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Journal Articles

Abstract 5517: Antitumor effect of LRIG1, negative regulator of ErbB, in lung cancer harboring mutant-EGFR

Hidejiro Torigoe, Shinichi Toyooka, Masakiyo Sakaguchi, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Shuta Tomida, Kazunori Tsukuda, Shinichiro Miyoshi

Cancer Res (2017) 77 (13_Supplement): 5517.

https://doi.org/10.1158/1538-7445.AM2017-5517

Published: 01 July 2017

View articletitled, Abstract 5517: Antitumor effect of LRIG1, negative regulator of ErbB, in lung cancer harboring mutant-EGFR

Journal Articles

Abstract 4194: Antitumor activity of multikinase inhibitors in HER2-positive gastric cancer cells

Takahiro Yoshioka, Kazuhiko Shien, Kei Namba, Hidejiro Torigoe, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Toshiyoshi Fujiwara, Shinichi Toyooka

Cancer Res (2017) 77 (13_Supplement): 4194.

https://doi.org/10.1158/1538-7445.AM2017-4194

Published: 01 July 2017

View articletitled, Abstract 4194: Antitumor activity of multikinase inhibitors in HER2-positive gastric cancer cells

Journal Articles

Abstract 3156: Multiple acquired resistance mechanisms against third generation EGFR-TKI osimeritinib in non-smal cell lung cancer cells

Kei Namba, Kazuhiko Shien, Takahiro Yoshioka, Hidejiro Torigoe, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichi Toyooka

Cancer Res (2017) 77 (13_Supplement): 3156.

https://doi.org/10.1158/1538-7445.AM2017-3156

Published: 01 July 2017

View articletitled, Abstract 3156: Multiple acquired resistance mechanisms against third generation EGFR-TKI osimeritinib in non-smal cell lung cancer cells

Journal Articles

Abstract 2249: Detection of EGFR mutations in circulating cell-free DNA of non-small cell lung cancer patients by next-generation sequencing

Ken Suzawa, Shuta Tomida, Takahiro Matsubara, Kadoaki Ohashi, Yuho Maki, Hiromasa Yamamoto, Mizuki Morita, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Katuyuki Kiura, Shinichiro Miyoshi, Shinichi Toyooka

Cancer Res (2016) 76 (14_Supplement): 2249.

https://doi.org/10.1158/1538-7445.AM2016-2249

Published: 15 July 2016

View articletitled, Abstract 2249: Detection of EGFR mutations in circulating cell-free DNA of non-small cell lung cancer patients by next-generation sequencing

Journal Articles

Abstract 4392: Yes1 is the key molecule for the resistance to trastuzumab in breast cancer, and dasatinib overcomes the resistance

Hiromasa Yamamoto, Tatsuaki Takeda, Hirotaka Kanzaki, Ken Suzawa, Kei Namba, Hiroki Sato, Hidejiro Torigoe, Mototsugu Watanabe, Yuho Maki, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Yoshihisa Kitamura, Toshiaki Sendo, Shinichi Toyooka

Cancer Res (2016) 76 (14_Supplement): 4392.

https://doi.org/10.1158/1538-7445.AM2016-4392

Published: 15 July 2016

View articletitled, Abstract 4392: Yes1 is the key molecule for the resistance to trastuzumab in breast cancer, and dasatinib overcomes the resistance

Journal Articles

Abstract 742: Effect of Hsp90 inhibitor NVP-AUY922 with radiation on lung adenocarcinoma cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors

Yuho Maki, Shinsuke Hashida, Hiromasa Yamamoto, Kazuhiko Shien, Tomoaki Ohtsuka, Ken Suzawa, Masashi Furukawa, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Susumu Kanazawa, Shinichi Toyooka

Cancer Res (2015) 75 (15_Supplement): 742.

https://doi.org/10.1158/1538-7445.AM2015-742

Published: 01 August 2015

View articletitled, Abstract 742: Effect of Hsp90 inhibitor NVP-AUY922 with radiation on lung adenocarcinoma cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors

Journal Articles

Abstract 358: The role of GDF-15 on docetaxel resistance in lung cancer

Mototsugu Watanabe, Yasutaka Masada, Shinsuke Hashida, Tomoaki Ohtsuka, Ken Suzawa, Yuho Maki, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichi Toyooka, Shinichiro Miyoshi

Cancer Res (2015) 75 (15_Supplement): 358.

https://doi.org/10.1158/1538-7445.AM2015-358

Published: 01 August 2015

View articletitled, Abstract 358: The role of GDF-15 on docetaxel resistance in lung cancer

Journal Articles

Abstract 48: Identification of a novel binding protein playing a critical role in HER2 activation in lung cancer cells

Tomoaki Ohtsuka, Masakiyo Sakaguchi, Katsuyoshi Takata, Shinsuke Hashida, Mototsugu Watanabe, Ken Suzawa, Yuho Maki, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka

Cancer Res (2015) 75 (15_Supplement): 48.

https://doi.org/10.1158/1538-7445.AM2015-48

Published: 01 August 2015

View articletitled, Abstract 48: Identification of a novel binding protein playing a critical role in HER2 activation in lung cancer cells

Journal Articles

Abstract 724: Anti-tumor effect of Dasatinib in HER2 positive breast cancer with Trastuzumab resistance

Tatsuaki Takeda, Hirotaka Kanzaki, Shinichi Toyooka, Mototsugu Watanabe, Tomoaki Ohtsuka, Ken Suzawa, Shinsuke Hashida, Yuho Maki, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Yoshihisa Kitamura, Toshiaki Sendo

Cancer Res (2015) 75 (15_Supplement): 724.

https://doi.org/10.1158/1538-7445.AM2015-724

Published: 01 August 2015

View articletitled, Abstract 724: Anti-tumor effect of Dasatinib in HER2 positive breast cancer with Trastuzumab resistance

Journal Articles

Abstract 5248: Non-invasive EGFR T790M detection using droplet digital PCR system

Shinsuke Hashida, Kadoaki Ohashi, Takehiro Matsubara, Tomoaki Ohtsuka, Mototsugu Watanabe, Ken Suzawa, Yuho Maki, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Katsuyuki Kiura, Shinichi Toyooka

Cancer Res (2015) 75 (15_Supplement): 5248.

https://doi.org/10.1158/1538-7445.AM2015-5248

Published: 01 August 2015

View articletitled, Abstract 5248: Non-invasive EGFR T790M detection using droplet digital PCR system

Journal Articles

Abstract 2588: Anti-tumor effect of afatinib, an irreversible EGFR/HER2 dual inhibitor, in lung cancers harboring HER2 oncogene

Ken Suzawa, Shinichi Toyooka, Masakiyo Sakaguchi, Tomoaki Ohtsuka, Mototsugu Watanabe, Shinsuke Hashida, Yuho Maki, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi

Cancer Res (2015) 75 (15_Supplement): 2588.

https://doi.org/10.1158/1538-7445.AM2015-2588

Published: 01 August 2015

View articletitled, Abstract 2588: Anti-tumor effect of afatinib, an irreversible EGFR/HER2 dual inhibitor, in lung cancers harboring HER2 oncogene

Journal Articles

Abstract LB-291: Novel germline G660D mutation in HER2 gene detected by whole-exome sequencing can predispose a patient to developing familial lung adenocarcinoma

Hiromasa Yamamoto, Koichiro Higasa, Masakiyo Sakaguchi, Kazuhiko Shien, Junichi Soh, Koichi Ichimura, Masashi Furukawa, Shinsuke Hashida, Kazunori Tsukuda, Nagio Takigawa, Keitaro Matsuo, Katsuyuki Kiura, Sinichiro Miyoshi, Fumihiko Matsuda, Shinichi Toyooka

Cancer Res (2014) 74 (19_Supplement): LB-291.

https://doi.org/10.1158/1538-7445.AM2014-LB-291

Published: 01 October 2014

View articletitled, Abstract LB-291: Novel germline G660D mutation in HER2 gene detected by whole-exome sequencing can predispose a patient to developing familial lung adenocarcinoma

