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Journal Articles

Abstract 5593: METTL3-NUP93 axis as a novel therapeutic target in castration-resistant prostate cancer (CRPC)

Jihoon Lee, Zhao Zhang, Juyeong Hong, Kexin Xu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5593.
https://doi.org/10.1158/1538-7445.AM2024-5593
Published: 22 March 2024
View article titled, Abstract 5593: METTL3-NUP93 axis as a novel therapeutic target in castration-resistant prostate cancer (CRPC)
Journal Articles

Abstract PR007: Von Hippel Lindau (VHL) tumor suppressor regulates m6A-dependent gene expression involved in renal tumorigenesis

Cheng Zhang, Zhao Zhang, Austin Hepperla, Miaomiao Yu, Jin Zhou, Lianxin Hu, Jun Fang, Qian Liang, Kexin Xu, Liwei Jia, Qing Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (16_Supplement): PR007.
https://doi.org/10.1158/1538-7445.KIDNEY23-PR007
Published: 15 August 2023
View article titled, Abstract PR007: Von Hippel Lindau (VHL) tumor suppressor regulates m6A-dependent gene expression involved in renal tumorigenesis
Journal Articles

PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer

Juyeong Hong, Ji Hoon Lee, Zhao Zhang, Yanming Wu, Mei Yang, Yiji Liao, Richard de la Rosa, Jessica Scheirer, Douglas Pechacek, Nu Zhang, Zhenming Xu, Tyler Curiel, Xi Tan, Tim H.-M. Huang, Kexin Xu
Journal: Cancer Research
Cancer Res (2022) 82 (24): 4624–4640.
https://doi.org/10.1158/0008-5472.CAN-22-0736
Published: 16 December 2022
View article titled, PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer
Open the PDF for PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 5203: Segregating activities of the estrogen receptor in gene regulation

Mei Yang, Zhao Zhang, Kexin Xu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 5203.
https://doi.org/10.1158/1538-7445.AM2019-5203
Published: 01 July 2019
View article titled, Abstract 5203: Segregating activities of the estrogen receptor in gene regulation
Journal Articles

Abstract IA03: Differential impact of RB pathway status on E2F1 reprogramming and disease progression in human prostate cancer

Christopher McNair, Kexin Xu, Amy C. Mandigo, Matteo Benelli, Benjamin Leiby, Daniel Rodrigues, Johan Lindberg, Henrik Gronberg, Bram De Laere, Luc Dirix, Tapio Visakorpi, Fugen Li, Felix Y. Feng, Johann de Bono, Francesca Demichelis, Mark A Rubin, Myles Brown, Karen E. Knudsen
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): IA03.
https://doi.org/10.1158/1538-7445.PRCA2017-IA03
Published: 14 August 2018
View article titled, Abstract IA03: Differential impact of RB pathway status on E2F1 reprogramming and disease progression in human prostate cancer
Journal Articles

Abstract B040: Differential impact of RB status on E2F1 reprogramming in human cancer

Christopher McNair, Kexin Xu, Amy C. Mandigo, Matteo Benelli, Benjamin Leiby, Daniel Rodrigues, Johan Lindberg, Henrik Gronberg, Mateus Crespo, Bram De Laere, Luc Dirix, Tapio Visakorpi, Fugen Li, Felix Y. Feng, Johann de Bono, Francesca Demichelis, Mark A. Rubin, Myles Brown, Karen E. Knudsen
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): B040.
https://doi.org/10.1158/1538-7445.PRCA2017-B040
Published: 14 August 2018
View article titled, Abstract B040: Differential impact of RB status on E2F1 reprogramming in human cancer
Journal Articles

Nuclear Receptor LRH-1 Functions to Promote Castration-Resistant Growth of Prostate Cancer via Its Promotion of Intratumoral Androgen Biosynthesis

