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Ker Yu
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Journal Articles

Abstract 723: Beyond temsirolimus: Discovery of PKI-587 a highly efficacious dual PI3K/mTOR inhibitor

Aranapakam M. Venkatesan, Christoph M. Dehnhardt, Efren Delos Santos, Zecheng Chen, Osvaldo Dos Santos, Semiramis Ayral-Kaloustian, Robert Mallon, Irwin Hollander, Larry Feldberg, Judy Lucas, Ker Yu, Natasja Brooijmans, Joel Bard, James Gibbons, Robert T. Abraham, Tarek S. Mansour
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 723.
https://doi.org/10.1158/1538-7445.AM10-723
Published: 15 April 2010
View article titled, Abstract 723: Beyond temsirolimus: Discovery of PKI-587 a highly efficacious dual PI3K/mTOR inhibitor
Journal Articles

Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2

Ker Yu, Celine Shi, Lourdes Toral-Barza, Judy Lucas, Boris Shor, Jae Eun Kim, Wei-Guo Zhang, Robert Mahoney, Christine Gaydos, LuAnna Tardio, Sung Kyoo Kim, Roger Conant, Kevin Curran, Joshua Kaplan, Jeroen Verheijen, Semiramis Ayral-Kaloustian, Tarek S. Mansour, Robert T. Abraham, Arie Zask, James J. Gibbons
Journal: Cancer Research
Cancer Res (2010) 70 (2): 621–631.
https://doi.org/10.1158/0008-5472.CAN-09-2340
Published: 13 January 2010
View article titled, Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2
Open the PDF for Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2 in another window
Includes: Supplementary data
Journal Articles

Biochemical, Cellular, and In vivo Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin

Ker Yu, Lourdes Toral-Barza, Celine Shi, Wei-Guo Zhang, Judy Lucas, Boris Shor, Jamie Kim, Jeroen Verheijen, Kevin Curran, David J. Malwitz, Derek C. Cole, John Ellingboe, Semiramis Ayral-Kaloustian, Tarek S. Mansour, James J. Gibbons, Robert T. Abraham, Pawel Nowak, Arie Zask
Journal: Cancer Research
Cancer Res (2009) 69 (15): 6232–6240.
https://doi.org/10.1158/0008-5472.CAN-09-0299
Published: 29 July 2009
View article titled, Biochemical, Cellular, and <em>In vivo</em> Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin
Open the PDF for Biochemical, Cellular, and <em>In vivo</em> Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin in another window
Includes: Supplementary data
Journal Articles

Abstract #3713: Preclinical pharmacology and antitumor activity of a new class of ATP-competitive and highly selective inhibitors of the mammalian target of rapamycin (mTOR)

Ker Yu, Lourdes Toral-Barza, Celine Shi, Wei-Guo Zhang, Judy Lucas, Michael Cinque, Jamie Kim, Boris Shor, Jeroen verheijen, Kevin Curran, Joshua Kaplan, David Richard, Pawel Nowak, Derek Cole, Inder Chaudhary, John Ellingboe, Semiramis Ayral-Kaloustian, Tarek Mansour, James Gibbons, Robert Abraham, Arie Zask
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3713.
Published: 01 May 2009
View article titled, Abstract #3713: Preclinical pharmacology and antitumor activity of a new class of ATP-competitive and highly selective inhibitors of the mammalian target of rapamycin (mTOR)
Journal Articles

Abstract #2017: Novel imidazolopyrimidines as dual PI3-kinase/ mTor inhibitors

Christoph Dehnhardt, Aranapakam Venkatesan, Zecheng Chen, Efren Delos Santos, Oswaldo Santos, Matthew Bursavich, Natasja Brooijmans, Robert Mallon, Irwin Hollander, Larry Feldberg, Judy Lucas, Ker Yu, Semiramis Ayral-Kaloustian, Jay Gibbons, Robert Abraham, Tarek Mansour
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2017.
Published: 01 May 2009
View article titled, Abstract #2017: Novel imidazolopyrimidines as dual PI3-kinase/ mTor inhibitors
Journal Articles

Abstract #2014: ATP competitive inhibitors of the mammalian target of rapamycin (mTOR): Design and synthesis of novel, highly selective pyrazolopyrimidines with potent in vivo antitumor activity

Arie Zask, Jeroen Verheijen, Joshua Kaplan, Kevin Curran, David Richard, Natasja Brooijmans, Judy Lucas, Lourdes Toral-Barza, Wei-Guo Zhang, Irwin Hollander, James Gibbons, Robert Abraham, Semiramis Ayral-Kaloustian, Tarek Mansour, Ker Yu
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2014.
Published: 01 May 2009
View article titled, Abstract #2014: ATP competitive inhibitors of the mammalian target of rapamycin (mTOR): Design and synthesis of novel, highly selective pyrazolopyrimidines with potent in vivo antitumor activity
Journal Articles

A New Pharmacologic Action of CCI-779 Involves FKBP12-Independent Inhibition of mTOR Kinase Activity and Profound Repression of Global Protein Synthesis

Boris Shor, Wei-Guo Zhang, Lourdes Toral-Barza, Jessica Lucas, Robert T. Abraham, James J. Gibbons, Ker Yu
Journal: Cancer Research
Cancer Res (2008) 68 (8): 2934–2943.
https://doi.org/10.1158/0008-5472.CAN-07-6487
Published: 15 April 2008
View article titled, A New Pharmacologic Action of CCI-779 Involves FKBP12-Independent Inhibition of mTOR Kinase Activity and Profound Repression of Global Protein Synthesis
Open the PDF for A New Pharmacologic Action of CCI-779 Involves FKBP12-Independent Inhibition of mTOR Kinase Activity and Profound Repression of Global Protein Synthesis in another window
Includes: Supplementary data