Search Results | Cancer Research | American Association for Cancer Research

1-17 of 17

Sort by

Sort Order Select

Journal Articles

Abstract CT025: BT8009-100 phase I/II study of novel bi-cyclic peptide and MMAE conjugate BT8009 in patients with advanced malignancies associated with nectin-4 expression

Meredith McKean, Capucine Baldini, Loic Verlingue, Bernard Doger, Gerald Falchook, Antoine Italiano, Julia Lostes, Oscar Reig, Roshawn Watson, Sebastien Hazard, Dominic Smethurst, Giulia Fulci, Hongmei Xu, Phil Jeffery, Kevin Lee, Irene Braña, Sophie Cousin, Elisa Fontana, Hendrik-Tobias Arkenau

Cancer Res (2022) 82 (12_Supplement): CT025.

DOI: https://doi.org/10.1158/1538-7445.AM2022-CT025

Published: 15 June 2022

View article

Journal Articles

Abstract 3864: A novel PDE10/β-catenin pathway inhibitor, MCI-030, for the treatment of colorectal cancer

Antonio B. Ward, Xi Chen, Jacob Valiyaveettil, Kevin Lee, Wen-Chi L. Chang, Yulia Maxuitenko, Veronica Ramirez-Alcantara, Kristy Berry, Luciana Madeira da Silva, Bing Zhu, Tyler Mattox, Michael R. Boyd, Adam B. Keeton, Margie L. Clapper, Harry S. Cooper, Gary A. Piazza

Cancer Res (2019) 79 (13_Supplement): 3864.

DOI: https://doi.org/10.1158/1538-7445.AM2019-3864

Published: 01 July 2019

View article

Journal Articles

Abstract 1937: Inhibition of a novel cancer target, PDE10, suppresses Wnt/β-catenin signaling and colon tumorigenesis: Benefits from combining with ornithine decarboxylase inhibitors

Gary A. Piazza, Ashleigh Neese, Kevin Lee, Adam Keeton, Yulia Maxuitenko, Veronica Ramirez Alcantara, Kristy Berry, Jacob Valiyaveettil, Antonio Ward, Luciana Madeira da Silva, Jennifer Scalici, Bing Zhu, Tyler Mattox, Xi Chen, Margie Clapper, Harry Cooper, Wen-Chi Chang

Cancer Res (2018) 78 (13_Supplement): 1937.

DOI: https://doi.org/10.1158/1538-7445.AM2018-1937

Published: 01 July 2018

View article

Journal Articles

Abstract 1167: Development of BT1718, a novel Bicycle Drug Conjugate for the treatment of lung cancer

Gavin Bennett, Robert Lutz, Peter Park, Helen Harrison, Kevin Lee

Cancer Res (2017) 77 (13_Supplement): 1167.

DOI: https://doi.org/10.1158/1538-7445.AM2017-1167

Published: 01 July 2017

View article

Journal Articles

Abstract 5144: BT1718, a novel bicyclic peptide-maytansinoid conjugate targeting MT1-MMP for the treatment of solid tumors: Design of bicyclic peptide and linker selection

Helen Harrison, Gavin Bennett, Diane Blakeley, Amy Brown, Spencer Campbell, Liuhong Chen, Robert J. Lutz, Silvia Pavan, Katerine van Rietschoten, Daniel Teufel, Peter U. Park, Kevin Lee

Cancer Res (2017) 77 (13_Supplement): 5144.

DOI: https://doi.org/10.1158/1538-7445.AM2017-5144

Published: 01 July 2017

View article

Journal Articles

Abstract 5166: Sensitivity of melanoma cells to a novel class of Ras inhibitors

Kate M. Saville, Kevin Lee, Tyler E. Mattox, Xi Chen, Jacob Valiyaveettil, Kristy Berry, Veronica Ramírez-Alcántara, Bing Zhu, Adam Keeton, Michael Boyd, Gary Piazza, Ashley S. Lindsey

Cancer Res (2017) 77 (13_Supplement): 5166.

