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Immune Determinants of the Association between Tumor Mutational Burden and Immunotherapy Response across Cancer Types

Neelam Sinha, Sanju Sinha, Cristina Valero, Alejandro A. Schäffer, Kenneth Aldape, Kevin Litchfield, Timothy A. Chan, Luc G.T. Morris, Eytan Ruppin

Cancer Res OF1–OF8.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-2542

Published: 03 May 2022

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Includes: Supplementary data

Journal Articles

Abstract LB020: Epigenomic tumor evolution modeling with single-cell methylation data profiling

Xuan C. Li, Yuelin Liu, Farid Rashidi, Salem Malikic, Stephen M. Mount, Eytan Ruppin, Kenneth Aldape, Cenk Sahinalp

Cancer Res (2021) 81 (13_Supplement): LB020.

DOI: https://doi.org/10.1158/1538-7445.AM2021-LB020

Published: 01 July 2021

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Journal Articles

Abstract 2795: Estimation of cell lineage and inter-cell interactions from spatial transcriptomics data

Beibei Ru, Jinlin Huang, Yu Zhang, Kenneth Aldape, Peng Jiang

Cancer Res (2021) 81 (13_Supplement): 2795.

DOI: https://doi.org/10.1158/1538-7445.AM2021-2795

Published: 01 July 2021

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Journal Articles

Abstract 29: The recently approved high-TMB criteria may introduce a sex bias in response to PD1 inhibitors

Neelam Sinha, Sanju Sinha, Kuoyuan Cheng, Sanna Madan, Alejandro Schaffer, Kenneth Aldape, Ayelet Erez, Brid M. Ryan, Eytan Ruppin

Cancer Res (2021) 81 (13_Supplement): 29.

DOI: https://doi.org/10.1158/1538-7445.AM2021-29

Published: 01 July 2021

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Journal Articles

Abstract 4671: Novel biological roles of the atypical WNT ligand, Norrin, on glioblastoma stem cells segregate with ASCL1 expression

Ahmed A. Elsehemy, Hayden Selvadurai, Arturo Ortin-Martinez, Nenad Pokrajac, Yasin Mamatjan, Katherine Rowland, Kenneth Aldape, Peter Dirks, Valerie Wallace

Cancer Res (2019) 79 (13_Supplement): 4671.

DOI: https://doi.org/10.1158/1538-7445.AM2019-4671

Published: 01 July 2019

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Journal Articles

Abstract 841: Meningioma subgroups associated with functional genomic elements defined by DNA methylation

Tathiane M. Malta, James Snyder, Michael Wells, Ana deCarvalho, Laila Poisson, Camila Souza, Gelareh Zadeh, Kenneth Aldape, Daniela Tirapelli, Carlos Carlotti, Yan Lee, Steven Kalkanis, Tobias Walbert, Houtan Noushmehr

Cancer Res (2019) 79 (13_Supplement): 841.

DOI: https://doi.org/10.1158/1538-7445.AM2019-841

Published: 01 July 2019

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Journal Articles

Abstract 5325: 5-hydroxymethylcytosine profiling identifies differential targeting in IDH1 mutant versus IDH1 wild-type high-grade gliomas

Wioletta Glowacka, Harshika Jain, Makiko Okura, Abulizi Maimaitiming, Romina Nejad, Mamatjan Yasin, Hamza Farooq, Kenneth Aldape, Paul Kongkham

Cancer Res (2018) 78 (13_Supplement): 5325.

DOI: https://doi.org/10.1158/1538-7445.AM2018-5325

Published: 01 July 2018

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Journal Articles

Abstract 907: Brain microenvironment induced PTEN loss by microRNAs promotes brain metastasis

Cancer Res (2016) 76 (14_Supplement): 907.

DOI: https://doi.org/10.1158/1538-7445.AM2016-907

Published: 15 July 2016

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Journal Articles

Abstract 5270: IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II-III diffuse gliomas

Adriana Olar, Khalida Wani, Kristin Diefes, Lindsey Heathcock, Hinke van Thuijl, Mark Gilbert, Terri Armstrong, Erik Sulman, Daniel Cahill, Jaap Reijneveld, Bauke Ylstra, Pieter Wesseling, Kenneth Aldape

Cancer Res (2015) 75 (15_Supplement): 5270.

