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Keun-Wook Lee
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Journal Articles

Abstract CT504: A phase 1 clinical trial to evaluate safety, tolerability, pharmacokinetics (PK) and efficacy of D-1553, a novel KRASG12C inhibitor, in patients with advanced or metastatic solid tumor harboring KRASG12C mutation

Timothy Price, Jaspreet Grewal, Afaf Abed, Melissa Moore, Yu-Min Yeh, Shirish Gadgeel, Gary Richardson, Craig Underhill, Vinod Ganju, Keun-Wook Lee, Seok Jae Huh, Sang-We Kim, Chih-Hsin Yang, Yuh-Min Chen, Ziyong Xiang, Zhe Shi, Yaolin Wang, Ling Zhang, Michael Millward
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT504.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT504
Published: 15 June 2022
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Journal Articles

Abstract CT015: Safety and efficacy of TTX-030, an anti-CD39 antibody, in combination with chemoimmunotherapy for the first line treatment of locally advanced or metastatic gastric/GEJ cancer

Zev Wainberg, Yoon-Koo Kang, Keun-Wook Lee, Seung Tae Kim, Joseph Chao, Daniel Catenacci, Sung Yong Oh, Heloisa P. Soares, J. Eva Selfridge, Yongjun Cha, Roland T. Skeel, Hyung-Don Kim, Anh Tran, Achim Moesta, Tracy Dela Cruz, Anil Singhal, Thomas M. Jahn, Farshid Dayyani
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT015.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT015
Published: 15 June 2022
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Journal Articles

Abstract 5138: Cetuximab resistance induced by hepatocyte growth factor is overcome by MET inhibition in KRAS, NRAS, and BRAF wild-type colorectal cancer

Sang-A Kim, Hyejoo Park, Kui-Jin Kim, Ji-Won Kim, Ji Hea Sung, Milang Nam, Ju Hyun Lee, Eun Hee Jung, Koung Jin Suh, Ji Yun Lee, Se Hyun Kim, Jeong-Ok Lee, Jin Won Kim, Yu Jung Kim, Jee Hyun Kim, Soo-Mee Bang, Jong Seok Lee, Keun-Wook Lee
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5138.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5138
Published: 15 June 2022
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Journal Articles

Abstract 6083: Evolutionary trajectories during carcinogenesis and metastasis in gallbladder adenocarcinoma

Minsu Kang, Hee Young Na, Soomin Ahn, Ji-Won Kim, Sejoon Lee, Soyeon Ahn, Ju Hyun Lee, Jeonghwan Youk, Haesook T. Kim, Kui-Jin Kim, Koung Jin Suh, Jun Suh Lee, Se Hyun Kim, Jin Won Kim, Yu Jung Kim, Keun-Wook Lee, Yoo-Seok Yoon, Jee Hyun Kim, Jin-Haeng Chung, Ho-Seong Han, Jong Seok Lee
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6083.
DOI: https://doi.org/10.1158/1538-7445.AM2022-6083
Published: 15 June 2022
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Journal Articles

Abstract P2-13-07: Zanidatamab (ZW25), a HER2-targeted bispecific antibody, in combination with chemotherapy (chemo) for HER2-positive breast cancer (BC): Results from a phase 1 study

Philippe L Bedard, Seock-Ah Im, Elena Elimova, Sun Young Rha, Rachel Goodwin, Cristiano Ferrario, Keun-Wook Lee, Diana Hanna, Funda Meric-Bernstam, Jose Mayordomo, Murali Beeram, Erika Hamilton, Jorge Chaves, Melody Cobleigh, Tony Mwatha, Joseph Woolery, Do-Youn Oh
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-13-07.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P2-13-07
Published: 15 February 2022
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Journal Articles

Abstract CT218: Phase 1/2 study of a novel HER2 targeting TLR7/8 immune-stimulating antibody conjugate (ISAC), BDC-1001, alone and in combination with pembrolizumab (pembro) in patients (pts) with HER2-expressing advanced solid tumors

Manish R. Sharma, Richard D. Carvajal, Daniel Catenacci, Leisha A. Emens, Glenn J. Hanna, Dejan Juric, Yoon-Koo Kang, Jeeyun Lee, Keun-Wook Lee, Bob T. Li, Kathleen Moore, Mark D. Pegram, Paula R. Pohlmann, Drew Rasco, Alexander Spira, Arielle L. Heeke, Ding Wang, Lawrence Garbo, Sudhir Manda, Jasgit Sachdev, Shelley E. Ackerman, Heidi LeBlanc, David Dornan, Marcin Kowanetz, Michael N. Alonso, Amreen Husain, Edith A. Perez, Ecaterina Ileana Dumbrava
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT218.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT218
Published: 01 July 2021
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Journal Articles

