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Journal Articles

Abstract 3430: FP008, a novel anti-PD-1×IL-10M fusion protein for cancer therapy

Ce Gu, Jiaojiao Ding, Baiguang Ren, Mengying Liang, Linhui Ye, Yingye Ou, Chang Zhou, Bingquan Shen, Jian Guo, Xiaodong Wu, Ke Chen, Yongting Huo, Di Lu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3430.
https://doi.org/10.1158/1538-7445.AM2025-3430
Published: 21 April 2025
View articletitled, Abstract 3430: FP008, a novel anti-PD-1×IL-10M fusion protein for cancer therapy
Journal Articles

Abstract 7016: PROTiNb: A novel platform for developing biodegraders targeting intracellular proteins

Hongzhuan Gu, Lijun Ye, Zexiu Huang, Dan Xu, Lizhen Zhan, Tian Wang, Liang Xiao, Yue Huang, Baiguang Ren, Chang Zhou, Ke Chen, Xiaodong Wu, Di Lu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7016.
https://doi.org/10.1158/1538-7445.AM2025-7016
Published: 21 April 2025
View articletitled, Abstract 7016: PROTiNb: A novel platform for developing biodegraders targeting intracellular proteins
Journal Articles

Abstract 3425: A novel anti-EGFR × IL-10M (FP010) fusion protein for solid tumor therapy

Jian Guo, Jiaojiao Ding, Ce Gu, Linhui Ye, Dujuan Zhu, Yingye Ou, Zhe Zhang, Baiguang Ren, Chang Zhou, Bingquan Shen, Xiaodong Wu, Ke Chen, Di Lu, Yongting Huo
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3425.
https://doi.org/10.1158/1538-7445.AM2025-3425
Published: 21 April 2025
View articletitled, Abstract 3425: A novel anti-EGFR × IL-10M (FP010) fusion protein for solid tumor therapy
Journal Articles

Abstract 7301: FP011, A tri-specific immune checkpoint inhibitor targeting PD-1 × TIGIT × PVRIG for cancer immunotherapy

Yuanyuan Wang, Liang Xiao, Fan Wu, Baiguang Ren, Chang Zhou, Peipei Hu, Ke Chen, Xiaodong Wu, Di Lu, Yongting Huo
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7301.
https://doi.org/10.1158/1538-7445.AM2025-7301
Published: 21 April 2025
View articletitled, Abstract 7301: FP011, A tri-specific immune checkpoint inhibitor targeting PD-1 × TIGIT × PVRIG for cancer immunotherapy
Journal Articles

Abstract 1634: Cyclin D1 induces Akt1 activity in RB deficient prostate cancer

Xuanmao Jiao, Anthony W. Ashton, Zhiping Li, Ritika Harish, Danni Li, Gordon Robertson, Duanwen Shen, Xiaoming Ju, Ke Chen, Wei Zhang, Samuel Archilefu, Kenneth A. Iczkowski, Hallgeir Rui, Beatrice Knudsen, Paul Timpson, Max Nobis, Richard G. Pestell
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1634.
https://doi.org/10.1158/1538-7445.AM2024-1634
Published: 22 March 2024
View articletitled, Abstract 1634: Cyclin D1 induces Akt1 activity in RB deficient prostate cancer
Journal Articles

Fatty Acid Oxidation Mediated by Malonyl-CoA Decarboxylase Represses Renal Cell Carcinoma Progression

Lijie Zhou, Yongbo Luo, Yuenan Liu, Youmiao Zeng, Junwei Tong, Mengting Li, Yaxin Hou, Kaixuan Du, Yabin Qi, Wenbang Pan, Yuanhao Liu, Rongli Wang, Fengyan Tian, Chaohui Gu, Ke Chen
Journal: Cancer Research
Cancer Res (2023) 83 (23): 3920–3939.
https://doi.org/10.1158/0008-5472.CAN-23-0969
Published: 01 December 2023
View articletitled, Fatty Acid Oxidation Mediated by Malonyl-CoA Decarboxylase Represses Renal Cell Carcinoma Progression
Open the PDF for Fatty Acid Oxidation Mediated by Malonyl-CoA Decarboxylase Represses Renal Cell Carcinoma Progression in another window
Includes: Supplementary data
Journal Articles

Abstract P2-17-05: Evaluation of safety, pharmacokinetics and pharmacodynamics of proxalutamide (GT0918), a potent androgen receptor (AR) blocker, in patients with metastatic breast cancer (mBC): Phase I dose escalation trial

Huiping Li, Ran Ran, Guohong Song, Hanfang Jiang, Ruyan Zhang, Yaxin Liu, Luping Meng, Phoebe Zhang, Ke Chen, Qiaoxia Zhou, Karl Zhou, Youzhi Tong
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P2-17-05.
https://doi.org/10.1158/1538-7445.SABCS19-P2-17-05
Published: 15 February 2020
View articletitled, Abstract P2-17-05: Evaluation of safety, pharmacokinetics and pharmacodynamics of proxalutamide (GT0918), a potent androgen receptor (AR) blocker, in patients with metastatic breast cancer (mBC): Phase I dose escalation trial
Journal Articles

