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Keiran S.M. Smalley
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Journal Articles

Abstract LB239: Downregulation of spliceosomal proteins hnRNPH1 and H2 in WM266-4 melanoma cells induces immune signaling

Maab Sultan, Juan Diez, Keiran S.M. Smalley, Vladimir Beljanski, Lubov Nathonson, Dmitriy Minond
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB239.
https://doi.org/10.1158/1538-7445.AM2023-LB239
Published: 14 April 2023
View article titled, Abstract LB239: Downregulation of spliceosomal proteins hnRNPH1 and H2 in WM266-4 melanoma cells induces immune signaling
Journal Articles

Space Is the Place: Mapping the Cell–Cell Interactions That Predict Immunotherapy Responses in Melanoma

Inna Smalley, Keiran S.M. Smalley
Journal: Cancer Research
Cancer Res (2022) 82 (18): 3198–3200.
https://doi.org/10.1158/0008-5472.CAN-22-2192
Published: 16 September 2022
View article titled, Space Is the Place: Mapping the Cell–Cell Interactions That Predict Immunotherapy Responses in Melanoma
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Journal Articles

MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer

Mengyu Xie, Hong Zheng, Ranjna Madan-Lala, Wenjie Dai, Nicholas T. Gimbrone, Zhihua Chen, Fumi Kinose, Sarah A. Blackstone, Keiran S.M. Smalley, W. Douglas Cress, Eric B. Haura, Uwe Rix, Amer A. Beg
Journal: Cancer Research
Cancer Res (2019) 79 (22): 5812–5825.
https://doi.org/10.1158/0008-5472.CAN-19-0698
Published: 15 November 2019
View article titled, MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer
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Includes: Supplementary data
Journal Articles

HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy

Michael F. Emmons, Fernanda Faião-Flores, Ritin Sharma, Ram Thapa, Jane L. Messina, Jurgen C. Becker, Dirk Schadendorf, Edward Seto, Vernon K. Sondak, John M. Koomen, Yian A. Chen, Eric K. Lau, Lixin Wan, Jonathan D. Licht, Keiran S.M. Smalley
Journal: Cancer Research
Cancer Res (2019) 79 (11): 2947–2961.
https://doi.org/10.1158/0008-5472.CAN-19-0040
Published: 03 June 2019
View article titled, HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy
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Includes: Supplementary data
Journal Articles

Abstract 1610: MAPK inhibitor resistance leads to ligand-independent Ephrin A2 receptor signaling and the formation of new melanoma metastases

Kim H. T. Paraiso, Meghna Das Thakur, Jobin K. John, Bin Fang, John M. Koomen, Inna V. Fedorenko, Hensin Tsao, Keith T. Flaherty, Jane L. Messina, Elena M. Pasquale, Alejandro Villagra, John M. Kirkwood, Friedegund Meier, Sarah Sloot, Geoffrey T. Gibney, Darrin Stuart, Hussein Tawbi, Keiran S.M. Smalley
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1610.
https://doi.org/10.1158/1538-7445.AM2014-1610
Published: 01 October 2014
View article titled, Abstract 1610: MAPK inhibitor resistance leads to ligand-independent Ephrin A2 receptor signaling and the formation of new melanoma metastases
Journal Articles

Senescent Fibroblasts in Melanoma Initiation and Progression: An Integrated Theoretical, Experimental, and Clinical Approach

Eunjung Kim, Vito Rebecca, Inna V. Fedorenko, Jane L. Messina, Rahel Mathew, Silvya S. Maria-Engler, David Basanta, Keiran S.M. Smalley, Alexander R.A. Anderson
Journal: Cancer Research
Cancer Res (2013) 73 (23): 6874–6885.
https://doi.org/10.1158/0008-5472.CAN-13-1720
Published: 01 December 2013
View article titled, Senescent Fibroblasts in Melanoma Initiation and Progression: An Integrated Theoretical, Experimental, and Clinical Approach
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Includes: Multimedia, Supplementary data
Journal Articles

Abstract 5370: PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression

Kim H. Paraiso, Vito Rebecca, Inna V. Fedorenko, Yun Xiang, Elizabeth Wood, Alexander R. Anderson, Vernon K. Sondak, Ethan V. Abel, John M. Koomen, Jane L. Messina, Keiran S.M Smalley
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5370.
https://doi.org/10.1158/1538-7445.AM2011-5370
Published: 15 April 2011
View article titled, Abstract 5370: PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression
Journal Articles

Abstract 5111: Integrative phospho-proteomic and genomic analyses identify AXL as a potential biomarker and therapeutic target for NRAS-mutated melanoma

Inna V. Fedorenko, Kim H.T. Paraiso, Beulah D. Joseph, Bin Fang, John Koomen, Steven Eschrich, Katherine L. Nathanson, Bradly Wubbenhorst, Rahel Mathew, Jane Messina, Keiran S.M. Smalley
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5111.
https://doi.org/10.1158/1538-7445.AM2011-5111
Published: 15 April 2011
View article titled, Abstract 5111: Integrative phospho-proteomic and genomic analyses identify AXL as a potential biomarker and therapeutic target for NRAS-mutated melanoma
Journal Articles

