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Kenneth Y. Tsai
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Journal Articles

Abstract 235: Targeting NOS sensitizes the NRAS-mutant melanomas to MEK inhibition and induces immunogenic cell death

Jyoti Srivastava, Vipin Kumar Yadav, Rachel V. Jimenez, Bin Fang, Alvaro de Mingo Pulido, John M. Koomen, Kenneth Y. Tsai, Keiran Smalley, SM, Paulo C. Rodriguez, Sanjay Premi
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 235.
https://doi.org/10.1158/1538-7445.AM2025-235
Published: 21 April 2025
View articletitled, Abstract 235: Targeting NOS sensitizes the NRAS-mutant melanomas to MEK inhibition and induces immunogenic cell death
Journal Articles

Abstract 2672: Eco-evolutionary profiling of the UV-driven clonal dynamics and tumor initiation

Stanislav S. Avdieiev, Leticia Tordesillas, Karol Prieto, Omar Chavez Chiang, Zhihua Chen, Nihir Patel, Sofia Cordero, Luiza Silva Simoes, Y. Ann Chen, Noemi Andor, Robert A. Gatenby, Elsa R. Flores, Christopher J. Whelan, Joel S. Brown, Kenneth Y. Tsai
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2672.
https://doi.org/10.1158/1538-7445.AM2025-2672
Published: 21 April 2025
View articletitled, Abstract 2672: Eco-evolutionary profiling of the UV-driven clonal dynamics and tumor initiation
Journal Articles

Abstract 5174: Exploring extinction therapy for advanced cutaneous squamous cell carcinoma using UV-induced mouse models

Karol M. Prieto-Sarmiento, Stanislav Avdieiev, Omar Chavez Chiang, Sofia Cordero, Irmak Aksit, Derek Weimer, Christopher J. Whelan, Joel S. Brown, Kenneth Y. Tsai
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5174.
https://doi.org/10.1158/1538-7445.AM2025-5174
Published: 21 April 2025
View articletitled, Abstract 5174: Exploring extinction therapy for advanced cutaneous squamous cell carcinoma using UV-induced mouse models
Journal Articles

spatialGE Is a User-Friendly Web Application That Facilitates Spatial Transcriptomics Data Analysis

Oscar E. Ospina, Roberto Manjarres-Betancur, Guillermo Gonzalez-Calderon, Alex C. Soupir, Inna Smalley, Kenneth Y. Tsai, Joseph Markowitz, Mariam L. Khaled, Ethan Vallebuona, Anders E. Berglund, Steven A. Eschrich, Xiaoqing Yu, Brooke L. Fridley
Journal: Cancer Research
Cancer Res (2025) 85 (5): 848–858.
https://doi.org/10.1158/0008-5472.CAN-24-2346
Published: 03 March 2025
View articletitled, spatialGE Is a User-Friendly Web Application That Facilitates Spatial Transcriptomics Data Analysis
Open the PDF for spatialGE Is a User-Friendly Web Application That Facilitates Spatial Transcriptomics Data Analysis in another window
Includes: Supplementary data
Journal Articles

PHGDH Induction by MAPK Is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability

Neel Jasani, Xiaonan Xu, Benjamin Posorske, Yumi Kim, Kaizhen Wang, Olga Vera, Kenneth Y. Tsai, Gina M. DeNicola, Florian A. Karreth
Journal: Cancer Research
Cancer Res (2025) 85 (2): 314–328.
https://doi.org/10.1158/0008-5472.CAN-24-2471
Published: 15 January 2025
View articletitled, PHGDH Induction by MAPK Is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability
Open the PDF for PHGDH Induction by MAPK Is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability in another window
Includes: Supplementary data
Journal Articles

Abstract 1163: Increased spatial coupling of integrin and collagen IV in the immunoresistant clear cell renal cell carcinoma tumor microenvironment

Alex C. Soupir, Mitchell T. Hayes, Taylor C. Peak, Oscar E. Ospina, Nicholas H. Chakiryan, Anders E. Berglund, Paul A. Stewart, Jonathan Nguyen, Carlos M. Moran-Segura, Natasha L. Francis, Paola M. Ramos-Echevarria, Jad Chahoud, Roger Li, Kenneth Y. Tsai, Jodi A. Balasi, Yamila Caraballo-Perez, Jasreman Dhillon, Lindsey A. Martinez, Warren E. Gloria, Nathan Schurman, Sean Kim, Mark Gregory, James J. Mule, Brooke L. Fridley, Brandon J. Manley
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1163.
https://doi.org/10.1158/1538-7445.AM2024-1163
Published: 22 March 2024
View articletitled, Abstract 1163: Increased spatial coupling of integrin and collagen IV in the immunoresistant clear cell renal cell carcinoma tumor microenvironment
Journal Articles

MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET

Ankit Srivastava, Cristina Tommasi, Dane Sessions, Angela Mah, Tomas Bencomo, Jasmine M. Garcia, Tiffany Jiang, Michael Lee, Joseph Y. Shen, Lek Wei Seow, Audrey Nguyen, Kimal Rajapakshe, Cristian Coarfa, Kenneth Y. Tsai, Vanessa Lopez-Pajares, Carolyn S. Lee
Journal: Cancer Research
Cancer Res (2022) 82 (17): 3143–3157.
https://doi.org/10.1158/0008-5472.CAN-22-0047
Published: 02 September 2022
View articletitled, MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET
Open the PDF for MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET in another window
Includes: Supplementary data
Journal Articles

Abstract A017: In vivo tracking of clonal dynamics during UV-induced skin carcinogenesis

Stanislav Avdieiev, Leticia Tordesillas, Omar Chavez Chiang, Zhihua Chen, Luiza Silva Simoes, Y. Ann Chen, Noemi Andor, Robert Gatenby, Elsa R. Flores, Joel S. Brown, Kenneth Y. Tsai
Journal: Cancer Research
Cancer Res (2022) 82 (10_Supplement): A017.
https://doi.org/10.1158/1538-7445.EVODYN22-A017
Published: 15 May 2022
View articletitled, Abstract A017: In vivo tracking of clonal dynamics during UV-induced skin carcinogenesis
Journal Articles

Abstract PR004: In vivo tracking of clonal dynamics during UV-induced skin carcinogenesis

Stanislav Avdieiev, Leticia Tordesillas, Omar Chavez Chiang, Zhihua Chen, Luiza Silva Simoes, Y. Ann Chen, Noemi Andor, Robert Gatenby, Elsa R. Flores, Joel S. Brown, Kenneth Y. Tsai
Journal: Cancer Research
Cancer Res (2022) 82 (10_Supplement): PR004.
https://doi.org/10.1158/1538-7445.EVODYN22-PR004
Published: 15 May 2022
View articletitled, Abstract PR004: In vivo tracking of clonal dynamics during UV-induced skin carcinogenesis
Journal Articles

Tumor Expression Quantitative Trait Methylation Screening Reveals Distinct CpG Panels for Deconvolving Cancer Immune Signatures

Xiaoqing Yu, Ling Cen, Y. Ann Chen, Joseph Markowitz, Timothy I. Shaw, Kenneth Y. Tsai, Jose R. Conejo-Garcia, Xuefeng Wang
Journal: Cancer Research
Cancer Res (2022) 82 (9): 1724–1735.
https://doi.org/10.1158/0008-5472.CAN-21-3113
Published: 03 May 2022
View articletitled, Tumor Expression Quantitative Trait Methylation Screening Reveals Distinct CpG Panels for Deconvolving Cancer Immune Signatures
Open the PDF for Tumor Expression Quantitative Trait Methylation Screening Reveals Distinct CpG Panels for Deconvolving Cancer Immune Signatures in another window
Includes: Supplementary data
Journal Articles

TAp63-Regulated miRNAs Suppress Cutaneous Squamous Cell Carcinoma through Inhibition of a Network of Cell-Cycle Genes

Andrew John Davis, Maksym Tsinkevich, Jason Rodencal, Hussein A. Abbas, Xiao-hua Su, Young-Jin Gi, Bin Fang, Kimal Rajapakshe, Cristian Coarfa, Preethi H. Gunaratne, John M. Koomen, Kenneth Y. Tsai, Elsa R. Flores
Journal: Cancer Research
Cancer Res (2020) 80 (12): 2484–2497.
https://doi.org/10.1158/0008-5472.CAN-19-1892
Published: 15 June 2020
View articletitled, TAp63-Regulated miRNAs Suppress Cutaneous Squamous Cell Carcinoma through Inhibition of a Network of Cell-Cycle Genes
Open the PDF for TAp63-Regulated miRNAs Suppress Cutaneous Squamous Cell Carcinoma through Inhibition of a Network of Cell-Cycle Genes in another window
Includes: Supplementary data
Journal Articles

Abstract 1227: Immune modulatory effect of pramlintide for cutaneous squamous cell carcinoma treatment

Leticia Tordesillas, Rebecca Hesterberg, Ivannie Ortiz-Rivera, Brittney R. Sell, Omar Chavez Chiang, Kimberly T. Nguyen, Brian L. Murphy, Pearlie K. Burnette, Elsa R. Flores, Kenneth Y. Tsai
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1227.
https://doi.org/10.1158/1538-7445.AM2019-1227
Published: 01 July 2019
View articletitled, Abstract 1227: Immune modulatory effect of pramlintide for cutaneous squamous cell carcinoma treatment
Journal Articles

