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Kimberly Stegmaier
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Journal Articles

Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia

Constanze Schneider, Hermes Spaink, Gabriela Alexe, Neekesh V. Dharia, Ashleigh Meyer, Lucy A. Merickel, Delan Khalid, Sebastian Scheich, Björn Häupl, Louis M. Staudt, Thomas Oellerich, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2024) 84 (20): 3354–3370.
https://doi.org/10.1158/0008-5472.CAN-23-3560
Published: 15 October 2024
View article titled, Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Open the PDF for Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Abstract A062 Therapeutic targeting of the SAGA KAT module impairs MYCN-amplified neuroblastoma growth through reduction of the MYCN oncogenic gene expression program

Nathaniel W. Mabe, Clare F. Malone, Alexandra B. Forman, Gabriela Alexe, Kathleen L. Engel, Ying-Jiun C. Chen, Melinda Soeung, Silvi Salhotra, Allen Basanthakumar, Bin Liu, Sharon YR Dent, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): A062.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-A062
Published: 05 September 2024
View article titled, Abstract A062 Therapeutic targeting of the SAGA KAT module impairs MYCN-amplified neuroblastoma growth through reduction of the MYCN oncogenic gene expression program
Journal Articles

Abstract 5777: Rewiring EWS/FLI1 with transcriptional chemical inducers of proximity (TCIPs)

Michael J. Bond, Ryan P. Golden, Roman C. Sarott, Giulia DiGiovanni, Basel A. Karim, Briana Howard, Kenneth Ross, Nathanael S. Gray, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5777.
https://doi.org/10.1158/1538-7445.AM2024-5777
Published: 22 March 2024
View article titled, Abstract 5777: Rewiring EWS/FLI1 with transcriptional chemical inducers of proximity (TCIPs)
Journal Articles

Abstract 3244: EWS-FLI1-driven upregulation of UGT3A2 unlocks drug sensitivity pathway in Ewing sarcoma

Olasunkanmi Olaoye, Colleen Harrington, Kenneth Ross, Bo Kyung A. Seong, Luk de Waal, Jun Qi, Jennifer Roth, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3244.
https://doi.org/10.1158/1538-7445.AM2024-3244
Published: 22 March 2024
View article titled, Abstract 3244: EWS-FLI1-driven upregulation of UGT3A2 unlocks drug sensitivity pathway in Ewing sarcoma
Journal Articles

Abstract 3912: ATM and PARP combined inhibition demonstrate synergistic antitumor efficacy in osteosarcoma models

Sona N. Kocinsky, Janeala J. Morsby, William C. Wright, Monika Wierdl, Caroline S. Wechsler, Gabriela Alexe, Paul Geeleher, Kimberly Stegmaier, Lillian M. Guenther
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3912.
https://doi.org/10.1158/1538-7445.AM2024-3912
Published: 22 March 2024
View article titled, Abstract 3912: ATM and PARP combined inhibition demonstrate synergistic antitumor efficacy in osteosarcoma models
Journal Articles

Abstract 5960: Targeting CDK8: A translatable therapeutic approach for fusion-positive aRMS

Susu Zhang, Clare Malone, Brian Guedes, Kathleen Engel, Marissa Just, Kenneth Ross, Assil Fahs, Giulia Digiovanni, Diyana Granum, Rex Bentley, Leen Barbar, Christian Cerda-Smith, Elizabeth Mendes, Ozgun Erdogan, Alexander Kovach, Kristianne Oristian, Seth Zimmerman, Jack F. Shern, Kris Wood, Chris Counter, Corinne M. Linardic, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5960.
https://doi.org/10.1158/1538-7445.AM2024-5960
Published: 22 March 2024
View article titled, Abstract 5960: Targeting CDK8: A translatable therapeutic approach for fusion-positive aRMS
Journal Articles

Abstract 3949: SMARCAL1 is a novel synthetic lethal target in ALT+ osteosarcoma and neuroblastoma

Monika Wierdl, Jerrel L. Catlett, Nicole Ocasio-Martinez, Jon D. Johnson, Amy Herman, Neekesh V. Dharia, Gabriela Alexe, E. Alejandro Sweet-Cordero, Emily Bernstein, Kimberly Stegmaier, Lillian M. Guenther
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3949.
https://doi.org/10.1158/1538-7445.AM2024-3949
Published: 22 March 2024
View article titled, Abstract 3949: SMARCAL1 is a novel synthetic lethal target in ALT+ osteosarcoma and neuroblastoma
Journal Articles

Abstract PR004: SMARCAL1 is a selective dependency and a novel synthetic lethal target in ATRX/DAXX mutant ALT+ osteosarcoma and neuroblastoma

