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Kimberly Stegmaier
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Journal Articles

EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes

Yeying Huang, R. Taylor Durall, Nhi M. Luong, Hans J. Hertzler, Julianna Huang, Prafulla C. Gokhale, Brittaney A. Leeper, Nicole S. Persky, David E. Root, Praju V. Anekal, Paula D.L.M. Montero Llopis, Clement N. David, Jeffery L. Kutok, Alejandra Raimondi, Karan Saluja, Jia Luo, Cynthia A. Zahnow, Biniam Adane, Kimberly Stegmaier, Catherine E. Hawkins, Christopher Ponne, Quan Le, Geoffrey I. Shapiro, Madeleine E. Lemieux, Kyle P. Eagen, Christopher A. French
Journal: Cancer Research
Cancer Res (2023) 83 (23): 3956–3973.
https://doi.org/10.1158/0008-5472.CAN-23-1475
Published: 01 December 2023
View article titled, EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes
Open the PDF for EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes in another window
Includes: Supplementary data
Journal Articles

Abstract 5749: Core transcriptional regulatory circuitry in AML

Taku Harada, Monika Perez, Jeremie Kalfon, Kenneth Eagle, Flora Dievenich Braes, Rashad Batley, Kimberly Stegmaier, Stuart Orkin, Maxim Pimkin
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5749.
https://doi.org/10.1158/1538-7445.AM2023-5749
Published: 04 April 2023
View article titled, Abstract 5749: Core transcriptional regulatory circuitry in AML
Journal Articles

Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors

Clare F. Malone, Minjee Kim, Gabriela Alexe, Kathleen Engel, Alexandra B. Forman, Amanda Robichaud, Amy Saur Conway, Amy Goodale, Ashleigh Meyer, Delan Khalid, Allen Thayakumar, John M. Hatcher, Nathanael S. Gray, Federica Piccioni, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2023) 83 (2): 285–300.
https://doi.org/10.1158/0008-5472.CAN-21-4309
Published: 18 January 2023
View article titled, Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors
Open the PDF for Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors in another window
Includes: Supplementary data
Journal Articles

Abstract PR005: Targeting EP300 and CBP for therapeutic benefit in pediatric solid tumors

Adam D. Durbin, Noha Shendy, Audrey Mercier, Yang Zhang, Melissa J. Bikowitz, Logan H. Sigua, Sarah Robinson, Tingjian Wang, Barbara Jonchere, A. Thomas Look, Mark W. Zimmerman, Martine Roussel, Brian J. Abraham, Ernst Schonbrunn, Kimberly Stegmaier, Jun Qi
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): PR005.
https://doi.org/10.1158/1538-7445.CancEpi22-PR005
Published: 01 December 2022
View article titled, Abstract PR005: Targeting EP300 and CBP for therapeutic benefit in pediatric solid tumors
Journal Articles

Abstract PR003: Lineage plasticity dictates responsiveness to anti-GD2 therapy in neuroblastoma

Nathaniel W. Mabe, Min Huang, Daniel A. Schaefer, Guillermo N. Dalton, Giulia Digiovanni, Gabriela Alexe, Anna C. Geraghty, Delan Khalid, Marius M. Mader, Michal Sheffer, Miles H. Linde, Nghi Ly, Maria Caterina Rotiroti, Benjamin A. H. Smith, Marius Wernig, Carolyn R. Bertozzi, Michelle Monje, Constantine Mitsiades, Ravindra Majeti, Ansuman T. Satpathy, Kimberly Stegmaier, Robbie G. Majzner
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): PR003.
https://doi.org/10.1158/1538-7445.CancEpi22-PR003
Published: 01 December 2022
View article titled, Abstract PR003: Lineage plasticity dictates responsiveness to anti-GD2 therapy in neuroblastoma
Journal Articles

Abstract 2147: Synthetic lethality of VRK1 in VRK2-methylated cancers

Jonathan So, Nathaniel Mabe, Bernhard Englinger, Jason Kwon, Brian Shim, Mariella Filbin, Kimberly Stegmaier, William Hahn
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2147.
https://doi.org/10.1158/1538-7445.AM2022-2147
Published: 15 June 2022
View article titled, Abstract 2147: Synthetic lethality of VRK1 in VRK2-methylated cancers
Journal Articles

Abstract 2010: Transcriptional antagonism by CDK8 inhibition improves therapeutic efficacy of MEK inhibitors

