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Kenneth D. Tew
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Journal Articles

Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1

Leilei Zhang, Jie Zhang, Zhiwei Ye, Yefim Manevich, Lauren E. Ball, Jennifer R. Bethard, Yu-Lin Jiang, Ann-Marie Broome, Annamarie C. Dalton, Gavin Y. Wang, Danyelle M. Townsend, Kenneth D. Tew
Journal: Cancer Research
Cancer Res (2019) 79 (16): 4072–4085.
https://doi.org/10.1158/0008-5472.CAN-18-3503
Published: 15 August 2019
View article titled, Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1
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Includes: Supplementary data
Journal Articles

Abstract 881: A role for microsomal glutathione transferase 1 in melanin biosynthesis in melanoma

Jie Zhang, Zhi-wei Ye, Danyelle M. Townsend, Ralf Morgenstern, Kenneth D. Tew
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 881.
https://doi.org/10.1158/1538-7445.AM2019-881
Published: 01 July 2019
View article titled, Abstract 881: A role for microsomal glutathione transferase 1 in melanin biosynthesis in melanoma
Journal Articles

Abstract 2657: GSTP mediated S-glutathionylation of GRP78 attributes to multiple myeloma resistance

Zhiwei Ye, Jie Zhang, Kenneth D. Tew, Danyelle M. Townsend
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2657.
https://doi.org/10.1158/1538-7445.AM2019-2657
Published: 01 July 2019
View article titled, Abstract 2657: GSTP mediated S-glutathionylation of GRP78 attributes to multiple myeloma resistance
Journal Articles

MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer

Aimin Yang, Shenghui Qin, Bradley A. Schulte, Stephen P. Ethier, Kenneth D. Tew, Gavin Y. Wang
Journal: Cancer Research
Cancer Res (2017) 77 (23): 6641–6650.
https://doi.org/10.1158/0008-5472.CAN-16-3452
Published: 30 November 2017
View article titled, MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer
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Includes: Supplementary data
Journal Articles

Commentary on “Proteasome Inhibitors: A Novel Class of Potent and Effective Antitumor Agents”

Kenneth D. Tew
Journal: Cancer Research
Cancer Res (2016) 76 (17): 4916–4917.
https://doi.org/10.1158/0008-5472.CAN-16-1974
Published: 31 August 2016
View article titled, Commentary on “Proteasome Inhibitors: A Novel Class of Potent and Effective Antitumor Agents”
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Journal Articles

Glutathione-Associated Enzymes In Anticancer Drug Resistance

Kenneth D. Tew
Journal: Cancer Research
Cancer Res (2016) 76 (1): 7–9.
https://doi.org/10.1158/0008-5472.CAN-15-3143
Published: 03 January 2016
View article titled, Glutathione-Associated Enzymes In Anticancer Drug Resistance
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Journal Articles

Abstract 5409: MEI-344, a novel isoflavone with activity as a mitochondrial oxygenase inhibitor

Yefim Manevich, Miguel Quintela-Fandino, Paloma Navarro, Carolyn Britten, Kenneth D. Tew, Danyelle M. Townsend
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5409.
https://doi.org/10.1158/1538-7445.AM2015-5409
Published: 01 August 2015
View article titled, Abstract 5409: MEI-344, a novel isoflavone with activity as a mitochondrial oxygenase inhibitor
Journal Articles

Abstract 3546: S-Glutathionylation of buccal mucosal cell proteins as biomarkers of oxidative stress.

Christina L. Grek, Yefim Manevich, Danyelle M. Townsend, Kenneth D. Tew
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3546.
https://doi.org/10.1158/1538-7445.AM2013-3546
Published: 15 April 2013
View article titled, Abstract 3546: S-Glutathionylation of buccal mucosal cell proteins as biomarkers of oxidative stress.
Journal Articles

S-Glutathionylated Serine Proteinase Inhibitors as Plasma Biomarkers in Assessing Response to Redox-Modulating Drugs

Christina L. Grek, Danyelle M. Townsend, Joachim D. Uys, Yefim Manevich, Woodrow J. Coker, III, Christopher J. Pazoles, Kenneth D. Tew
Journal: Cancer Research
Cancer Res (2012) 72 (9): 2383–2393.
https://doi.org/10.1158/0008-5472.CAN-11-4088
Published: 30 April 2012
View article titled, <em>S</em>-Glutathionylated Serine Proteinase Inhibitors as Plasma Biomarkers in Assessing Response to Redox-Modulating Drugs
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Includes: Supplementary data
Journal Articles

Abstract 2077: Interactions between sulfiredoxin, S100A4 and non-muscle myosin IIA regulate cancer cell adhesion and motility

Robert R. Bowers, Yefim Manevich, Danyelle M. Townsend, Kenneth D. Tew
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2077.
https://doi.org/10.1158/1538-7445.AM2011-2077
Published: 15 April 2011
View article titled, Abstract 2077: Interactions between sulfiredoxin, S100A4 and non-muscle myosin IIA regulate cancer cell adhesion and motility
Journal Articles

