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Journal Articles

Abstract 822: Combination of carboplatin and CHK1 inhibition to overcome platinum resistance in high grade serous ovarian cancer

Mackenzie Cummings, Jaden Williams, Jennifer Pierce, Nathaniel Jones, Kevin Lee

Cancer Res (2025) 85 (8_Supplement_1): 822.

https://doi.org/10.1158/1538-7445.AM2025-822

Published: 21 April 2025

View articletitled, Abstract 822: Combination of carboplatin and CHK1 inhibition to overcome platinum resistance in high grade serous ovarian cancer

Journal Articles

Abstract 5033: Sub-0.01% KRAS G12C dPCR variant detection by mutation specific blocker (MSB) cassettes

Ashley Beams, Kevin Lee, Samantha Addison, Nathan Riccitelli

Cancer Res (2024) 84 (6_Supplement): 5033.

https://doi.org/10.1158/1538-7445.AM2024-5033

Published: 22 March 2024

View articletitled, Abstract 5033: Sub-0.01% KRAS G12C dPCR variant detection by mutation specific blocker (MSB) cassettes

Journal Articles

Abstract 327: A comparison of Illumina and Element Biosciences sequencing platforms

Sarah Johnson, Kevin Lee, Nathan Riccitelli

Cancer Res (2024) 84 (6_Supplement): 327.

https://doi.org/10.1158/1538-7445.AM2024-327

Published: 22 March 2024

View articletitled, Abstract 327: A comparison of Illumina and Element Biosciences sequencing platforms

Journal Articles

Abstract A032: The role of ASIC2 and calcium influx in epithelial ovarian cancer pathogenesis

Tanvi Joshi, Annelise Wilhite, Sagar Chokshi, Mary Howard Singleton, Jennifer Scalici, Kevin Lee

Cancer Res (2024) 84 (5_Supplement_2): A032.

https://doi.org/10.1158/1538-7445.OVARIAN23-A032

Published: 04 March 2024

View articletitled, Abstract A032: The role of ASIC2 and calcium influx in epithelial ovarian cancer pathogenesis

Journal Articles

Abstract A020: NAD+ Boosting through NRH supplementation enhances treatment efficacy in EOC

Kevin Lee, Tanvi Joshi, Catherine Lyons, Mary Howard Singleton, Elizabeth Catranis, Sagar Chokshi, Luciana Madiera da Silva, Marie Migaud, Jennifer Scalici

Cancer Res (2024) 84 (5_Supplement_2): A020.

https://doi.org/10.1158/1538-7445.OVARIAN23-A020

Published: 04 March 2024

View articletitled, Abstract A020: NAD+ Boosting through NRH supplementation enhances treatment efficacy in EOC

Journal Articles

Abstract CT025: BT8009-100 phase I/II study of novel bi-cyclic peptide and MMAE conjugate BT8009 in patients with advanced malignancies associated with nectin-4 expression

Meredith McKean, Capucine Baldini, Loic Verlingue, Bernard Doger, Gerald Falchook, Antoine Italiano, Julia Lostes, Oscar Reig, Roshawn Watson, Sebastien Hazard, Dominic Smethurst, Giulia Fulci, Hongmei Xu, Phil Jeffery, Kevin Lee, Irene Braña, Sophie Cousin, Elisa Fontana, Hendrik-Tobias Arkenau

Cancer Res (2022) 82 (12_Supplement): CT025.

https://doi.org/10.1158/1538-7445.AM2022-CT025

Published: 15 June 2022

View articletitled, Abstract CT025: BT8009-100 phase I/II study of novel bi-cyclic peptide and MMAE conjugate BT8009 in patients with advanced malignancies associated with nectin-4 expression

Journal Articles

Abstract 3864: A novel PDE10/β-catenin pathway inhibitor, MCI-030, for the treatment of colorectal cancer