DOI: https://doi.org/10.1158/1538-7445.AM2017-5166

Published: 01 July 2017

View article

Journal Articles

Abstract 4972: Novel Ras inhibitor DC070-547 potently and selectively blocks Ras-RBD binding, EGFR binding to Ras signaling complex, EGFR activation of Ras signaling, and growth of Ras-driven lung tumor cells

Bing Zhu, Xi Chen, Jacob Valiyaveettil, Joshua Canzoneri, Kevin Lee, Kate Saville, Kristy Berry, Luciana Barnes, Tyler Maddox, Ashley Lindsey, Antonio Ward, Veronica Ramirez-Alcantara, Adam Keeton, Michael Boyd, Gary Piazza

Cancer Res (2017) 77 (13_Supplement): 4972.

DOI: https://doi.org/10.1158/1538-7445.AM2017-4972

Published: 01 July 2017

View article

Journal Articles

Abstract B21: PDE10A overexpression in colon cancer cells and tumors relative to normal colonocytes and colon mucosa

Ashley S. Lindsey, Kevin Lee, Joel Andrews, Wen-Chi L. Chang, Veronica Ramirez-Alcantara, Marcus Tan, William Grizzle, Margie L. Clapper, Gary Piazza

Cancer Res (2017) 77 (3_Supplement): B21.

DOI: https://doi.org/10.1158/1538-7445.CRC16-B21

Published: 31 January 2017

View article

Journal Articles

Abstract 1238: A novel Ras inhibitor potently and selectively suppresses lung tumor cell growth by blocking Ras-Raf binding

Bing Zhu, Xi Chen, Veronica Ramirez-Alcantara, Kevin Lee, Jacob Valiyaveettil, Joshua Canzoneri, Sara Sigler, Kristy Berry, Ashley Lindsey, Adam Keeton, Michael R. Boyd, Gary A. Piazza

Cancer Res (2016) 76 (14_Supplement): 1238.

DOI: https://doi.org/10.1158/1538-7445.AM2016-1238

Published: 15 July 2016

View article

Journal Articles

Abstract 4736: PDE10A overexpression in cancer cells and tumors as compared to normal cells and tissues

Ashley S. Lindsey, Kevin Lee, Bing Zhu, Ritu Arora, Dennis Otali, Veronica Ramirez-Alacantara, William Grizzle, Gary Piazza

Cancer Res (2016) 76 (14_Supplement): 4736.

DOI: https://doi.org/10.1158/1538-7445.AM2016-4736

Published: 15 July 2016

View article

Journal Articles

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

Cancer Res (2015) 75 (23): 5106–5119.

DOI: https://doi.org/10.1158/0008-5472.CAN-15-0236

Published: 30 November 2015

View article

Includes: Supplementary data

Journal Articles

Abstract 4360: Validation of phosphodiesterase 10A as a cancer target

Kevin Lee, Nan Li, Xi Chen, Bing Zhu, Larry Yet, Luciana Madeira da Silva, Suzanne Russo, Adam B. Keeton, Michael R. Boyd, Gary A. Piazza

Cancer Res (2015) 75 (15_Supplement): 4360.

DOI: https://doi.org/10.1158/1538-7445.AM2015-4360

Published: 01 August 2015

View article

Journal Articles

Abstract 4372: Phosphodiesterase 10A inhibition suppresses lung tumor cell growth by activating PKG to inhibit ras and Wnt signaling

Bing Zhu, Kevin Lee, Joshua Canzoneri, Veronica Ramirez-Alcantara, Sara Sigler, Bernard Gary, Ethan Butler, Adam Keeton, Xi Chen, Michael Boyd, Gary Piazza

Cancer Res (2015) 75 (15_Supplement): 4372.