Gary D. Kruh: In Memoriam (1951–2011)

Kenneth D. Tew
Journal: Cancer Research
Cancer Res (2011) 71 (7): 2801–2802.
https://doi.org/10.1158/0008-5472.CAN-11-0533
Published: 31 March 2011
View article titled, Gary D. Kruh: In Memoriam (1951–2011)
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Journal Articles

Abstract 1615: The redox modulator NOV-002 inhibits proliferation of ovarian tumor cells but increases proliferation of myeloid cells

Robert Bowers, Danyelle M. Townsend, Yefim Manevich, Christopher J. Pazoles, Kenneth D. Tew
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1615.
https://doi.org/10.1158/1538-7445.AM10-1615
Published: 15 April 2010
View article titled, Abstract 1615: The redox modulator NOV-002 inhibits proliferation of ovarian tumor cells but increases proliferation of myeloid cells
Journal Articles

Abstract 430: Serpin-A1 and A3 as potential pharmacodynamic biomarkers for NOV-002, a redox-modulating anti-cancer agent

Christina L. Grek, Danyelle M. Townsend, Joachim D. Uys, Christopher J. Pazoles, Kenneth D. Tew
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 430.
https://doi.org/10.1158/1538-7445.AM10-430
Published: 15 April 2010
View article titled, Abstract 430: Serpin-A1 and A3 as potential pharmacodynamic biomarkers for NOV-002, a redox-modulating anti-cancer agent
Journal Articles

Abstract 5136: Sulfiredoxin promotes cell migration through direct interaction with non muscle myosin IIa

Robert Bowers, Danyelle M. Townsend, Yefim Manevich, Kenneth D. Tew
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5136.
https://doi.org/10.1158/1538-7445.AM10-5136
Published: 15 April 2010
View article titled, Abstract 5136: Sulfiredoxin promotes cell migration through direct interaction with non muscle myosin IIa
Journal Articles

Nitrosative Stress–Induced S-Glutathionylation of Protein Disulfide Isomerase Leads to Activation of the Unfolded Protein Response

Danyelle M. Townsend, Yefim Manevich, Lin He, Ying Xiong, Robert R. Bowers, Jr., Steven Hutchens, Kenneth D. Tew
Journal: Cancer Research
Cancer Res (2009) 69 (19): 7626–7634.
https://doi.org/10.1158/0008-5472.CAN-09-0493
Published: 01 October 2009
View article titled, Nitrosative Stress–Induced <em>S</em>-Glutathionylation of Protein Disulfide Isomerase Leads to Activation of the Unfolded Protein Response
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Journal Articles

NOV-002, a Glutathione Disulfide Mimetic, as a Modulator of Cellular Redox Balance

Danyelle M. Townsend, Lin He, Steven Hutchens, Tracy E. Garrett, Christopher J. Pazoles, Kenneth D. Tew
Journal: Cancer Research
Cancer Res (2008) 68 (8): 2870–2877.
https://doi.org/10.1158/0008-5472.CAN-07-5957
Published: 15 April 2008
View article titled, NOV-002, a Glutathione Disulfide Mimetic, as a Modulator of Cellular Redox Balance
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Journal Articles

A Novel Role for Human Sulfiredoxin in the Reversal of Glutathionylation

Victoria J. Findlay, Danyelle M. Townsend, Taylor E. Morris, Jacob P. Fraser, Lin He, Kenneth D. Tew
Journal: Cancer Research
Cancer Res (2006) 66 (13): 6800–6806.
https://doi.org/10.1158/0008-5472.CAN-06-0484
Published: 03 July 2006
View article titled, A Novel Role for Human Sulfiredoxin in the Reversal of Glutathionylation
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Journal Articles

A role for sulfiredoxin in cysteine deglutathionylation and the regulation of proliferation

Victoria J. Findlay, Lin He, Danyelle M. Townsend, Kenneth D. Tew
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 885.
Published: 15 April 2006
View article titled, A role for sulfiredoxin in cysteine deglutathionylation and the regulation of proliferation
Journal Articles

Old enzyme, new function: Glutathione S- transferase π mediates S-glutathionylation of proteins following oxidative and nitrosative stress

Danyelle M. Townsend, Erica Kemmpa, Molly Ogle, Victoria J. Findlay, Kenneth D. Tew
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 885.
Published: 15 April 2006
View article titled, Old enzyme, new function: Glutathione S- transferase π mediates S-glutathionylation of proteins following oxidative and nitrosative stress
Journal Articles

A role for human sulfiredoxin in stress response and redox regulation of protein glutathionylation

Victoria J. Findlay, Taylor E. Morris, Danyelle M. Townsend, Kenneth D. Tew
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 621.
Published: 01 May 2005
View article titled, A role for human sulfiredoxin in stress response and redox regulation of protein glutathionylation