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Kim E. Nichols
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Journal Articles

Abstract 1428: DNA methylation predicts early onset of primary tumor in patients with Li-Fraumeni syndrome

Vallijah Subasri, Benjamin Brew, Lauren Erdman, Tanya Guha, Jordan R. Hansford, Elizabeth Cairney, Carol Portwine, Christine Elser, Jonathan L. Finlay, Kim E. Nichols, Wendy Kohlmann, Noa Alon, Ana Novokmet, Ledia Brunga, Anita Villani, Kelvin C. de Andrade, Payal P. Khincha, Sharon A. Savage, Joshua D. Schiffman, David Malkin, Anna Goldenberg
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1428.
DOI: https://doi.org/10.1158/1538-7445.AM2022-1428
Published: 15 June 2022
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Transient Inhibition of the JAK/STAT Pathway Prevents B-ALL Development in Genetically Predisposed Mice

Ana Casado-García, Marta Isidro-Hernández, Ninad Oak, Andrea Mayado, Christine Mann-Ran, Javier Raboso-Gallego, Silvia Alemán-Arteaga, Alexandra Buhles, Dario Sterker, Elena G. Sánchez, Jorge Martínez-Cano, Oscar Blanco, Alberto Orfao, Diego Alonso-López, Javier De Las Rivas, Susana Riesco, Pablo Prieto-Matos, África González-Murillo, Francisco Javier García Criado, María Begoña García Cenador, Thomas Radimerski, Manuel Ramírez-Orellana, César Cobaleda, Jun J. Yang, Carolina Vicente-Dueñas, Andreas Weiss, Kim E. Nichols, Isidro Sánchez-García
Journal: Cancer Research
Cancer Res (2022) 82 (6): 1098–1109.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-3386
Published: 15 March 2022
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Includes: Supplementary data
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Abstract 642: Genomes for Kids: Comprehensive DNA and RNA sequencing defining the scope of actionable mutations in pediatric cancer

David A. Wheeler, Scott Newman, Joy Nakitandwe, Chimene A. Kesserwan, Elizabeth M. Azzato, Michael C. Rusch, Sheila Shurtleff, Armita Bahrami, Brent Orr, Jeffery M. Klco, Dale J. Hedges, Kayla V. Hamilton, Scott G. Foy, Michael N. Edmonson, Andrew Thrasher, Jiali Gu, Lynn W. Harrison, Lu Wang, Roya Mostafavi, Manish Kubal, Jamie Maciaszek, Michael Clay, Annastasia Ouma, Antonina Silkov, Yanling Liu, Zhaojie Zhang, Yu Liu, Samuel W. Brady, Xin Zhou, Mark Wilkinson, Delaram Rahbarinia, Jay Knight, Jian Wang, Charles G. Mullighan, Rose B. McGee, Emily A. Quinn, Elsie L. Gerhardt, Leslie M. Taylor, Regina Nuccio, Jessica M. Valdez, Stacy J. Hines-Dowell, Alberto Pappo, Giles Robinson, Liza-Marie Johnson, Ching-Hon Pui, David W. Ellison, James R. Downing, Jinghui Zhang, Kim E. Nichols
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 642.
DOI: https://doi.org/10.1158/1538-7445.AM2021-642
Published: 01 July 2021
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Journal Articles

Abstract 3651: Increased prevalence of germline monoallelic RECQL4 mutations in children with cancer

Jamie L. Maciaszek, Gang Wu, Kayla Hamilton, Rose B. McGee, Zhaoming Wang, Regina Nuccio, Stacy Hines-Dowell, Lynn Harrison, Elsie L. Gerhardt, Annastasia Ouma, Scott Newman, Aman Patel, Joy Nakitandwe, Elizabeth Azzato, Alberto S. Pappo, Sheila A. Shurtleff, David W. Ellison, James R. Downing, Melissa M. Hudson, Leslie L. Robison, Victor Santana, Jinghui Zhang, Kim E. Nichols, Chimene A. Kesserwan
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3651.
DOI: https://doi.org/10.1158/1538-7445.AM2019-3651
Published: 01 July 2019
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Journal Articles

