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Kenneth J. Pienta
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Journal Articles

Abstract 2205: KRTAP 2-3 is a novel potential biomarker of cells in the polyaneuploid cancer cell (PACC) state to predict cancer recurrence

Sabrina A. Mendez, Reema Sharma, Kenneth J. Pienta, Sarah R. Amend
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2205.
https://doi.org/10.1158/1538-7445.AM2023-2205
Published: 04 April 2023
View article titled, Abstract 2205: KRTAP 2-3 is a novel potential biomarker of cells in the polyaneuploid cancer cell (PACC) state to predict cancer recurrence
Journal Articles

Abstract 6055: Polyaneuploid cancer cells are metabolically active and utilize lipid droplets to survive toxic stress

Laurie Gayle Kostecka, Anne Le, Sarah Amend, Kenneth J. Pienta
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6055.
https://doi.org/10.1158/1538-7445.AM2023-6055
Published: 04 April 2023
View article titled, Abstract 6055: Polyaneuploid cancer cells are metabolically active and utilize lipid droplets to survive toxic stress
Journal Articles

Abstract 1686: Leiomyosarcoma poly-aneuploid cancer cells form in response to chemotherapy and contribute to chemoresistance

Lisa M. Abegglen, Niraja Bhachech, Gareth Mitchell, Ryan Kennington, Brad Nelson, Miranda Sharp, Matthew Buccilli, Anthony Iovino, Aarushi Rohaj, Jonathan A. Fletcher, Ting Liu, Matt van de Rijn, Sarah R. Amend, Kenneth J. Pienta, Joshua D. Schiffman
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1686.
https://doi.org/10.1158/1538-7445.AM2023-1686
Published: 04 April 2023
View article titled, Abstract 1686: Leiomyosarcoma poly-aneuploid cancer cells form in response to chemotherapy and contribute to chemoresistance
Journal Articles

Abstract 4842: Stress-induced mitochondrial adaptations in the polyaneuploid cancer cell state

Melvin Li, Laurie G. Kostecka, Sarah R. Amend, Kenneth J. Pienta
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4842.
https://doi.org/10.1158/1538-7445.AM2023-4842
Published: 04 April 2023
View article titled, Abstract 4842: Stress-induced mitochondrial adaptations in the polyaneuploid cancer cell state
Journal Articles

Abstract 1690: Myc suppression permits entry into the cancer endocycle to evade toxic effects of chemotherapy

Michael Loycano, Kenneth J. Pienta, Sarah R. Amend
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1690.
https://doi.org/10.1158/1538-7445.AM2023-1690
Published: 04 April 2023
View article titled, Abstract 1690: Myc suppression permits entry into the cancer endocycle to evade toxic effects of chemotherapy
Journal Articles

Abstract A017: Polyaneuploid Cancer Cells (PACCs) as metastasis-competent cells

Mikaela M. Mallin, Nicholas Kim, Mohammad Ikbal Choudhury, SeJong Lee, Steven S. An, Sean X. Sun, Konstantinos Konstantopoulos, Sarah R. Amend, Kenneth J. Pienta
Journal: Cancer Research
Cancer Res (2023) 83 (2_Supplement_2): A017.
https://doi.org/10.1158/1538-7445.METASTASIS22-A017
Published: 15 January 2023
View article titled, Abstract A017: Polyaneuploid Cancer Cells (PACCs) as metastasis-competent cells
Journal Articles

Retraction: Characterization of Phosphoglycerate Kinase-1 Expression of Stromal Cells Derived from Tumor Microenvironment in Prostate Cancer Progression

Jianhua Wang, Gigi Ying, Jingchen Wang, Younghun Jung, Jian Lu, Jiang Zhu, Kenneth J. Pienta, Russell S. Taichman
Journal: Cancer Research
Cancer Res (2022) 82 (18): 3405.
https://doi.org/10.1158/0008-5472.CAN-22-2398
Published: 16 September 2022
View article titled, Retraction: Characterization of Phosphoglycerate Kinase-1 Expression of Stromal Cells Derived from Tumor Microenvironment in Prostate Cancer Progression
Open the PDF for Retraction: Characterization of Phosphoglycerate Kinase-1 Expression of Stromal Cells Derived from Tumor Microenvironment in Prostate Cancer Progression in another window
Journal Articles

