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Journal Articles

The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission

Kenneth C. Anderson, Lewis C. Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A. Diaz, Raymond N. DuBois, Keith T. Flaherty, Philip D. Greenberg, Massimo Loda, Elaine R. Mardis, Elizabeth A. Platz, Michael N. Pollak, Robert D. Schreiber, Lillian L. Siu, Beverly A. Teicher
Journal: Cancer Research
Cancer Res (2022) 82 (21): 3861–3867.
https://doi.org/10.1158/0008-5472.CAN-22-2453
Published: 02 November 2022
View article titled, The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission
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Journal Articles

Abstract 2074: ORIC-533, a small molecule CD73 inhibitor with best-in-class properties, reversesimmunosuppression and has potential as an immunomodulatory therapy in patients with multiple myeloma

Melissa R. Junttila, Arghya Ray, Robert Warne, Xi Chen, Ting Du, Dena Sutimantanapi, Jae H. Chang, Brian Blank, Jared Moore, Chudi O. Ndubaku, Tatiana Zavorotinskaya, Pratik Multani, Omar Nadeem, Dharminder Chauhan, Kenneth C. Anderson, Lori S. Friedman
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2074.
https://doi.org/10.1158/1538-7445.AM2022-2074
Published: 15 June 2022
View article titled, Abstract 2074: ORIC-533, a small molecule CD73 inhibitor with best-in-class properties, reversesimmunosuppression and has potential as an immunomodulatory therapy in patients with multiple myeloma
Journal Articles

Abstract LB110: Multiple myeloma cells depend on the NRF1-DDI2 proteasome stress response pathway for survival

Tianzeng Chen, Matthew Ho, Jenna Briere, Maria Moscvin, Peter G. Czarnecki, Kenneth C. Anderson, T. Keith Blackwell, Giada Bianchi
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB110.
https://doi.org/10.1158/1538-7445.AM2021-LB110
Published: 01 July 2021
View article titled, Abstract LB110: Multiple myeloma cells depend on the NRF1-DDI2 proteasome stress response pathway for survival
Journal Articles

Abstract LB217: ROBO1 promotes homing, dissemination, and survival of multiple myeloma within the bone marrow microenvironment

Giada Bianchi, Peter G. Czarnecki, Matthew Ho, Aldo M. Roccaro, Antonio Sacco, Yawara Kawano, Annamaria Gulla, Anil Aktas Samur, Tianzeng Cheng, Kenneth Wen, Yu-Tzu Tai, Maria Moscvin, Xinchen Wu, Gulden Camci-Unal, Matteo Claudio Da VIa, Niccolo Bolli, Ruben D. Carrasco, Irene M. Ghobrial, Kenneth C. Anderson
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB217.
https://doi.org/10.1158/1538-7445.AM2021-LB217
Published: 01 July 2021
View article titled, Abstract LB217: ROBO1 promotes homing, dissemination, and survival of multiple myeloma within the bone marrow microenvironment
Journal Articles

Abstract LB193: Lysine demethylase 5A is required for MYC driven transcription in multiple myeloma

Jun Qi, hiroto Ohguchi, Paul MC Park, tingjian wang, Kenneth C. Anderson, Teru Hideshima, Catrine Johansson, Udo Oppermann, Adam D. Durbin, Berkley Gryder, Javed Khan, xiaofeng zhang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB193.
https://doi.org/10.1158/1538-7445.AM2021-LB193
Published: 01 July 2021
View article titled, Abstract LB193: Lysine demethylase 5A is required for MYC driven transcription in multiple myeloma
Journal Articles

Cisplatin-Mediated Upregulation of APE2 Binding to MYH9 Provokes Mitochondrial Fragmentation and Acute Kidney Injury

Yi Hu, Chun Yang, Tania Amorim, Mohsin Maqbool, Jenny Lin, Chen Li, Chuanfeng Fang, Li Xue, Ariel Kwart, Hua Fang, Mei Yin, Allison J. Janocha, Daisuke Tsuchimoto, Yusaku Nakabeppu, Xiaofeng Jiang, Alex Mejia-Garcia, Faiz Anwer, Jack Khouri, Xin Qi, Qing Y. Zheng, Jennifer S. Yu, Shan Yan, Thomas LaFramboise, Kenneth C. Anderson, Leal C. Herlitz, Nikhil C. Munshi, Jianhong Lin, Jianjun Zhao
Journal: Cancer Research
Cancer Res (2021) 81 (3): 713–723.
https://doi.org/10.1158/0008-5472.CAN-20-1010
Published: 01 February 2021
View article titled, Cisplatin-Mediated Upregulation of APE2 Binding to MYH9 Provokes Mitochondrial Fragmentation and Acute Kidney Injury
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Includes: Supplementary data
Journal Articles