Monika Wierdl, Jerrel L. Catlett, Nicole Ocasio-Martinez, John D. Johnson, Jr, Amy Herman, Neekesh V. Dharia, Gabriela Alexe, E. Alejandro Sweet-Cordero, Emily Bernstein, Kimberly Stegmaier, Lillian M. Guenther
Journal: Cancer Research
Cancer Res (2024) 84 (1_Supplement): PR004.
https://doi.org/10.1158/1538-7445.DNAREPAIR24-PR004
Published: 09 January 2024
View article titled, Abstract PR004: SMARCAL1 is a selective dependency and a novel synthetic lethal target in ATRX/DAXX mutant ALT+ osteosarcoma and neuroblastoma
Journal Articles

EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes

Yeying Huang, R. Taylor Durall, Nhi M. Luong, Hans J. Hertzler, Julianna Huang, Prafulla C. Gokhale, Brittaney A. Leeper, Nicole S. Persky, David E. Root, Praju V. Anekal, Paula D.L.M. Montero Llopis, Clement N. David, Jeffery L. Kutok, Alejandra Raimondi, Karan Saluja, Jia Luo, Cynthia A. Zahnow, Biniam Adane, Kimberly Stegmaier, Catherine E. Hawkins, Christopher Ponne, Quan Le, Geoffrey I. Shapiro, Madeleine E. Lemieux, Kyle P. Eagen, Christopher A. French
Journal: Cancer Research
Cancer Res (2023) 83 (23): 3956–3973.
https://doi.org/10.1158/0008-5472.CAN-23-1475
Published: 01 December 2023
View article titled, EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes
Open the PDF for EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes in another window
Includes: Supplementary data
Journal Articles

Abstract 5749: Core transcriptional regulatory circuitry in AML

Taku Harada, Monika Perez, Jeremie Kalfon, Kenneth Eagle, Flora Dievenich Braes, Rashad Batley, Kimberly Stegmaier, Stuart Orkin, Maxim Pimkin
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5749.
https://doi.org/10.1158/1538-7445.AM2023-5749
Published: 04 April 2023
View article titled, Abstract 5749: Core transcriptional regulatory circuitry in AML
Journal Articles

Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors

Clare F. Malone, Minjee Kim, Gabriela Alexe, Kathleen Engel, Alexandra B. Forman, Amanda Robichaud, Amy Saur Conway, Amy Goodale, Ashleigh Meyer, Delan Khalid, Allen Thayakumar, John M. Hatcher, Nathanael S. Gray, Federica Piccioni, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2023) 83 (2): 285–300.
https://doi.org/10.1158/0008-5472.CAN-21-4309
Published: 18 January 2023
View article titled, Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors
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Includes: Supplementary data
Journal Articles

Abstract PR005: Targeting EP300 and CBP for therapeutic benefit in pediatric solid tumors

Adam D. Durbin, Noha Shendy, Audrey Mercier, Yang Zhang, Melissa J. Bikowitz, Logan H. Sigua, Sarah Robinson, Tingjian Wang, Barbara Jonchere, A. Thomas Look, Mark W. Zimmerman, Martine Roussel, Brian J. Abraham, Ernst Schonbrunn, Kimberly Stegmaier, Jun Qi
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): PR005.
https://doi.org/10.1158/1538-7445.CancEpi22-PR005
Published: 01 December 2022
View article titled, Abstract PR005: Targeting EP300 and CBP for therapeutic benefit in pediatric solid tumors
Journal Articles

Abstract PR003: Lineage plasticity dictates responsiveness to anti-GD2 therapy in neuroblastoma

Nathaniel W. Mabe, Min Huang, Daniel A. Schaefer, Guillermo N. Dalton, Giulia Digiovanni, Gabriela Alexe, Anna C. Geraghty, Delan Khalid, Marius M. Mader, Michal Sheffer, Miles H. Linde, Nghi Ly, Maria Caterina Rotiroti, Benjamin A. H. Smith, Marius Wernig, Carolyn R. Bertozzi, Michelle Monje, Constantine Mitsiades, Ravindra Majeti, Ansuman T. Satpathy, Kimberly Stegmaier, Robbie G. Majzner
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): PR003.
https://doi.org/10.1158/1538-7445.CancEpi22-PR003
Published: 01 December 2022
View article titled, Abstract PR003: Lineage plasticity dictates responsiveness to anti-GD2 therapy in neuroblastoma
Journal Articles

Abstract 2010: Transcriptional antagonism by CDK8 inhibition improves therapeutic efficacy of MEK inhibitors