Abstract 3671: Visualize 10,000 whole-genomes from pediatric cancer patients on St. Jude Cloud

Xin Zhou, Clay Mcleod, Scott Newman, Zhaoming Wang, Michael Rusch, Kirby Birch, Michael Macias, Jobin Sunny, Gang Wu, Jian Wang, Edgar Sioson, Shaohua Lei, Robert J. Michael, Aman Patel, Michael N. Edmonson, Stephen V. Rice, Andrew Frantz, Ed Suh, Keith Perry, Carmen Wilson, Leslie L. Robinson, Yutaka Yasui, Kim E. Nichols, Gregory T. Armstrong, James R. Downing, Jinghui Zhang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3671.
DOI: https://doi.org/10.1158/1538-7445.AM2019-3671
Published: 01 July 2019
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Journal Articles

Abstract 731: Clinical genome sequencing uncovers potentially targetable truncations and fusions of MAP3K8 in spitzoid and other melanomas

Scott Newman, Liying Fan, Allison Pribnow, Antonina Silkov, Stephen V. Rice, Seungjae Lee, Ying Shao, Bridget Shaner, Heather Mulder, Joy Nakitandwe, Sheila Shurtleff, Elizabeth Azzato, Gang Wu, Xin Zhou, Raymond Barnhill, John Easton, Kim E. Nichols, David W. Ellison, Downing R. James, Alberto Pappo, Philip M. Potter, Jinghui Zhang, Armita Bahrami
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 731.
DOI: https://doi.org/10.1158/1538-7445.AM2019-731
Published: 01 July 2019
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Journal Articles

Abstract 4178: Germline mutations in BRCA2 and pediatric/adolescent non-Hodgkin's lymphoma: A report from the St. Jude Lifetime (SJLIFE) and Childhood Cancer Survivor Study (CCSS) cohorts

Zhaoming Wang, Ti-Cheng Chang, Carmen L. Wilson, Chimene A. Kesserwan, Todd M. Gibson, Nan Li, John Easton, Heather L. Mulder, Gang Wu, Michael N. Edmonson, Michael C. Rusch, James R. Downing, Kim E. Nichols, Smita Bhatia, Gregory T. Armstrong, Melissa M. Hudson, Jinghui Zhang, Yutaka Yasui, Leslie L. Robison
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4178.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4178
Published: 01 July 2019
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Journal Articles

Abstract 2406: A general probabilistic algorithm to predict de novo mutations in familial diseases as demonstrated in Li-Fraumeni Syndrome

Xuedong Pan, Fan Gao, Elissa B. Dodd, Jasmina Bojadzieva, Phuong L. Mai, Valen E. Johnson, Kristin Zelley, Kim E. Nichols, Judy E. Garber, Sharon A. Savage, Louise C. Strong, Wenyi Wang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2406.
DOI: https://doi.org/10.1158/1538-7445.AM2019-2406
Published: 01 July 2019
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Journal Articles

Abstract 3007: Monogenic and polygenic associations with subsequent breast cancer risk in survivors of childhood cancer: The St. Jude Lifetime Cohort Study (SJLIFE)

Zhaoming Wang, Carmen L. Wilson, Qi Liu, John Easton, Heather L. Mulder, Michael Rusch, Michael Edmonson, Shawn Levy, Aman Patel, Ying Shao, Ti-Cheng Chang, Stephen V. Rice, Yadav Sapkota, Russell J. Brooke, Wonjong Moon, Evadnie Rampersaud, Xiaotu Ma, Cynthia Pepper, Xin Zhou, Xiang Chen, Wenan Chen, Angela Jones, Braden Boone, Matthew J. Ehrhardt, Rebecca M. Howell, Nicholas Phillips, Courtney Lewis, Chimene A. Kesserwan, Gang Wu, Kim E. Nichols, James R. Downing, Melissa M. Hudson, Jinghui Zhang, Yutaka Yasui, Leslie L. Robison
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3007.
DOI: https://doi.org/10.1158/1538-7445.AM2018-3007
Published: 01 July 2018
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Journal Articles