DOI: https://doi.org/10.1158/1538-7445.AM2015-5270

Published: 01 August 2015

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Journal Articles

Abstract 936: Comprehensive and integrative genomic characterization of diffuse lower grade gliomas

Roel G.W. Verhaak, Lee A.D. Cooper, Sofie S. Salama, Kenneth Aldape, W.K. Alfred Yung, Daniel J. Brat

Cancer Res (2014) 74 (19_Supplement): 936.

DOI: https://doi.org/10.1158/1538-7445.AM2014-936

Published: 01 October 2014

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Journal Articles

Abstract B82: Immune signatures of glioblastoma subtypes: Extrapolation from the Cancer Genome Atlas.

Tiffany Doucette, Ganesh Rao, Kenneth Aldape, Jun Wei, Kristine Dziurzynski, Arvind Rao, Li Shen, Mark R. Gilbert, Amy B. Heimberger

Cancer Res (2013) 73 (1_Supplement): B82.

DOI: https://doi.org/10.1158/1538-7445.TUMIMM2012-B82

Published: 02 April 2014

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Journal Articles

Abstract 3314: Phenotypic plasticity in glioma stem cells mediated by NFκB signaling

Krishna P. L. Bhat, Brian Vaillant, Veerakumar Balasubramainyan, Ravesanker Ezhilarasan, Faith Hollingsworth, Johanna James, Kahlida Wani, Lindsey Goodman, Erik Sulman, Howard Colman, Kenneth Aldape

Cancer Res (2012) 72 (8_Supplement): 3314.

DOI: https://doi.org/10.1158/1538-7445.AM2012-3314

Published: 15 April 2012

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Journal Articles

Abstract 5545: MethyMeter^® - A quantitative, bisulfite-free DNA methylation assay for improved clinical diagnostic and prognostic analysis of glioma biomarkers in FFPE tumor samples

David R. McCarthy, Kristen Diefes, Kenneth Aldape, Derek Maetzold, Karl Anderson, Jeffrey Falk, Michelle M. Hanna

Cancer Res (2012) 72 (8_Supplement): 5545.

DOI: https://doi.org/10.1158/1538-7445.AM2012-5545

Published: 15 April 2012

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Journal Articles

Abstract 887: Development of a robust nanoimmunoassay and immunohistochemical assay for asparagine synthetase

Philip L. Lorenzi, Lindsey E. Heathcock, Kenneth Aldape, John N. Weinstein

Cancer Res (2012) 72 (8_Supplement): 887.

DOI: https://doi.org/10.1158/1538-7445.AM2012-887

Published: 15 April 2012

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Journal Articles

Abstract LB-123: Analyses of anti-cancer testis antigen antibodies in glioma patients treated with Delta-24 oncolytic adenovirus

Juan Fueyo, Charles Conrad, Candelaria Gomez-Manzano, Amy Heimberger, Luis Vence, Kenneth Aldape, Alfred Yung, Raymond Sawaya, Gregory Fuller, Frederick Lang

Cancer Res (2012) 72 (8_Supplement): LB-123.

DOI: https://doi.org/10.1158/1538-7445.AM2012-LB-123

Published: 15 April 2012

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Journal Articles

Abstract 4588: Frequency and clinical characteristics of c-MET mutation in malignant melanoma

Sharon Kim, Nydia Gonzalez, Raja Luthra, Kenneth Aldape, Zhuang Zuo, Ping Liu, David Barron, Kevin B. Kim

Cancer Res (2012) 72 (8_Supplement): 4588.

DOI: https://doi.org/10.1158/1538-7445.AM2012-4588

Published: 15 April 2012

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Journal Articles

Abstract 3313: A proliferating population of glioma stem-like cells as characterized by expression of the cell surface glycoprotein CD58

Lindsey D. Goodman, Krishna Bhat, Joy Gumin, Ravesanker Ezhilarasan, Feng Gao, Patrice Love, Howard Colman, Frederick Lang, Kenneth Aldape, Erik Sulman

Cancer Res (2011) 71 (8_Supplement): 3313.

