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Kenji Tamura
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Journal Articles

Abstract CT517: Amcenestrant, an oral selective estrogen receptor (ER) degrader (SERD), in ER+/HER2- advanced breast cancer (aBC): combined biomarker analyses from a Phase 1/2 study in postmenopausal women and a Phase 1 study in postmenopausal Japanese women

Hiroji Iwata, Aditya Bardia, Simon Lord, Hannah M. Linden, Mario Campone, Kenji Tamura, Kan Yonemori, Toru Mukohara, Cécile Combeau, Nils Ternes, Dimitri Carene, Jeff Ming, Joon Sang Lee, Marina Celanovic, Anne-Laure Bauchet, Monsif Bouaboula, Tomoyuki Tanaka, Yumiko Kawabata, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT517.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT517
Published: 15 June 2022
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Journal Articles

Abstract CT124: Evaluation of rucaparib in Japanese patients (pts) with a previously treated advanced solid tumor

Kenji Tamura, Koji Matsumoto, Kan Yonemori, Kosei Hasegawa, Jenn Habeck, Eric Jones, Jim Xiao, Aaron Enke, Keiichi Fujiwara
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT124.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT124
Published: 01 July 2021
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Abstract PD3-11: A randomized, open-label, phase III trial of pertuzumab re-treatment in HER2-positive, locally advanced/metastatic breast cancer patients previously treated with pertuzumab, trastuzumab, and chemotherapy: The Japan Breast Cancer Research Group-M05 (PRECIOUS) study

Yutaka Yamamoto, Hiroji Iwata, Taira Naruto, Norikazu Masuda, Masato Takahashi, Tetsuhiro Yoshinami, Takayuki Ueno, Tatsuya Toyama, Takashi Yamanaka, Toshimi Takano, Masahiro Kashiwaba, Koichiro Tsugawa, Yoshie Hasegawa, Kenji Tamura, Hiroshi Tada, Fumikata Hara, Shigehira Saji, Satoshi Morita, Masakazu Toi, Shinji Ohno, Japan Breast Cancer Research Group
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD3-11.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PD3-11
Published: 15 February 2021
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Journal Articles

Abstract GS1-01: Primary outcome analysis of invasive disease-free survival for monarchE: abemaciclib combined with adjuvant endocrine therapy for high risk early breast cancer

Joyce A. O'Shaughnessy, Stephen Johnston, Nadia Harbeck, Masakazu Toi, Young-Hyuck Im, Mattea Reinisch, Zhimin Shao, Pirkko Liisa Kellokumpu Lehtinen, Chiun-Sheng Huang, Alexey Tryakin, Matthew Goetz, Hope S Rugo, Elzbieta Senkus, Laura Testa, Michael Andersson, Kenji Tamura, Guenther G. Steger, Lucia Del Mastro, Joanne Cox, Tammy Forrester, Sarah Sherwood, Xuelin Li, Ran Wei, Miguel Martin, Priya Rastogi
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): GS1-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-GS1-01
Published: 15 February 2021
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Abstract PD14-04: Contribution of tumor and immune cells to PD-L1 as a predictive biomarker in triple-negative breast cancer (TNBC): Analysis from KEYNOTE-119

Eric P. Winer, Oleg Lipatov, Seock-Ah Im, Anthony Goncalves, Eva Muñoz-Couselo, Keun Seok Lee, Zbigniew Nowecki, Peter Schmid, Kenji Tamura, Laura Testa, Isabell Witzel, Shoichiro Ohtani, Stephanie Hund, Karina Kulangara, Vassiliki Karantza, Jaime A. Mejia, Junshui Ma, Petar Jelinic, Lingkang Huang, Kenneth Emancipator, Javier Cortes
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD14-04.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PD14-04
Published: 15 February 2021
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Journal Articles

Abstract PD3-06: Updated results from DESTINY-breast01, a phase 2 trial of trastuzumab deruxtecan (T-DXd ) in HER2 positive metastatic breast cancer

