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Journal Articles

Abstract 4007: Efficacy of vepafestinib in preclinical models of RET fusion-driven sarcoma models

Igor Odintsov, Ryan C. Cheng, Allan J. Lui, Tom Zhang, Yue C. Lu, Renate I. Kurth, Morana Vojnic, Inna Khodos, Qing Chang, Kevin Chen, Claudio Giuliano, Annalisa Bonifacio, Isao Miyazaki, Elisa de Stanchina, Emanuela Lovati, Marc Ladanyi, Romel Somwar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4007.
https://doi.org/10.1158/1538-7445.AM2023-4007
Published: 04 April 2023
View article titled, Abstract 4007: Efficacy of vepafestinib in preclinical models of <em>RET</em> fusion-driven sarcoma models
Journal Articles

Abstract 3475: RMC-9805, a first-in-class, mutant-selective, covalent and orally bioavailable KRASG12D(ON) inhibitor, promotes cancer-associated neoantigen recognition and synergizes with immunotherapy in preclinical models

Marie J. Menard, Christopher Chow, Kevin Chen, Cristina Blaj, Nataliya Tovbis Shifrin, Haley Courtney, Nicole M. Nasholm, Anna Pham, Alice Kumamoto, Swetha Ganesh, James W. Evans, Lindsey Lawrence, Brian Vonmelchert, Amy C. Kwok-Parkhill, Jingjing Jiang, John E. Knox, Jacqueline Smith, Elsa Quintana
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3475.
https://doi.org/10.1158/1538-7445.AM2023-3475
Published: 04 April 2023
View article titled, Abstract 3475: RMC-9805, a first-in-class, mutant-selective, covalent and orally bioavailable KRAS<sup>G12D</sup>(ON) inhibitor, promotes cancer-associated neoantigen recognition and synergizes with immunotherapy in preclinical models
Journal Articles

Abstract 2219: Urine cell-free DNA multi-omics to detect molecular residual disease and predict survival in bladder cancer patients

Pradeep Singh Chauhan, Alexander L. Shiang, Irfan Alahi, R. Taylor Sundby, Wenjia Feng, Bilge Gungoren, Cayce Nawaf, Kevin Chen, Ramandeep K. Babbra, Peter K. Harris, Faridi Qaium, Casey Hatscher, Anna Antiporda, Lindsey Brunt, Lindsey R. Mayer, Jack F. Shern, Brian C. Baumann, Eric H. Kim, Melissa A. Reimers, Zachary L. Smith, Aadel A. Chaudhuri
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2219.
https://doi.org/10.1158/1538-7445.AM2023-2219
Published: 04 April 2023
View article titled, Abstract 2219: Urine cell-free DNA multi-omics to detect molecular residual disease and predict survival in bladder cancer patients
Journal Articles

Abstract 3359: Sensitive detection of locoregional MRD after head and neck cancer surgery

Noah Earland, Ricardo J. Ramirez, Sophie P. Gerndt, Peter K. Harris, Andrew I. Hearn, Matthew Inkman, Jeffrey J. Szymanski, Nick Semenkovich, Benjamin M. Wahle, Zhongping Xu, Kevin Chen, Jin Zhang, Jose P. Zevallos, Aadel A. Chaudhuri
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3359.
https://doi.org/10.1158/1538-7445.AM2023-3359
Published: 04 April 2023
View article titled, Abstract 3359: Sensitive detection of locoregional MRD after head and neck cancer surgery
Journal Articles

Abstract 2594: Discovery and characterization of ZL-2201, a potent, highly-selective, and orally bioavailable small-molecule DNA-PK inhibitor

Shruti Lal, Bee-Chun Sun, Yuping Chen, Tom Huang, Neil Bhola, Vivian Morton, Kevin Chen, Shanghua Xia, Haoyu Zhang, Qiuping Ye, Petter Veiby, David I. Bellovin, Yuhua Ji
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2594.
https://doi.org/10.1158/1538-7445.AM2022-2594
Published: 15 June 2022
View article titled, Abstract 2594: Discovery and characterization of ZL-2201, a potent, highly-selective, and orally bioavailable small-molecule DNA-PK inhibitor
Journal Articles

Abstract LB225: Toward comprehensive, single-molecule proteomics: Protein identification by short-epitope mapping