PTEN Loss Confers BRAF Inhibitor Resistance to Melanoma Cells through the Suppression of BIM Expression

Kim H.T. Paraiso, Yun Xiang, Vito W. Rebecca, Ethan V. Abel, Y. Ann Chen, A. Cecilia Munko, Elizabeth Wood, Inna V. Fedorenko, Vernon K. Sondak, Alexander R.A. Anderson, Antoni Ribas, Maurizia Dalla Palma, Katherine L. Nathanson, John M. Koomen, Jane L. Messina, Keiran S.M. Smalley
Journal: Cancer Research
Cancer Res (2011) 71 (7): 2750–2760.
https://doi.org/10.1158/0008-5472.CAN-10-2954
Published: 31 March 2011
View article titled, PTEN Loss Confers BRAF Inhibitor Resistance to Melanoma Cells through the Suppression of BIM Expression
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Includes: Supplementary data
Journal Articles

Genetic Subgrouping of Melanoma Reveals New Opportunities for Targeted Therapy

Keiran S.M. Smalley, Katherine L. Nathanson, Keith T. Flaherty
Journal: Cancer Research
Cancer Res (2009) 69 (8): 3241–3244.
https://doi.org/10.1158/0008-5472.CAN-08-4305
Published: 15 April 2009
View article titled, Genetic Subgrouping of Melanoma Reveals New Opportunities for Targeted Therapy
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Journal Articles

Identification of a Novel Subgroup of Melanomas with KIT/Cyclin-Dependent Kinase-4 Overexpression

Keiran S.M. Smalley, Rooha Contractor, Thiennga K. Nguyen, Min Xiao, Robin Edwards, Viswanathan Muthusamy, Alastair J. King, Keith T. Flaherty, Marcus Bosenberg, Meenhard Herlyn, Katherine L. Nathanson
Journal: Cancer Research
Cancer Res (2008) 68 (14): 5743–5752.
https://doi.org/10.1158/0008-5472.CAN-08-0235
Published: 15 July 2008
View article titled, Identification of a Novel Subgroup of Melanomas with KIT/Cyclin-Dependent Kinase-4 Overexpression
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Includes: Supplementary data
Journal Articles

An Organometallic Protein Kinase Inhibitor Pharmacologically Activates p53 and Induces Apoptosis in Human Melanoma Cells

Keiran S.M. Smalley, Rooha Contractor, Nikolas K. Haass, Angela N. Kulp, G. Ekin Atilla-Gokcumen, Douglas S. Williams, Howard Bregman, Keith T. Flaherty, Maria S. Soengas, Eric Meggers, Meenhard Herlyn
Journal: Cancer Research
Cancer Res (2007) 67 (1): 209–217.
https://doi.org/10.1158/0008-5472.CAN-06-1538
Published: 08 January 2007
View article titled, An Organometallic Protein Kinase Inhibitor Pharmacologically Activates p53 and Induces Apoptosis in Human Melanoma Cells
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Includes: Supplementary data
Journal Articles

Demonstration of a Genetic Therapeutic Index for Tumors Expressing Oncogenic BRAF by the Kinase Inhibitor SB-590885

Alastair J. King, Denis R. Patrick, Roberta S. Batorsky, Maureen L. Ho, Hieu T. Do, Shu Yun Zhang, Rakesh Kumar, David W. Rusnak, Andrew K. Takle, David M. Wilson, Erin Hugger, Lifu Wang, Florian Karreth, Julie C. Lougheed, Jae Lee, David Chau, Thomas J. Stout, Earl W. May, Cynthia M. Rominger, Michael D. Schaber, Lusong Luo, Ami S. Lakdawala, Jerry L. Adams, Rooja G. Contractor, Keiran S.M. Smalley, Meenhard Herlyn, Michael M. Morrissey, David A. Tuveson, Pearl S. Huang
Journal: Cancer Research
Cancer Res (2006) 66 (23): 11100–11105.
https://doi.org/10.1158/0008-5472.CAN-06-2554
Published: 04 December 2006
View article titled, Demonstration of a Genetic Therapeutic Index for Tumors Expressing Oncogenic <em>BRAF</em> by the Kinase Inhibitor SB-590885
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Includes: Supplementary data
Journal Articles

Notch1 Signaling Promotes Primary Melanoma Progression by Activating Mitogen-Activated Protein Kinase/Phosphatidylinositol 3-Kinase-Akt Pathways and Up-regulating N-Cadherin Expression

Zhao-Jun Liu, Min Xiao, Klara Balint, Keiran S.M. Smalley, Patricia Brafford, Ruihua Qiu, Chelsea C. Pinnix, Xueli Li, Meenhard Herlyn
Journal: Cancer Research
Cancer Res (2006) 66 (8): 4182–4190.
https://doi.org/10.1158/0008-5472.CAN-05-3589
Published: 17 April 2006
View article titled, Notch1 Signaling Promotes Primary Melanoma Progression by Activating Mitogen-Activated Protein Kinase/Phosphatidylinositol 3-Kinase-Akt Pathways and Up-regulating N-Cadherin Expression
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