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Journal Articles

Abstract 1991: Leiomyosarcoma poly-aneuploid cancer cells form in response to chemotherapy, contribute to chemoresistance, and lead to higher rates of metastatic recurrence

Ryan Kennington, Gareth Mitchell, Emily Payne, Niraja Bhachech, Jonathan A. Fletcher, Ting Liu, Matt van de Rijn, Sarah Amend, Kenneth J. Pienta, Joshua D. Schiffman, Lisa M. Abegglen

Cancer Res (2024) 84 (6_Supplement): 1991.

https://doi.org/10.1158/1538-7445.AM2024-1991

Published: 22 March 2024

View article titled, Abstract 1991: Leiomyosarcoma poly-aneuploid cancer cells form in response to chemotherapy, contribute to chemoresistance, and lead to higher rates of metastatic recurrence

Journal Articles

Abstract 6612: Therapy-resistant endocycling cancer cells alter mitochondrial structure and metabolism to survive therapeutic stress

Melvin Li, Sarah R. Amend, Kenneth J. Pienta

Cancer Res (2024) 84 (6_Supplement): 6612.

https://doi.org/10.1158/1538-7445.AM2024-6612

Published: 22 March 2024

View article titled, Abstract 6612: Therapy-resistant endocycling cancer cells alter mitochondrial structure and metabolism to survive therapeutic stress

Journal Articles

Abstract 4896: A high throughput method of identifying cells with increased genomic content across diverse cancer tissues

Shilpa Priyadarsini Nair, Kenneth J. Pienta, Sarah R. Amend

Cancer Res (2024) 84 (6_Supplement): 4896.

https://doi.org/10.1158/1538-7445.AM2024-4896

Published: 22 March 2024

View article titled, Abstract 4896: A high throughput method of identifying cells with increased genomic content across diverse cancer tissues

Journal Articles

Abstract 527: Cancer cells in the resistant, endocycling cell state exhibit centrosome amplification

Madison Purkerson, Sarah Amend, Kenneth J. Pienta

Cancer Res (2024) 84 (6_Supplement): 527.

https://doi.org/10.1158/1538-7445.AM2024-527

Published: 22 March 2024

View article titled, Abstract 527: Cancer cells in the resistant, endocycling cell state exhibit centrosome amplification

Journal Articles

Abstract 515: Endocycling cancer cells undergo multiple S phases while repressing myc activity

Michael A. Loycano, Kenneth J. Pienta, Sarah R. Amend

Cancer Res (2024) 84 (6_Supplement): 515.

https://doi.org/10.1158/1538-7445.AM2024-515

Published: 22 March 2024

View article titled, Abstract 515: Endocycling cancer cells undergo multiple S phases while repressing myc activity

Journal Articles

Abstract 2205: KRTAP 2-3 is a novel potential biomarker of cells in the polyaneuploid cancer cell (PACC) state to predict cancer recurrence

Sabrina A. Mendez, Reema Sharma, Kenneth J. Pienta, Sarah R. Amend

Cancer Res (2023) 83 (7_Supplement): 2205.

https://doi.org/10.1158/1538-7445.AM2023-2205

Published: 04 April 2023

View article titled, Abstract 2205: KRTAP 2-3 is a novel potential biomarker of cells in the polyaneuploid cancer cell (PACC) state to predict cancer recurrence

Journal Articles

Abstract 4842: Stress-induced mitochondrial adaptations in the polyaneuploid cancer cell state

Melvin Li, Laurie G. Kostecka, Sarah R. Amend, Kenneth J. Pienta

Cancer Res (2023) 83 (7_Supplement): 4842.

https://doi.org/10.1158/1538-7445.AM2023-4842

Published: 04 April 2023

View article titled, Abstract 4842: Stress-induced mitochondrial adaptations in the polyaneuploid cancer cell state

Journal Articles

Abstract 6055: Polyaneuploid cancer cells are metabolically active and utilize lipid droplets to survive toxic stress

Laurie Gayle Kostecka, Anne Le, Sarah Amend, Kenneth J. Pienta

Cancer Res (2023) 83 (7_Supplement): 6055.

https://doi.org/10.1158/1538-7445.AM2023-6055

Published: 04 April 2023

View article titled, Abstract 6055: Polyaneuploid cancer cells are metabolically active and utilize lipid droplets to survive toxic stress