Lijia Xiao, Yuliang Wang, Kexin Xu, Hao Hu, Zhenyu Xu, Dinglan Wu, Zhu Wang, Wenxing You, Chi-Fai Ng, Shan Yu, Franky Leung Chan
Journal: Cancer Research
Cancer Res (2018) 78 (9): 2205–2218.
https://doi.org/10.1158/0008-5472.CAN-17-2341
Published: 30 April 2018
View article titled, Nuclear Receptor LRH-1 Functions to Promote Castration-Resistant Growth of Prostate Cancer via Its Promotion of Intratumoral Androgen Biosynthesis
Open the PDF for Nuclear Receptor LRH-1 Functions to Promote Castration-Resistant Growth of Prostate Cancer via Its Promotion of Intratumoral Androgen Biosynthesis in another window
Includes: Supplementary data
Journal Articles

Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2–ERα–GREB1 Transcriptional Axis

Yanming Wu, Zhao Zhang, Mauro E. Cenciarini, Cecilia J. Proietti, Matias Amasino, Tao Hong, Mei Yang, Yiji Liao, Huai-Chin Chiang, Virginia G. Kaklamani, Rinath Jeselsohn, Ratna K. Vadlamudi, Tim Hui-Ming Huang, Rong Li, Carmine De Angelis, Xiaoyong Fu, Patricia V. Elizalde, Rachel Schiff, Myles Brown, Kexin Xu
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (3): 671–684.
https://doi.org/10.1158/0008-5472.CAN-17-1327
Published: 31 January 2018
View article titled, Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2–ERα–GREB1 Transcriptional Axis
Open the PDF for Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2–ERα–GREB1 Transcriptional Axis in another window
Includes: Supplementary data
Journal Articles

Abstract LB-087: Stage specific re-calibration of E2F1 function after RB loss

Amy C. Mandigo, Christopher McNair, Kexin Xu, Fugen Li, Matthew J. Schiewer, Myles Brown, Karen E. Knudsen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-087.
https://doi.org/10.1158/1538-7445.AM2017-LB-087
Published: 01 July 2017
View article titled, Abstract LB-087: Stage specific re-calibration of E2F1 function after RB loss
Journal Articles

Abstract LB-085: RB loss-induced genome wide E2F1 reprogramming drive advanced prostate cancer

Christopher McNair, Kexin Xu, Amy Mandigo, Matteo Benelli, Benjamin Leiby, Daniel Rodrigues, Johan Lindberg, Henrik Gronberg, Tapio Visakorpi, Fugen Li, Johann De Bono, Francesca Demichelis, Mark Rubin, Myles Brown, Karen E. Knudsen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-085.
https://doi.org/10.1158/1538-7445.AM2017-LB-085
Published: 01 July 2017
View article titled, Abstract LB-085: RB loss-induced genome wide E2F1 reprogramming drive advanced prostate cancer
Journal Articles

Abstract 4089: Differential regulation of androgen receptor by PIM-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases.

Douglas Linn, Xi Yang, Yingqiu Xie, Alan Alfano, Dhanraj Deshmukh, Xin Wang, Hermela Shimelis, Hegang Chen, Wei Li, Kexin Xu, Mingyuan Chen, Yun Qiu
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4089.
https://doi.org/10.1158/1538-7445.AM2013-4089
Published: 15 April 2013
View article titled, Abstract 4089: Differential regulation of androgen receptor by PIM-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases.
Journal Articles

Compensatory Upregulation of Tyrosine Kinase Etk/BMX in Response to Androgen Deprivation Promotes Castration-Resistant Growth of Prostate Cancer Cells

Bojie Dai, Hege Chen, Shengjie Guo, Xi Yang, Douglas E. Linn, Feng Sun, Wei Li, Zhiyong Guo, Kexin Xu, Oekyung Kim, Xiangtian Kong, Jonathan Melamed, Shaopeng Qiu, Hegang Chen, Yun Qiu
Journal: Cancer Research
Cancer Res (2010) 70 (13): 5587–5596.
https://doi.org/10.1158/0008-5472.CAN-09-4610
Published: 30 June 2010
View article titled, Compensatory Upregulation of Tyrosine Kinase Etk/BMX in Response to Androgen Deprivation Promotes Castration-Resistant Growth of Prostate Cancer Cells
Open the PDF for Compensatory Upregulation of Tyrosine Kinase Etk/BMX in Response to Androgen Deprivation Promotes Castration-Resistant Growth of Prostate Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract #2393: Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced atypical polyubiquitination