Abstract 642: TRAF2 mediates sensitivity to immunomodulatory drugs via NF-κB and ERK signaling in myeloma cells

Jiye Liu, Teru Hideshima, Lijie Xing, Su Wang, Wenrong Zhou, Daisuke Ogiya, Kenneth Wen, Yu-Tzu Tai, Yong Cang, Kenneth C. Anderson
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 642.
https://doi.org/10.1158/1538-7445.AM2020-642
Published: 15 August 2020
View article titled, Abstract 642: TRAF2 mediates sensitivity to immunomodulatory drugs via NF-κB and ERK signaling in myeloma cells
Journal Articles

Targeting of CD38 by the Tumor Suppressor miR-26a Serves as a Novel Potential Therapeutic Agent in Multiple Myeloma

Yi Hu, Huimin Liu, Chuanfeng Fang, Chen Li, Fjorela Xhyliu, Hayley Dysert, Juraj Bodo, Gabriel Habermehl, Benjamin E. Russell, Wenjun Li, Marcia Chappell, Xiaofeng Jiang, Sarah L. Ondrejka, Eric D. Hsi, Jaroslaw P. Maciejewski, Qing Yi, Kenneth C. Anderson, Nikhil C. Munshi, Geyou Ao, Jason N. Valent, Jianhong Lin, Jianjun Zhao
Journal: Cancer Research
Cancer Res (2020) 80 (10): 2031–2044.
https://doi.org/10.1158/0008-5472.CAN-19-1077
Published: 15 May 2020
View article titled, Targeting of CD38 by the Tumor Suppressor miR-26a Serves as a Novel Potential Therapeutic Agent in Multiple Myeloma
Open the PDF for Targeting of CD38 by the Tumor Suppressor miR-26a Serves as a Novel Potential Therapeutic Agent in Multiple Myeloma in another window
Includes: Supplementary data
Journal Articles

Abstract 2954: Immunomodulator maintenance post autologous stem cell transplant predicts better outcome in multiple myeloma patients with clonal hematopoiesis of indeterminate potential

Tarek H. Mouhieddine, Jihye Park, Robert Redd, Christopher J. Gibson, Salomon Manier, Amin Nassar, Kalvis Hornburg, Marzia Capelletti, Daisy Huynh, Romanos Sklavenitits Pistofidis, Mark W. Bustoros, Saud H. AlDubayan, Brendan Reardon, Cody J. Boehner, Henry Dumke, Chia-Jen Lui, Darlys Schott, Eliezer M. Van Allen, Robert L. Schlossman, Nikhil C. Munshi, Kenneth C. Anderson, David P. Steensma, Jacob P. Laubach, Paul G. Richardson, Jerome Ritz, Benjamin L. Ebert, Robert J. Soiffer, Donna Neuberg, Irene M. Ghobrial
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2954.
https://doi.org/10.1158/1538-7445.AM2018-2954
Published: 01 July 2018
View article titled, Abstract 2954: Immunomodulator maintenance post autologous stem cell transplant predicts better outcome in multiple myeloma patients with clonal hematopoiesis of indeterminate potential
Journal Articles

Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma

Xiaomu Wei, M. Nieves Calvo-Vidal, Siwei Chen, Gang Wu, Maria V. Revuelta, Jian Sun, Jinghui Zhang, Michael F. Walsh, Kim E. Nichols, Vijai Joseph, Carrie Snyder, Celine M. Vachon, James D. McKay, Shu-Ping Wang, David S. Jayabalan, Lauren M. Jacobs, Dina Becirovic, Rosalie G. Waller, Mykyta Artomov, Agnes Viale, Jayeshkumar Patel, Jude Phillip, Selina Chen-Kiang, Karen Curtin, Mohamed Salama, Djordje Atanackovic, Ruben Niesvizky, Ola Landgren, Susan L. Slager, Lucy A. Godley, Jane Churpek, Judy E. Garber, Kenneth C. Anderson, Mark J. Daly, Robert G. Roeder, Charles Dumontet, Henry T. Lynch, Charles G. Mullighan, Nicola J. Camp, Kenneth Offit, Robert J. Klein, Haiyuan Yu, Leandro Cerchietti, Steven M. Lipkin
Journal: Cancer Research
Cancer Res (2018) 78 (10): 2747–2759.
https://doi.org/10.1158/0008-5472.CAN-17-1900
Published: 14 May 2018
View article titled, Germline Lysine-Specific Demethylase 1 (<em>LSD1/KDM1A</em>) Mutations Confer Susceptibility to Multiple Myeloma
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Includes: Supplementary data
Journal Articles