Journal Articles

Abstract 1690: Myc suppression permits entry into the cancer endocycle to evade toxic effects of chemotherapy

Michael Loycano, Kenneth J. Pienta, Sarah R. Amend

Cancer Res (2023) 83 (7_Supplement): 1690.

https://doi.org/10.1158/1538-7445.AM2023-1690

Published: 04 April 2023

View article titled, Abstract 1690: Myc suppression permits entry into the cancer endocycle to evade toxic effects of chemotherapy

Journal Articles

Abstract 1686: Leiomyosarcoma poly-aneuploid cancer cells form in response to chemotherapy and contribute to chemoresistance

Lisa M. Abegglen, Niraja Bhachech, Gareth Mitchell, Ryan Kennington, Brad Nelson, Miranda Sharp, Matthew Buccilli, Anthony Iovino, Aarushi Rohaj, Jonathan A. Fletcher, Ting Liu, Matt van de Rijn, Sarah R. Amend, Kenneth J. Pienta, Joshua D. Schiffman

Cancer Res (2023) 83 (7_Supplement): 1686.

https://doi.org/10.1158/1538-7445.AM2023-1686

Published: 04 April 2023

View article titled, Abstract 1686: Leiomyosarcoma poly-aneuploid cancer cells form in response to chemotherapy and contribute to chemoresistance

Journal Articles

Abstract A017: Polyaneuploid Cancer Cells (PACCs) as metastasis-competent cells

Mikaela M. Mallin, Nicholas Kim, Mohammad Ikbal Choudhury, SeJong Lee, Steven S. An, Sean X. Sun, Konstantinos Konstantopoulos, Sarah R. Amend, Kenneth J. Pienta

Cancer Res (2023) 83 (2_Supplement_2): A017.

https://doi.org/10.1158/1538-7445.METASTASIS22-A017

Published: 15 January 2023

View article titled, Abstract A017: Polyaneuploid Cancer Cells (PACCs) as metastasis-competent cells

Journal Articles

Retraction: Characterization of Phosphoglycerate Kinase-1 Expression of Stromal Cells Derived from Tumor Microenvironment in Prostate Cancer Progression

Jianhua Wang, Gigi Ying, Jingchen Wang, Younghun Jung, Jian Lu, Jiang Zhu, Kenneth J. Pienta, Russell S. Taichman

Cancer Res (2022) 82 (18): 3405.

https://doi.org/10.1158/0008-5472.CAN-22-2398

Published: 16 September 2022

View article titled, Retraction: Characterization of Phosphoglycerate Kinase-1 Expression of Stromal Cells Derived from Tumor Microenvironment in Prostate Cancer Progression

Journal Articles

Abstract SY39-02: Accessing evolutionary programs to enable therapeutic resistance

Kenneth J. Pienta

Cancer Res (2022) 82 (12_Supplement): SY39-02.

https://doi.org/10.1158/1538-7445.AM2022-SY39-02

Published: 15 June 2022

View article titled, Abstract SY39-02: Accessing evolutionary programs to enable therapeutic resistance

Journal Articles

Abstract 123: Reactive oxygen species (ROS) as mediators of the cancer cell’s transition into the polyaneuploid cancer cell (PACC) state

Morgan D. Kuczler, Kenneth J. Pienta, Sarah R. Amend

Cancer Res (2022) 82 (12_Supplement): 123.

https://doi.org/10.1158/1538-7445.AM2022-123

Published: 15 June 2022

View article titled, Abstract 123: Reactive oxygen species (ROS) as mediators of the cancer cell’s transition into the polyaneuploid cancer cell (PACC) state

Journal Articles

Abstract 2546: Targeting MerTK-mediated efferocytosis in the prostate cancer TME

Kayla V. Myers, Amber E. de Groot, Anna L. Gonye, Luke V. Loftus, Sarah R. Amend, Kenneth J. Pienta

Cancer Res (2022) 82 (12_Supplement): 2546.

https://doi.org/10.1158/1538-7445.AM2022-2546

Published: 15 June 2022

View article titled, Abstract 2546: Targeting MerTK-mediated efferocytosis in the prostate cancer TME

Journal Articles

Abstract 125: The role of oxidative stress on the polyaneuploid cancer cell state in metastatic cancer

Melvin Li, Sarah R. Amend, Kenneth J. Pienta

Cancer Res (2022) 82 (12_Supplement): 125.