Jarrett D. Egertson, Cassandra Stawicki, Taryn E. Gillies, James H. Joly, Noah Steiner, Kevin Cardenas, Jonathan B. Leano, Kevin Chen, Sophie Watts, Hunter B. Boyce, Dan DiPasquo, Alana Killeen, Vadim Lobanov, Greg Kapp, Sujal Patel, Parag Mallick
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB225.
https://doi.org/10.1158/1538-7445.AM2022-LB225
Published: 15 June 2022
View article titled, Abstract LB225: Toward comprehensive, single-molecule proteomics: Protein identification by short-epitope mapping
Journal Articles

Abstract 920: Harnessing multiple mechanisms of action to target Nectin-4 as anti-tumor therapeutics

Yi Pei, Thomas Pohl, Ahmed Hassan, Anna Przybyla, Raymond Yu, Huarui Lu, Fangqiang Tang, Kevin Chen, Wei Jin, Krizia Dominguez, Haichun Huang, Ming Lei, Zhong Liu, Han Li
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 920.
https://doi.org/10.1158/1538-7445.AM2021-920
Published: 01 July 2021
View article titled, Abstract 920: Harnessing multiple mechanisms of action to target Nectin-4 as anti-tumor therapeutics
Journal Articles

Abstract 547: Urine tumor DNA MRD detection and correlation with pathologic complete response in muscle-invasive bladder cancer treated with curative-intent radical cystectomy

Kevin Chen, Pradeep S. Chauhan, Ramandeep K. Babbra, Wenjia Feng, Peter K. Harris, Katherine Dienstbach, Andrew Atkocius, Lenon Maguire, Faridi Qaium, Armaan Nallicheri, Brian C. Baumann, Melissa A. Reimers, Eric H. Kim, Zachary L. Smith, Vivek K. Arora, Aadel A. Chaudhuri
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 547.
https://doi.org/10.1158/1538-7445.AM2021-547
Published: 01 July 2021
View article titled, Abstract 547: Urine tumor DNA MRD detection and correlation with pathologic complete response in muscle-invasive bladder cancer treated with curative-intent radical cystectomy
Journal Articles

Abstract 3006: Melanoma cell lines derived from patient derived xenografts (PDX) can contain murine chromosomes resultant from cell fusions

Agustin Vega-Crespo, Ignacio Baselga-Carretero, Ivan Perez-Garcilaso, Sameeha Jilani, Kevin Chen, Vaneet Khullar, Egmidio Medina, Yaroslav Teper, Antoni Ribas, Begoña Comin-Anduix
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3006.
https://doi.org/10.1158/1538-7445.AM2021-3006
Published: 01 July 2021
View article titled, Abstract 3006: Melanoma cell lines derived from patient derived xenografts (PDX) can contain murine chromosomes resultant from cell fusions
Journal Articles

Abstract 1893: The dynamics of T cell clonal repertoire under targeted therapy vs. immunotherapy in melanoma

Lizhong Ding, Katie M. Campbell, Egmidio Medina, Kevin Chen, Willy Hugo
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1893.
https://doi.org/10.1158/1538-7445.AM2021-1893
Published: 01 July 2021
View article titled, Abstract 1893: The dynamics of T cell clonal repertoire under targeted therapy vs. immunotherapy in melanoma
Journal Articles

Abstract 1869: Novel TNFR2 antibodies to overcome T cell exhaustion and suppressive tumor microenvironment

Chi Shing Sum, Makenzie Danton, Qii hu, Alla Pritsker, Ray Lin, Raymond Yu, Kevin Chen, Fangqiang Tang, Thomas Pohl, Samantha Wallner, Ahmed Hassan, Huarui Lu, Haichun Huang, James Pei, Zhong Liu, Han Li, Ming Lei
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1869.
https://doi.org/10.1158/1538-7445.AM2021-1869
Published: 01 July 2021
View article titled, Abstract 1869: Novel TNFR2 antibodies to overcome T cell exhaustion and suppressive tumor microenvironment
Journal Articles

Abstract 2979: The effect of interferon gamma on melanoma progression under MAPK inhibitor therapy

Kevin Chen, Rachel McMillan, Mona Chatrizeh, Willy Hugo
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2979.
https://doi.org/10.1158/1538-7445.AM2020-2979
Published: 15 August 2020
View article titled, Abstract 2979: The effect of interferon gamma on melanoma progression under MAPK inhibitor therapy
Journal Articles

Abstract 5195: NBL-015, a next-generation fully human anti-claudin 18.2 antibody with enhanced ADCC and CDC for treating gastric and pancreatic cancers