Shanu Modi, Cristina Saura, Toshinari Yamashita, Yeon Hee Park, Sung-Bae Kim, Kenji Tamura, Fabrice Andre, Hiroji Iwata, Yoshinori Ito, Junji Tsurutani, Joohyuk Sohn, Neelima Denduluri, Christophe Perrin, Kenjiro Aogi, Eriko Tokunaga, Seock-Ah Im, Keun Seok Lee, Sara A Hurvitz, Javier Cortes, Caleb Lee, Yali Liu, Lin Zhang, Javad Shahidi, Antoine Yver, Jose Baselga, Ian E Krop
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD3-06.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PD3-06
Published: 15 February 2021
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Abstract PO-118: Novel mechanisms of EGFR-TKI resistance and clonal evolution of lung adenocarcinoma by overexpression of a cell adhesion molecule, CADM1

Takehiro Tsuchiya, Hideki Kuwano, Takeshi Ito, Masayoshi Nagata, Taketo Kawai, Yumi Tsuboi, Daisuke Matsubara, Isami Okamoto, Kenji Tamura, Jun Nakajima, Motoi Oba, Yoshinori Murakami
Journal: Cancer Research
Cancer Res (2020) 80 (21_Supplement): PO-118.
DOI: https://doi.org/10.1158/1538-7445.TUMHET2020-PO-118
Published: 03 November 2020
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Abstract 1975: Development and validation of detection of ESR1 mutations in circulating tumor DNA using PNA-LNA mediated PCR clamping

Yuki Kojima, Kan Yonemori, Tomomi Yoshino, Shigehiro Yagishita, Emi Noguchi, Hiroshi Terasaki, Sachiro Asano, Akinobu Hamada, Kenji Tamura
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1975.
DOI: https://doi.org/10.1158/1538-7445.AM2020-1975
Published: 15 August 2020
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Abstract 2913: Entinostat (KHK2375), class I histone deacetylase inhibitor, regulates human Treg function by decreasing Foxp3 expression and effector Treg population

Hiromichi Kosaka, Yozo Nishimura, Ayumi Kaneda, Norikazu Masuda, Kenji Tamura, Shigehira Saji, Hiroji Iwata, Kiyotoshi Mori
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2913.
DOI: https://doi.org/10.1158/1538-7445.AM2020-2913
Published: 15 August 2020
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Journal Articles

Abstract 3551: Simple vs. comprehensive prediction models of homologous recombination deficiency based on mutational and clinical features in three independent breast cancer datasets

Maki Tanioka, Tomoko Watanabe, Takayuki Honda, Hirohiko Totsuka, Eri Arai, Yae Kanai, Kouya Shiraishi, Kenji Tamura, Takashi Kohno
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3551.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3551
Published: 15 August 2020
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Journal Articles

Abstract GS1-03: [Fam-] trastuzumab deruxtecan (T-DXd; DS-8201a) in subjects with HER2-positive metastatic breast cancer previously treated with T-DM1: A phase 2, multicenter, open-label study (DESTINY-Breast01)

Ian E Krop, Cristina Saura, Toshinari Yamashita, Yeon Hee Park, Sung-Bae Kim, Kenji Tamura, Fabrice André, Hiroji Iwata, Yoshinori Ito, Junji Tsurutani, Joohyuk Sohn, Neelima Denduluri, Christophe Perrin, Kenjiro Aogi, Eriko Tokunaga, Seock-Ah Im, Keun Seok Lee, Sara Hurvitz, Javier Cortes, Caleb Lee, Shuquan Chen, Lin Zhang, Javad Shahidi, Antoine Yver, Shanu Modi
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): GS1-03.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-GS1-03
Published: 15 February 2020
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Journal Articles

Abstract 2951: A genome-wide association study identifies five novel genetic markers for trastuzumab-induced cardiotoxicity

Chihiro Udagawa, Mari Hara, Arata Shimo, Yasuyuki Kojima, Reiko Yoshie, Hisamitsu Zaha, Norie Abe, Tokiwa Motonari, Mikiko Unesoko, Kenji Tamura, Tatsunori Shimoi, Masayuki Yoshida, Teruhiko Yoshida, Hiroshi Okamura, Taisei Mushiroda, Koichiro Tsugawa, Hitoshi Zembutsu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2951.
DOI: https://doi.org/10.1158/1538-7445.AM2019-2951
Published: 01 July 2019
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Journal Articles

Abstract 3887: Whole exome sequencing to identify genetic markers for trastuzumab-induced cardiotoxicity