DOI: https://doi.org/10.1158/1538-7445.AM2015-4372

Published: 01 August 2015

View article

Journal Articles

Abstract 701: A novel class of Ras selective inhibitors

Joshua C. Canzoneri, Xi Chen, Adam B. Keeton, Kevin Lee, Bernard Gary, Ethan B. Butler, William E. Grizzle, Landon Wilson, Stephen Barnes, Michael R. Boyd, Gary A. Piazza

Cancer Res (2015) 75 (15_Supplement): 701.

DOI: https://doi.org/10.1158/1538-7445.AM2015-701

Published: 01 August 2015

View article

Journal Articles

Abstract 1773: Phosphodiesterase 10A: A novel target for selective inhibition of colon tumor cell growth and Wnt/β-catenin signaling

Cancer Res (2014) 74 (19_Supplement): 1773.

DOI: https://doi.org/10.1158/1538-7445.AM2014-1773

Published: 01 October 2014

View article

Journal Articles

Abstract 1761: PDE10, a novel therapeutic target for lung cancer

Bing Zhu, Nan Li, Veronica Ramirez-Alcantara, Joshua Canzoneri, Evrim Gurpinar, Alexandra Fajardo, Kevin Lee, Sara Sigler, Bernard Gary, Meagan Thomas, Adam Keeton, Xi Chen, William Grizzle, Gary Piazza

Cancer Res (2014) 74 (19_Supplement): 1761.

DOI: https://doi.org/10.1158/1538-7445.AM2014-1761

Published: 01 October 2014

View article

Journal Articles

Role of Metabolism and Oxidation-Reduction Cycling in the Cytotoxicity of Antitumor Quinoneimines and Quinonediimines

Garth Powis, Ernest M. Hodnett, Kenneth S. Santone, Kevin Lee See, Deborah C. Melder

Cancer Res (1987) 47 (9): 2363–2370.

Published: 01 May 1987

View article

NARROW

Abstract CT025: BT8009-100 phase I/II study of novel bi-cyclic peptide and MMAE conjugate BT8009 in patients with advanced malignancies associated with nectin-4 expression

Abstract 3864: A novel PDE10/β-catenin pathway inhibitor, MCI-030, for the treatment of colorectal cancer

Abstract 1937: Inhibition of a novel cancer target, PDE10, suppresses Wnt/β-catenin signaling and colon tumorigenesis: Benefits from combining with ornithine decarboxylase inhibitors

Abstract 1167: Development of BT1718, a novel Bicycle Drug Conjugate for the treatment of lung cancer

Abstract 5144: BT1718, a novel bicyclic peptide-maytansinoid conjugate targeting MT1-MMP for the treatment of solid tumors: Design of bicyclic peptide and linker selection

Abstract 5166: Sensitivity of melanoma cells to a novel class of Ras inhibitors

Abstract 4972: Novel Ras inhibitor DC070-547 potently and selectively blocks Ras-RBD binding, EGFR binding to Ras signaling complex, EGFR activation of Ras signaling, and growth of Ras-driven lung tumor cells

Abstract B21: PDE10A overexpression in colon cancer cells and tumors relative to normal colonocytes and colon mucosa

Abstract 1238: A novel Ras inhibitor potently and selectively suppresses lung tumor cell growth by blocking Ras-Raf binding

Abstract 4736: PDE10A overexpression in cancer cells and tumors as compared to normal cells and tissues

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

Abstract 4360: Validation of phosphodiesterase 10A as a cancer target

Abstract 4372: Phosphodiesterase 10A inhibition suppresses lung tumor cell growth by activating PKG to inhibit ras and Wnt signaling

Abstract 701: A novel class of Ras selective inhibitors

Abstract 1773: Phosphodiesterase 10A: A novel target for selective inhibition of colon tumor cell growth and Wnt/β-catenin signaling

Abstract 1761: PDE10, a novel therapeutic target for lung cancer

Role of Metabolism and Oxidation-Reduction Cycling in the Cytotoxicity of Antitumor Quinoneimines and Quinonediimines

Email alerts

AACR Journals

Email alerts

AACR Journals

This Feature Is Available To Subscribers Only