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Kenichi Nomoto
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Journal Articles

Abstract LB288: Reducing the effect of cellular stress in murine oral tumors with pharmacological blockade of β-catenin/CBP activity

Free
Mohammed Muzamil Khan, Eric Reed, Lina Kroehling, Kenichi Nomoto, Junji Matsui, Manish Bais, Xaralabos Varelas, Maria Kukuruzinska, Stefano Monti
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB288.
https://doi.org/10.1158/1538-7445.AM2024-LB288
Published: 05 April 2024
View articletitled, Abstract LB288: Reducing the effect of cellular stress in murine oral tumors with pharmacological blockade of β-catenin/CBP activity
Journal Articles

Abstract LB156: Targeting epigenetic activity of beta-catenin/CBP impedes oral cancer progression

Free
Emily Fisher, Anthony Spinella, Junji Matsui, Kenichi Nomoto, Xaralabos Varelas, Manish Bais, Maria Kukuruzinska
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB156.
https://doi.org/10.1158/1538-7445.AM2024-LB156
Published: 05 April 2024
View articletitled, Abstract LB156: Targeting epigenetic activity of beta-catenin/CBP impedes oral cancer progression
Journal Articles

E7386, a Selective Inhibitor of the Interaction between β-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling

Free
Kazuhiko Yamada, Yusaku Hori, Satoshi Inoue, Yuji Yamamoto, Kentaro Iso, Hiroshi Kamiyama, Atsumi Yamaguchi, Takayuki Kimura, Mai Uesugi, Junichi Ito, Masahiro Matsuki, Kazutaka Nakamoto, Hitoshi Harada, Naoki Yoneda, Atsushi Takemura, Ikuo Kushida, Naomi Wakayama, Kenji Kubara, Yu Kato, Taro Semba, Akira Yokoi, Masayuki Matsukura, Takenao Odagami, Masao Iwata, Akihiko Tsuruoka, Toshimitsu Uenaka, Junji Matsui, Tomohiro Matsushima, Kenichi Nomoto, Hiroyuki Kouji, Takashi Owa, Yasuhiro Funahashi, Yoichi Ozawa
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (4): 1052–1062.
https://doi.org/10.1158/0008-5472.CAN-20-0782
Published: 15 February 2021
View articletitled, E7386, a Selective Inhibitor of the Interaction between β-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling
Open the PDF for E7386, a Selective Inhibitor of the Interaction between β-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling in another window
Includes: Supplementary data
Journal Articles

Abstract 5940: Inhibition of β-catenin/CBP signaling alters EGFR fucosylation status in head and neck squamous cell carcinoma

Free
Kevin B. Chandler, Khalid Alamoud, Bac-Cuc Nguyen, Vanessa L. Stahl, Takashi Owa, Kenichi Nomoto, Stefano Monti, Maria A. Kukuruzinska, Catherine E. Costello
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5940.
https://doi.org/10.1158/1538-7445.AM2020-5940
Published: 15 August 2020
View articletitled, Abstract 5940: Inhibition of β-catenin/CBP signaling alters EGFR fucosylation status in head and neck squamous cell carcinoma
Journal Articles

Abstract 6566: Defining the effects of inhibiting the beta-catenin-CBP signaling axis with the small molecule E7386 by integrative analysis of omics data

Free
Anthony Federico, Takashi Owa, Kenichi Nomoto, Xaralabos Varelas, Maria Kukuruzinksa, Stefano Monti
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6566.
https://doi.org/10.1158/1538-7445.AM2020-6566
Published: 15 August 2020
View articletitled, Abstract 6566: Defining the effects of inhibiting the beta-catenin-CBP signaling axis with the small molecule E7386 by integrative analysis of omics data
Journal Articles

Abstract 4419: Subtyping of HNSCC single-cell RNA-seq identifies transcriptional programs characterized by suppression of Mtorc1 and Wnt signaling pathways and better patient prognosis

Free
Eric Reed, Takashi Owa, Kenichi Nomoto, Xaralabos Varelas, Maria Kukuruzinska, Stefano Monti
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4419.
https://doi.org/10.1158/1538-7445.AM2020-4419
Published: 15 August 2020
View articletitled, Abstract 4419: Subtyping of HNSCC single-cell RNA-seq identifies transcriptional programs characterized by suppression of Mtorc1 and Wnt signaling pathways and better patient prognosis
Journal Articles

Abstract 1485: E7011, a novel anti-angiogenesis inhibitor targeting Notch4 receptor signal pathway

Free
Yusuke Adachi, Yoshimasa Sakamoto, Youya Nakazawa, Sho Tachino, Ken Ito, Takanori Abe, Yukinori Minoshima, Kana Hoshino-Negishi, Hideaki Ogasawara, Tomomi Kawakatsu, Miyuki Nishimura, Masashi Shimizu, Kazuhiro Tahara, Toshitaka Sato, Katsuhisa Suzuki, Kishan Agarwala, Masao Iwata, Yasuhiro Funahashi, Kenichi Nomoto, Yoichi Ozawa, Junji Matsui, Toshio Imai, Yu Kato
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1485.
https://doi.org/10.1158/1538-7445.AM2020-1485
Published: 15 August 2020
View articletitled, Abstract 1485: E7011, a novel anti-angiogenesis inhibitor targeting Notch4 receptor signal pathway
Journal Articles