Chihiro Udagawa, Hiromi Nakamura, Hiroshi Ohnishi, Kenji Tamura, Tatsunori Shimoi, Masayuki Yoshida, Teruhiko Yoshida, Hiroshi Okamura, Yasushi Totoki, Tatsuhiro Shibata, Hitoshi Zembutsu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3887.
DOI: https://doi.org/10.1158/1538-7445.AM2018-3887
Published: 01 July 2018
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Journal Articles

Abstract 5049: Application of population pharmacokinetic and exposure-response modeling for DS-8201a, a HER2-targeting ADC, predicts 50% ORR in patients with heavily pretreated breast cancer

Kazutaka Yoshihara, Seiko Endo, Kenji Tamura, Toshihiko Doi, Taro Tokui
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5049.
DOI: https://doi.org/10.1158/1538-7445.AM2017-5049
Published: 01 July 2017
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Journal Articles

Abstract 1792: Immune system pathway activation for prediction of the response to neoadjuvant chemotherapy in triple-negative breast cancer

Takeshi Sawada, Riet Hilhorst, Savithri Rangarajan, Masayuki Yoshida, Kenji Tamura, Rinie van Beuningen, Rob Ruijtenbeek, Hitoshi Tsuda, Fumiaki Koizumi
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1792.
DOI: https://doi.org/10.1158/1538-7445.AM2017-1792
Published: 01 July 2017
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Abstract 3117: Eribulin is a novel TERT-targeting inhibitor that penetrates into intracerebrally grown glioblastomas and suppresses their growth in mice

Masamichi Takahashi, Shunichiro Miki, Yuko Matsushita, Kohei Fukuoka, Yoshiko Maida, Mami Yasukawa, Mitsuhiro Hayashi, Akinobu Hamada, Akitake Mukasa, Ryo Nishikawa, Kenji Tamura, Yoshitaka Narita, Kenkichi Masutomi, Koichi Ichimura
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3117.
DOI: https://doi.org/10.1158/1538-7445.AM2017-3117
Published: 01 July 2017
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Journal Articles

Abstract CT147: Phase I studies of AZD1208, a PIM kinase inhibitor, in patients with recurrent or refractory acute myelogenous leukemia or advanced solid tumors

Jorge Cortes, Kenji Tamura, Daniel J. DeAngelo, Johann de Bono, David Lorente, Mark Minden, Geoffrey L. Uy, Hagop Kantarjian, Karen Keating, Kristen McEachern, Karthick Vishwanathan, Robert E. Godin, Janet Elizabeth Pease, Emma Dean
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): CT147.
DOI: https://doi.org/10.1158/1538-7445.AM2016-CT147
Published: 15 July 2016
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Journal Articles

Abstract 500: Prognostic impact of CTC detected using a novel fluidic cell microarray chip CTC detection system in patients with breast cancer

Takeshi Sawada, Jungo Araki, Toshinari Yamashita, Manami Masubuchi, Tsuneko Chiyoda, Mayu Yunokawa, Kumiko Hoshi, Shoichi Tao, Shohei Yamamura, Shouki Yatsushiro, Kaori Abe, Masatoshi Kataoka, Tatsu Shimoyama, Yoshiharu Maeda, Katsumasa Kuroi, Kenji Tamura, Tsuneo Sawazumi, Hironobu Minami, Yoshihiko Suda, Fumiaki Koizumi
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 500.
DOI: https://doi.org/10.1158/1538-7445.AM2016-500
Published: 15 July 2016
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Journal Articles

Abstract 3480: Germline PARP4 mutations in patients with primary thyroid and breast cancers

Yuji Ikeda, Kazuma Kiyotani, Poh Yin Yew, Taigo Kato, Kenji Tamura, Kai Lee Yap, Jessica L. Mester, Sarah H. Nielsen, Grogan H. Raymon, Charis Eng, Yusuke Nakamura
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3480.
DOI: https://doi.org/10.1158/1538-7445.AM2016-3480
Published: 15 July 2016
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Abstract 4896: A novel method for evaluating antibody-dependent cell-mediated cytotoxicity by flow cytometry using cryopreserved human peripheral blood mononuclear cells

Shigehisa Kitano, Makiko Yamashita, Hiroaki Aikawa, Aya Kuchiba, Mitsuhiro Hayashi, Noboru Yamamoto, Kenji Tamura, Akinobu Hamada
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4896.
DOI: https://doi.org/10.1158/1538-7445.AM2016-4896
Published: 15 July 2016
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