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Journal Articles

HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma

Rigney E. Turnham, Adriana Pitea, Gwendolyn M. Jang, Zhong Xu, Huat Chye Lim, Alex L. Choi, John Von Dollen, Rebecca S. Levin, James T. Webber, Elizabeth McCarthy, Junjie Hu, Xiaolei Li, Li Che, Ananya Singh, Alex Yoon, Gary Chan, Robin K. Kelley, Danielle L. Swaney, Wei Zhang, Sourav Bandyopadhyay, Fabian J. Theis, Manon Eckhardt, Xin Chen, Kevan M. Shokat, Trey Ideker, Nevan J. Krogan, John D. Gordan
Journal: Cancer Research
Cancer Res (2024)
https://doi.org/10.1158/0008-5472.CAN-24-0456
Published: 09 December 2024
View article titled, HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma
Open the PDF for HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract B102: Development of covalent inhibitors targeting Ras Q61 hotspot mutants

Julius Pampel, Johannes Morstein, Qinheng Zheng, David M. Peacock, Kevan M. Shokat
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B102.
https://doi.org/10.1158/1538-7445.PANCA2023-B102
Published: 16 January 2024
View article titled, Abstract B102: Development of covalent inhibitors targeting Ras Q61 hotspot mutants
Journal Articles

Abstract B066: Genome-wide CRISPR screens identify PTGES3 as a druggable AR modulator

Haolong Li, James E. Melnyk, Becky Xu Hua Fu, Siyu Feng, Martin Sjöström, Raunak Shrestha, Meng Zhang, Lisa N. Chesner, Hyun Jin Shin, Marsha Calvert, Jonathan Chou, Rajdeep Das, Emily A. Egusa, Aidan Winters, Jun Zhu, Ashutosh Maheshwari, Junjie T. Hua, Mohammed Alshalalfa, William S. Chen, Bradley A. Stohr, Javed Siddiqui, Bo Huang, Eric J. Small, David A. Quigley, Kevan M. Shokat, Luke A. Gilbert, Felix Y. Feng
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B066.
https://doi.org/10.1158/1538-7445.PRCA2023-B066
Published: 02 June 2023
View article titled, Abstract B066: Genome-wide CRISPR screens identify PTGES3 as a druggable AR modulator
Journal Articles

Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

Adam J. Wolpaw, Richard Bayliss, Gabriele Büchel, Chi V. Dang, Martin Eilers, W. Clay Gustafson, Gwenn H. Hansen, Natalia Jura, Stefan Knapp, Mark A. Lemmon, David Levens, John M. Maris, Ronen Marmorstein, Steven J. Metallo, Julie R. Park, Linda Z. Penn, Michael Rape, Martine F. Roussel, Kevan M. Shokat, William P. Tansey, Kliment A. Verba, Seychelle M. Vos, William A. Weiss, Elmar Wolf, Yaël P. Mossé
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (7): 1627–1632.
https://doi.org/10.1158/0008-5472.CAN-20-3108
Published: 01 April 2021
View article titled, Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers
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Journal Articles

Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma

Robyn A. Wong, Xujun Luo, Mimi Lu, Zhenyi An, Daphne A. Haas-Kogan, Joanna J. Phillips, Kevan M. Shokat, William A. Weiss, Qi Wen Fan
Journal: Cancer Research
Cancer Res (2020) 80 (4): 709–718.
https://doi.org/10.1158/0008-5472.CAN-18-2808
Published: 14 February 2020
View article titled, Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma
Open the PDF for Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract IA25: Third-generation inhibitors of mTOR

Kevan M. Shokat
Journal: Cancer Research
Cancer Res (2017) 77 (6_Supplement): IA25.
https://doi.org/10.1158/1538-7445.Transcontrol16-IA25
Published: 14 March 2017
View article titled, Abstract IA25: Third-generation inhibitors of mTOR
Journal Articles

Abstract 3904: Overcoming resistance to HER2 inhibitors through cell based screening

Chris J. Novotny, Sirkku Pollari, Jin H. Park, Mark A. Lemmon, Peter G. Schultz, Weijun Shen, Kevan M. Shokat
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3904.
https://doi.org/10.1158/1538-7445.AM2016-3904
Published: 15 July 2016
View article titled, Abstract 3904: Overcoming resistance to HER2 inhibitors through cell based screening
Journal Articles

Abstract 2147: Overcoming mTOR resistance mutations with a new generation mTOR inhibitor