Antonio B. Ward, Xi Chen, Jacob Valiyaveettil, Kevin Lee, Wen-Chi L. Chang, Yulia Maxuitenko, Veronica Ramirez-Alcantara, Kristy Berry, Luciana Madeira da Silva, Bing Zhu, Tyler Mattox, Michael R. Boyd, Adam B. Keeton, Margie L. Clapper, Harry S. Cooper, Gary A. Piazza

Cancer Res (2019) 79 (13_Supplement): 3864.

https://doi.org/10.1158/1538-7445.AM2019-3864

Published: 01 July 2019

View articletitled, Abstract 3864: A novel PDE10/β-catenin pathway inhibitor, MCI-030, for the treatment of colorectal cancer

Journal Articles

Abstract 1937: Inhibition of a novel cancer target, PDE10, suppresses Wnt/β-catenin signaling and colon tumorigenesis: Benefits from combining with ornithine decarboxylase inhibitors

Gary A. Piazza, Ashleigh Neese, Kevin Lee, Adam Keeton, Yulia Maxuitenko, Veronica Ramirez Alcantara, Kristy Berry, Jacob Valiyaveettil, Antonio Ward, Luciana Madeira da Silva, Jennifer Scalici, Bing Zhu, Tyler Mattox, Xi Chen, Margie Clapper, Harry Cooper, Wen-Chi Chang

Cancer Res (2018) 78 (13_Supplement): 1937.

https://doi.org/10.1158/1538-7445.AM2018-1937

Published: 01 July 2018

View articletitled, Abstract 1937: Inhibition of a novel cancer target, PDE10, suppresses Wnt/β-catenin signaling and colon tumorigenesis: Benefits from combining with ornithine decarboxylase inhibitors

Journal Articles

Abstract 5144: BT1718, a novel bicyclic peptide-maytansinoid conjugate targeting MT1-MMP for the treatment of solid tumors: Design of bicyclic peptide and linker selection

Helen Harrison, Gavin Bennett, Diane Blakeley, Amy Brown, Spencer Campbell, Liuhong Chen, Robert J. Lutz, Silvia Pavan, Katerine van Rietschoten, Daniel Teufel, Peter U. Park, Kevin Lee

Cancer Res (2017) 77 (13_Supplement): 5144.

https://doi.org/10.1158/1538-7445.AM2017-5144

Published: 01 July 2017

View articletitled, Abstract 5144: BT1718, a novel bicyclic peptide-maytansinoid conjugate targeting MT1-MMP for the treatment of solid tumors: Design of bicyclic peptide and linker selection

Journal Articles

Abstract 1167: Development of BT1718, a novel Bicycle Drug Conjugate for the treatment of lung cancer

Gavin Bennett, Robert Lutz, Peter Park, Helen Harrison, Kevin Lee

Cancer Res (2017) 77 (13_Supplement): 1167.

https://doi.org/10.1158/1538-7445.AM2017-1167

Published: 01 July 2017

View articletitled, Abstract 1167: Development of BT1718, a novel Bicycle Drug Conjugate for the treatment of lung cancer

Journal Articles

Abstract 5166: Sensitivity of melanoma cells to a novel class of Ras inhibitors

Kate M. Saville, Kevin Lee, Tyler E. Mattox, Xi Chen, Jacob Valiyaveettil, Kristy Berry, Veronica Ramírez-Alcántara, Bing Zhu, Adam Keeton, Michael Boyd, Gary Piazza, Ashley S. Lindsey

Cancer Res (2017) 77 (13_Supplement): 5166.

https://doi.org/10.1158/1538-7445.AM2017-5166

Published: 01 July 2017

View articletitled, Abstract 5166: Sensitivity of melanoma cells to a novel class of Ras inhibitors

Journal Articles

Abstract 4972: Novel Ras inhibitor DC070-547 potently and selectively blocks Ras-RBD binding, EGFR binding to Ras signaling complex, EGFR activation of Ras signaling, and growth of Ras-driven lung tumor cells