https://doi.org/10.1158/1538-7445.AM2022-125

Published: 15 June 2022

View article titled, Abstract 125: The role of oxidative stress on the polyaneuploid cancer cell state in metastatic cancer

Journal Articles

Abstract B018: Targeting Notch4 and HIF2α signaling reduces the ability of cells to survive chemotherapy by undergoing the polyaneuploid transition

Christopher P. Carroll, Emma Hammarlund, Kenneth J. Pienta, Sarah R. Amend

Cancer Res (2022) 82 (10_Supplement): B018.

https://doi.org/10.1158/1538-7445.EVODYN22-B018

Published: 15 May 2022

View article titled, Abstract B018: Targeting Notch4 and HIF2α signaling reduces the ability of cells to survive chemotherapy by undergoing the polyaneuploid transition

Journal Articles

Abstract A001: Modeling cancer’s ecological and evolutionary dynamics

Anuraag Bukkuri, Kenneth J. Pienta, Ian Hockett, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, Joel S. Brown

Cancer Res (2022) 82 (10_Supplement): A001.

https://doi.org/10.1158/1538-7445.EVODYN22-A001

Published: 15 May 2022

View article titled, Abstract A001: Modeling cancer’s ecological and evolutionary dynamics

Journal Articles

Abstract B015: Eco-evolutionary dynamics of poly-aneuploid cancer cells: A life history model

Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, Joel S. Brown

Cancer Res (2022) 82 (10_Supplement): B015.

https://doi.org/10.1158/1538-7445.EVODYN22-B015

Published: 15 May 2022

View article titled, Abstract B015: Eco-evolutionary dynamics of poly-aneuploid cancer cells: A life history model

Journal Articles

Abstract B022: The polyaneuploid transition as a hedge against failures in resistance acquisition

George Butler, Julia Bos, Robert H. Austin, Sarah R. Amend, Kenneth J. Pienta

Cancer Res (2022) 82 (10_Supplement): B022.

https://doi.org/10.1158/1538-7445.EVODYN22-B022

Published: 15 May 2022

View article titled, Abstract B022: The polyaneuploid transition as a hedge against failures in resistance acquisition

NARROW

Abstract 1991: Leiomyosarcoma poly-aneuploid cancer cells form in response to chemotherapy, contribute to chemoresistance, and lead to higher rates of metastatic recurrence

Abstract 6612: Therapy-resistant endocycling cancer cells alter mitochondrial structure and metabolism to survive therapeutic stress

Abstract 4896: A high throughput method of identifying cells with increased genomic content across diverse cancer tissues

Abstract 527: Cancer cells in the resistant, endocycling cell state exhibit centrosome amplification

Abstract 515: Endocycling cancer cells undergo multiple S phases while repressing myc activity

Abstract 2205: KRTAP 2-3 is a novel potential biomarker of cells in the polyaneuploid cancer cell (PACC) state to predict cancer recurrence

Abstract 4842: Stress-induced mitochondrial adaptations in the polyaneuploid cancer cell state

Abstract 6055: Polyaneuploid cancer cells are metabolically active and utilize lipid droplets to survive toxic stress

Abstract 1690: Myc suppression permits entry into the cancer endocycle to evade toxic effects of chemotherapy

Abstract 1686: Leiomyosarcoma poly-aneuploid cancer cells form in response to chemotherapy and contribute to chemoresistance

Abstract A017: Polyaneuploid Cancer Cells (PACCs) as metastasis-competent cells

Retraction: Characterization of Phosphoglycerate Kinase-1 Expression of Stromal Cells Derived from Tumor Microenvironment in Prostate Cancer Progression

Abstract SY39-02: Accessing evolutionary programs to enable therapeutic resistance

Abstract 123: Reactive oxygen species (ROS) as mediators of the cancer cell’s transition into the polyaneuploid cancer cell (PACC) state

Abstract 2546: Targeting MerTK-mediated efferocytosis in the prostate cancer TME

Abstract 125: The role of oxidative stress on the polyaneuploid cancer cell state in metastatic cancer

Abstract B018: Targeting Notch4 and HIF2α signaling reduces the ability of cells to survive chemotherapy by undergoing the polyaneuploid transition

Abstract A001: Modeling cancer’s ecological and evolutionary dynamics

Abstract B015: Eco-evolutionary dynamics of poly-aneuploid cancer cells: A life history model

Abstract B022: The polyaneuploid transition as a hedge against failures in resistance acquisition

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