Clare F. Malone, Minjee Kim, Gabriela Alexe, Alexandra B. Forman, Amanda Robichaud, Amy Saur Conway, Amy Goodale, John M. Hatcher, Nathanael S. Gray, Federica Piccioni, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2010.
https://doi.org/10.1158/1538-7445.AM2022-2010
Published: 15 June 2022
View article titled, Abstract 2010: Transcriptional antagonism by CDK8 inhibition improves therapeutic efficacy of MEK inhibitors
Journal Articles

Abstract LB076: Unleashing cell-intrinsic inflammation as a strategy to kill AML blasts

Jana M. Ellegast, Gabriela Alexe, Amanda Hamze, Shan Lin, Hannah J. Uckelmann, Philipp J. Rauch, Maxim Pimkin, Linda Ross, Neekesh V. Dharia, Amanda L. Robichaud, Amy Conway Saur, Delan Khalid, Mark Wunderlich, Lina Benajiba, Behnam Nabet, Nathanael S. Gray, Stuart H. Orkin, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB076.
https://doi.org/10.1158/1538-7445.AM2022-LB076
Published: 15 June 2022
View article titled, Abstract LB076: Unleashing cell-intrinsic inflammation as a strategy to kill AML blasts
Journal Articles

Abstract 3889: Identification of ADRN-specific, MES-specific, and pan-subtype therapeutic targets in neuroblastoma

Nathan M. Kendsersky, Nathaniel W. Mabe, Alvin Farrel, Liron D. Grossmann, Michal Odrobina, Kimberly Stegmaier, John M. Maris
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3889.
https://doi.org/10.1158/1538-7445.AM2022-3889
Published: 15 June 2022
View article titled, Abstract 3889: Identification of ADRN-specific, MES-specific, and pan-subtype therapeutic targets in neuroblastoma
Journal Articles

Abstract 2147: Synthetic lethality of VRK1 in VRK2-methylated cancers

Jonathan So, Nathaniel Mabe, Bernhard Englinger, Jason Kwon, Brian Shim, Mariella Filbin, Kimberly Stegmaier, William Hahn
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2147.
https://doi.org/10.1158/1538-7445.AM2022-2147
Published: 15 June 2022
View article titled, Abstract 2147: Synthetic lethality of VRK1 in VRK2-methylated cancers
Journal Articles

Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival

Riaz Gillani, Bo Kyung A. Seong, Jett Crowdis, Jake R. Conway, Neekesh V. Dharia, Saif Alimohamed, Brian J. Haas, Kyuho Han, Jihye Park, Felix Dietlein, Meng Xiao He, Alma Imamovic, Clement Ma, Michael C. Bassik, Jesse S. Boehm, Francisca Vazquez, Alexander Gusev, David Liu, Katherine A. Janeway, James M. McFarland, Kimberly Stegmaier, Eliezer M. Van Allen
Journal: Cancer Research
Cancer Res (2021) 81 (15): 3971–3984.
https://doi.org/10.1158/0008-5472.CAN-21-0791
Published: 01 August 2021
View article titled, Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival
Open the PDF for Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival in another window
Includes: Supplementary data
Journal Articles

Abstract NG01: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q

Jasper E. Neggers, Brenton Paolella, Adhana Asfaw, Michael V. Rothberg, Tom A. Skipper, Radha Kalekar, Michael Burger, Neekesh Dharia, Guillaume Kugener, Jeremie Kalfon, Nancy Dumont, Yvonne Li, Liam Spurr, Annan Yang, Wenbo Wu, AndrewAdam Durbin, Brian M. Wolpin, David E. Root, Jesse Boehm, Andrew D. Cherniack, Aviad Tsherniak, Andrew L. Hong, William C. Hahn, Kimberly Stegmaier, Todd Golub, Francisca Vazquez, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): NG01.
https://doi.org/10.1158/1538-7445.AM2021-NG01
Published: 01 July 2021
View article titled, Abstract NG01: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q
Journal Articles

Abstract 96: Gene fusions create partner and collateral dependencies that are essential to cancer cell survival

Riaz Gillani, Bo Kyung A. Seong, Jett Crowdis, Jake R. Conway, Neekesh V. Dharia, Saif Alimohamed, Brian J. Haas, Kyuho Han, Jihye Park, David Liu, Felix Dietlein, Meng Xiao He, Alma Imamovic, Clement Ma, Michael C. Bassik, Jesse S. Boehm, Francisca Vazquez, Alexander Gusev, Katherine A. Janeway, James M. McFarland, Kimberly Stegmaier, Eliezer M. Van Allen
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 96.
https://doi.org/10.1158/1538-7445.AM2021-96
Published: 01 July 2021
View article titled, Abstract 96: Gene fusions create partner and collateral dependencies that are essential to cancer cell survival