Targeting the miR-221–222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma

Jian-Jun Zhao, Zhang-Bo Chu, Yu Hu, Jianhong Lin, Zhongqiu Wang, Meng Jiang, Ming Chen, Xujun Wang, Yue Kang, Yangsheng Zhou, Triona Ni Chonghaile, Melanie E. Johncilla, Yu-Tzu Tai, Jin Q. Cheng, Antony Letai, Nikhil C. Munshi, Kenneth C. Anderson, Ruben D. Carrasco
Journal: Cancer Research
Cancer Res (2015) 75 (20): 4384–4397.
https://doi.org/10.1158/0008-5472.CAN-15-0457
Published: 14 October 2015
View article titled, Targeting the miR-221–222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma
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Includes: Supplementary data
Journal Articles

Abstract 2004: Phenotypic and molecular characterization of inter- and intraclonal heterogeneity in multiple myeloma and Waldenstrom macroglobulinemia

Jana Jakubikova, Danka Cholujova, Teru Hideshima, Jacob Laubach, Nikhil C. Munshi, Steven P. Treon, Paul G. Richardson, Efstathios Kastritis, David M. Dorfman, Kenneth C. Anderson
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2004.
https://doi.org/10.1158/1538-7445.AM2015-2004
Published: 01 August 2015
View article titled, Abstract 2004: Phenotypic and molecular characterization of inter- and intraclonal heterogeneity in multiple myeloma and Waldenstrom macroglobulinemia
Journal Articles

Abstract 4629: Multiple myeloma susceptibility loci examined in African and European ancestry populations

Kristin A. Rand, Chi Song, Eric Dean, Daniel Serie, Karen Curtin, Dennis Hazelett, Amie E. Hwang, Xin Sheng, Alex Stram, David J. Van Den Berg, Carol Ann Huff, Leon Bernal-Mizrachi, Michael H. Tomasson, Sikander Ailawadhi, Anneclaire De Roos, Seema Singhal, Karen Pawlish, Edward Peters, Catherine Bock, David V. Conti, Graham Colditz, Todd Zimmerman, Scott Huntsman, John Graff, African Ancestry Prostate Cancer GWAS Consortium, African Ancestry Breast Cancer GWAS Consortium, Stephen J. Chanock, Michael Lieber, Jayesh Mehta, Eric A. Klein, Nalini Janakiraman, Richard K. Severson, Angela R. Brooks-Wilson, Vincent Rajkumar, Elizabeth E. Brown, Laurence Kolonel, Susan Slager, Brian E. Henderson, Graham G. Giles, John J. Spinelli, Brian Chiu, Kenneth C. Anderson, Jeffrey Zonder, Robert Z. Orlowski, Sagar Lonial, Nicola Camp, Celine Vachon, Elad Ziv, Dan O. Stram, Christopher A. Haiman, Wendy Cozen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4629.
https://doi.org/10.1158/1538-7445.AM2015-4629
Published: 01 August 2015
View article titled, Abstract 4629: Multiple myeloma susceptibility loci examined in African and European ancestry populations
Journal Articles

Abstract 394: A novel anti-a proliferation-inducing ligand hAPRIL.01A monoclonal antibody targets multiple myeloma cells in the bone marrow microenvironment

Yu-Tzu Tai, Chirag Acharya, Gang An, Mike Y. Zhong, Xiaoyan Feng, Hua Jiang, Hans van Eenennaam, Andrea van Elsas, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 394.
https://doi.org/10.1158/1538-7445.AM2015-394
Published: 01 August 2015
View article titled, Abstract 394: A novel anti-a proliferation-inducing ligand hAPRIL.01A monoclonal antibody targets multiple myeloma cells in the bone marrow microenvironment
Journal Articles

