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Kenneth K. Chan
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Journal Articles

Abstract 4426: Metabolism and tissue distribution of curcumin in mouse GI tract.

Yu Cao, Ming Chiu, Kenneth K. Chan, Ronald Xu, Zhongfa Liu
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4426.
https://doi.org/10.1158/1538-7445.AM2013-4426
Published: 15 April 2013
View articletitled, Abstract 4426: Metabolism and tissue distribution of curcumin in mouse GI tract.
Journal Articles

Abstract 119: AR42, a histone deacetylase inhibitor (HDACI), increases microRNA (miR)-29b and sensitizes cells to decitabine (DAC) treatment: A novel epigenetic-targeting approach in acute myeloid leukemia (AML)

Alice S. Mims, Alison R. Walker, Pia Hoellerbauer, Xiaomeng Huang, Kenneth K. Chan, Rebecca B. Klisovic, Danilo Perrotti, Michael A. Caligiuri, John C. Byrd, Ching-Shih Chen, William Blum, Ramiro Garzon, Sebastian Schwind, Guido Marcucci
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 119.
https://doi.org/10.1158/1538-7445.AM2012-119
Published: 15 April 2012
View articletitled, Abstract 119: AR42, a histone deacetylase inhibitor (HDACI), increases microRNA (miR)-29b and sensitizes cells to decitabine (DAC) treatment: A novel epigenetic-targeting approach in acute myeloid leukemia (AML)
Journal Articles

Abstract 581: Complementary reactivation of tumor suppressor genes in breast cancer cells by curcumin and curcumin O-glucuronide

Zhongfa Liu, Liping Du, Shujun Liu, Zhiliang Xie, Xiaokui Mo, Jianhua Yu, Lai-chu Wu, Lisa D. Yee, Susan R. Mallery, Gary Stoner, Kenneth K. Chan
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 581.
https://doi.org/10.1158/1538-7445.AM2012-581
Published: 15 April 2012
View articletitled, Abstract 581: Complementary reactivation of tumor suppressor genes in breast cancer cells by curcumin and curcumin O-glucuronide
Journal Articles

Abstract 756: Pharmacokinetics of curcumin and curcumin O-glucuronide in healthy volunteers characterized by liquid chromatography-tandem mass spectrometry

Zhongfa Liu, Wei Chen, Patty Fan-Havard, Lisa D. Yee, Xiao-Kui Mo, Gary D. Stoner, Kenneth K. Chan
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 756.
https://doi.org/10.1158/1538-7445.AM2012-756
Published: 15 April 2012
View articletitled, Abstract 756: Pharmacokinetics of curcumin and curcumin O-glucuronide in healthy volunteers characterized by liquid chromatography-tandem mass spectrometry
Journal Articles

CCI-779 Inhibits Cell-Cycle G2–M Progression and Invasion of Castration-Resistant Prostate Cancer via Attenuation of UBE2C Transcription and mRNA Stability

Hongyan Wang, Chunpeng Zhang, Anna Rorick, Dayong Wu, Ming Chiu, Jennifer Thomas-Ahner, Zhong Chen, Hongyan Chen, Steven K. Clinton, Kenneth K. Chan, Qianben Wang
Journal: Cancer Research
Cancer Res (2011) 71 (14): 4866–4876.
https://doi.org/10.1158/0008-5472.CAN-10-4576
Published: 14 July 2011
View articletitled, CCI-779 Inhibits Cell-Cycle G2–M Progression and Invasion of Castration-Resistant Prostate Cancer via Attenuation of UBE2C Transcription and mRNA Stability
Open the PDF for CCI-779 Inhibits Cell-Cycle G2–M Progression and Invasion of Castration-Resistant Prostate Cancer via Attenuation of UBE2C Transcription and mRNA Stability in another window
Includes: Supplementary data
Journal Articles

Abstract 1721: Resistance to silvestrol is mediated by MDR1/Pgp over-expression in a lymphoblastic leukemia cell line and is reversible by treatment with rapamycin

Sneha V. Gupta, Ellen J. Sass, Melanie E. Davis, Ryan B. Edwards, Gerard Lozanski, Nyla A. Heerema, Amy Lehman, Xiaoli Zhang, David Jarjoura, John C. Byrd, Kenneth K. Chan, A. Douglas Kinghorn, Michael Grever, Mitch A. Phelps, David M. Lucas
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1721.
https://doi.org/10.1158/1538-7445.AM2011-1721
Published: 15 April 2011
View articletitled, Abstract 1721: Resistance to silvestrol is mediated by MDR1/Pgp over-expression in a lymphoblastic leukemia cell line and is reversible by treatment with rapamycin
Journal Articles