Abstract 922: Access, visualize and analyze 5,000 whole-genomes from pediatric cancer patients on St. Jude Cloud

Scott Newman, Xin Zhou, Clay McLeod, Michael Rusch, Gang Wu, Edgar Sioson, Shuoguo Wang, J. Robert Michael, Aman Patel, Michael N. Edmonson, Andrew Frantz, Ti-Cheng Chang, Yongjin Li, Robert I. Davidson, Singer Ma, Irina McGuire, Nedra Robison, Xing Tang, Lance Palmer, Ed Suh, Leigh Tanner, James McMurry, Keith Perry, Zhaoming Wang, Carmen Wilson, Yong Cheng, Mitch Weiss, Leslie L. Robison, Yutaka Yasui, Kim E. Nichols, David W. Ellison, James R. Downing, Jinghui Zhang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 922.
DOI: https://doi.org/10.1158/1538-7445.AM2018-922
Published: 01 July 2018
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Journal Articles

Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma

Xiaomu Wei, M. Nieves Calvo-Vidal, Siwei Chen, Gang Wu, Maria V. Revuelta, Jian Sun, Jinghui Zhang, Michael F. Walsh, Kim E. Nichols, Vijai Joseph, Carrie Snyder, Celine M. Vachon, James D. McKay, Shu-Ping Wang, David S. Jayabalan, Lauren M. Jacobs, Dina Becirovic, Rosalie G. Waller, Mykyta Artomov, Agnes Viale, Jayeshkumar Patel, Jude Phillip, Selina Chen-Kiang, Karen Curtin, Mohamed Salama, Djordje Atanackovic, Ruben Niesvizky, Ola Landgren, Susan L. Slager, Lucy A. Godley, Jane Churpek, Judy E. Garber, Kenneth C. Anderson, Mark J. Daly, Robert G. Roeder, Charles Dumontet, Henry T. Lynch, Charles G. Mullighan, Nicola J. Camp, Kenneth Offit, Robert J. Klein, Haiyuan Yu, Leandro Cerchietti, Steven M. Lipkin
Journal: Cancer Research
Cancer Res (2018) 78 (10): 2747–2759.
DOI: https://doi.org/10.1158/0008-5472.CAN-17-1900
Published: 14 May 2018
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Includes: Supplementary data
Journal Articles

Abstract NG05: TP53-mediated human cancer susceptibility is defined by epigenetic dysregulation of microRNA-34A

Nardin Samuel, Gavin Wilson, Genevieve Deblois, Badr Id Said, Nicholas W. Fischer, Mathieu Lemire, Youliang Lou, Weili Li, Roumiana Alexandrova, Ana Novokmet, James Tran, Kim E. Nichols, Jonathan L. Finlay, Sanaa Choufani, Marc Remke, Vijay Ramaswamy, Florence M.G. Cavalli, Christine Elser, Lynn Meister, Michael D. Taylor, Uri Tabori, Meredith Irwin, Rosanna Weksberg, Jonathan D. Wasserman, Jean Gariepy, Mathieu Lupien, Daniele Merico, Andrew Paterson, Jordan R. Hansford, Maria Isabel W. Achatz, Thomas J. Hudson, David Malkin
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): NG05.
DOI: https://doi.org/10.1158/1538-7445.AM2017-NG05
Published: 01 July 2017
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Journal Articles

Abstract 3001: Germline mutations in cancer predisposition genes and risk for subsequent neoplasms among long-term survivors of childhood cancer in the St. Jude Lifetime Cohort

Zhaoming Wang, Carmen L. Wilson, John Easton, Dale Hedges, Qi Liu, Gang Wu, Michael Rusch, Michael Edmonson, Shawn Levy, Jennifer Q. Lanctot, Eric Caron, Kyla Shelton, Kelsey Currie, Matthew Lear, Heather L. Mulder, Donald Yergeau, Celeste Rosencrance, Bhavin Vadodaria, Yadav Sapkota, Russell J. Brooke, Wonjong Moon, Evadnie Rampersaud, Xiaotu Ma, Shuoguo Wang, Ti-Cheng Chang, Stephen Rice, Andrew Thrasher, Aman Patel, Cynthia Pepper, Xin Zhou, Xiang Chen, Wenan Chen, Angela Jones, Braden Boone, Deo Kumar Srivastava, Chimene A. Kesserwan, Kim E. Nichols, James R. Downing, Melissa M. Hudson, Yutaka Yasui, Leslie L. Robison, Jinghui Zhang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3001.
DOI: https://doi.org/10.1158/1538-7445.AM2017-3001
Published: 01 July 2017
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Journal Articles

Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice

Bernard Leroy, Mandy L. Ballinger, Fanny Baran-Marszak, Gareth L. Bond, Antony Braithwaite, Nicole Concin, Lawrence A. Donehower, Wafik S. El-Deiry, Pierre Fenaux, Gianluca Gaidano, Anita Langerød, Eva Hellstrom-Lindberg, Richard Iggo, Jacqueline Lehmann-Che, Phuong L. Mai, David Malkin, Ute M. Moll, Jeffrey N. Myers, Kim E. Nichols, Sarka Pospisilova, Patricia Ashton-Prolla, Davide Rossi, Sharon A. Savage, Louise C. Strong, Patricia N. Tonin, Robert Zeillinger, Thorsten Zenz, Joseph F. Fraumeni, Jr, Peter E.M. Taschner, Pierre Hainaut, Thierry Soussi
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (6): 1250–1260.
DOI: https://doi.org/10.1158/0008-5472.CAN-16-2179
Published: 14 March 2017
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Includes: Supplementary data
Journal Articles

Abstract 2033: Germline mutations in ETV6 confer risk of thrombocytopenia and acute lymphocytic leukemia

Vijai Joseph, Michael F. Walsh, Sabine Topka, Gang Wu, Rose B. McGee, Emily Quinn, Hiroto Inaba, Christine Hartford, Ching-Hon Pui, Alberto S. Pappo, Michael Edmonson, Lauren Jacobs, Villano Danylo, Kasmintan Schrader, Pragna Gaddam, Zsofia Stadler, Michael Zhang, Polina Stepensky, Peter Steinherz, James Bussel, M Harit, Michael Weintraub, Akiko Shimamura, Jinghui Zhang, James R. Downing, Kenneth Offit, Kim E. Nichols
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2033.
DOI: https://doi.org/10.1158/1538-7445.AM2015-2033
Published: 01 August 2015
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Abstract 4294: Cancer immunotherapeutic potential of NKTT320, a novel human invariant natural killer T-cell activating monoclonal antibody

Rupali Das, Felix Scheuplein, Peng Guan, Robert Schaub, Kim E. Nichols
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4294.
DOI: https://doi.org/10.1158/1538-7445.AM2015-4294
Published: 01 August 2015
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Abstract 653: NKTT320, a novel monoclonal antibody activates the immuno-stimulatory functions of human invariant natural killer T cells

Rupali Das, Felix Scheuplein, Nishant P. Patel, Peng Guan, Robert G. Schaub, Kim E. Nichols
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 653.
DOI: https://doi.org/10.1158/1538-7445.AM2014-653
Published: 01 October 2014
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Destabilization of CHK2 by a Missense Mutation Associated with Li-Fraumeni Syndrome

Sean Bong Lee, Sang Hyon Kim, Daphne W. Bell, Doke C. R. Wahrer, Taryn A. Schiripo, Melissa M. Jorczak, Dennis C. Sgroi, Judy E. Garber, Frederick P. Li, Kim E. Nichols, Jenny M. Varley, Andrew K. Godwin, Kristen M. Shannon, Ed Harlow, Daniel A. Haber
Journal: Cancer Research
Cancer Res (2001) 61 (22): 8062–8067.
Published: 01 November 2001
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WT1 Induces Expression of Insulin-like Growth Factor 2 in Wilms' Tumor Cells

Kim E. Nichols, Gian G. Re, Yu Xin Yan, A. Julian Garvin, Daniel A. Haber
Journal: Cancer Research
Cancer Res (1995) 55 (20): 4540–4543.
Published: 01 October 1995
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