Abstract 3035: HDAC8 is recruited to DNA double strand breaks sites and affects the homologous recombination efficiency in multiple myeloma

Maria Gkotzamanidou, Masood Shammas, Jesús Martín Sánchez, Mehmet Kemal Samur, Stephane Minvielle, Florence Magrangeas, Herve Avet-Loiseau, Athanasios-Meletios Dimopoulos, Kenneth C. Anderson, Nikhil C. Munshi
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3035.
https://doi.org/10.1158/1538-7445.AM2015-3035
Published: 01 August 2015
View article titled, Abstract 3035: HDAC8 is recruited to DNA double strand breaks sites and affects the homologous recombination efficiency in multiple myeloma
Journal Articles

Abstract 638: Lenalidomide treatment enhances the anti-tumor activities of XBP1 specific cytotoxic T lymphocytes by increasing the frequency and tumor-specific response of central memory CD3+CD8+ T cells

Jooeun Bae, Rao Prabhala, Ruben Carrasco, Paul Richardson, Glen Dranoff, Kenneth C. Anderson, Nikhil C. Munshi
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 638.
https://doi.org/10.1158/1538-7445.AM2014-638
Published: 01 October 2014
View article titled, Abstract 638: Lenalidomide treatment enhances the anti-tumor activities of XBP1 specific cytotoxic T lymphocytes by increasing the frequency and tumor-specific response of central memory CD3+CD8+ T cells
Journal Articles

Abstract 644: Novel anti-B cell maturation antigen-monomethyl auristatin F antibody-drug conjugate (GSK2857916) induces potent and selective anti-multiple myeloma activity via enhanced effector function and direct tumor cell killing

Yu-Tzu Tai, Chirag Acharya, Mike Y. Zhong, Michele Cea, Antonia Cagnetta, Patrick A. Mayes, Jenny Craigen, Louise Gliddon, James Smothers, Amanda L. Christie, Andrew L. Kung, Paul Richardson, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 644.
https://doi.org/10.1158/1538-7445.AM2014-644
Published: 01 October 2014
View article titled, Abstract 644: Novel anti-B cell maturation antigen-monomethyl auristatin F antibody-drug conjugate (GSK2857916) induces potent and selective anti-multiple myeloma activity via enhanced effector function and direct tumor cell killing
Journal Articles

Abstract 2894: Novel heteroclitic XBP1 peptides induce antigen-specific memory CD3+CD8+ T cells expressing critical T cell markers and transcription regulators

Jooeun Bae, Rao Prabhala, Ruben Carrasco, Ann-Hwee Lee, Alec Kimmelman, Kenneth C. Anderson, Nikhil Munshi
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2894.
https://doi.org/10.1158/1538-7445.AM2014-2894
Published: 01 October 2014
View article titled, Abstract 2894: Novel heteroclitic XBP1 peptides induce antigen-specific memory CD3+CD8+ T cells expressing critical T cell markers and transcription regulators
Journal Articles

Abstract 972: B-cell maturation antigen (BCMA) activation in human multiple myeloma cells promotes myeloma cell growth and survival in the bone marrow microenvironment via upregulated MCL-1 and NFκB signaling

Yu-Tzu Tai, Chirag Acharya, Mike Y. Zhong, Michele Cea, Antonia Cagnetta, Paul Richardson, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 972.
https://doi.org/10.1158/1538-7445.AM2014-972
Published: 01 October 2014
View article titled, Abstract 972: B-cell maturation antigen (BCMA) activation in human multiple myeloma cells promotes myeloma cell growth and survival in the bone marrow microenvironment via upregulated MCL-1 and NFκB signaling
Journal Articles

Abstract 4762: Deficient double strand breaks repair of bone marrow plasma cells correlates with better clinical outcome of multiple myeloma patients

Maria Gkotzamanidou, Masood Shammas, Evangelos Terpos, Sathees C. Raghavan, Kenneth C. Anderson, Nikhil C. Munshi, Meletios - Athanasios Dimopoulos, Vassilis L. Souliotis
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4762.
https://doi.org/10.1158/1538-7445.AM2014-4762
Published: 01 October 2014
View article titled, Abstract 4762: Deficient double strand breaks repair of bone marrow plasma cells correlates with better clinical outcome of multiple myeloma patients