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Journal Articles

NK012, SN-38-incorporating micellar nanoparticle, improves tumor disposition of SN-38 and elicits superior antitumor activity to irinotecan.

Shin-ichi Matsumoto, Rika Goda, Takeshi Onda, Eiji Ichimura, Iwao Nakamura, Takashi Kawashiro, Kazuya Okamoto, Kiyohiro Nishikawa, Yuh-ichiro Ichikawa

Cancer Res (2008) 68 (9_Supplement): 5627.

Published: 01 May 2008

View articletitled, NK012, SN-38-incorporating micellar nanoparticle, improves tumor disposition of SN-38 and elicits superior antitumor activity to irinotecan.

Journal Articles

Sequence-dependent combination effect of NK012, a novel micellar nanoparticle of SN-38, with 5-fluorouracil in mouse colon cancer model.

Takeshi Onda, Hiroko Mashiba, Chieko Seno, Shin-ichi Matsumoto, Eiji Ichimura, Takemitsu Nagahata, Kazuya Okamoto, Kiyohiro Nishikawa

Cancer Res (2008) 68 (9_Supplement): 5626.

Published: 01 May 2008

View articletitled, Sequence-dependent combination effect of NK012, a novel micellar nanoparticle of SN-38, with 5-fluorouracil in mouse colon cancer model.

Journal Articles

ATM and DNA-PK play important roles in cell survival in response to a DNA intercalator, NK314

Lei Guo, Xiaojun Liu, Kiyohiro Nishikawa, William Plunkett

Cancer Res (2008) 68 (9_Supplement): 645.

Published: 01 May 2008

View articletitled, ATM and DNA-PK play important roles in cell survival in response to a DNA intercalator, NK314

Journal Articles

NK314 is a topoisomerase IIα specific inhibitor inducing stable cleavage complex and rapid DNA double strand breaks.

Eriko Toyoda, Shigehide Kagaya, Kazuya Okamoto, Hideki Koyama, Noritaka Adachi, Kiyohiro Nishikawa

Cancer Res (2007) 67 (9_Supplement): 782.

Published: 01 May 2007

View articletitled, NK314 is a topoisomerase IIα specific inhibitor inducing stable cleavage complex and rapid DNA double strand breaks.

Journal Articles

Marked antitumor activity of NK012, 7-ethyl-10-hydroxycamptothecin-incorporating micellar nanoparticle, in liver metastatic tumor model of colorectal cancer

Takeshi Onda, Eiji Ichimura, Shin-ichi Matsumoto, Kazuya Okamoto, Kiyohiro Nishikawa

Cancer Res (2007) 67 (9_Supplement): 1495.

Published: 01 May 2007

View articletitled, Marked antitumor activity of NK012, 7-ethyl-10-hydroxycamptothecin-incorporating micellar nanoparticle, in liver metastatic tumor model of colorectal cancer

Journal Articles

Induction of DNA double-strand breaks by NK314 via stabilization of topoisomerase II cleavage complexes, and inhibition of DNA-PK sensitizes cells to NK314

Lei Guo, Xiaojun Liu, Elaine Willmore, Kiyohiro Nishikawa, William Plunkett

Cancer Res (2007) 67 (9_Supplement): 4030.

Published: 01 May 2007

View articletitled, Induction of DNA double-strand breaks by NK314 via stabilization of topoisomerase II cleavage complexes, and inhibition of DNA-PK sensitizes cells to NK314

Journal Articles

NK314, a novel antitumor agent, induces rapid double strand DNA breaks by specific inhibition of topoisomerase IIα.

Shigehide Kagaya, Eriko Toyoda, Kazuhiro Tokunaka, Akira Masuda, Hirofumi Yokoyama, Kazuya Okamoto, Kiyohiro Nishikawa

Cancer Res (2006) 66 (8_Supplement): 1299.

Published: 15 April 2006

View articletitled, NK314, a novel antitumor agent, induces rapid double strand DNA breaks by specific inhibition of topoisomerase IIα.

Journal Articles

G2 arrest by NK314 and consequence of checkpoint abrogation

Lei Guo, Xiaojun Liu, Kiyohiro Nishikawa, William Plunkett

Cancer Res (2006) 66 (8_Supplement): 490.

Published: 15 April 2006

View articletitled, G2 arrest by NK314 and consequence of checkpoint abrogation

Journal Articles

Superior antitumor activity of NK012, 7-ethyl-10-hydroxycamptothecin-incorporating micellar nanoparticle, to irinotecan

Takeshi Onda, Iwao Nakamura, Chieko Seno, Shinichi Matsumoto, Masayuki Kitagawa, Kazuya Okamoto, Kiyohiro Nishikawa, Masanobu Suzuki

Cancer Res (2006) 66 (8_Supplement): 720.

