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Keitaro Matsuo
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Journal Articles

Abstract 2286: Integrating multi-ancestry genomic and proteomic data to identify blood risk biomarkers and target proteins for breast cancer genetic risk loci

Guochong Jia, Jie Ping, Ran Tao, Jirong Long, Lili Liu, Shuai Xu, Stefan Ambs, Mollie E. Barnard, Yu Chen, Ji-Yeob Choi, Yu-Tang Gao, Montserrat Garcia-Closas, Jian Gu, Jennifer J. Hu, Motoki Iwasaki, Esther M. John, Sun-Seog Kweon, Koichi Matsuda, Keitaro Matsuo, Katherine L. Nathanson, Barbara Nemesure, Olufunmilayo I. Olopade, Tuya Pal, Sue K. Park, Boyoung Park, Michael F. Press, Maureen Sanderson, Dale P. Sandler, Song Yao, Ying Zheng, Prisca O. Adejumo, Thomas Ahearn, Abenaa M. Brewster, Anselm J. Hennis, Hidemi Ito, Michiaki Kubo, Eun-Sook Lee, Siew-Kee Low, Timothy Makumbi, Paul Ndom, Dong-Young Noh, Katie M. O'Brien, Andrew F. Olshan, Mojisola M. Oluwasanu, Min-Ho Park, Sonya Reid, Taiki Yamaji, Gary Zirpoli, Ebonee N. Butler, Wei Zheng
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2286.
https://doi.org/10.1158/1538-7445.AM2025-2286
Published: 21 April 2025
View articletitled, Abstract 2286: Integrating multi-ancestry genomic and proteomic data to identify blood risk biomarkers and target proteins for breast cancer genetic risk loci
Journal Articles

Abstract 6149: Polygenic risk score and lung adenocarcinoma risk among never-smokers by EGFR mutation status

Batel Blechter, Chao Agnes Hsiung, Keitaro Matsuo, Kouya Shiraishi, Kevin Wang, Haoyu Zhang, Wei Jie Seow, Jianxin Shi, Nilanjan Chatterjee, Jason Y.Y. Wong, Juncheng Dai, H. Dean Hosgood, I-Shou Chang, Jiyeon Choi, Wei Hu, Wei Zheng, Young Tae Kim, Xiao-Ou Shu, Qiuyin Cai, Pan-Chyr Yang, Dongxin Lin, Kexin Chen, Yi-Long Wu, Hongbin Shen, Takashi Kohno, Stephen J. Chanock, Nathaniel Rothman, Qing Lan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6149.
https://doi.org/10.1158/1538-7445.AM2024-6149
Published: 22 March 2024
View articletitled, Abstract 6149: Polygenic risk score and lung adenocarcinoma risk among never-smokers by EGFR mutation status
Journal Articles

Abstract 4200: Association between reproductive factors with lung cancer incidence and mortality: A pooled analysis of over 308,000 females in the Asia Cohort Consortium

Xin Yin, Rie Kishida, Sarah Krull Abe, Md. Rashedul Islam, Md. Shafiur Rahman, Eiko Saito, Qing Lan, Batel Bletcher, Melissa Merritt, Ji-Yeob Choi, Aesun Shin, Ryoko Katagiri, Xiao-Ou Shu, Norie Sawada, Akiko Tamakoshi, Woon-Puay Koh, Ichiro Tsuji, Chisato Nagata, Sue K. Park, Sun-Seog Kweon, Yu-Tang Gao, Shoichiro Tsugane, Takashi Kimura, Jian-Min Yuan, Yukai Lu, Seiki Kanemura, Yumi Sugawara, Keiko Wada, Min-Ho Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang, Wei Jie Seow
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4200.
https://doi.org/10.1158/1538-7445.AM2023-4200
Published: 04 April 2023
View articletitled, Abstract 4200: Association between reproductive factors with lung cancer incidence and mortality: A pooled analysis of over 308,000 females in the Asia Cohort Consortium
Journal Articles

Abstract 2248: Environmental factors associated with residual disease after ovarian cancer primary cytoreduction surgery

Minh Tung Phung, Andrew Berchuck, Ellen L. Goode, Marc T. Goodman, Gillian E. Hanley, Jean Richardson, Bronwyn Grout, Anne Chase, Cindy McKinnon Deurloo, Beth Y. Karlan, Toon Van Gorp, Keitaro Matsuo, Karen McLean, Malcolm C. Pike, Joellen M. Schildkraut, Kathryn L. Terry, Anna DeFazio, Penelope M. Webb, Paul D. P. Pharoah, Susan J. Ramus, Celeste Leigh Pearce
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2248.
https://doi.org/10.1158/1538-7445.AM2022-2248
Published: 15 June 2022
View articletitled, Abstract 2248: Environmental factors associated with residual disease after ovarian cancer primary cytoreduction surgery
Journal Articles