Bing Zhu, Xi Chen, Jacob Valiyaveettil, Joshua Canzoneri, Kevin Lee, Kate Saville, Kristy Berry, Luciana Barnes, Tyler Maddox, Ashley Lindsey, Antonio Ward, Veronica Ramirez-Alcantara, Adam Keeton, Michael Boyd, Gary Piazza

Cancer Res (2017) 77 (13_Supplement): 4972.

https://doi.org/10.1158/1538-7445.AM2017-4972

Published: 01 July 2017

View articletitled, Abstract 4972: Novel Ras inhibitor DC070-547 potently and selectively blocks Ras-RBD binding, EGFR binding to Ras signaling complex, EGFR activation of Ras signaling, and growth of Ras-driven lung tumor cells

Journal Articles

Abstract B21: PDE10A overexpression in colon cancer cells and tumors relative to normal colonocytes and colon mucosa

Ashley S. Lindsey, Kevin Lee, Joel Andrews, Wen-Chi L. Chang, Veronica Ramirez-Alcantara, Marcus Tan, William Grizzle, Margie L. Clapper, Gary Piazza

Cancer Res (2017) 77 (3_Supplement): B21.

https://doi.org/10.1158/1538-7445.CRC16-B21

Published: 31 January 2017

View articletitled, Abstract B21: PDE10A overexpression in colon cancer cells and tumors relative to normal colonocytes and colon mucosa

Journal Articles

Abstract 1238: A novel Ras inhibitor potently and selectively suppresses lung tumor cell growth by blocking Ras-Raf binding

Bing Zhu, Xi Chen, Veronica Ramirez-Alcantara, Kevin Lee, Jacob Valiyaveettil, Joshua Canzoneri, Sara Sigler, Kristy Berry, Ashley Lindsey, Adam Keeton, Michael R. Boyd, Gary A. Piazza

Cancer Res (2016) 76 (14_Supplement): 1238.

https://doi.org/10.1158/1538-7445.AM2016-1238

Published: 15 July 2016

View articletitled, Abstract 1238: A novel Ras inhibitor potently and selectively suppresses lung tumor cell growth by blocking Ras-Raf binding

Journal Articles

Abstract 4736: PDE10A overexpression in cancer cells and tumors as compared to normal cells and tissues

Ashley S. Lindsey, Kevin Lee, Bing Zhu, Ritu Arora, Dennis Otali, Veronica Ramirez-Alacantara, William Grizzle, Gary Piazza

Cancer Res (2016) 76 (14_Supplement): 4736.

https://doi.org/10.1158/1538-7445.AM2016-4736

Published: 15 July 2016

View articletitled, Abstract 4736: PDE10A overexpression in cancer cells and tumors as compared to normal cells and tissues

Journal Articles

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

Cancer Res (2015) 75 (23): 5106–5119.

https://doi.org/10.1158/0008-5472.CAN-15-0236

Published: 30 November 2015

View articletitled, Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

Includes: Supplementary data

Journal Articles

Abstract 4360: Validation of phosphodiesterase 10A as a cancer target

Kevin Lee, Nan Li, Xi Chen, Bing Zhu, Larry Yet, Luciana Madeira da Silva, Suzanne Russo, Adam B. Keeton, Michael R. Boyd, Gary A. Piazza

Cancer Res (2015) 75 (15_Supplement): 4360.

https://doi.org/10.1158/1538-7445.AM2015-4360

Published: 01 August 2015

View articletitled, Abstract 4360: Validation of phosphodiesterase 10A as a cancer target

Journal Articles

Abstract 4372: Phosphodiesterase 10A inhibition suppresses lung tumor cell growth by activating PKG to inhibit ras and Wnt signaling

Bing Zhu, Kevin Lee, Joshua Canzoneri, Veronica Ramirez-Alcantara, Sara Sigler, Bernard Gary, Ethan Butler, Adam Keeton, Xi Chen, Michael Boyd, Gary Piazza