Abstract 4615: eIF4B is a key effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways during Abl-mediated cellular transformation

Ke Chen, Jianning Li, Jilong Chen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4615.
https://doi.org/10.1158/1538-7445.AM2016-4615
Published: 15 July 2016
View articletitled, Abstract 4615: eIF4B is a key effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways during Abl-mediated cellular transformation
Journal Articles

Cyclin D1 Promotes Androgen-Dependent DNA Damage Repair in Prostate Cancer Cells

Mathew C. Casimiro, Gabriele Di Sante, Xiaoming Ju, Zhiping Li, Ke Chen, Marco Crosariol, Ismail Yaman, Michael Gormley, Hui Meng, Michael P. Lisanti, Richard G. Pestell
Journal: Cancer Research
Cancer Res (2016) 76 (2): 329–338.
https://doi.org/10.1158/0008-5472.CAN-15-0999
Published: 14 January 2016
View articletitled, Cyclin D1 Promotes Androgen-Dependent DNA Damage Repair in Prostate Cancer Cells
Open the PDF for Cyclin D1 Promotes Androgen-Dependent DNA Damage Repair in Prostate Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 4976: Inhibition of eIF4B suppresses the growth and induces the apoptosis of Bcr-Abl positive cells

Ke Chen, Jian-Ling Yang, Guijie Guo, Jilong Chen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4976.
https://doi.org/10.1158/1538-7445.AM2015-4976
Published: 01 August 2015
View articletitled, Abstract 4976: Inhibition of eIF4B suppresses the growth and induces the apoptosis of Bcr-Abl positive cells
Journal Articles

The Endogenous Cell-Fate Factor Dachshund Restrains Prostate Epithelial Cell Migration via Repression of Cytokine Secretion via a CXCL Signaling Module

Ke Chen, Kongming Wu, Xuanmao Jiao, Liping Wang, Xiaoming Ju, Min Wang, Gabriele Di Sante, Shaohua Xu, Qiong Wang, Kevin Li, Xin Sun, Congwen Xu, Zhiping Li, Mathew C. Casimiro, Adam Ertel, Sankar Addya, Peter A. McCue, Michael P. Lisanti, Chenguang Wang, Richard J. Davis, Graeme Mardon, Richard G. Pestell
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (10): 1992–2004.
https://doi.org/10.1158/0008-5472.CAN-14-0611
Published: 13 May 2015
View articletitled, The Endogenous Cell-Fate Factor Dachshund Restrains Prostate Epithelial Cell Migration via Repression of Cytokine Secretion via a CXCL Signaling Module
Open the PDF for The Endogenous Cell-Fate Factor Dachshund Restrains Prostate Epithelial Cell Migration via Repression of Cytokine Secretion via a CXCL Signaling Module in another window
Includes: Supplementary data
Journal Articles

Abstract A21: DACH1 blocks prostate cancer cell growth and interleukin-6 signaling

Kongming Wu, Ke Chen, Kevin Li, Jennifer D. Wu, Richard G. Pestell
Journal: Cancer Research
Cancer Res (2011) 71 (18_Supplement): A21.
https://doi.org/10.1158/1538-7445.FBCR11-A21
Published: 28 October 2014
View articletitled, Abstract A21: DACH1 blocks prostate cancer cell growth and interleukin-6 signaling
Journal Articles

Cyclin D1 Integrates Estrogen-Mediated DNA Damage Repair Signaling

Zhiping Li, Ke Chen, Xuanmao Jiao, Chenguang Wang, Nicole E. Willmarth, Mathew C. Casimiro, Weihua Li, Xiaoming Ju, Sung Hoon Kim, Michael P. Lisanti, John A. Katzenellenbogen, Richard G. Pestell
Journal: Cancer Research
Series: Author Choice
Cancer Res (2014) 74 (14): 3959–3970.
https://doi.org/10.1158/0008-5472.CAN-13-3137
Published: 14 July 2014
View articletitled, Cyclin D1 Integrates Estrogen-Mediated DNA Damage Repair Signaling
Open the PDF for Cyclin D1 Integrates Estrogen-Mediated DNA Damage Repair Signaling in another window
Includes: Supplementary data
Journal Articles

Cell Fate Factor DACH1 Represses YB-1–Mediated Oncogenic Transcription and Translation