Clare F. Malone, Minjee Kim, Gabriela Alexe, Alexandra B. Forman, Amanda Robichaud, Amy Saur Conway, Amy Goodale, John M. Hatcher, Nathanael S. Gray, Federica Piccioni, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2010.
https://doi.org/10.1158/1538-7445.AM2022-2010
Published: 15 June 2022
View article titled, Abstract 2010: Transcriptional antagonism by CDK8 inhibition improves therapeutic efficacy of MEK inhibitors
Journal Articles

Abstract 3889: Identification of ADRN-specific, MES-specific, and pan-subtype therapeutic targets in neuroblastoma

Nathan M. Kendsersky, Nathaniel W. Mabe, Alvin Farrel, Liron D. Grossmann, Michal Odrobina, Kimberly Stegmaier, John M. Maris
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3889.
https://doi.org/10.1158/1538-7445.AM2022-3889
Published: 15 June 2022
View article titled, Abstract 3889: Identification of ADRN-specific, MES-specific, and pan-subtype therapeutic targets in neuroblastoma
Journal Articles

Abstract LB076: Unleashing cell-intrinsic inflammation as a strategy to kill AML blasts

Jana M. Ellegast, Gabriela Alexe, Amanda Hamze, Shan Lin, Hannah J. Uckelmann, Philipp J. Rauch, Maxim Pimkin, Linda Ross, Neekesh V. Dharia, Amanda L. Robichaud, Amy Conway Saur, Delan Khalid, Mark Wunderlich, Lina Benajiba, Behnam Nabet, Nathanael S. Gray, Stuart H. Orkin, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB076.
https://doi.org/10.1158/1538-7445.AM2022-LB076
Published: 15 June 2022
View article titled, Abstract LB076: Unleashing cell-intrinsic inflammation as a strategy to kill AML blasts
Journal Articles

Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival

Riaz Gillani, Bo Kyung A. Seong, Jett Crowdis, Jake R. Conway, Neekesh V. Dharia, Saif Alimohamed, Brian J. Haas, Kyuho Han, Jihye Park, Felix Dietlein, Meng Xiao He, Alma Imamovic, Clement Ma, Michael C. Bassik, Jesse S. Boehm, Francisca Vazquez, Alexander Gusev, David Liu, Katherine A. Janeway, James M. McFarland, Kimberly Stegmaier, Eliezer M. Van Allen
Journal: Cancer Research
Cancer Res (2021) 81 (15): 3971–3984.
https://doi.org/10.1158/0008-5472.CAN-21-0791
Published: 01 August 2021
View article titled, Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival
Open the PDF for Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival in another window
Includes: Supplementary data
Journal Articles

Abstract 96: Gene fusions create partner and collateral dependencies that are essential to cancer cell survival

Riaz Gillani, Bo Kyung A. Seong, Jett Crowdis, Jake R. Conway, Neekesh V. Dharia, Saif Alimohamed, Brian J. Haas, Kyuho Han, Jihye Park, David Liu, Felix Dietlein, Meng Xiao He, Alma Imamovic, Clement Ma, Michael C. Bassik, Jesse S. Boehm, Francisca Vazquez, Alexander Gusev, Katherine A. Janeway, James M. McFarland, Kimberly Stegmaier, Eliezer M. Van Allen
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 96.
https://doi.org/10.1158/1538-7445.AM2021-96
Published: 01 July 2021
View article titled, Abstract 96: Gene fusions create partner and collateral dependencies that are essential to cancer cell survival
Journal Articles

Abstract NG01: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q

Jasper E. Neggers, Brenton Paolella, Adhana Asfaw, Michael V. Rothberg, Tom A. Skipper, Radha Kalekar, Michael Burger, Neekesh Dharia, Guillaume Kugener, Jeremie Kalfon, Nancy Dumont, Yvonne Li, Liam Spurr, Annan Yang, Wenbo Wu, AndrewAdam Durbin, Brian M. Wolpin, David E. Root, Jesse Boehm, Andrew D. Cherniack, Aviad Tsherniak, Andrew L. Hong, William C. Hahn, Kimberly Stegmaier, Todd Golub, Francisca Vazquez, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): NG01.
https://doi.org/10.1158/1538-7445.AM2021-NG01
Published: 01 July 2021
View article titled, Abstract NG01: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q
Journal Articles

Abstract 2318: EP300 selectively controls the enhancer landscape of high risk neuroblastoma

Adam D. Durbin, Tingjian Wang, Virangika K. Wimalasena, Mark W. Zimmerman, Deyao Li, Neekesh V. Dharia, Luca Mariani, Paul M. Park, Logan H. Sigua, Ken Morita, Amy S. Conway, Amanda L. Robichaud, Antonio Perez-Atayde, Melissa Bikowitz, Taylor Quinn, Olaf Wiest, Ernst Schonbrunn, Martha Bulyk, Brian J. Abraham, Kimberly Stegmaier, A. Thomas Look, Jun Qi
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2318.
https://doi.org/10.1158/1538-7445.AM2021-2318
Published: 01 July 2021
View article titled, Abstract 2318: EP300 selectively controls the enhancer landscape of high risk neuroblastoma
Journal Articles