Journal Articles

Abstract 1834: The molecular characters of acquired resistant non-small cell lung cancer cells to afatinib

Shinsuke Hashida, Shinichi Toyooka, Tomoaki Ohtsuka, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi

Cancer Res (2014) 74 (19_Supplement): 1834.

https://doi.org/10.1158/1538-7445.AM2014-1834

Published: 01 October 2014

View articletitled, Abstract 1834: The molecular characters of acquired resistant non-small cell lung cancer cells to afatinib

Journal Articles

Abstract 2879: Anti-cancer effects of REIC/Dkk-3-encoding adenoviral vector for the treatment of non-small cell lung cancer

Ken Suzawa, Shinichi Toyooka, Kazuhiko Shien, Norimitsu Tanaka, Masami Watanabe, Junichi Soh, Masakiyo Sakaguchi, Keitaro Matsuo, Hiromasa Yamamoto, Masashi Furukawa, Hiroaki Asano, Kazunori Tsukuda, Yasutomo Nasu, Nam-Ho Huh, Shinichiro Miyoshi, Hiromi Kumon

Cancer Res (2014) 74 (19_Supplement): 2879.

https://doi.org/10.1158/1538-7445.AM2014-2879

Published: 01 October 2014

View articletitled, Abstract 2879: Anti-cancer effects of REIC/Dkk-3-encoding adenoviral vector for the treatment of non-small cell lung cancer

Journal Articles

Abstract 5194: MiR-200c expression and methylation status determines epithelial characteristics of NSCLC

Kazuhiko Shien, Shinichi Toyooka, Junichi Soh, Hiromasa Yamamoto, Shinsuke Hashida, Ken Suzawa, Tomoaki Otsuka, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi

Cancer Res (2014) 74 (19_Supplement): 5194.

https://doi.org/10.1158/1538-7445.AM2014-5194

Published: 01 October 2014

View articletitled, Abstract 5194: MiR-200c expression and methylation status determines epithelial characteristics of NSCLC

Journal Articles

Acquired Resistance to EGFR Inhibitors Is Associated with a Manifestation of Stem Cell–like Properties in Cancer Cells

Kazuhiko Shien, Shinichi Toyooka, Hiromasa Yamamoto, Junichi Soh, Masaru Jida, Kelsie L. Thu, Shinsuke Hashida, Yuho Maki, Eiki Ichihara, Hiroaki Asano, Kazunori Tsukuda, Nagio Takigawa, Katsuyuki Kiura, Adi F. Gazdar, Wan L. Lam, Shinichiro Miyoshi

Cancer Res (2013) 73 (10): 3051–3061.

https://doi.org/10.1158/0008-5472.CAN-12-4136

Published: 12 May 2013

View articletitled, Acquired Resistance to EGFR Inhibitors Is Associated with a Manifestation of Stem Cell–like Properties in Cancer Cells

Includes: Supplementary data

Journal Articles

Abstract 2795: Establishment and molecular characterization of cell lines from Japanese patients with malignant pleural mesothelioma.

Ryuhei Tada, Hiromasa Yamamoto, Masashi Furukawa, Kazuhiko Shien, Shinsuke Hashida, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichi Toyooka, Shinichiro Miyoshi

Cancer Res (2013) 73 (8_Supplement): 2795.

https://doi.org/10.1158/1538-7445.AM2013-2795

Published: 15 April 2013

View articletitled, Abstract 2795: Establishment and molecular characterization of cell lines from Japanese patients with malignant pleural mesothelioma.

Journal Articles

Abstract 4460: Acquisition of stem cell-like properties during acquired resistance to epidermal growth factor receptor inhibitors.

Kazuhiko Shien, Shinichi Toyooka, Hiromasa Yamamoto, Junichi Soh, Kelsie L. Thu, Shinsuke Hashida, Yuho Maki, Eiki Ichihara, Hiroaki Asano, Kazunori Tsukuda, Nagio Takigawa, Katsuyuki Kiura, Adi F. Gazdar, Wan L. Lam, Shinichiro Miyoshi

Cancer Res (2013) 73 (8_Supplement): 4460.

https://doi.org/10.1158/1538-7445.AM2013-4460

Published: 15 April 2013

View articletitled, Abstract 4460: Acquisition of stem cell-like properties during acquired resistance to epidermal growth factor receptor inhibitors.

