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Kenneth H. Shain
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Journal Articles

The Functional Transcriptomic Landscape Informs Therapeutic Strategies in Multiple Myeloma

Praneeth Reddy Sudalagunta, Rafael R. Canevarolo, Mark B. Meads, Maria Silva, Xiaohong Zhao, Christopher L. Cubitt, Samer S. Sansil, Gabriel DeAvila, Raghunandan Reddy Alugubelli, Ryan T. Bishop, Alexandre Tungesvik, Qi Zhang, Oliver Hampton, Jamie K. Teer, Eric A. Welsh, Sean J. Yoder, Bijal D. Shah, Lori Hazlehurst, Robert A. Gatenby, Dane R. Van Domelen, Yi Chai, Feng Wang, Andrew DeCastro, Amanda M. Bloomer, Erin M. Siegel, Conor C. Lynch, Daniel M. Sullivan, Melissa Alsina, Taiga Nishihori, Jason Brayer, John L. Cleveland, William Dalton, Christopher J. Walker, Yosef Landesman, Rachid Baz, Ariosto S. Silva, Kenneth H. Shain
Journal: Cancer Research
Cancer Res (2025) 85 (2): 378–398.
https://doi.org/10.1158/0008-5472.CAN-24-0886
Published: 15 January 2025
View articletitled, The Functional Transcriptomic Landscape Informs Therapeutic Strategies in Multiple Myeloma
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Includes: Supplementary data
Journal Articles

Abstract 4406: Single cell multiomic analysis reveals how genomic, epigenomic and transcriptomic events drive progression of multiple myeloma precursor states

Rafael Canevarolo, Praneeth Sudalagunta, Maria Silva, Mark Meads, Rachid Baz, Melissa Alsina, Kenneth H. Shain, Ariosto Siqueira Silva
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4406.
https://doi.org/10.1158/1538-7445.AM2024-4406
Published: 22 March 2024
View articletitled, Abstract 4406: Single cell multiomic analysis reveals how genomic, epigenomic and transcriptomic events drive progression of multiple myeloma precursor states
Journal Articles

Abstract B019: The bone microenvironment's impact on the heterogeneity of resistance to proteasome inhibitors in multiple myeloma

David Basanta, Ryan Bishop, Anna Miller, Conor C. Lynch, Matthew Froid, Ariosto S. Silva, Kenneth H. Shain
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_2): B019.
https://doi.org/10.1158/1538-7445.CANEVOL23-B019
Published: 01 February 2024
View articletitled, Abstract B019: The bone microenvironment's impact on the heterogeneity of resistance to proteasome inhibitors in multiple myeloma
Journal Articles

CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma

Karen L. Burger, Mario R. Fernandez, Mark B. Meads, Praneeth Sudalagunta, Paula S. Oliveira, Rafael Renatino Canevarolo, Raghunandan Reddy Alugubelli, Alexandre Tungsevik, Gabe De Avila, Maria Silva, Allison I. Graeter, Hongyue A. Dai, Nicole D. Vincelette, Antony Prabhu, Dario Magaletti, Chunying Yang, Weimin Li, Amit Kulkarni, Oliver Hampton, John M. Koomen, William R. Roush, Andrii Monastyrskyi, Anders E. Berglund, Ariosto S. Silva, John L. Cleveland, Kenneth H. Shain
Journal: Cancer Research
Cancer Res (2023) 83 (23): 3901–3919.
https://doi.org/10.1158/0008-5472.CAN-22-2350
Published: 01 December 2023
View articletitled, CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma
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Includes: Supplementary data
Journal Articles

Abstract 452: Novel autophagy inhibitory strategies to overcome chemotherapy resistance in multiple myeloma

Marilena Tauro, Tao Li, Mark Meads, Praneeth R. Sudalagunta, Raghunandan R. Alugubelli, Nicholas J. Lawrence, Ernst Schonbrunn, Harshani Lawrence, Kenneth H. Shain, Conor C. Lynch
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 452.
https://doi.org/10.1158/1538-7445.AM2023-452
Published: 04 April 2023
View articletitled, Abstract 452: Novel autophagy inhibitory strategies to overcome chemotherapy resistance in multiple myeloma
Journal Articles

Abstract 4313: A novel gene regulatory network model identifies master regulators in cancer

Praneeth Reddy Sudalagunta, Rafael Renatino Canevarolo, Mark Meads, Maria Coelho Silva, Xiaohong Zhao, Raghunandan Reddy Alugubelli, Joon-hyun Song, Erez Persi, Mehdi Damaghi, Kenneth H. Shain, Ariosto Silva
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4313.
https://doi.org/10.1158/1538-7445.AM2023-4313
Published: 04 April 2023
View articletitled, Abstract 4313: A novel gene regulatory network model identifies master regulators in cancer
Journal Articles