Vanessa S. Rodrik-Outmezguine, Masanori Okaniwa, Zhan Yao, Chris Novotny, Claire McWhirter, Arpitha Banaji, Helen Won, Wai Wong, Mike Berger, Elisa de Stanchina, Derek G. Barratt, Sabina Cosulich, Teresa Klinowska, Neal Rosen, Kevan M. Shokat
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2147.
https://doi.org/10.1158/1538-7445.AM2016-2147
Published: 15 July 2016
View article titled, Abstract 2147: Overcoming mTOR resistance mutations with a new generation mTOR inhibitor
Journal Articles

Abstract PR15: Functional analysis of diverse oncogenic driver mutations using an isogenic cell line library identifies novel drug responses and alterations in metabolism

Maria M. Martins, Alicia Y. Zhou, Alexandra Corella, Dai Horiuchi, Christina Yau, Taha Rakshandehroo, John D. Gordan, Rebecca S. Levin, Jeff Johnson, John Jascur, Mike Shales, Antonio Sorrentino, Jaime Cheah, Paul A. Clemons, Alykhan Shamji, Stuart Schreiber, Stuart Schreiber, Nevan J. Krogan, Kevan M. Shokat, Kevan M. Shokat, Frank McCormick, Daniel Nomura, Sourav Bandyopadhyay, Andrei Goga
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_1): PR15.
https://doi.org/10.1158/1538-7445.TRANSCAGEN-PR15
Published: 15 November 2015
View article titled, Abstract PR15: Functional analysis of diverse oncogenic driver mutations using an isogenic cell line library identifies novel drug responses and alterations in metabolism
Journal Articles

Abstract PR07: Functional analysis of diverse oncogenic driver mutations using an isogenic cell line library identifies novel drug responses and alterations in metabolism

Maria M. Martins, Alicia Y. Zhou, Alexandra Corella, Dai Horiuchi, Christina Yau, Taha Rakshandehroo, John D. Gordan, Rebecca S. Levin, Jeff Johnson, John Jascur, Mike Shales, Antonio Sorrentino, Jaime Cheah, Paul A. Clemons, Alykhan Shamji, Stuart Schreiber, Stuart Schreiber, Nevan J. Krogan, Kevan M. Shokat, Kevan M. Shokat, Frank McCormick, Daniel Nomura, Sourav Bandyopadhyay, Andrei Goga
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_2): PR07.
https://doi.org/10.1158/1538-7445.COMPSYSBIO-PR07
Published: 15 November 2015
View article titled, Abstract PR07: Functional analysis of diverse oncogenic driver mutations using an isogenic cell line library identifies novel drug responses and alterations in metabolism
Journal Articles

Abstract 2450: Identifying novel substrates of PLK2 using a chemical genetics approach

Poornima Ramkumar, Rebecca S. Levin, Miriam Sansó, Shashidhar Jatiani, Arvin C. Dar, Robert P. Fisher, Kevan M. Shokat, E Premkumar Reddy
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2450.
https://doi.org/10.1158/1538-7445.AM2015-2450
Published: 01 August 2015
View article titled, Abstract 2450: Identifying novel substrates of PLK2 using a chemical genetics approach
Journal Articles

Abstract B78: Targeting the translational apparatus in MYCN-driven medulloblastoma

Justin G. Meyerowitz, W. Clay Gustafson, Erin Nekritz, Fredrik Swartling, Kevan M. Shokat, Davide Ruggero, William A. Weiss
Journal: Cancer Research
Cancer Res (2014) 74 (20_Supplement): B78.
https://doi.org/10.1158/1538-7445.PEDCAN-B78
Published: 09 October 2014
View article titled, Abstract B78: Targeting the translational apparatus in MYCN-driven medulloblastoma
Journal Articles

Abstract PR08: Drugging MYCN protein stability through an allosteric transition in Aurora kinase A

W. Clay Gustafson, Justin G. Meyerowitz, Erin A. Nekritz, Elise Charron, Katherine K. Matthay, Nicholas T. Hertz, Martin Eilers, Kevan M. Shokat, William A. Weiss
Journal: Cancer Research
Cancer Res (2014) 74 (20_Supplement): PR08.
https://doi.org/10.1158/1538-7445.PEDCAN-PR08
Published: 09 October 2014
View article titled, Abstract PR08: Drugging MYCN protein stability through an allosteric transition in Aurora kinase A
Journal Articles

Abstract A46: Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers

Michael Pourdehnad, Morgan L. Truitt, Imran N. Siddiqi, Gregory S. Ducker, Kevan M. Shokat, Davide Ruggero
Journal: Cancer Research
Cancer Res (2013) 73 (19_Supplement): A46.
https://doi.org/10.1158/1538-7445.FBCR13-A46
Published: 15 May 2014
View article titled, Abstract A46: Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers
Journal Articles

Abstract LB-311: Development of mutant-specific small molecule inhibitors of K-Ras.