DOI: https://doi.org/10.1158/1538-7445.AM2011-3313

Published: 15 April 2011

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Journal Articles

Abstract 978: A regulatory role for TAZ in mesenchymal differentiation of glioblastoma

Krishna P. L Bhat, Katrina Salazar, Brian Vaillant, Kenneth Aldape

Cancer Res (2011) 71 (8_Supplement): 978.

DOI: https://doi.org/10.1158/1538-7445.AM2011-978

Published: 15 April 2011

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Journal Articles

Abstract 1789: NFKBIA deletion in malignant gliomas

Markus Bredel, Ajay Yadav, Jaclyn Renfrow, Denise Scholtens, James Chandler, Claudia Bredel, Michael Tagge, Paul Lukac, Pierre Robe, Hannes Vogel, Adrienne Scheck, Kenneth Aldape, Arnab Chakravarti, Griffith Harsh

Cancer Res (2010) 70 (8_Supplement): 1789.

DOI: https://doi.org/10.1158/1538-7445.AM10-1789

Published: 15 April 2010

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Journal Articles

Abstract #2450: Analyzing the TCGA glioblastoma samples: Co-occurrence and mutual exclusivity of gene aberrations in the key p53, Rb, and RTK pathways

John Weinstein, Lawrence Donehower, Kenneth Aldape, Matthew Meyerson, Lynda Chin, Nikolaus Schultz, Alfred Yung, Chris Sander, David Wheeler

Cancer Res (2009) 69 (9_Supplement): 2450.

Published: 01 May 2009

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NARROW

Immune Determinants of the Association between Tumor Mutational Burden and Immunotherapy Response across Cancer Types

Abstract LB020: Epigenomic tumor evolution modeling with single-cell methylation data profiling

Abstract 2795: Estimation of cell lineage and inter-cell interactions from spatial transcriptomics data

Abstract 29: The recently approved high-TMB criteria may introduce a sex bias in response to PD1 inhibitors

Abstract 4671: Novel biological roles of the atypical WNT ligand, Norrin, on glioblastoma stem cells segregate with ASCL1 expression

Abstract 841: Meningioma subgroups associated with functional genomic elements defined by DNA methylation

Abstract 5325: 5-hydroxymethylcytosine profiling identifies differential targeting in IDH1 mutant versus IDH1 wild-type high-grade gliomas

Abstract 907: Brain microenvironment induced PTEN loss by microRNAs promotes brain metastasis

Abstract 5270: IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II-III diffuse gliomas

Abstract 936: Comprehensive and integrative genomic characterization of diffuse lower grade gliomas

Abstract B82: Immune signatures of glioblastoma subtypes: Extrapolation from the Cancer Genome Atlas.

Abstract 3314: Phenotypic plasticity in glioma stem cells mediated by NFκB signaling

Abstract 5545: MethyMeter^® - A quantitative, bisulfite-free DNA methylation assay for improved clinical diagnostic and prognostic analysis of glioma biomarkers in FFPE tumor samples

Abstract 887: Development of a robust nanoimmunoassay and immunohistochemical assay for asparagine synthetase

Abstract LB-123: Analyses of anti-cancer testis antigen antibodies in glioma patients treated with Delta-24 oncolytic adenovirus

Abstract 4588: Frequency and clinical characteristics of c-MET mutation in malignant melanoma

Abstract 3313: A proliferating population of glioma stem-like cells as characterized by expression of the cell surface glycoprotein CD58

Abstract 978: A regulatory role for TAZ in mesenchymal differentiation of glioblastoma

Abstract 1789: NFKBIA deletion in malignant gliomas

Abstract #2450: Analyzing the TCGA glioblastoma samples: Co-occurrence and mutual exclusivity of gene aberrations in the key p53, Rb, and RTK pathways

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