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Keren Paz
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Journal Articles

Abstract 7539: First-in-class anti-PVR mAb NTX1088 advancing through Phase I: Safe and potent in restoring DNAM1 expression to enhance antitumor immunity

Anas Atieh, Akram Obeidat, Alon Vitenshtein, Guy Cinamon, Keren Paz, Tihana Roviš, Paola Brilc, Ofer Mandelboim, Stipan Jonjic, Pini Tsukerman
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7539.
https://doi.org/10.1158/1538-7445.AM2024-7539
Published: 22 March 2024
View article titled, Abstract 7539: First-in-class anti-PVR mAb NTX1088 advancing through Phase I: Safe and potent in restoring DNAM1 expression to enhance antitumor immunity
Journal Articles

Abstract 6657: Phase I trial of first-in-class anti-PVR mAb NTX1088: Restoration of DNAM1 expression as MOA for enhanced antitumor immunity

Anas Atieh, Akram Obiedat, Alon Vitenshtein, Guy Cinamon, Keren Paz, Tihana lenac, Paola Kucan, Marija Mazor, Ofer Mandelboim, Stipan Jonji, Pini Tsukerman
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6657.
https://doi.org/10.1158/1538-7445.AM2023-6657
Published: 04 April 2023
View article titled, Abstract 6657: Phase I trial of first-in-class anti-PVR mAb NTX1088: Restoration of DNAM1 expression as MOA for enhanced antitumor immunity
Journal Articles

Abstract 5534: NTX-1088, a first-in-class anti-PVR mAb mediates DNAM1-dependent antitumor immunity

Akram Obiedat, Anas Atieh, Guy Cinamon, Keren Paz, Paola Kucan Brilc, Lea Hirsl, Tihana Lenac Roviš, Ofer Mandelboim, Stipan Jonjic, Pini Tsukerman
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5534.
https://doi.org/10.1158/1538-7445.AM2022-5534
Published: 15 June 2022
View article titled, Abstract 5534: NTX-1088, a first-in-class anti-PVR mAb mediates DNAM1-dependent antitumor immunity
Journal Articles

Abstract 3640: Validation of qBiomarker as an accurate and efficient mutation detection method in a comprehensive analysis of patient-derived tumor xenografts

Mariana Brait, Evgeny Izumchenko, Luciane Kagohara, Samuel Long, Piotr Wysocki, Brian Faherty, Elana Fertig, Tin Khor, Elizabeth Bruckheimer, Gilson Baia, Daniel Ciznadija, Ido Sloma, Ido Ben-Zvi, Keren Paz, David Sidransky
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3640.
https://doi.org/10.1158/1538-7445.AM2016-3640
Published: 15 July 2016
View article titled, Abstract 3640: Validation of qBiomarker as an accurate and efficient mutation detection method in a comprehensive analysis of patient-derived tumor xenografts
Journal Articles

Abstract 5031: A humanized mouse model for translational assessment of targeted immune checkpoint blockade

Gilson Baia, David Vasquez-Dunddel, Daniel Ciznadija, David Sidransky, Amanda Katz, Keren Paz
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5031.
https://doi.org/10.1158/1538-7445.AM2015-5031
Published: 01 August 2015
View article titled, Abstract 5031: A humanized mouse model for translational assessment of targeted immune checkpoint blockade
Journal Articles

Abstract 3219: A patient-centric repository of PDX models for translational oncology research

Tin O. Khor, Ido Ben Zvi, Amanda Katz, David Vasquez-Dunddel, Ido Sloma, Daniel Ciznadija, David Sidransky, Keren Paz
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3219.
https://doi.org/10.1158/1538-7445.AM2015-3219
Published: 01 August 2015
View article titled, Abstract 3219: A patient-centric repository of PDX models for translational oncology research
Journal Articles

Abstract P3-06-31: Patient-derived xenografts accurately predict patient response in breast cancer patients

Lisa Stow, Amanda Katz, Hanna Irie, Elisa Port, Justin Stebbing, Daniel Ciznadija, Angela Davies, Keren Paz
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P3-06-31.
https://doi.org/10.1158/1538-7445.SABCS14-P3-06-31
Published: 01 May 2015
View article titled, Abstract P3-06-31: Patient-derived xenografts accurately predict patient response in breast cancer patients
Journal Articles

Abstract 1674: Humanized mouse models for personalized preclinical testing of monoclonal antibodies targeting immune checkpoints

Gilson S. Baia, David Vasquez, Daniel Ciznadija, Brandy Wilkinson, David Sidransky, Amanda Katz, Keren Paz
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1674.
https://doi.org/10.1158/1538-7445.AM2014-1674
Published: 01 October 2014
View article titled, Abstract 1674: Humanized mouse models for personalized preclinical testing of monoclonal antibodies targeting immune checkpoints
Journal Articles

Abstract 1187: The Champions TumorGraft Bank: A demographically-rich repository of preclinical TumorGraft models

Tin Khor, David Vasquez, Amanda Katz, Gilson Baia, Daniel Ciznadija, David Sidransky, Keren Paz
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1187.
https://doi.org/10.1158/1538-7445.AM2014-1187
Published: 01 October 2014
View article titled, Abstract 1187: The Champions TumorGraft Bank: A demographically-rich repository of preclinical TumorGraft models
Journal Articles

Abstract 4410: KRAS mutation status is associated with enhanced dependency on purine biosynthesis and related pathways in non small cell lung cancer cells