Ming Lei, Anna Przybyla, Ahmed Hassan, Qingtai Su, Gabriela Hrebikova, Samantha Wallner, Danielle Lavery, Kevin Chen, Raymond Yu, Joshua Dewe, Samruddhi Patil, Haichun Huang, Yi Pei, Zhong Liu, Han Li
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5195.
https://doi.org/10.1158/1538-7445.AM2020-5195
Published: 15 August 2020
View article titled, Abstract 5195: NBL-015, a next-generation fully human anti-claudin 18.2 antibody with enhanced ADCC and CDC for treating gastric and pancreatic cancers
Journal Articles

Abstract 5706: Identifying regulators of cancer heterogeneity with phenotypic sorting and single cell sequencing

Kevin Chen, Stephanie Irene Fraley
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5706.
https://doi.org/10.1158/1538-7445.AM2020-5706
Published: 15 August 2020
View article titled, Abstract 5706: Identifying regulators of cancer heterogeneity with phenotypic sorting and single cell sequencing
Journal Articles

Cell Adhesiveness Serves as a Biophysical Marker for Metastatic Potential

Pranjali Beri, Anna Popravko, Benjamin Yeoman, Aditya Kumar, Kevin Chen, Enio Hodzic, Alyssa Chiang, Afsheen Banisadr, Jesse K. Placone, Hannah Carter, Stephanie I. Fraley, Parag Katira, Adam J. Engler
Journal: Cancer Research
Cancer Res (2020) 80 (4): 901–911.
https://doi.org/10.1158/0008-5472.CAN-19-1794
Published: 14 February 2020
View article titled, Cell Adhesiveness Serves as a Biophysical Marker for Metastatic Potential
Open the PDF for Cell Adhesiveness Serves as a Biophysical Marker for Metastatic Potential in another window
Includes: Supplementary data
Journal Articles

Abstract 2912: Nitric oxide mediates metabolic coupling of omentum-derived adipose to ovarian and endometrial cancer cells

Bahar Salimian Rizi, Kevin Chen, Inka Cajo Didelija, Juan Marini, Ann H. Klopp, Deepak Nagrath
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2912.
https://doi.org/10.1158/1538-7445.AM2015-2912
Published: 01 August 2015
View article titled, Abstract 2912: Nitric oxide mediates metabolic coupling of omentum-derived adipose to ovarian and endometrial cancer cells
Journal Articles

Nitric Oxide Mediates Metabolic Coupling of Omentum-Derived Adipose Stroma to Ovarian and Endometrial Cancer Cells

Bahar Salimian Rizi, Christine Caneba, Aleksandra Nowicka, Ahmad W. Nabiyar, Xinran Liu, Kevin Chen, Ann Klopp, Deepak Nagrath
Journal: Cancer Research
Cancer Res (2015) 75 (2): 456–471.
https://doi.org/10.1158/0008-5472.CAN-14-1337
Published: 14 January 2015
View article titled, Nitric Oxide Mediates Metabolic Coupling of Omentum-Derived Adipose Stroma to Ovarian and Endometrial Cancer Cells
Open the PDF for Nitric Oxide Mediates Metabolic Coupling of Omentum-Derived Adipose Stroma to Ovarian and Endometrial Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 5029: The role of estrogen receptor signaling in rhabdomyosarcoma.

Zainab A. Motala, Kevin Chen, David Malkin
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5029.
https://doi.org/10.1158/1538-7445.AM2013-5029
Published: 15 April 2013
View article titled, Abstract 5029: The role of estrogen receptor signaling in rhabdomyosarcoma.
Journal Articles

Abstract 4505: Development of small molecules to target ezrin as anti-metastatic agents

Gülay Bulut, Sung-Hyeok Hong, Kevin Chen, Said Rahim, George W. Kosturko, Elspeth M. Beauchamp, Eric Glasgow, Jeffrey A. Toretsky, Chand Khanna, Aykut Uren
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4505.
https://doi.org/10.1158/1538-7445.AM2011-4505
Published: 15 April 2011
View article titled, Abstract 4505: Development of small molecules to target ezrin as anti-metastatic agents
Journal Articles

Abstract 749: Predicting and improving potential anticancer proteomimetics with computational modeling

Kevin Chen
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 749.
https://doi.org/10.1158/1538-7445.AM10-749
Published: 15 April 2010
View article titled, Abstract 749: Predicting and improving potential anticancer proteomimetics with computational modeling