Abstract 5473: The contribution of P-glycoprotein to clinical pharmacokinetic interactions between lenalidomide and temsirolimus

Xiaoxia Yang, Hofmeister C. Craig, Darlene M. Rozewski, Seungsoo Lee, Ping Chen, Amy J. Johnson, Zhongfa Liu, Erinn M. Hade, Jia Ji, Larry J. Schaaf, Don M. Benson, Eric H. Kraut, William J. Hicks, Kenneth K. Chan, Ching-Shih Chen, Sherif S. Farag, Michael R. Grever, John C. Byrd, Mitch A. Phelps
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5473.
https://doi.org/10.1158/1538-7445.AM2011-5473
Published: 15 April 2011
View articletitled, Abstract 5473: The contribution of P-glycoprotein to clinical pharmacokinetic interactions between lenalidomide and temsirolimus
Journal Articles

Abstract 2014: Modulation of DNA methyltransferases in leukemia cells by curcumin and its associated anti-leukemia activities

Zhongfa Liu, Hongyan Wang, Lai-chu Wu, Zhiliang Xie, Liping Du, Xiaokui Mo, Ming Chiu, Danilo Perrotti, Michael Grever, John C. Byrd, Shujun Liu, Guido Marcucci, Kenneth K. Chan
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2014.
https://doi.org/10.1158/1538-7445.AM2011-2014
Published: 15 April 2011
View articletitled, Abstract 2014: Modulation of DNA methyltransferases in leukemia cells by curcumin and its associated anti-leukemia activities
Journal Articles

Abstract 5494: A liquid chromatography-tandem mass spectrometric method for quantification of curcuminoids in cell culture medium and mouse plasma and their pharmacokinetics in mice

U.V.R. Vijaya Saradhi, Ming Chiu, Yonghua Ling, Xiaodong Yin, Eric B. Schwartz, James R. Fuchs, Kenneth K. Chan, Zhongfa Liu
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5494.
https://doi.org/10.1158/1538-7445.AM10-5494
Published: 15 April 2010
View articletitled, Abstract 5494: A liquid chromatography-tandem mass spectrometric method for quantification of curcuminoids in cell culture medium and mouse plasma and their pharmacokinetics in mice
Journal Articles

Abstract 3558: The natural product silvestrol decreases oncogenic FLT3 and miR-155 levels in FLT3-ITD positive Acute Myeloid Leukemia (AML) cells

Houda Alachkar, Shujun Liu, Sebastian Schwind, Heiko Becker, Klaus H. Metzeler, Christopher Hickey, Jiuxia Pang, Susan P. Whitman, Kenneth K. Chan, Ramiro Garzon, David M. Lucas, Danilo Perrotti, Lai-Chu Wu, Michael R. Grever, A D. Kinghorn, Guido Marcucci
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3558.
https://doi.org/10.1158/1538-7445.AM10-3558
Published: 15 April 2010
View articletitled, Abstract 3558: The natural product silvestrol decreases oncogenic FLT3 and miR-155 levels in FLT3-ITD positive Acute Myeloid Leukemia (AML) cells
Journal Articles

The proteasome inhibitor bortezomib alters epigenetic profiling through impairing Sp1/NF-kB-dependent DNA methyltransferase activity in acute myeloid leukemia

Shujun Liu, Jiuxia Pang, Zhongfa Liu, Zhiliang Xie, Jianhua Yu, Haiming Ding, Lenguyen Huynh, Rebecca B. Klisovic, Robert A. Baiocchi, Ramiro Garzon, Danilo Perrotti, Kenneth K. Chan, Lai-Chu Wu, William Blum, Guido Marcucci
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2622.
Published: 01 May 2008
View articletitled, The proteasome inhibitor bortezomib alters epigenetic profiling through impairing Sp1/NF-kB-dependent DNA methyltransferase activity in acute myeloid leukemia
Journal Articles

New daunorubicin analog exhibits anticancer activity and overcomes P-gp-mediated drug resistance.