Journal Articles

Abstract 3149: Genetic alteration of lung adenocarcinomas with micropapillary component.

Masashi Furukawa, Shinichi Toyooka, Hiromasa Yamamoto, Ryuhei Tada, Shinsuke Hashida, Kazuhiko Shien, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Mamoru Ouchida, Kouichi Ichimura, Shinichiro Miyoshi

Cancer Res (2013) 73 (8_Supplement): 3149.

https://doi.org/10.1158/1538-7445.AM2013-3149

Published: 15 April 2013

View articletitled, Abstract 3149: Genetic alteration of lung adenocarcinomas with micropapillary component.

Journal Articles

Abstract 4219: A novel high-sensitive assay for detection of EGFR T790M mutation using high resolution melting analysis with mutant-enriched COLD PCR.

Shinsuke Hashida, Junichi Soh, Shinichi Toyooka, Ryuhei Tada, Kazuhiko Shien, Masashi Furukawa, Hiromasa Yamamoto, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi

Cancer Res (2013) 73 (8_Supplement): 4219.

https://doi.org/10.1158/1538-7445.AM2013-4219

Published: 15 April 2013

View articletitled, Abstract 4219: A novel high-sensitive assay for detection of EGFR T790M mutation using high resolution melting analysis with mutant-enriched COLD PCR.

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Abstract 5517: Antitumor effect of LRIG1, negative regulator of ErbB, in lung cancer harboring mutant-EGFR

Abstract 4194: Antitumor activity of multikinase inhibitors in HER2-positive gastric cancer cells

Abstract 3156: Multiple acquired resistance mechanisms against third generation EGFR-TKI osimeritinib in non-smal cell lung cancer cells

Abstract 2249: Detection of EGFR mutations in circulating cell-free DNA of non-small cell lung cancer patients by next-generation sequencing

Abstract 4392: Yes1 is the key molecule for the resistance to trastuzumab in breast cancer, and dasatinib overcomes the resistance

Abstract 742: Effect of Hsp90 inhibitor NVP-AUY922 with radiation on lung adenocarcinoma cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors

Abstract 358: The role of GDF-15 on docetaxel resistance in lung cancer

Abstract 48: Identification of a novel binding protein playing a critical role in HER2 activation in lung cancer cells

Abstract 724: Anti-tumor effect of Dasatinib in HER2 positive breast cancer with Trastuzumab resistance

Abstract 5248: Non-invasive EGFR T790M detection using droplet digital PCR system

Abstract 2588: Anti-tumor effect of afatinib, an irreversible EGFR/HER2 dual inhibitor, in lung cancers harboring HER2 oncogene

Abstract LB-291: Novel germline G660D mutation in HER2 gene detected by whole-exome sequencing can predispose a patient to developing familial lung adenocarcinoma

Abstract 1834: The molecular characters of acquired resistant non-small cell lung cancer cells to afatinib

Abstract 2879: Anti-cancer effects of REIC/Dkk-3-encoding adenoviral vector for the treatment of non-small cell lung cancer

Abstract 5194: MiR-200c expression and methylation status determines epithelial characteristics of NSCLC

Acquired Resistance to EGFR Inhibitors Is Associated with a Manifestation of Stem Cell–like Properties in Cancer Cells

Abstract 2795: Establishment and molecular characterization of cell lines from Japanese patients with malignant pleural mesothelioma.

Abstract 4460: Acquisition of stem cell-like properties during acquired resistance to epidermal growth factor receptor inhibitors.

Abstract 3149: Genetic alteration of lung adenocarcinomas with micropapillary component.

Abstract 4219: A novel high-sensitive assay for detection of EGFR T790M mutation using high resolution melting analysis with mutant-enriched COLD PCR.

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