Published: 15 April 2006

View articletitled, Superior antitumor activity of NK012, 7-ethyl-10-hydroxycamptothecin-incorporating micellar nanoparticle, to irinotecan

Journal Articles

Rapid DNA breakage induced by a novel antitumor agent, NK314

Kazuya Okamoto, Chieko Seno, Takeshi Onda, Eriko Toyoda, Kiyohiro Nishikawa

Cancer Res (2005) 65 (9_Supplement): 319.

Published: 01 May 2005

View articletitled, Rapid DNA breakage induced by a novel antitumor agent, NK314

Journal Articles

Molecular basis for G2 arrest by the novel antitumor agent NK314

Lei Guo, Xiaojun Liu, Kiyohiro Nishikawa, William Plunkett

Cancer Res (2005) 65 (9_Supplement): 397.

Published: 01 May 2005

View articletitled, Molecular basis for G2 arrest by the novel antitumor agent NK314

Journal Articles

Resistance of Human Cervical Carcinoma Cells to Tumor Necrosis Factor Correlates with Their Increased Sensitivity to Cisplatin: Evidence of a Role for DNA Repair and Epidermal Growth Factor Receptor

Kiyohiro Nishikawa, Michael G. Rosenblum, Robert A. Newman, Tej K. Pandita, Walter N. Hittelman, Nicholas J. Donato

Cancer Res (1992) 52 (17): 4758–4765.

Published: 01 September 1992

View articletitled, Resistance of Human Cervical Carcinoma Cells to Tumor Necrosis Factor Correlates with Their Increased Sensitivity to Cisplatin: Evidence of a Role for DNA Repair and Epidermal Growth Factor Receptor

Journal Articles

Liblomycin-mediated DNA Cleavage in Human Head and Neck Squamous Carcinoma Cells and Purified DNA

Karsten Wassermann, Leonard A. Zwelling, J. William Lown, John A. Hartley, Kiyohiro Nishikawa, Juan-Ru Lin, Robert A. Newman

Cancer Res (1990) 50 (6): 1732–1737.

Published: 01 March 1990

View articletitled, Liblomycin-mediated DNA Cleavage in Human Head and Neck Squamous Carcinoma Cells and Purified DNA

Journal Articles

Involvement of Cytotoxic T-Lymphocytes in the Antitumor Activity of Spergualin against L1210 Cells

Hamao Umezawa, Kiyohiro Nishikawa, Chieko Shibasaki, Katsutoshi Takahashi, Teruya Nakamura, Tomio Takeuchi

Cancer Res (1987) 47 (12): 3062–3065.

Published: 01 June 1987

View articletitled, Involvement of Cytotoxic T-Lymphocytes in the Antitumor Activity of Spergualin against L1210 Cells

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NK012, SN-38-incorporating micellar nanoparticle, improves tumor disposition of SN-38 and elicits superior antitumor activity to irinotecan.

Sequence-dependent combination effect of NK012, a novel micellar nanoparticle of SN-38, with 5-fluorouracil in mouse colon cancer model.

ATM and DNA-PK play important roles in cell survival in response to a DNA intercalator, NK314

NK314 is a topoisomerase IIα specific inhibitor inducing stable cleavage complex and rapid DNA double strand breaks.

Marked antitumor activity of NK012, 7-ethyl-10-hydroxycamptothecin-incorporating micellar nanoparticle, in liver metastatic tumor model of colorectal cancer

Induction of DNA double-strand breaks by NK314 via stabilization of topoisomerase II cleavage complexes, and inhibition of DNA-PK sensitizes cells to NK314

NK314, a novel antitumor agent, induces rapid double strand DNA breaks by specific inhibition of topoisomerase IIα.

G2 arrest by NK314 and consequence of checkpoint abrogation

Superior antitumor activity of NK012, 7-ethyl-10-hydroxycamptothecin-incorporating micellar nanoparticle, to irinotecan

Rapid DNA breakage induced by a novel antitumor agent, NK314

Molecular basis for G2 arrest by the novel antitumor agent NK314

Resistance of Human Cervical Carcinoma Cells to Tumor Necrosis Factor Correlates with Their Increased Sensitivity to Cisplatin: Evidence of a Role for DNA Repair and Epidermal Growth Factor Receptor

Liblomycin-mediated DNA Cleavage in Human Head and Neck Squamous Carcinoma Cells and Purified DNA

Involvement of Cytotoxic T-Lymphocytes in the Antitumor Activity of Spergualin against L1210 Cells

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