Lanyan Fang, Guisheng Zhang, Chenglong Li, Xincheng Zheng, Lizhi Zhu, Jim J. Xiao, Gergely Szakacs, Kenneth K. Chan, George P. Wang, Duxin Sun
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1270.
Published: 15 April 2006
View articletitled, New daunorubicin analog exhibits anticancer activity and overcomes P-gp-mediated drug resistance.
Journal Articles

Quantification of global DNA methylation levels in acute leukemia cell lines before and after decitabine treatment using a rapid, specific and sensitive LC-MS/MS method

Zhongfa Liu, Zhiliang Xie, Shujun Liu, Guido Marcucci, Kenneth K. Chan
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 379.
Published: 15 April 2006
View articletitled, Quantification of global DNA methylation levels in acute leukemia cell lines before and after decitabine treatment using a rapid, specific and sensitive LC-MS/MS method
Journal Articles

Preclinical pharmacokinetic studies with s-HDAC-42 (NSC 736012), an inhibitor of histone deacetylase, by LC-MS/MS

Hao Cheng, Zhongfa Liu, Samuel K. Kulp, Ching-Shih Chen, Joseph M. Covey, Kenneth K. Chan
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 727.
Published: 15 April 2006
View articletitled, Preclinical pharmacokinetic studies with s-HDAC-42 (NSC 736012), an inhibitor of histone deacetylase, by LC-MS/MS
Journal Articles

Analytical method development and pharmacokinetics studies with parthenolide (NSC 157035) and a water-soluble analog (NSC 734325)

Deping Cheng, Jim J. Xiao, Hao Cheng, Zhongfa Liu, Joseph M. Covey, Kenneth K. Chan
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 988.
Published: 01 May 2005
View articletitled, Analytical method development and pharmacokinetics studies with parthenolide (NSC 157035) and a water-soluble analog (NSC 734325)
Journal Articles

Preclinical pharmacokinetics of Akt inhibitors NSC 728209 and NSC 728210 in mice as determined by LC/MS/MS method

Zhongfa Liu, Yilong Zhang, Deping Cheng, Yousheng Hua, Samuel K. Kulp, Jiuxiang Zhu, Ching-Shih Chen, Joseph M. Covey, Kenneth K. Chan
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 987.
Published: 01 May 2005
View articletitled, Preclinical pharmacokinetics of Akt inhibitors NSC 728209 and NSC 728210 in mice as determined by LC/MS/MS method
Journal Articles

Pharmacokinetics and intracellular levels of GTI 2040, an antisense oligonucleotide targeting ribonucleotide reductase, in patients with AML

Xiaohui Wei, Guido Marcucci, Guowei Dai, Michael Grever, Kenneth K. Chan
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 139.
Published: 01 May 2005
View articletitled, Pharmacokinetics and intracellular levels of GTI 2040, an antisense oligonucleotide targeting ribonucleotide reductase, in patients with AML
Journal Articles

MDR1-induction is a major determinant for acquired resistance of depsipeptide FK228

Jim J. Xiao, Ying Huang, Zunyan Dai, Wolfgang Sadee, Jiyun Chen, John C. Byrd, Guido Marcucci, Michael Grever, John Wright, Kenneth K. Chan
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 114.
Published: 01 April 2004
View articletitled, MDR1-induction is a major determinant for acquired resistance of depsipeptide FK228
Journal Articles

Chloroquinoxaline Sulfonamide (NSC 339004) Is a Topoisomerase IIα/β Poison

Hanlin Gao, Edith F. Yamasaki, Kenneth K. Chan, Linus L. Shen, Robert M. Snapka
Journal: Cancer Research
Cancer Res (2000) 60 (21): 5937–5940.
Published: 01 November 2000
View articletitled, Chloroquinoxaline Sulfonamide (NSC 339004) Is a Topoisomerase IIα/β Poison
Open the PDF for Chloroquinoxaline Sulfonamide (NSC 339004) Is a Topoisomerase IIα/β Poison in another window
Journal Articles

Clinical Pharmacokinetics of Cyclophosphamide and Metabolites with and without SR-2508

Kenneth K. Chan, Phillip S. Hong, Kendra Tutsch, Donald L. Trump
Journal: Cancer Research
Cancer Res (1994) 54 (24): 6421–6429.
Published: 01 December 1994
View articletitled, Clinical Pharmacokinetics of Cyclophosphamide and Metabolites with and without SR-2508
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