Abstract 2442: Identification of a novel role for the β-catenin/CBP signaling in epigenetic regulation of the N-glycosylation gene, DPAGT1, in head and neck cancer

Free
Khalid A. Alamoud, Vinay Kartha, Huamei Yang, Andrew Tilston-Lunel, Anthony Federico, Manish Bais, Takachi Owa, Kenichi Nomoto, Xalarabos Varelas, Stefano Monti, Maria A. Kukuruzinska
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2442.
https://doi.org/10.1158/1538-7445.AM2020-2442
Published: 15 August 2020
View articletitled, Abstract 2442: Identification of a novel role for the β-catenin/CBP signaling in epigenetic regulation of the N-glycosylation gene, DPAGT1, in head and neck cancer
Journal Articles

Abstract 2453: Inhibition of β-catenin/CBP signaling with E7386 targets epigenetic changes associated with cancer stem cells in head and neck cancer

Free
Huamei Yang, Vinay Kartha, Khalid A. Alamoud, Anthony Federico, Andrew Tilston-Lunel, Bach-Cuc Nguyen, Takashi Owa, Kenichi Nomoto, Xaralabos Varelas, Stefano Monti, Maria A. Kukuruzinska
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2453.
https://doi.org/10.1158/1538-7445.AM2020-2453
Published: 15 August 2020
View articletitled, Abstract 2453: Inhibition of β-catenin/CBP signaling with E7386 targets epigenetic changes associated with cancer stem cells in head and neck cancer
Journal Articles

Abstract P4-10-08: Absolute lymphocyte count (ALC) is a predictor of eribulin benefit in advanced or metastatic breast cancer (MBC)

Free
Javier Cortes, Jose Manuel Perez-Garcia, Kenichi Nomoto, Karenza Alexis, Kenichi Saito, Yuta Yoshimura, Kenzo Muramoto, Yasuo Miyoshi
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P4-10-08.
https://doi.org/10.1158/1538-7445.SABCS19-P4-10-08
Published: 15 February 2020
View articletitled, Abstract P4-10-08: Absolute lymphocyte count (ALC) is a predictor of eribulin benefit in advanced or metastatic breast cancer (MBC)
Journal Articles

Abstract 4719: Synergistic anticancer activity of triple combinations of eribulin, palbociclib and fulvestrant in hormone dependent patient-derived xenograft (PDX) models of human breast cancer

Free
Marc Hillairet de Boisferon, Elodie Marie Dit Chatel, Kenichi Nomoto, Bruce A. Littlefield
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4719.
https://doi.org/10.1158/1538-7445.AM2019-4719
Published: 01 July 2019
View articletitled, Abstract 4719: Synergistic anticancer activity of triple combinations of eribulin, palbociclib and fulvestrant in hormone dependent patient-derived xenograft (PDX) models of human breast cancer
Journal Articles

Abstract 190: Lenvatinib induced cell death of cultured human hepatocellular carcinoma (HCC) under nutrient-starved condition through inhibition of FGFR signaling pathway

Free
Taisuke Hoshi, Saori Watanabe Miyano, Regina Mikie Kanada Sonobe, Hideki Watanabe, Yuki Seki, Etsuko Ohta, Kenichi Nomoto, Junji Matsui, Yasuhiro Funahashi
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 190.
https://doi.org/10.1158/1538-7445.AM2019-190
Published: 01 July 2019
View articletitled, Abstract 190: Lenvatinib induced cell death of cultured human hepatocellular carcinoma (HCC) under nutrient-starved condition through inhibition of FGFR signaling pathway
Journal Articles

Abstract 3961: Role for neuropilin1 in mode of action of chlorotoxin

Free
Donna Kolber-Simonds, Jiayi Wu, Utpal Majumder, Daniel Custar, Danyang Li, Hong Du, Maarten H. Postema, Thomas Noland, Andrew Hart, George Lai, Sean Eckley, Vaishali Dixit, Karen Tendyke, Kenichi Nomoto, Mary Woodall-Jappe, Sharon McGonigle
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3961.
https://doi.org/10.1158/1538-7445.AM2018-3961
Published: 01 July 2018
View articletitled, Abstract 3961: Role for neuropilin1 in mode of action of chlorotoxin
Journal Articles

Peripheral Neuropathy Induced by Microtubule-Targeted Chemotherapies: Insights into Acute Injury and Long-term Recovery

