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Kazufumi Ohshiro
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Journal Articles

Abstract 6671: Metabolic predictors in hepatocellular cancer

Brandon Mathew, Kazufumi Ohshiro, Krishanu Bhowmick, Xiyan Xiang, Srinivasan Dasarathy, Adrian R. Krainer, Lopa Mishra
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6671.
https://doi.org/10.1158/1538-7445.AM2025-6671
Published: 21 April 2025
View articletitled, Abstract 6671: Metabolic predictors in hepatocellular cancer
Journal Articles

Abstract 5181: SPTBN1D1089Y/+ aggravates liver carcinogenesis via activating SIRT6 and TGF-beta signaling

Kazufumi Ohshiro, Xiyan Xiang, Xiaochun Yang, Krishanu Bhowmick, Lopa Mishra
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5181.
https://doi.org/10.1158/1538-7445.AM2025-5181
Published: 21 April 2025
View articletitled, Abstract 5181: SPTBN1D1089Y/+ aggravates liver carcinogenesis via activating SIRT6 and TGF-beta signaling
Journal Articles

Abstract 6272: Loss of SIRT6 diverts TGF-β signaling to promote liver cancer

Kazufumi Ohshiro, Xiyan Xiang, Xiaochun Yang, Krishanu Bhowmick, Mohammad I. Hassan, Taj Mohammad, Lopa Mishra
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6272.
https://doi.org/10.1158/1538-7445.AM2024-6272
Published: 22 March 2024
View articletitled, Abstract 6272: Loss of SIRT6 diverts TGF-β signaling to promote liver cancer
Journal Articles

Abstract 753: CEACAM1 induces microbiome and metabolite driven diversion of TGF-β signaling to promote colon cancer

Krishanu Bhowmick, Kazufumi Ohshiro, Xiyan Xiang, Sahara John, Xiaochun Yang, Kevin Idicula, Nicole Beauchemin, Raja Mazumder, Keith A. Crandall, Mohammad I. Hassan, Taj Mohammad, Lopa Mishra
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 753.
https://doi.org/10.1158/1538-7445.AM2024-753
Published: 22 March 2024
View articletitled, Abstract 753: CEACAM1 induces microbiome and metabolite driven diversion of TGF-β signaling to promote colon cancer
Journal Articles

Abstract 3388: Targeting liver specific βII-Spectrin to prevent the development of metabolic dysfunction associated steatohepatitis (MASH) through CEACAM1 axis

Krishanu Bhowmick, Kazufumi Ohshiro, Xiyan Xiang, Sahara John, Xiaochun Yang, Nicole Beauchemin, Mohammad I. Hassan, Taj Mohammad, Lopa Mishra
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3388.
https://doi.org/10.1158/1538-7445.AM2024-3388
Published: 22 March 2024
View articletitled, Abstract 3388: Targeting liver specific βII-Spectrin to prevent the development of metabolic dysfunction associated steatohepatitis (MASH) through CEACAM1 axis
Journal Articles

Abstract 771: A TGF-β superfamily member, myostatin contributes to MASH and HCC via muscle atrophy by disrupting TGF-β signaling, and is a potential marker with PKM2 for human HCC

Kazufumi Ohshiro, Krishanu Bhowmick, Xiyan Xiang, Shivani Kapoor, Richard Amdur, Srinivasan Dasarathy, Adrian R. Krainer, Lopa Mishra
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 771.
https://doi.org/10.1158/1538-7445.AM2024-771
Published: 22 March 2024
View articletitled, Abstract 771: A TGF-β superfamily member, myostatin contributes to MASH and HCC via muscle atrophy by disrupting TGF-β signaling, and is a potential marker with PKM2 for human HCC
Journal Articles

Abstract 645: Impact of sex differences on cross-talk between the gut microbiome, CEACAMs, and TGF-β signaling in cancers