Jonathan M. Ostrem, Ulf Peters, Pingda Ren, Yi Liu, James A. Wells, Kevan M. Shokat
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-311.
https://doi.org/10.1158/1538-7445.AM2013-LB-311
Published: 15 April 2013
View article titled, Abstract LB-311: Development of mutant-specific small molecule inhibitors of K-Ras.
Journal Articles

Abstract SY19-01: Chemical genetic investigations of protein and lipid kinase signaling.

Kevan M. Shokat
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): SY19-01.
https://doi.org/10.1158/1538-7445.AM2013-SY19-01
Published: 15 April 2013
View article titled, Abstract SY19-01: Chemical genetic investigations of protein and lipid kinase signaling.
Journal Articles

Abstract 1201: PTEN null expression is concordant in colorectal cancer primaries and metastases and associates with poor survival.

Chloe E. Atreya, Zaina Sangale, Nafei Xu, Mary R. Matli, Eliso Tikishvili, William Welbourn, Steve Stone, Kevan M. Shokat, Robert S. Warren
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1201.
https://doi.org/10.1158/1538-7445.AM2013-1201
Published: 15 April 2013
View article titled, Abstract 1201: PTEN null expression is concordant in colorectal cancer primaries and metastases and associates with poor survival.
Journal Articles

Carbonyl Reductase 1 Offers a Novel Therapeutic Target to Enhance Leukemia Treatment by Arsenic Trioxide

Miran Jang, Yeonghwan Kim, Hyeran Won, Sangbin Lim, Jyothi K.R, Amarjargal Dashdorj, Yoo Hong Min, Si-Young Kim, Kevan M. Shokat, Joohun Ha, Sung Soo Kim
Journal: Cancer Research
Cancer Res (2012) 72 (16): 4214–4224.
https://doi.org/10.1158/0008-5472.CAN-12-1110
Published: 14 August 2012
View article titled, Carbonyl Reductase 1 Offers a Novel Therapeutic Target to Enhance Leukemia Treatment by Arsenic Trioxide
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Includes: Supplementary data
Journal Articles

Abstract LB-190: RAF inhibitors transactivate RAF dimers and ERK signaling in a wild-type BRAF-dependent manner

Poulikos I. Poulikakos, Chao Zhang, Eric W. Joseph, Yogindra Persaud, Christine A. Pratilas, Gideon Bollag, David B. Solit, Kevan M. Shokat, Neal Rosen
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-190.
https://doi.org/10.1158/1538-7445.AM10-LB-190
Published: 15 April 2010
View article titled, Abstract LB-190: RAF inhibitors transactivate RAF dimers and ERK signaling in a wild-type BRAF-dependent manner
Journal Articles

Basal Subtype and MAPK/ERK Kinase (MEK)-Phosphoinositide 3-Kinase Feedback Signaling Determine Susceptibility of Breast Cancer Cells to MEK Inhibition

Olga K. Mirzoeva, Debopriya Das, Laura M. Heiser, Sanchita Bhattacharya, Doris Siwak, Rina Gendelman, Nora Bayani, Nicholas J. Wang, Richard M. Neve, Yinghui Guan, Zhi Hu, Zachary Knight, Heidi S. Feiler, Philippe Gascard, Bahram Parvin, Paul T. Spellman, Kevan M. Shokat, Andrew J. Wyrobek, Mina J. Bissell, Frank McCormick, Wen-Lin Kuo, Gordon B. Mills, Joe W. Gray, W. Michael Korn
Journal: Cancer Research
Cancer Res (2009) 69 (2): 565–572.
https://doi.org/10.1158/0008-5472.CAN-08-3389
Published: 15 January 2009
View article titled, Basal Subtype and MAPK/ERK Kinase (MEK)-Phosphoinositide 3-Kinase Feedback Signaling Determine Susceptibility of Breast Cancer Cells to MEK Inhibition
Open the PDF for Basal Subtype and MAPK/ERK Kinase (MEK)-Phosphoinositide 3-Kinase Feedback Signaling Determine Susceptibility of Breast Cancer Cells to MEK Inhibition in another window
Includes: Supplementary data