Abstract 3486: Body mass index and colorectal cancer risk in Japanese populations: a Mendelian randomization study

Shiori Suzuki, Atsushi Goto, Masahiro Nakatochi, Akira Narita, Taiki Yamaji, Norie Sawada, Ryoko Katagiri, Tsuyoshi Hachiya, Yoichi Sutoh, Isao Oze, Yuriko Koyanagi, Yumiko Kasugai, Hidemi Ito, Hiroaki Ikezaki, Keitaro Tanaka, Takashi Tamura, Haruo Mikami, Toshiro Takezaki, Sadao Suzuki, Nagato Kuriyama, Kiyonori Kuriki, Yoshikuni Kita, Kokichi Arisawa, Kenji Takeuchi, Kozo Tanno, Atsushi Shimizu, Gen Tamiya, Atsushi Hozawa, Kengo Kinoshita, Kenji Wakai, Makoto Sasaki, Masayuki Yamamoto, Keitaro Matsuo, Shoichiro Tsugane, Motoki Iwasaki
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3486.
https://doi.org/10.1158/1538-7445.AM2020-3486
Published: 15 August 2020
View articletitled, Abstract 3486: Body mass index and colorectal cancer risk in Japanese populations: a Mendelian randomization study
Journal Articles

Across-Site Differences in the Mechanism of Alcohol-Induced Digestive Tract Carcinogenesis: An Evaluation by Mediation Analysis

Yuriko N. Koyanagi, Etsuji Suzuki, Issei Imoto, Yumiko Kasugai, Isao Oze, Tomotaka Ugai, Madoka Iwase, Yoshiaki Usui, Yukino Kawakatsu, Michi Sawabe, Yutaka Hirayama, Tsutomu Tanaka, Tetsuya Abe, Seiji Ito, Koji Komori, Nobuhiro Hanai, Masahiro Tajika, Yasuhiro Shimizu, Yasumasa Niwa, Hidemi Ito, Keitaro Matsuo
Journal: Cancer Research
Cancer Res (2020) 80 (7): 1601–1610.
https://doi.org/10.1158/0008-5472.CAN-19-2685
Published: 02 April 2020
View articletitled, Across-Site Differences in the Mechanism of Alcohol-Induced Digestive Tract Carcinogenesis: An Evaluation by Mediation Analysis
Open the PDF for Across-Site Differences in the Mechanism of Alcohol-Induced Digestive Tract Carcinogenesis: An Evaluation by Mediation Analysis in another window
Includes: Supplementary data
Journal Articles

Abstract LB-174: Genome-wide association meta-analysis identifies novel GP2 gene risk variants for pancreatic cancer in the Japanese population

Yingsong Lin, Masahiro Nakatochi, Hidemi Ito, Yoichiro Kamatani, Hiromi Sakamoto, Hiroshi Ishii, Naoki Sasahira, Makoto Ueno, Naoto Egawa, Mitsuru Mori, Haruhisa Nakao, Yasushi Adachi, Kenji Wakai, Shoichiro Tsugane, Masayuki Yamamoto, Atsushi Shimizu, Takashi Kadowaki, Teruhiko Yoshida, Fumihiko Matsuda, Michiaki Kubo, Shogo Kikuchi, Keitaro Matsuo
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-174.
https://doi.org/10.1158/1538-7445.AM2019-LB-174
Published: 01 July 2019
View articletitled, Abstract LB-174: Genome-wide association meta-analysis identifies novel GP2 gene risk variants for pancreatic cancer in the Japanese population
Journal Articles

Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk

Yaohua Yang, Lang Wu, Xiang Shu, Yingchang Lu, Xiao-Ou Shu, Qiuyin Cai, Alicia Beeghly-Fadiel, Bingshan Li, Fei Ye, Andrew Berchuck, Hoda Anton-Culver, Susana Banerjee, Javier Benitez, Line Bjørge, James D. Brenton, Ralf Butzow, Ian G. Campbell, Jenny Chang-Claude, Kexin Chen, Linda S. Cook, Daniel W. Cramer, Anna deFazio, Joe Dennis, Jennifer A. Doherty, Thilo Dörk, Diana M. Eccles, Digna Velez Edwards, Peter A. Fasching, Renée T. Fortner, Simon A. Gayther, Graham G. Giles, Rosalind M. Glasspool, Ellen L. Goode, Marc T. Goodman, Jacek Gronwald, Holly R. Harris, Florian Heitz, Michelle A. Hildebrandt, Estrid Høgdall, Claus K. Høgdall, David G. Huntsman, Siddhartha P. Kar, Beth Y. Karlan, Linda E. Kelemen, Lambertus A. Kiemeney, Susanne K. Kjaer, Anita Koushik, Diether Lambrechts, Nhu D. Le, Douglas A. Levine, Leon F. Massuger, Keitaro Matsuo, Taymaa May, Iain A. McNeish, Usha Menon, Francesmary Modugno, Alvaro N. Monteiro, Patricia G. Moorman, Kirsten B. Moysich, Roberta B. Ness, Heli Nevanlinna, Håkan Olsson, N. Charlotte Onland-Moret, Sue K. Park, James Paul, Celeste L. Pearce, Tanja Pejovic, Catherine M. Phelan, Malcolm C. Pike, Susan J. Ramus, Elio Riboli, Cristina Rodriguez-Antona, Isabelle Romieu, Dale P. Sandler, Joellen M. Schildkraut, Veronica W. Setiawan, Kang Shan, Nadeem Siddiqui, Weiva Sieh, Meir J. Stampfer, Rebecca Sutphen, Anthony J. Swerdlow, Lukasz M. Szafron, Soo Hwang Teo, Shelley S. Tworoger, Jonathan P. Tyrer, Penelope M. Webb, Nicolas Wentzensen, Emily White, Walter C. Willett, Alicja Wolk, Yin Ling Woo, Anna H. Wu, Li Yan, Drakoulis Yannoukakos, Georgia Chenevix-Trench, Thomas A. Sellers, Paul D.P. Pharoah, Wei Zheng, Jirong Long
Journal: Cancer Research
Cancer Res (2019) 79 (3): 505–517.
https://doi.org/10.1158/0008-5472.CAN-18-2726
Published: 01 February 2019
View articletitled, Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk
Open the PDF for Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk in another window
Includes: Supplementary data
Journal Articles

Abstract 3369: Mosaic chromosome X copy-number aberrations in leukocytes of never-smoking lung cancer patients: The Female Lung Cancer Consortium in Asia (FLCCA)

Jason Y. Wong, Mitchell Machiela, Weiyin Zhou, Wei Jie Seow, Bryan Bassig, Jinming Zhang, Meredith Yeager, Wei Zheng, Xiao-Ou Shu, Hongbing Shen, Keitaro Matsuo, Chao Agnes Hsiung, Maria P. Wong, Yun-Chul Hong, Jiu-cun Wang, Yi-Long Wu, Baosen Zhou, Robert Klein, Zhihua Yin, Tangchun Wu, Pan-Chyr Yang, Yong-Bing Xiang, Adeline Seow, Yu-Tang Gao, Chen Wu, Jianjun Liu, Zhibin Hu, Laurie Burdett, Qiuyin Cai, Juncheng Dai, Dongxin Lin, Kexin Chen, Stephen Chanock, Nathaniel Rothman, Qing Lan
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3369.
https://doi.org/10.1158/1538-7445.AM2018-3369
Published: 01 July 2018
View articletitled, Abstract 3369: Mosaic chromosome X copy-number aberrations in leukocytes of never-smoking lung cancer patients: The Female Lung Cancer Consortium in Asia (FLCCA)
Journal Articles

Abstract 2282: Smoking and alcohol and the risk of myelodysplastic syndrome: The JPHC study

Tomotaka Ugai, Keitaro Matsuo, Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Taichi Shimazu, Shizuka Sasazuki, Manami Inoue, Yoshinobu Kanda, Shoichiro Tsugane
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2282.
https://doi.org/10.1158/1538-7445.AM2017-2282
Published: 01 July 2017
View articletitled, Abstract 2282: Smoking and alcohol and the risk of myelodysplastic syndrome: The JPHC study
Journal Articles

BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer

Hermela Shimelis, Romy L.S. Mesman, Catharina Von Nicolai, Asa Ehlen, Lucia Guidugli, Charlotte Martin, Fabienne M.G.R. Calléja, Huong Meeks, Emily Hallberg, Jamie Hinton, Jenna Lilyquist, Chunling Hu, Cora M. Aalfs, Kristiina Aittomäki, Irene Andrulis, Hoda Anton-Culver, Volker Arndt, Matthias W. Beckmann, Javier Benitez, Natalia V. Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Anne-Lise Borresen-Dale, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Annegien Broeks, Barbara Brouwers, Thomas Brüning, Barbara Burwinkel, Jenny Chang-Claude, Georgia Chenevix-Trench, Ching-Yu Cheng, Ji-Yeob Choi, J. Margriet Collée, Angela Cox, Simon S. Cross, Kamila Czene, Hatef Darabi, Joe Dennis, Thilo Dörk, Isabel dos-Santos-Silva, Alison M. Dunning, Peter A. Fasching, Jonine Figueroa, Henrik Flyger, Montserrat García-Closas, Graham G. Giles, Gord Glendon, Pascal Guénel, Christopher A. Haiman, Per Hall, Ute Hamann, Mikael Hartman, Frans B. Hogervorst, Antoinette Hollestelle, John L. Hopper, Hidemi Ito, Anna Jakubowska, Daehee Kang, Veli-Matti Kosma, Vessela Kristensen, Kah-Nyin Lai, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Annika Lindblom, Artitaya Lophatananon, Jan Lubinski, Eva Machackova, Arto Mannermaa, Sara Margolin, Frederik Marme, Keitaro Matsuo, Hui Miao, Kyriaki Michailidou, Roger L. Milne, Kenneth Muir, Susan L. Neuhausen, Heli Nevanlinna, Janet E. Olson, Curtis Olswold, Jan J.C. Oosterwijk, Ana Osorio, Paolo Peterlongo, Julian Peto, Paul D.P. Pharoah, Katri Pylkäs, Paolo Radice, Muhammad Usman Rashid, Valerie Rhenius, Anja Rudolph, Suleeporn Sangrajrang, Elinor J. Sawyer, Marjanka K. Schmidt, Minouk J. Schoemaker, Caroline Seynaeve, Mitul Shah, Chen-Yang Shen, Martha Shrubsole, Xiao-Ou Shu, Susan Slager, Melissa C. Southey, Daniel O. Stram, Anthony Swerdlow, Soo H. Teo, Ian Tomlinson, Diana Torres, Thérèse Truong, Christi J. van Asperen, Lizet E. van der Kolk, Qin Wang, Robert Winqvist, Anna H. Wu, Jyh-Cherng Yu, Wei Zheng, Ying Zheng, Jennifer Leary, Logan Walker, Lenka Foretova, Florentia Fostira, Kathleen B.M. Claes, Liliana Varesco, Setareh Moghadasi, Douglas F. Easton, Amanda Spurdle, Peter Devilee, Harry Vrieling, Alvaro N.A. Monteiro, David E. Goldgar, Aura Carreira, Maaike P.G. Vreeswijk, Fergus J. Couch
Journal: Cancer Research
Cancer Res (2017) 77 (11): 2789–2799.
https://doi.org/10.1158/0008-5472.CAN-16-2568
Published: 31 May 2017
View articletitled, BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer
Open the PDF for BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2568: Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women

Qing Lan, Zhaoming Wang, Wei Jie Seow, Kouya Shiraishi, Hongbing Shen, Chao A. Hsiung, Keitaro Matsuo, Jie Liu, Kexin Chen, Taiki Yamji, Yang Yang, I-Shou Chang, Chen Wu, Meredith Yeager, Takashi Kohno, Wei Zheng, Xiao-Ou Shu, Pan-Chyr Yang, Tangchun Wu, Dongxin Lin, Baosen Zhou, Jinming Yu, Michiaki Kubo, Stephen J. Chanock, Nathaniel Rothman
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2568.
https://doi.org/10.1158/1538-7445.AM2016-2568
Published: 15 July 2016
View articletitled, Abstract 2568: Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women
Journal Articles

Abstract 820: Molecular epidemiological studies of germinal center-associated nuclear protein (ganp) in the development of human sporadic breast cancers

Kazuhiko Kuwahara, Hidemi Ito, Kiyotaka Kuzushima, Hiroji Iwata, Hideo Tanaka, Keitaro Matsuo
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 820.
https://doi.org/10.1158/1538-7445.AM2016-820
Published: 15 July 2016
View articletitled, Abstract 820: Molecular epidemiological studies of germinal center-associated nuclear protein (ganp) in the development of human sporadic breast cancers
Journal Articles

Abstract 2591: Risk prediction for stomach cancer using helicobacter pylori infection and atrophic gastritis, fruits and vegetables, smoking and GWAS-identified genetic polymorphism (PSCA-rs2294008) in a Japanese population