Kongming Wu, Ke Chen, Chenguang Wang, Xuanmao Jiao, Liping Wang, Jie Zhou, Jing Wang, Zhiping Li, Sankar Addya, Poul H. Sorensen, Michael P. Lisanti, Andrew Quong, Adam Ertel, Richard G. Pestell
Journal: Cancer Research
Series: Author Choice
Cancer Res (2014) 74 (3): 829–839.
https://doi.org/10.1158/0008-5472.CAN-13-2466
Published: 02 February 2014
View articletitled, Cell Fate Factor DACH1 Represses YB-1–Mediated Oncogenic Transcription and Translation
Open the PDF for Cell Fate Factor DACH1 Represses YB-1–Mediated Oncogenic Transcription and Translation in another window
Includes: Supplementary data
Journal Articles

Identification of a Cyclin D1 Network in Prostate Cancer That Antagonizes Epithelial–Mesenchymal Restraint

Xiaoming Ju, Mathew C. Casimiro, Michael Gormley, Hui Meng, Xuanmao Jiao, Sanjay Katiyar, Marco Crosariol, Ke Chen, Min Wang, Andrew A. Quong, Michael P. Lisanti, Adam Ertel, Richard G. Pestell
Journal: Cancer Research
Cancer Res (2014) 74 (2): 508–519.
https://doi.org/10.1158/0008-5472.CAN-13-1313
Published: 16 January 2014
View articletitled, Identification of a Cyclin D1 Network in Prostate Cancer That Antagonizes Epithelial–Mesenchymal Restraint
Open the PDF for Identification of a Cyclin D1 Network in Prostate Cancer That Antagonizes Epithelial–Mesenchymal Restraint in another window
Includes: Supplementary data
Journal Articles

eIF4B Phosphorylation by Pim Kinases Plays a Critical Role in Cellular Transformation by Abl Oncogenes

Jianling Yang, Jun Wang, Ke Chen, Guijie Guo, Ruijiao Xi, Paul B. Rothman, Douglas Whitten, Lianfeng Zhang, Shile Huang, Ji-Long Chen
Journal: Cancer Research
Cancer Res (2013) 73 (15): 4898–4908.
https://doi.org/10.1158/0008-5472.CAN-12-4277
Published: 31 July 2013
View articletitled, eIF4B Phosphorylation by Pim Kinases Plays a Critical Role in Cellular Transformation by Abl Oncogenes
Open the PDF for eIF4B Phosphorylation by Pim Kinases Plays a Critical Role in Cellular Transformation by Abl Oncogenes in another window
Includes: Supplementary data
Journal Articles

EYA1 Phosphatase Function Is Essential to Drive Breast Cancer Cell Proliferation through Cyclin D1

Kongming Wu, Zhaoming Li, Shaoxin Cai, Lifeng Tian, Ke Chen, Jing Wang, Junbo Hu, Ye Sun, Xue Li, Adam Ertel, Richard G. Pestell
Journal: Cancer Research
Cancer Res (2013) 73 (14): 4488–4499.
https://doi.org/10.1158/0008-5472.CAN-12-4078
Published: 15 July 2013
View articletitled, EYA1 Phosphatase Function Is Essential to Drive Breast Cancer Cell Proliferation through Cyclin D1
Open the PDF for EYA1 Phosphatase Function Is Essential to Drive Breast Cancer Cell Proliferation through Cyclin D1 in another window
Includes: Supplementary data
Journal Articles

Dachshund Binds p53 to Block the Growth of Lung Adenocarcinoma Cells

Ke Chen, Kongming Wu, Shaoxin Cai, Wei Zhang, Jie Zhou, Jing Wang, Adam Ertel, Zhiping Li, Hallgeir Rui, Andrew Quong, Michael P. Lisanti, Aydin Tozeren, Ceylan Tanes, Sankar Addya, Michael Gormley, Chenguang Wang, Steven B. McMahon, Richard G. Pestell
Journal: Cancer Research
Cancer Res (2013) 73 (11): 3262–3274.
https://doi.org/10.1158/0008-5472.CAN-12-3191
Published: 30 May 2013
View articletitled, Dachshund Binds p53 to Block the Growth of Lung Adenocarcinoma Cells
Open the PDF for Dachshund Binds p53 to Block the Growth of Lung Adenocarcinoma Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 1319: Regulation of AR transcriptional activity and prostate cancer cellular proliferation by DACH1/Eya1/Six1 pathway.

Jing Wang, Shaoxin Cai, Ke Chen, Sean Li, Richard Pestell, Kongming Wu
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1319.
https://doi.org/10.1158/1538-7445.AM2013-1319
Published: 15 April 2013
View articletitled, Abstract 1319: Regulation of AR transcriptional activity and prostate cancer cellular proliferation by DACH1/Eya1/Six1 pathway.
Journal Articles

Abstract LB-16: DACH1 inhibited prostate cancer cellular proliferation and interleukin-6 signaling

Zhaoming Li, Junbo Hu, Ke Chen, Jennifer Wu, Richard G. Pestell, Kongming Wu
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-16.
https://doi.org/10.1158/1538-7445.AM2012-LB-16
Published: 15 April 2012
View articletitled, Abstract LB-16: DACH1 inhibited prostate cancer cellular proliferation and interleukin-6 signaling