Abstract PS11-18: Ceralasertib (cer) in combination with olaparib (ola) in patients (pts) with advanced breast cancer (BC): Results of phase I expansion cohorts

Emma Dean, Matthew G Krebs, Seock-Ah Im, Mario Campone, Sophie Postel-Vinay, Tobias Arkenau, Juanita Lopez, Wassim Abida, Duncan Jodrell, Keun-Wook Lee, SunYoung Rha, Irene Kang, Rebecca Roylance, Graeme Parr, Claire Smith, Andrew Goldwin, Elhan Sanay, Natasha Lukashchuk, Alan Lau, Andrew Pierce, Bienvenu Loembe
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS11-18.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS11-18
Published: 15 February 2021
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Journal Articles

Abstract OT-03-02: Phase 1/2 study of a novel HER2 targeting TLR7/8 immune-stimulating antibody conjugate (ISAC), BDC-1001, as a single agent and in combination with an immune checkpoint inhibitor in patients with advanced HER2-expressing solid tumors

Ecaterina Ileana Dumbrava, Manish R. Sharma, Richard D. Carvajal, Daniel Catenacci, Leisha A. Emens, Shirish M. Gadgeel, Glenn J. Hanna, Dejan Juric, Yoon-Koo Kang, Jeeyun Lee, Keun-Wook Lee, Bob T. Li, Kathleen Moore, Mark D. Pegram, Paula R. Pohlmann, Drew Rasco, Alexander Spira, Antoinette R. Tan, Shelley E. Ackerman, Heidi LeBlanc, David Dornan, Marcin Kowanetz, Michael N. Alonso, Edith A. Perez
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): OT-03-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-OT-03-02
Published: 15 February 2021
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Journal Articles

Abstract 3818: BGJ398, a pan-FGFR inhibitor, overcomes paclitaxel resistance in urothelial carcinoma with FGFR1 overexpression

Haram Ryu, Se Hyun Kim, Chan-Young Ock, Koung Jin Suh, Ji Yun Lee, Ji-Won Kim, Jin Won Kim, Jeong-Ok Lee, Yu Jung Kim, Keun-Wook Lee, Soo-Mee Bang, Jee Hyun Kim, Jong Seok Lee, Joong Bae Ahn, Kui-Jin Kim, Sun Young Rha
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3818.
DOI: https://doi.org/10.1158/1538-7445.AM2019-3818
Published: 01 July 2019
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Journal Articles

Abstract CT057: Safety and efficacy of durvalumab in combination with tremelimumab in patients with advanced gastric cancer with elevated tumor interferon-γ gene signature

Geoffrey Ku, Jeeyun Lee, Heinz-Josef Lenz, Cheng Ean Chee, Takeshi Omori, Keun-Wook Lee, Yee Chao, Daniel Catenacci, Michael Gibson, Deirdre Cohen, Zev Wainberg, Philip Z. Brohawn, Peng He, Siddharth Sheth, Judson Englert, Ronan Kelly, Yung-Jue Bang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT057.
DOI: https://doi.org/10.1158/1538-7445.AM2019-CT057
Published: 01 July 2019
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Journal Articles

Abstract CT149: A Phase II study of Genexol-PM and cisplatin as induction chemotherapy in locally advanced head and neck squamous cell carcinoma

Keun-Wook Lee, Bhumsuk Keam, Jin-Soo Kim, Se-Hoon Lee
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT149.
DOI: https://doi.org/10.1158/1538-7445.AM2019-CT149
Published: 01 July 2019
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Journal Articles

Abstract 4903: Identification of immune-related mechanisms of cetuximab induced skin toxicity in colorectal cancer patients

Jin Hyun Park, Mi Young Kim, In Sil Choi, Ji-Won Kim, Jin Won Kim, Keun-Wook Lee, Jin-Soo Kim
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4903.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4903
Published: 01 July 2019
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Journal Articles

Abstract 3750: Conversion surgery in unresectable advanced gastric cancer and cancer dormancy as a prognostic marker