Abstract 5453: Individualized risk stratification in newly diagnosed multiple myeloma

Arjun Raj Rajanna, Francesco Maura, Andriy Derkach, Bachisio Ziccheddu, Niels Weinhold, Kylee Maclachlan, Benjamin Diamond, Faith Davies, Eileen Boyle, Brian Walker, Alexandra Pos, Malin Hulcrantz, Ariosto Silva, Oliver Hampton, Jamie K. Teer, Niccolò Bolli, Graham Jackson, Martin Kaiser, Charlotte Pawlyn, Gordon Cook, Dennis Verducci, Dickran Kazandjian, Fritz Van Rhee, Saad Usmani, Kenneth H. Shain, Marc S. Raab, Gareth Morgan, Ola Landgren
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5453.
https://doi.org/10.1158/1538-7445.AM2023-5453
Published: 04 April 2023
View articletitled, Abstract 5453: Individualized risk stratification in newly diagnosed multiple myeloma
Journal Articles

Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma–Induced Osteolysis and Reduces Overall Survival

Chen Hao Lo, Gemma Shay, Jeremy J. McGuire, Tao Li, Kenneth H. Shain, Jun Yong Choi, Rita Fuerst, William R. Roush, Anna M. Knapinska, Gregg B. Fields, Conor C. Lynch
Journal: Cancer Research
Cancer Res (2021) 81 (9): 2415–2428.
https://doi.org/10.1158/0008-5472.CAN-20-2705
Published: 01 May 2021
View articletitled, Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma–Induced Osteolysis and Reduces Overall Survival
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Includes: Supplementary data
Journal Articles

Abstract 359: Dual BET/kinase inhibitors as a novel strategy for the treatment of multiple myeloma

Marilena Tauro, Muhammad Ayaz, Harshani R. Lawrence, Nicholas J. Lawrence, Kenneth H. Shain, Ernst Schonbrunn, Conor C. Lynch
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 359.
https://doi.org/10.1158/1538-7445.AM2019-359
Published: 01 July 2019
View articletitled, Abstract 359: Dual BET/kinase inhibitors as a novel strategy for the treatment of multiple myeloma
Journal Articles

An Ex Vivo Platform for the Prediction of Clinical Response in Multiple Myeloma

Ariosto Silva, Maria C. Silva, Praneeth Sudalagunta, Allison Distler, Timothy Jacobson, Aunshka Collins, Tuan Nguyen, Jinming Song, Dung-Tsa Chen, Lu Chen, Christopher Cubitt, Rachid Baz, Lia Perez, Dmitri Rebatchouk, William Dalton, James Greene, Robert Gatenby, Robert Gillies, Eduardo Sontag, Mark B. Meads, Kenneth H. Shain
Journal: Cancer Research
Cancer Res (2017) 77 (12): 3336–3351.
https://doi.org/10.1158/0008-5472.CAN-17-0502
Published: 14 June 2017
View articletitled, An Ex Vivo Platform for the Prediction of Clinical Response in Multiple Myeloma
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Includes: Supplementary data
Journal Articles

Abstract 1772: Overcoming drug-resistance in multiple myeloma by CRM1 inhibitor combination therapy

Joel G. Turner, Kenneth H. Shain, Yun Dai, Jana L. Dawson, Christopher L. Cubitt, Sharon Shacham, Michael Kauffman, Steven Grant, Daniel M. Sullivan
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1772.
https://doi.org/10.1158/1538-7445.AM2014-1772
Published: 01 October 2014
View articletitled, Abstract 1772: Overcoming drug-resistance in multiple myeloma by CRM1 inhibitor combination therapy
Journal Articles

Abstract 4892: PYK2 mediates microenvironment-specific myeloma survival

Mark B. Meads, Bin Fang, Linda Mathews, Jennifer Gemmer, Liang Nong, Robert MacCleod, Lori Hazlehurst, John Koomen, Kenneth H. Shain
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4892.
https://doi.org/10.1158/1538-7445.AM2014-4892
Published: 01 October 2014
View articletitled, Abstract 4892: PYK2 mediates microenvironment-specific myeloma survival
Journal Articles

Abstract 5504: FANCF over expression correlates with selected resistance to topoisomerase II inhibitors independent of other FA/BRCA DNA repair core complex constituents

Liang Nong, Linda Mathews, William S. Dalton, Danielle Yarde, Kenneth H. Shain
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5504.
https://doi.org/10.1158/1538-7445.AM2011-5504
Published: 15 April 2011
View articletitled, Abstract 5504: FANCF over expression correlates with selected resistance to topoisomerase II inhibitors independent of other FA/BRCA DNA repair core complex constituents
Journal Articles

Abstract 5112: Proteomic investigation of melphalan resistance in multiple myeloma to support selection of combination therapy