Kexin Xu, Hermela Shimelis, Richeng Jiang, Douglas Linn, Xi Yang, Feng Sun, Zhiyong Guo, Yun Qiu
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2393.
Published: 01 May 2009
View article titled, Abstract #2393: Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced atypical polyubiquitination
Journal Articles

RING-Finger protein 6 (Rnf6) is upregulated during prostate cancer progression and promotes prostate cancer growth via inducing atypical ubiquitylation of androgen receptor

Kexin Xu, Yun Qiu, Hermela Shimelis, Xi Yang
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1219.
Published: 01 May 2008
View article titled, RING-Finger protein 6 (Rnf6) is upregulated during prostate cancer progression and promotes prostate cancer growth via inducing atypical ubiquitylation of androgen receptor
Journal Articles

The 44 kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug resistant activity in human prostate cancer cells

Yingqiu Xie, Kexin Xu, Douglas Linn, Zhiyong Guo, Takeo Nakanishi, Douglas Ross, Yun Qiu
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3244.
Published: 01 May 2008
View article titled, The 44 kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug resistant activity in human prostate cancer cells
Journal Articles

Tyrosine Kinase Etk/BMX Is Up-regulated in Human Prostate Cancer and Its Overexpression Induces Prostate Intraepithelial Neoplasia in Mouse

Bojie Dai, Oekyung Kim, Yingqiu Xie, Zhiyong Guo, Kexin Xu, Bin Wang, Xiangtian Kong, Jonathan Melamed, Hegang Chen, Charles J. Bieberich, Alexander D. Borowsky, Hsing-Jien Kung, Guo Wei, Michael C. Ostrowski, Angela Brodie, Yun Qiu
Journal: Cancer Research
Cancer Res (2006) 66 (16): 8058–8064.
https://doi.org/10.1158/0008-5472.CAN-06-1364
Published: 15 August 2006
View article titled, Tyrosine Kinase Etk/BMX Is Up-regulated in Human Prostate Cancer and Its Overexpression Induces Prostate Intraepithelial Neoplasia in Mouse
Open the PDF for Tyrosine Kinase Etk/BMX Is Up-regulated in Human Prostate Cancer and Its Overexpression Induces Prostate Intraepithelial Neoplasia in Mouse in another window
Includes: Supplementary data
Journal Articles

Regulation of androgen receptor activity by tyrosine phosphorylation

Zhiyong Guo, Bojie Dai, Tianyun Jiang, Kexin Xu, Yingqiu Xie, Oekyung Kim, Issa Nesheiwat, Venkatesh D. Handratta, Vincent C.o
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 689.
Published: 15 April 2006
View article titled, Regulation of androgen receptor activity by tyrosine phosphorylation
Journal Articles

The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/Bmx and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs

Yingqiu Xie, Kexin Xu, Bojie Dai, Zhiyong Guo, Tianyun Jiang, Hegang Chen, Yun Qiu
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 995.
Published: 15 April 2006
View article titled, The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/Bmx and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs
Journal Articles

Tyrosine kinase Etk/Bmx is upregulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse prostate

Bojie Dai, Yingqiu Xie, Zhiyong Guo, Oekyung Kim, Kexin Xu, Bin Wang, Hegang Chen, Charles Biebereich, Angela Brodie, Alexander D. Borowsky, Robert D. Cardiff, Hsing-Jien Kung, Yun Qiu
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 389.
Published: 15 April 2006
View article titled, Tyrosine kinase Etk/Bmx is upregulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse prostate