Hun Jee Choe, Jin Won Kim, Song-Hee Han, Kui-Jin Kim, Jeong-Min Kim, Koung Jin Suh, Ji-Won Kim, Keun-Wook Lee, Hye Seung Lee
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3750.
DOI: https://doi.org/10.1158/1538-7445.AM2019-3750
Published: 01 July 2019
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Journal Articles

Abstract 1370: Association of the ATM mRNA, protein expression and the somatic mutation counts in human cancers and its impact on overall survival in breast and gastric cancer

Koung Jin Suh, Kwangsoo Kim, Seongmin Choi, Kyung-Hun Lee, Jin Won Kim, Keun-Wook Lee, Jee Hyun Kim, Seongyeong Kim, Ahrum Min, Tae-Yong Kim, Seock-Ah Im
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1370.
DOI: https://doi.org/10.1158/1538-7445.AM2018-1370
Published: 01 July 2018
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Journal Articles

Abstract CT111: Avelumab (anti-PD-L1) as first-line maintenance (1L mn) or second-line (2L) therapy in patients with advanced gastric or gastroesophageal junction cancer (GC/GEJC): updated phase Ib results from the JAVELIN Solid Tumor trial

Hyun Cheol Chung, Hendrik-Tobias Arkenau, Jeeyun Lee, Sun Young Rha, Do-Youn Oh, Lucjan Wyrwicz, Yoon-Koo Kang, Keun-Wook Lee, Todd M. Bauer, Sung Sook Lee, Margaret Kemeny, Ulrich Keilholz, Bohuslav Melichar, Alain Mita, Ruth Plummer, Denis Smith, Arnold B. Gelb, Huiling Xiong, Janet Hong, Vikram Chand, Howard Safran
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): CT111.
DOI: https://doi.org/10.1158/1538-7445.AM2018-CT111
Published: 01 July 2018
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Journal Articles

Abstract 5136: HER2 or EGFR inhibition interacts with tumor microenvironment by downregulation of PD-L1 and chemokines

Jin Won Kim, Ji Hea Sung, Mi Hyun Kang, Ji-Won Kim, Se-Hyun Kim, Keun-Wook Lee, Hye Seung Lee, Jee Hyun Kim
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5136.
DOI: https://doi.org/10.1158/1538-7445.AM2016-5136
Published: 15 July 2016
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Journal Articles

Abstract 4931: Validation of Trastuzumab immunohistochemistry as a predictive and prognostic biomarker in gastric cancer patients

Jiwon Koh, Soo Kyung Nam, Younwoo Lee, Chan-Young Ock, Jin Won Kim, Keun-Wook Lee, Do-Youn Oh, Do Joong Park, Hyung-Ho Kim, Keon-Wook Kang, Woo Ho Kim, Ho-Young Lee, Hye Seung Lee
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4931.
DOI: https://doi.org/10.1158/1538-7445.AM2016-4931
Published: 15 July 2016
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Journal Articles

Abstract 4734: Activation of yap1 is significantly associated with poor prognosis and cetuximab resistance in colorectal cancer patients

Keun-Wook Lee, Sung Sook Lee, Sang-Bae Kim, Yun-Yong Park, Bo Hwa Sohn, Hyun-Sung Lee, Ju-Seog Lee
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4734.
DOI: https://doi.org/10.1158/1538-7445.AM2014-4734
Published: 01 October 2014
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Abstract 912: P21-activated kinase 4 (PAK4) as a predictive marker for gemcitabine in pancreatic cancer cell line

Sung Ung Moon, Jin Won Kim, Ji Hea Sung, Mi Hyun Kang, Hyun Chang, Jeong Ok Lee, Yu Jung Kim, Keun Wook Lee, Jee Hyun Kim, Soo Mee Bang, Jong Seok Lee
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 912.
DOI: https://doi.org/10.1158/1538-7445.AM2014-912
Published: 01 October 2014
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Journal Articles

Abstract 4525: p21 as a predictive marker of pathologic complete response after 5-FU based chemoradiotherapy for patients with rectal cancer

Sung Hoon Sim, Mi-Hyun Kang, Yu Jung Kim, Keun-Wook Lee, Duck-Woo Kim, Sung-Bum Kang, Na Young Jang, Jae-Sung Kim, Hye Seung Lee, Jee Hyun Kim
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4525.
DOI: https://doi.org/10.1158/1538-7445.AM2012-4525
Published: 15 April 2012
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