Yun Xiang, Elizabeth R. Wood, Jessica Gancar, Umut Oguz, Christopher L. Cubitt, William S. Dalton, Kenneth H. Shain, John M. Koomen
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5112.
https://doi.org/10.1158/1538-7445.AM2011-5112
Published: 15 April 2011
View articletitled, Abstract 5112: Proteomic investigation of melphalan resistance in multiple myeloma to support selection of combination therapy
Journal Articles

Abstract 550: Transcriptional regulation of the Fanconi Anemia/BRCA DNA repair pathway component FANCD2 following co-culture of bone marrow stroma with multiple myeloma cell lines

Kenneth H. Shain, Vasco Oliveira, Danielle Yarde, Linda Mathews, William S. Dalton
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 550.
https://doi.org/10.1158/1538-7445.AM10-550
Published: 15 April 2010
View articletitled, Abstract 550: Transcriptional regulation of the Fanconi Anemia/BRCA DNA repair pathway component FANCD2 following co-culture of bone marrow stroma with multiple myeloma cell lines
Journal Articles

Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma

Danielle N. Yarde, Vasco Oliveira, Linda Mathews, Xingyu Wang, Alejandro Villagra, David Boulware, Kenneth H. Shain, Lori A. Hazlehurst, Melissa Alsina, Dung-Tsa Chen, Amer A. Beg, William S. Dalton
Journal: Cancer Research
Cancer Res (2009) 69 (24): 9367–9375.
https://doi.org/10.1158/0008-5472.CAN-09-2616
Published: 14 December 2009
View articletitled, Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma
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Includes: Supplementary data
Journal Articles

β1 Integrin Adhesion Enhances IL-6–Mediated STAT3 Signaling in Myeloma Cells: Implications for Microenvironment Influence on Tumor Survival and Proliferation

Kenneth H. Shain, Danielle N. Yarde, Mark B. Meads, Mei Huang, Richard Jove, Lori A. Hazlehurst, William S. Dalton
Journal: Cancer Research
Cancer Res (2009) 69 (3): 1009–1015.
https://doi.org/10.1158/0008-5472.CAN-08-2419
Published: 29 January 2009
View articletitled, β1 Integrin Adhesion Enhances IL-6–Mediated STAT3 Signaling in Myeloma Cells: Implications for Microenvironment Influence on Tumor Survival and Proliferation
Open the PDF for β1 Integrin Adhesion Enhances IL-6–Mediated STAT3 Signaling in Myeloma Cells: Implications for Microenvironment Influence on Tumor Survival and Proliferation in another window
Journal Articles

Genotypic and Phenotypic Comparisons of de Novo and Acquired Melphalan Resistance in an Isogenic Multiple Myeloma Cell Line Model

Lori A. Hazlehurst, Steven A. Enkemann, Craig A. Beam, Raul F. Argilagos, Jeffrey Painter, Kenneth H. Shain, Sara Saporta, David Boulware, Lynn Moscinski, Melissa Alsina, William S. Dalton
Journal: Cancer Research
Cancer Res (2003) 63 (22): 7900–7906.
Published: 21 November 2003
View articletitled, Genotypic and Phenotypic Comparisons of de Novo and Acquired Melphalan Resistance in an Isogenic Multiple Myeloma Cell Line Model
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Journal Articles

Regulation of Caspase Expression and Apoptosis by Adenomatous Polyposis Coli

Tingan Chen, Ivana Yang, Rosalyn Irby, Kenneth H. Shain, Hong Gang Wang, John Quackenbush, Domenico Coppola, Jin Q. Cheng, Timothy J. Yeatman
Journal: Cancer Research
Cancer Res (2003) 63 (15): 4368–4374.
Published: 07 August 2003
View articletitled, Regulation of Caspase Expression and Apoptosis by Adenomatous Polyposis Coli
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Includes: Supplementary data
Journal Articles

Overexpression of a Dominant-Negative Signal Transducer and Activator of Transcription 3 Variant in Tumor Cells Leads to Production of SolubleFactors That Induce Apoptosis and Cell Cycle Arrest

Guilian Niu, Kenneth H. Shain, Mei Huang, Rajani Ravi, Atul Bedi, William S. Dalton, Richard Jove, Hua Yu
Journal: Cancer Research
Cancer Res (2001) 61 (8): 3276–3280.
Published: 15 April 2001
View articletitled, Overexpression of a Dominant-Negative Signal Transducer and Activator of Transcription 3 Variant in Tumor Cells Leads to Production of SolubleFactors That Induce Apoptosis and Cell Cycle Arrest
Open the PDF for Overexpression of a Dominant-Negative Signal Transducer and Activator of Transcription 3 Variant in Tumor Cells Leads to Production of SolubleFactors That Induce Apoptosis and Cell Cycle Arrest in another window