Free
Krystyna M. Wozniak, James J. Vornov, Ying Wu, Ying Liu, Valentina A. Carozzi, Virginia Rodriguez-Menendez, Elisa Ballarini, Paola Alberti, Eleonora Pozzi, Sara Semperboni, Brett M. Cook, Bruce A. Littlefield, Kenichi Nomoto, Krista Condon, Sean Eckley, Christopher DesJardins, Leslie Wilson, Mary A. Jordan, Stuart C. Feinstein, Guido Cavaletti, Michael Polydefkis, Barbara S. Slusher
Journal: Cancer Research
Cancer Res (2018) 78 (3): 817–829.
https://doi.org/10.1158/0008-5472.CAN-17-1467
Published: 31 January 2018
View articletitled, Peripheral Neuropathy Induced by Microtubule-Targeted Chemotherapies: Insights into Acute Injury and Long-term Recovery
Open the PDF for Peripheral Neuropathy Induced by Microtubule-Targeted Chemotherapies: Insights into Acute Injury and Long-term Recovery in another window
Includes: Supplementary data
Journal Articles

Abstract 5172: E7386, an orally active CBP/beta-catenin modulator, induces T cells infiltration into tumor and enhances antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model

Free
Yusaku Hori, Kazuhiko Yamada, Yu Kato, Yoichi Ozawa, Takenao Odagami, Junji Matsui, Tomohiro Matsushima, Kenichi Nomoto, Hiroyuki Kouji, Takashi Owa
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5172.
https://doi.org/10.1158/1538-7445.AM2017-5172
Published: 01 July 2017
View articletitled, Abstract 5172: E7386, an orally active CBP/beta-catenin modulator, induces T cells infiltration into tumor and enhances antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model
Journal Articles

Sustained Accumulation of Microtubule-Binding Chemotherapy Drugs in the Peripheral Nervous System: Correlations with Time Course and Neurotoxic Severity

Free
Krystyna M. Wozniak, James J. Vornov, Ying Wu, Kenichi Nomoto, Bruce A. Littlefield, Christopher DesJardins, Yanke Yu, George Lai, Larisa Reyderman, Nancy Wong, Barbara S. Slusher
Journal: Cancer Research
Cancer Res (2016) 76 (11): 3332–3339.
https://doi.org/10.1158/0008-5472.CAN-15-2525
Published: 31 May 2016
View articletitled, Sustained Accumulation of Microtubule-Binding Chemotherapy Drugs in the Peripheral Nervous System: Correlations with Time Course and Neurotoxic Severity
Open the PDF for Sustained Accumulation of Microtubule-Binding Chemotherapy Drugs in the Peripheral Nervous System: Correlations with Time Course and Neurotoxic Severity in another window
Journal Articles

The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations

Free
Weiguo Zhang, Gautam Borthakur, Chen Gao, Ye Chen, Hong Mu, Vivian R. Ruvolo, Kenichi Nomoto, Nanding Zhao, Marina Konopleva, Michael Andreeff
Journal: Cancer Research
Cancer Res (2016) 76 (6): 1528–1537.
https://doi.org/10.1158/0008-5472.CAN-15-1580
Published: 14 March 2016
View articletitled, The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations
Open the PDF for The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations in another window
Includes: Supplementary data
Journal Articles

Abstract 1374: Lenvatinib, tri-specific targeted therapy to VEGFR/FGFR/RET, suppresses angiogenesis through the inhibition of both VEGFR and FGFR signaling pathways

Free
Kenji Ichikawa, Saori Watanabe Miyano, Yusuke Adachi, Yuji Yamamoto, Yoichi Ozawa, Yasuhiro Funahashi, Kiyoshi Okamoto, Kenichi Nomoto, Junji Matsui
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1374.
https://doi.org/10.1158/1538-7445.AM2015-1374
Published: 01 August 2015
View articletitled, Abstract 1374: Lenvatinib, tri-specific targeted therapy to VEGFR/FGFR/RET, suppresses angiogenesis through the inhibition of both VEGFR and FGFR signaling pathways
Journal Articles

Abstract 4503: Pharmacokinetics and pharmacodynamic analysis of eribulin mesylate and paclitaxel in mouse

Free
Krystyna Wozniak, Ying Wu, Bruce A. Littlefield, Kenichi Nomoto, Christopher DesJardins, Yanke Yu, George Lai, Larisa Reyderman, Barbara S. Slusher
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4503.
https://doi.org/10.1158/1538-7445.AM2015-4503
Published: 01 August 2015
View articletitled, Abstract 4503: Pharmacokinetics and pharmacodynamic analysis of eribulin mesylate and paclitaxel in mouse
Journal Articles

Abstract 4543: Characterization of the liposomal formulation of eribulin mesylate (E7389) in mice

Free
Makoto Asano, Kenji Hyodo, Yanke Yu, Edgar Schuck, Junji Matsui, Hiroshi Ishihara, Hiroshi Kikuchi, Kenichi Nomoto
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4543.
https://doi.org/10.1158/1538-7445.AM2015-4543
Published: 01 August 2015
View articletitled, Abstract 4543: Characterization of the liposomal formulation of eribulin mesylate (E7389) in mice