Hidemi Ito, Isao Oze, Satoyo Hosono, Miki Watanabe, Hideo Tanaka, Keitaro Matsuo
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2591.
https://doi.org/10.1158/1538-7445.AM2016-2591
Published: 15 July 2016
View articletitled, Abstract 2591: Risk prediction for stomach cancer using helicobacter pylori infection and atrophic gastritis, fruits and vegetables, smoking and GWAS-identified genetic polymorphism (PSCA-rs2294008) in a Japanese population
Journal Articles

Abstract 4751: Genetic subtype-specific prognostic significance of genetic alterations in lower-grade gliomas

Kosuke Aoki, Hiromichi Suzuki, Hideo Nakamura, Keitaro Matsuo, Kazuya Motomura, Fumiharu Ohka, Masahiro Mizoguchi, Yasutomo Momii, Yasuhiro Muragaki, Satoru Miyano, Toshihiko Wakabayashi, Atsushi Natsume, Seishi Ogawa
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4751.
https://doi.org/10.1158/1538-7445.AM2016-4751
Published: 15 July 2016
View articletitled, Abstract 4751: Genetic subtype-specific prognostic significance of genetic alterations in lower-grade gliomas
Journal Articles

Abstract 794: A genetic polymorphism of ALDH2 and breast cancer risk: an analysis of 6,624 cases and 5,750 controls from the Breast Cancer Association Consortium

Tomotaka Ugai, Roger L. Milne, Hidemi Ito, Keitaro Matsuo
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 794.
https://doi.org/10.1158/1538-7445.AM2016-794
Published: 15 July 2016
View articletitled, Abstract 794: A genetic polymorphism of ALDH2 and breast cancer risk: an analysis of 6,624 cases and 5,750 controls from the Breast Cancer Association Consortium
Journal Articles

Abstract 4618: The risk prediction for esophageal cancer by drinking, smoking, and the polymorphisms of ALDH2 and ADH1B

Hidemi Ito, Isao Oze, Satoyo Hosono, Miki Watanabe, Hideo Tanaka, Keitaro Matsuo
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4618.
https://doi.org/10.1158/1538-7445.AM2015-4618
Published: 01 August 2015
View articletitled, Abstract 4618: The risk prediction for esophageal cancer by drinking, smoking, and the polymorphisms of ALDH2 and ADH1B
Journal Articles

Abstract 4596: Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: A report from the Female Lung Cancer Consortium in Asia

Mitchell J. Machiela, Chao A. Hsiung, Xiao-Ou Shu, Wei J. Seow, Zhaoming Wang, Keitaro Matsuo, Yun-Chul Hong, Adeline Seow, Chen Wu, H Dean Hosgood, Kexin Chen, Jiu-Cun Wang, Wanqing Wen, Tangchun Wu, Maria P. Wong, Yi-Long Wu, Pan-Chyr Yang, Baosen Zhou, Min-Ho Shin, Joseph F. Fraumeni, Wei Zheng, Dongxin Lin, Stephen J. Chanock, Nathaniel Rothman, Qing Lan
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4596.
https://doi.org/10.1158/1538-7445.AM2015-4596
Published: 01 August 2015
View articletitled, Abstract 4596: Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: A report from the Female Lung Cancer Consortium in Asia
Journal Articles

Abstract 2780: Evaluation of genetic variants in high and moderate-penetrance breast cancer susceptibility genes in East Asians

Mi-Ryung Han, Xiao-Ou Shu, Qiuyin Cai, Yu-Tang Gao, Ying Zheng, Kyriaki Michailidou, Joe Dennis, Manjeet K. Bolla, Qin Wang, Ji-Yeob Choi, Mikael Hartman, Daehee Kang, Artitaya Lophatananon, Hui Miao, Keitaro Matsuo, Kenneth Muir, Sulee Sangrajrang, Chen-Yang Shen, Soo Hwang Teo, Anna H Wu, Alison M. Dunning, Paul D. P. Pharoah, Douglas F. Easton, Wei Zheng, Jirong Long
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2780.
https://doi.org/10.1158/1538-7445.AM2015-2780
Published: 01 August 2015
View articletitled, Abstract 2780: Evaluation of genetic variants in high and moderate-penetrance breast cancer susceptibility genes in East Asians
Journal Articles

Abstract 2210: Cumulative risks of gastric cancer by PSCA polymorphism, Helicobacter Pylori infection and smoking history in Japan

Hidemi Ito, Isao Oze, Satoyo Hosono, Miki Watanabe, Hideo Tanaka, Keitaro Matsuo
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2210.
https://doi.org/10.1158/1538-7445.AM2014-2210
Published: 01 October 2014
View articletitled, Abstract 2210: Cumulative risks of gastric cancer by PSCA polymorphism, Helicobacter Pylori infection and smoking history in Japan