Abstract PD7-08: Igf1r mediates cdk4/6 inhibitor (cdk4/6i) resistance in tumor samples and in cellular models

Seth A. Wander, Pingping Mao, Maxwell R. Lloyd, Gabriela N. Johnson, Kailey Kowalski, Utthara Nayar, Lillian M. Guenther, Kimberly Stegmaier, Eric P. Winer, Nancy U. Lin, Nikhil Wagle
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD7-08.
https://doi.org/10.1158/1538-7445.SABCS20-PD7-08
Published: 15 February 2021
View article titled, Abstract PD7-08: Igf1r mediates cdk4/6 inhibitor (cdk4/6i) resistance in tumor samples and in cellular models
Journal Articles

Abstract PO-041: Genome-wide CRISPR/Cas9 screen reveals mitochondrial gene mutation as a driver for drug resistance in Ewing sarcoma

Jack P. Tokarsky, Jesse Crow, Lillian Guenther, Emily Theisen, Kimberly Stegmaier, Stephen Lessnick
Journal: Cancer Research
Cancer Res (2020) 80 (23_Supplement): PO-041.
https://doi.org/10.1158/1538-7445.EPIMETAB20-PO-041
Published: 02 December 2020
View article titled, Abstract PO-041: Genome-wide CRISPR/Cas9 screen reveals mitochondrial gene mutation as a driver for drug resistance in Ewing sarcoma
Journal Articles

Abstract PO-011: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in SMAD4 or CDH1-deleted cancers

Jasper E. Neggers, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Radha L. Kalekar, Michael J. Krill-Burger, Neekesh V. Dharia, Guillaume Kugener, Adam D. Durbin, Annan Yang, Nancy Dumont, Yvonne Y. Li, Brian M. Wolpin, Federica Piccioni, David E. Root, Jesse S. Boehm, Andrew D. Cherniack, Aviad Tsherniak, Andrew L. Hong, William C. Hahn, Kimberly Stegmaier, Todd R. Golub, Francisca Vazquez, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-011.
https://doi.org/10.1158/1538-7445.PANCA20-PO-011
Published: 13 November 2020
View article titled, Abstract PO-011: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in SMAD4 or CDH1-deleted cancers
Journal Articles

Abstract CT195: A phase 2 clinical trial of palbociclib and ganitumab for relapsed/refractory Ewing sarcoma

David S. Shulman, Katherine Thornton, Edwin Choy, Lillian M. Guenther, Kerri Cavanaugh, Megan Forsyth, Kylene DeSmith, Catherine Clinton, Kimberly Stegmaier, Brian Crompton, Wendy B. London, Steven G. DuBois
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT195.
https://doi.org/10.1158/1538-7445.AM2020-CT195
Published: 15 August 2020
View article titled, Abstract CT195: A phase 2 clinical trial of palbociclib and ganitumab for relapsed/refractory Ewing sarcoma
Journal Articles

Abstract IA17: From functional genomics to new targets in pediatric oncology

Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): IA17.
https://doi.org/10.1158/1538-7445.PEDCA19-IA17
Published: 15 July 2020
View article titled, Abstract IA17: From functional genomics to new targets in pediatric oncology
Journal Articles

Abstract B52: Ewing sarcoma: A case study of clonal aneuploidy and DNA damage repair in pediatric cancer

Xiaofeng A. Su, Duanduan Ma, James V. Parsons, John M. Replogle, James F. Amatruda, Charles A. Whittaker, Kimberly Stegmaier, Angelika Amon
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): B52.
https://doi.org/10.1158/1538-7445.PEDCA19-B52
Published: 15 July 2020
View article titled, Abstract B52: Ewing sarcoma: A case study of clonal aneuploidy and DNA damage repair in pediatric cancer
Journal Articles

Abstract B50: Targeting EWS/FLI fusion oncoprotein stability/degradation in Ewing sarcoma

Bo Kyung Alex Seong, Shan Lin, Katherine Donovan, Amanda Robichaud, Bjorn Stolte, Emily Wang, Neekesh Dharia, Behnam Nabet, Federica Piccioni, Nathanael Gray, Eric Fischer, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): B50.
https://doi.org/10.1158/1538-7445.PEDCA19-B50
Published: 15 July 2020
View article titled, Abstract B50: Targeting EWS/FLI fusion oncoprotein stability/degradation in Ewing sarcoma