Diarmuid M. Moran, Patricia B. Trusk, Karen Pry, David Sidransky, Keren Paz, Sarah S. Bacus
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4410.
https://doi.org/10.1158/1538-7445.AM2014-4410
Published: 01 October 2014
View article titled, Abstract 4410: KRAS mutation status is associated with enhanced dependency on purine biosynthesis and related pathways in non small cell lung cancer cells
Journal Articles

Abstract 1190: Multifactorial biological processes govern engraftment of patient-derived tumor tissue in immunodeficient mice

David M. Vasquez-Dunddel, Gilson Baia, Amanda Katz, Daniel Ciznadija, David Sidransky, Keren Paz
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1190.
https://doi.org/10.1158/1538-7445.AM2014-1190
Published: 01 October 2014
View article titled, Abstract 1190: Multifactorial biological processes govern engraftment of patient-derived tumor tissue in immunodeficient mice
Journal Articles

The TGFβ–miR200–MIG6 Pathway Orchestrates the EMT-Associated Kinase Switch That Induces Resistance to EGFR Inhibitors

Evgeny Izumchenko, Xiaofei Chang, Christina Michailidi, Luciane Kagohara, Rajani Ravi, Keren Paz, Mariana Brait, Mohammad O. Hoque, Shizhang Ling, Atul Bedi, David Sidransky
Journal: Cancer Research
Cancer Res (2014) 74 (14): 3995–4005.
https://doi.org/10.1158/0008-5472.CAN-14-0110
Published: 14 July 2014
View article titled, The TGFβ–miR200–MIG6 Pathway Orchestrates the EMT-Associated Kinase Switch That Induces Resistance to EGFR Inhibitors
Open the PDF for The TGFβ–miR200–MIG6 Pathway Orchestrates the EMT-Associated Kinase Switch That Induces Resistance to EGFR Inhibitors in another window
Includes: Supplementary data
Journal Articles

Abstract 2205: Integrated next generation sequencing and patient-derived xenografts to personalized cancer treatment.

Elena Garralda, Keren Paz, Pedro P. López-Casas, Siân Jones, Amanda Katz, Lisa M. Kann, Fernando López-Rios, Francesca Sarno, Fátima Al-Shahrour, David Vasquez, Elizabeth Bruckheimer, Samuel V. Angiuoli, Luis A. Diaz, Alfonso Valencia, Victor E. Velculescu, David Sidransky, Manuel Hidalgo
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2205.
https://doi.org/10.1158/1538-7445.AM2013-2205
Published: 15 April 2013
View article titled, Abstract 2205: Integrated next generation sequencing and patient-derived xenografts to personalized cancer treatment.
Journal Articles

Abstract 2793: Development of an androgen-dependent prostate Champions TumorGraft™ cancer model.

Tin Oo Khor, Keren Paz, Dhanrajan Tiruchinapalli, David Sidransky, Elizabeth M. Bruckheimer
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2793.
https://doi.org/10.1158/1538-7445.AM2013-2793
Published: 15 April 2013
View article titled, Abstract 2793: Development of an androgen-dependent prostate Champions TumorGraft™ cancer model.
Journal Articles

Abstract 1329: Personalizing gastrointestinal cancer treatment by the utilization of TumorGraft™ technology

Meredith James, Elizabeth Bruckheimer, Ronnie Morris, Eric Rowinsky, David Sidransky, Keren Paz
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1329.
https://doi.org/10.1158/1538-7445.AM2012-1329
Published: 15 April 2012
View article titled, Abstract 1329: Personalizing gastrointestinal cancer treatment by the utilization of TumorGraft™ technology
Journal Articles

Abstract 5252: Utilization of TumorGraft technology for personalized breast cancer treatment

Meredith James, Ronnie Morris, Elizabeth Bruckheimer, Eric Rowinsky, Sarah Bacus, David Sidransky, Keren Paz
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5252.
https://doi.org/10.1158/1538-7445.AM2012-5252
Published: 15 April 2012
View article titled, Abstract 5252: Utilization of TumorGraft technology for personalized breast cancer treatment
Journal Articles

Abstract 3641: Breaking through the ceiling: A program to significantly increase efficacy in KRAS and BRAF mutant colorectal cancer xenograft tumors whose growth is arrested by Cetuximab + irinotecan therapy

Erik Corcoran, Anthony Pennello, David Surguladze, Keren Paz, James Tonra
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3641.
https://doi.org/10.1158/1538-7445.AM2011-3641
Published: 15 April 2011
View article titled, Abstract 3641: Breaking through the ceiling: A program to significantly increase efficacy in KRAS and BRAF mutant colorectal cancer xenograft tumors whose growth is arrested by Cetuximab + irinotecan therapy
Journal Articles

Abstract 1187: The role of PI3K as a biomarker

Michael Amatulli, Laura A. Brennan, Dhanvanthri S. Deevi, Marie Prewett, James R. Tonra, Keren Paz
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1187.
https://doi.org/10.1158/1538-7445.AM10-1187
Published: 15 April 2010
View article titled, Abstract 1187: The role of PI3K as a biomarker
Journal Articles

Abstract #701: The role of KRAS as a biomarker

Michael Amatulli, Jaimie Slade, Jennifer O'Toole, Dhanvanthri Deevi, Marie Prewett, James Tonra, Laura Brennan, Keren Paz
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 701.
Published: 01 May 2009
View article titled, Abstract #701: The role of KRAS as a biomarker
Journal Articles

Abstract #694: The role of BRAF as a biomarker

Michael Amatulli, Laura Brennan, Jaimie Slade, Jennifer O'Toole, Dhanvanthri Deevi, Marie Prewett, James Tonra, Keren Paz
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 694.
Published: 01 May 2009
View article titled, Abstract #694: The role of BRAF as a biomarker