Abstract 3872: Targeting multi-functional ERK-protein complexes in vivo

Tamer S. Kaoud, William H. Johnson, Nancy D. Ebelt, Andrea Piserchio, Diana Zamora-Olivares, Sabrina V. Ravenstein, Jacey R. Pridgen, Ramakrishna Edupuganti, Rachel Sammons, Micael Cano, Mangalika Warthaka, Pengyu Ren, Eric V. Anslyn, Kenneth Y. Tsai, Ranajeet Ghose, Kevin N. Dalby
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3872.
https://doi.org/10.1158/1538-7445.AM2019-3872
Published: 01 July 2019
View articletitled, Abstract 3872: Targeting multi-functional ERK-protein complexes in vivo
Journal Articles

Abstract 406: A proteome-transcriptome-miRnome integrated analysis identifies similarity between UV-exposed skin and wounding skin

Tran N. Nguyen, Kimal Rajapakshe, Stanislav Avdieiev, Courtney Nicholas, Vida Chitsazzadeh, Eric Welsh, Bin Fang, John Koomen, Cristian Coarfa, Janine Einspahr, Kenneth Y. Tsai
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 406.
https://doi.org/10.1158/1538-7445.AM2018-406
Published: 01 July 2018
View articletitled, Abstract 406: A proteome-transcriptome-miRnome integrated analysis identifies similarity between UV-exposed skin and wounding skin
Journal Articles

Abstract 4003: Comprehensive genomic profiling of Merkel cell carcinoma samples reveals bimodal distribution of tumor mutational burden and two mutually exclusive candidate mechanisms of malignant transformation

Meagan Montesion, Ethan S. Sokol, Todd C. Knepper, Andrew S. Brohl, Garrett M. Frampton, Phil J. Stephens, James A. DeCaprio, Kenneth Y. Tsai, Lee A. Albacker
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4003.
https://doi.org/10.1158/1538-7445.AM2018-4003
Published: 01 July 2018
View articletitled, Abstract 4003: Comprehensive genomic profiling of Merkel cell carcinoma samples reveals bimodal distribution of tumor mutational burden and two mutually exclusive candidate mechanisms of malignant transformation
Journal Articles

Distinct TP63 Isoform-Driven Transcriptional Signatures Predict Tumor Progression and Clinical Outcomes

Hussein A. Abbas, Ngoc Hoang Bao Bui, Kimal Rajapakshe, Justin Wong, Preethi Gunaratne, Kenneth Y. Tsai, Cristian Coarfa, Elsa R. Flores
Journal: Cancer Research
Cancer Res (2018) 78 (2): 451–462.
https://doi.org/10.1158/0008-5472.CAN-17-1803
Published: 15 January 2018
View articletitled, Distinct TP63 Isoform-Driven Transcriptional Signatures Predict Tumor Progression and Clinical Outcomes
Open the PDF for Distinct TP63 Isoform-Driven Transcriptional Signatures Predict Tumor Progression and Clinical Outcomes in another window
Includes: Supplementary data
Journal Articles

Abstract 1899: MKK4/JNK2 down-regulation in NSCLC suppresses tumor growth and metastasis

Tamer Saad Kaoud, Nancy D. Ebelt, Lili Du, Sabrina Van Ravenstein, Kenneth Y. Tsai, Kevin N. Dalby
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1899.
https://doi.org/10.1158/1538-7445.AM2017-1899
Published: 01 July 2017
View articletitled, Abstract 1899: MKK4/JNK2 down-regulation in NSCLC suppresses tumor growth and metastasis
Journal Articles

Abstract 43: MicroRNA-130b mediates a metabolic switch to promote cutaneous squamous cell carcinoma development

Tran N. Nguyen, Sydney Moyer, Charles H. Adelmann, Vida Chitsazzadeh, Kenneth Y. Tsai
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 43.
https://doi.org/10.1158/1538-7445.AM2016-43
Published: 15 July 2016
View articletitled, Abstract 43: MicroRNA-130b mediates a metabolic switch to promote cutaneous squamous cell carcinoma development
Journal Articles

Abstract 2613: MEK is a therapeutic and chemopreventative target in squamous cell carcinoma

Charles H. Adelmann, Kimberly Truong, Roger Liang, Varun Bansal, Rachael Saporito, Woojin Lee, Lili Du, Courtney Nicholas, Marco Napoli, Elsa R. Flores, Kenneth Y. Tsai
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2613.
https://doi.org/10.1158/1538-7445.AM2016-2613
Published: 15 July 2016
View articletitled, Abstract 2613: MEK is a therapeutic and chemopreventative target in squamous cell carcinoma
Journal Articles

Abstract 1941: Distinct roles of c-Jun N-terminal kinase (JNK) isoforms in skin cancer

Lili Du, Tinghu Zhang, Tamer Kaoud, Nathanael Gray, Kevin Dalby, Kenneth Y. Tsai
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1941.
https://doi.org/10.1158/1538-7445.AM2015-1941
Published: 01 August 2015
View articletitled, Abstract 1941: Distinct roles of c-Jun N-terminal kinase (JNK) isoforms in skin cancer