Cancer Res (2015) 75 (15_Supplement): 4372.

https://doi.org/10.1158/1538-7445.AM2015-4372

Published: 01 August 2015

View articletitled, Abstract 4372: Phosphodiesterase 10A inhibition suppresses lung tumor cell growth by activating PKG to inhibit ras and Wnt signaling

Journal Articles

Abstract 701: A novel class of Ras selective inhibitors

Joshua C. Canzoneri, Xi Chen, Adam B. Keeton, Kevin Lee, Bernard Gary, Ethan B. Butler, William E. Grizzle, Landon Wilson, Stephen Barnes, Michael R. Boyd, Gary A. Piazza

Cancer Res (2015) 75 (15_Supplement): 701.

https://doi.org/10.1158/1538-7445.AM2015-701

Published: 01 August 2015

View articletitled, Abstract 701: A novel class of Ras selective inhibitors

Journal Articles

Abstract 1773: Phosphodiesterase 10A: A novel target for selective inhibition of colon tumor cell growth and Wnt/β-catenin signaling

Cancer Res (2014) 74 (19_Supplement): 1773.

https://doi.org/10.1158/1538-7445.AM2014-1773

Published: 01 October 2014

View articletitled, Abstract 1773: Phosphodiesterase 10A: A novel target for selective inhibition of colon tumor cell growth and Wnt/β-catenin signaling

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Abstract 822: Combination of carboplatin and CHK1 inhibition to overcome platinum resistance in high grade serous ovarian cancer

Abstract 5033: Sub-0.01% KRAS G12C dPCR variant detection by mutation specific blocker (MSB) cassettes

Abstract 327: A comparison of Illumina and Element Biosciences sequencing platforms

Abstract A032: The role of ASIC2 and calcium influx in epithelial ovarian cancer pathogenesis

Abstract A020: NAD+ Boosting through NRH supplementation enhances treatment efficacy in EOC

Abstract CT025: BT8009-100 phase I/II study of novel bi-cyclic peptide and MMAE conjugate BT8009 in patients with advanced malignancies associated with nectin-4 expression

Abstract 3864: A novel PDE10/β-catenin pathway inhibitor, MCI-030, for the treatment of colorectal cancer

Abstract 1937: Inhibition of a novel cancer target, PDE10, suppresses Wnt/β-catenin signaling and colon tumorigenesis: Benefits from combining with ornithine decarboxylase inhibitors

Abstract 5144: BT1718, a novel bicyclic peptide-maytansinoid conjugate targeting MT1-MMP for the treatment of solid tumors: Design of bicyclic peptide and linker selection

Abstract 1167: Development of BT1718, a novel Bicycle Drug Conjugate for the treatment of lung cancer

Abstract 5166: Sensitivity of melanoma cells to a novel class of Ras inhibitors

Abstract 4972: Novel Ras inhibitor DC070-547 potently and selectively blocks Ras-RBD binding, EGFR binding to Ras signaling complex, EGFR activation of Ras signaling, and growth of Ras-driven lung tumor cells

Abstract B21: PDE10A overexpression in colon cancer cells and tumors relative to normal colonocytes and colon mucosa

Abstract 1238: A novel Ras inhibitor potently and selectively suppresses lung tumor cell growth by blocking Ras-Raf binding

Abstract 4736: PDE10A overexpression in cancer cells and tumors as compared to normal cells and tissues

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

Abstract 4360: Validation of phosphodiesterase 10A as a cancer target

Abstract 4372: Phosphodiesterase 10A inhibition suppresses lung tumor cell growth by activating PKG to inhibit ras and Wnt signaling

Abstract 701: A novel class of Ras selective inhibitors

Abstract 1773: Phosphodiesterase 10A: A novel target for selective inhibition of colon tumor cell growth and Wnt/β-catenin signaling

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