NSC680410) inhibits multiple myeloma bone marrow angiogenesis in in vitro and in vivo studies

Klaus Podar, Jing Zhang, Marc Raab, Sonia Vallet, Giovanni Tonon, Martin Sattler, Yutaka Ikeda, Teru Hideshima, Dharminder Chauhan, Kenneth Anderson
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5529.
Published: 01 May 2008
View article titled, The tyrophostin adaphostin (NSC680410) inhibits multiple myeloma bone marrow angiogenesis in <em>in vitro</em> and <em>in vivo</em> studies
Journal Articles

Targeting PKC alters ER-stress and β-catenin signaling in multiple myeloma: Therapeutic implications

Marc Raab, Klaus Podar, Jing Zhang, Giovanni Tonon, Iris Breitkreutz, Johannes Fruehauf, Boris Lin, Teru Hideshima, Dharminder Chauhan, Kenneth Anderson
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2564.
Published: 01 May 2008
View article titled, Targeting PKC alters ER-stress and β-catenin signaling in multiple myeloma: Therapeutic implications
Journal Articles

The novel, orally available small- molecule PKC inhibitor enzastaurin (LY317615.HCl) in multiple myeloma: in vitro and in vivo effects and therapeutic implications

Marc Raab, Klaus Podar, Jing Zhang, Douglas McMillin, Iris Breitkreutz, Teru Hideshima, Nikhil Munshi, Boris Lin, Dharminder Chauhan, Kenneth Anderson
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3262.
Published: 01 May 2007
View article titled, The novel, orally available small- molecule PKC inhibitor enzastaurin (LY317615.HCl) in multiple myeloma: <em>in vitro</em> and <em>in vivo</em> effects and therapeutic implications
Journal Articles

Inhibition of MAPK/ERK1/2 activity by MEK1/2 inhibitor AZD6244 (ARRY-142886) induces human multiple myeloma (MM) cell apoptosis and blocks MM interactions within the bone marrow microenvironment: a new therapeutic strategy for MM

Yu-Tzu Tai, Teru Hideshima, Weihua Song, Xian-Feng Li, Matthew Rumizen, Peter Burger, Aileen Morrison, Klaus Podar, Robert Schlossman, Paul Richardson, Nikhil Munshi, Irene Ghobria, Paul Smith, Kenneth Anderson
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3242.
Published: 01 May 2007
View article titled, Inhibition of MAPK/ERK1/2 activity by MEK1/2 inhibitor AZD6244 (ARRY-142886) induces human multiple myeloma (MM) cell apoptosis and blocks MM interactions within the bone marrow microenvironment: a new therapeutic strategy for MM
Journal Articles

Upregulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma and other malignancies

Klaus Podar, Marc Raab, Giovanni Tonon, Martin Sattler, Daniela Barila, Jing Zhang, Yu-Tzu Tai, Noopur Raje, Ronald DePinho, Teru Hideshima, Dharminder Chauhan, Kenneth Anderson
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5143.
Published: 01 May 2007
View article titled, Upregulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma and other malignancies
Journal Articles

Up-Regulation of c-Jun Inhibits Proliferation and Induces Apoptosis via Caspase-Triggered c-Abl Cleavage in Human Multiple Myeloma

Klaus Podar, Marc S. Raab, Giovanni Tonon, Martin Sattler, Daniela Barilà, Jing Zhang, Yu-Tzu Tai, Hiroshi Yasui, Noopur Raje, Ronald A. DePinho, Teru Hideshima, Dharminder Chauhan, Kenneth C. Anderson
Journal: Cancer Research
Cancer Res (2007) 67 (4): 1680–1688.
https://doi.org/10.1158/0008-5472.CAN-06-1863
Published: 16 February 2007
View article titled, Up-Regulation of c-Jun Inhibits Proliferation and Induces Apoptosis via Caspase-Triggered c-Abl Cleavage in Human Multiple Myeloma
Open the PDF for Up-Regulation of c-Jun Inhibits Proliferation and Induces Apoptosis via Caspase-Triggered c-Abl Cleavage in Human Multiple Myeloma in another window
Includes: Supplementary data
Journal Articles

Role of B-Cell–Activating Factor in Adhesion and Growth of Human Multiple Myeloma Cells in the Bone Marrow Microenvironment

Yu-Tzu Tai, Xian-Feng Li, Iris Breitkreutz, Weihua Song, Paola Neri, Laurence Catley, Klaus Podar, Teru Hideshima, Dharminder Chauhan, Noopur Raje, Robert Schlossman, Paul Richardson, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Cancer Research
Cancer Res (2006) 66 (13): 6675–6682.
https://doi.org/10.1158/0008-5472.CAN-06-0190
Published: 03 July 2006
View article titled, Role of B-Cell–Activating Factor in Adhesion and Growth of Human Multiple Myeloma Cells in the Bone Marrow Microenvironment
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Journal Articles

In vitro and in vivo activity of the VEGF receptor inhibitor PAZOPANIB (GW786034) in Multiple Myeloma: Therapeutic implications.

Klaus Podar, Giovanni Tonon, Dean Abtahi, Laurence P. Catley, Yu-Tzu Tai, Steven Legouill, Hiroshi Yasui, Martin Sattler, Rakesh Kumar, Lini N. Pandite, Teru Hideshima, Dharminder Chauhan, Kenneth C. Anderson
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1330.
Published: 15 April 2006
View article titled, In vitro and in vivo activity of the VEGF receptor inhibitor PAZOPANIB (GW786034) in Multiple Myeloma: Therapeutic implications.