Abstract SY39-02: Accessing evolutionary programs to enable therapeutic resistance

Kenneth J. Pienta
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): SY39-02.
https://doi.org/10.1158/1538-7445.AM2022-SY39-02
Published: 15 June 2022
View article titled, Abstract SY39-02: Accessing evolutionary programs to enable therapeutic resistance
Journal Articles

Abstract 2546: Targeting MerTK-mediated efferocytosis in the prostate cancer TME

Kayla V. Myers, Amber E. de Groot, Anna L. Gonye, Luke V. Loftus, Sarah R. Amend, Kenneth J. Pienta
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2546.
https://doi.org/10.1158/1538-7445.AM2022-2546
Published: 15 June 2022
View article titled, Abstract 2546: Targeting MerTK-mediated efferocytosis in the prostate cancer TME
Journal Articles

Abstract 123: Reactive oxygen species (ROS) as mediators of the cancer cell’s transition into the polyaneuploid cancer cell (PACC) state

Morgan D. Kuczler, Kenneth J. Pienta, Sarah R. Amend
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 123.
https://doi.org/10.1158/1538-7445.AM2022-123
Published: 15 June 2022
View article titled, Abstract 123: Reactive oxygen species (ROS) as mediators of the cancer cell’s transition into the polyaneuploid cancer cell (PACC) state
Journal Articles

Abstract 125: The role of oxidative stress on the polyaneuploid cancer cell state in metastatic cancer

Melvin Li, Sarah R. Amend, Kenneth J. Pienta
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 125.
https://doi.org/10.1158/1538-7445.AM2022-125
Published: 15 June 2022
View article titled, Abstract 125: The role of oxidative stress on the polyaneuploid cancer cell state in metastatic cancer
Journal Articles

Abstract B018: Targeting Notch4 and HIF2α signaling reduces the ability of cells to survive chemotherapy by undergoing the polyaneuploid transition

Christopher P. Carroll, Emma Hammarlund, Kenneth J. Pienta, Sarah R. Amend
Journal: Cancer Research
Cancer Res (2022) 82 (10_Supplement): B018.
https://doi.org/10.1158/1538-7445.EVODYN22-B018
Published: 15 May 2022
View article titled, Abstract B018: Targeting Notch4 and HIF2α signaling reduces the ability of cells to survive chemotherapy by undergoing the polyaneuploid transition
Journal Articles

Abstract A001: Modeling cancer’s ecological and evolutionary dynamics

Anuraag Bukkuri, Kenneth J. Pienta, Ian Hockett, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, Joel S. Brown
Journal: Cancer Research
Cancer Res (2022) 82 (10_Supplement): A001.
https://doi.org/10.1158/1538-7445.EVODYN22-A001
Published: 15 May 2022
View article titled, Abstract A001: Modeling cancer’s ecological and evolutionary dynamics
Journal Articles

Abstract B015: Eco-evolutionary dynamics of poly-aneuploid cancer cells: A life history model

Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, Joel S. Brown
Journal: Cancer Research
Cancer Res (2022) 82 (10_Supplement): B015.
https://doi.org/10.1158/1538-7445.EVODYN22-B015
Published: 15 May 2022
View article titled, Abstract B015: Eco-evolutionary dynamics of poly-aneuploid cancer cells: A life history model
Journal Articles

Abstract B022: The polyaneuploid transition as a hedge against failures in resistance acquisition

George Butler, Julia Bos, Robert H. Austin, Sarah R. Amend, Kenneth J. Pienta
Journal: Cancer Research
Cancer Res (2022) 82 (10_Supplement): B022.
https://doi.org/10.1158/1538-7445.EVODYN22-B022
Published: 15 May 2022
View article titled, Abstract B022: The polyaneuploid transition as a hedge against failures in resistance acquisition
Journal Articles

Abstract IA017: The polyaneuploid cancer cell state as a mediator of therapeutic resistance

Kenneth J. Pienta
Journal: Cancer Research
Cancer Res (2022) 82 (10_Supplement): IA017.
https://doi.org/10.1158/1538-7445.EVODYN22-IA017
Published: 15 May 2022
View article titled, Abstract IA017: The polyaneuploid cancer cell state as a mediator of therapeutic resistance
Journal Articles

Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer

Rajendra Kumar, Janet Mendonca, Olutosin Owoyemi, Kavya Boyapati, Naiju Thomas, Suthicha Kanacharoen, Max Coffey, Deven Topiwala, Carolina Gomes, Busra Ozbek, Tracy Jones, Marc Rosen, Liang Dong, Sadie Wiens, W. Nathaniel Brennen, John T. Isaacs, Angelo M. De Marzo, Mark C. Markowski, Emmanuel S. Antonarakis, David Z. Qian, Kenneth J. Pienta, Drew M. Pardoll, Michael A. Carducci, Samuel R. Denmeade, Sushant K. Kachhap
Journal: Cancer Research
Cancer Res (2021) 81 (23): 5948–5962.
https://doi.org/10.1158/0008-5472.CAN-20-3607
Published: 01 December 2021
View article titled, Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer
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Includes: Supplementary data
Journal Articles

Correction: CXCL12γ Promotes Metastatic Castration-Resistant Prostate Cancer by Inducing Cancer Stem Cell and Neuroendocrine Phenotypes

Younghun Jung, Frank C. Cackowski, Kenji Yumoto, Ann M. Decker, Jingcheng Wang, Jin Koo Kim, Eunsohl Lee, Yugang Wang, Jae-Seung Chung, Amy M. Gursky, Paul H. Krebsbach, Kenneth J. Pienta, Todd M. Morgan, Russell S. Taichman
Journal: Cancer Research
Cancer Res (2021) 81 (22): 5777.
https://doi.org/10.1158/0008-5472.CAN-21-3087
Published: 15 November 2021
View article titled, Correction: CXCL12γ Promotes Metastatic Castration-Resistant Prostate Cancer by Inducing Cancer Stem Cell and Neuroendocrine Phenotypes
Open the PDF for Correction: CXCL12γ Promotes Metastatic Castration-Resistant Prostate Cancer by Inducing Cancer Stem Cell and Neuroendocrine Phenotypes in another window
Journal Articles

Retraction: A Glycolytic Mechanism Regulating an Angiogenic Switch in Prostate Cancer

Jianhua Wang, Jincheng Wang, Jinlu Dai, Younghun Jung, Chuen-Long Wei, Yu Wang, Aaron M. Havens, Phillip J. Hogg, Evan T. Keller, Kenneth J. Pienta, Jacques E. Nor, Cun-Yu Wang, Russell S. Taichman
Journal: Cancer Research
Cancer Res (2021) 81 (6): 1623.
https://doi.org/10.1158/0008-5472.CAN-21-0464
Published: 15 March 2021
View article titled, Retraction: A Glycolytic Mechanism Regulating an Angiogenic Switch in Prostate Cancer
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Journal Articles

Abstract 342: Profiling mRNAs of parental prostate cancer cells with different phenotypes and their daughter extracellular vesicles using the NanoString low RNA input nCounter assay

Liang Dong, Chung-Ying Huang, Richard Zieren, Kengo Horie, Sarah R. Amend, Kenneth J. Pienta
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 342.
https://doi.org/10.1158/1538-7445.AM2020-342
Published: 15 August 2020
View article titled, Abstract 342: Profiling mRNAs of parental prostate cancer cells with different phenotypes and their daughter extracellular vesicles using the NanoString low RNA input nCounter assay