Krishanu Bhowmick, Addison Klebanov, Sahara John, Xiaochun Yang, Xiyan Xiang, Anil Vegesna, Kazufumi Ohshiro, James M. Crawford, Nicole Beauchemin, Raja Mazumder, Keith A. Crandall, Lopa Mishra
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 645.
https://doi.org/10.1158/1538-7445.AM2023-645
Published: 04 April 2023
View articletitled, Abstract 645: Impact of sex differences on cross-talk between the gut microbiome, CEACAMs, and TGF-β signaling in cancers
Journal Articles

Abstract 4854: PKM2 Modulates hepatic macrophage regulation of NASH, ferroptosis and HCC through TGF-β signaling

Kazufumi Ohshiro, Krishanu Bhowmick, Xiaochun Yang, Addison Klebanov, Sahara John, Dillon Voss, Adrian Krainer, Lopa Mishra
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4854.
https://doi.org/10.1158/1538-7445.AM2023-4854
Published: 04 April 2023
View articletitled, Abstract 4854: PKM2 Modulates hepatic macrophage regulation of NASH, ferroptosis and HCC through TGF-β signaling
Journal Articles

Abstract 5730: Targeting intrinsically disordered protein βII-spectrin prevents metabolic syndrome and hepatocellular carcinoma on a sex-based bias

Xiaochun Yang, Krishanu Bhowmick, Xiyan Xiang, Kazufumi Ohshiro, Anil Vegesna, Lopa Mishra
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5730.
https://doi.org/10.1158/1538-7445.AM2023-5730
Published: 04 April 2023
View articletitled, Abstract 5730: Targeting intrinsically disordered protein βII-spectrin prevents metabolic syndrome and hepatocellular carcinoma on a sex-based bias
Journal Articles

Abstract 1821: SPTBN1 Is a potential target to prevent progression of steatohepatitis to hepatocellular carcinoma

Xiaochun Yang, Shuyun Rao, Xiyan Xiang, Kazufumi Ohshiro, Patricia Latham, Kirti Shetty, Lopa Mishra
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1821.
https://doi.org/10.1158/1538-7445.AM2022-1821
Published: 15 June 2022
View articletitled, Abstract 1821: SPTBN1 Is a potential target to prevent progression of steatohepatitis to hepatocellular carcinoma
Journal Articles

Abstract 1463: Impaired reciprocal regulation between SIRT6 and TGF-β signaling as a potential mechanism for development and progression of fatty liver

Kazufumi Ohshiro, Xiyan Xiang, David Bernstein, James M. Crawford, Bibhuti Mishra, Patricia S. Latham, Nancy R. Gough, Shuyun Rao, Lopa Mishra
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1463.
https://doi.org/10.1158/1538-7445.AM2022-1463
Published: 15 June 2022
View articletitled, Abstract 1463: Impaired reciprocal regulation between SIRT6 and TGF-β signaling as a potential mechanism for development and progression of fatty liver
Journal Articles

Abstract 2910: A TGF-β-ALDH2 axis controls liver- brain-gut microbiome driven obesity, metabolic syndrome and cancer

Shuyun Rao, Xiaochun Yang, Zhanhuai Wang, Kazufumi Ohshiro, Sobia Zaidi, Wilma Jogunoori, Bryan Nguyen, Keith A. Crandall, Patricia S. Latham, Kirti Shetty, Lopa Mishra
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2910.
https://doi.org/10.1158/1538-7445.AM2021-2910
Published: 01 July 2021
View articletitled, Abstract 2910: A TGF-β-ALDH2 axis controls liver- brain-gut microbiome driven obesity, metabolic syndrome and cancer
Journal Articles

Abstract 89: A TGF-beta Pathway-SREBP1 axis controls liver diseases from nonalcoholic steatohepatitis to hepatocellular carcinoma

Shuyun Rao, Zhanhuai Wang, Kazufumi Ohshiro, Sobia Zaidi, Xiaochun Yang, Patricia Latham, Wilma Jogunoori, Xianyan Xiang, Inhee Chung, Kirti Shetty, Michele Vacca, Antonio Vidal-Puig, Lopa Mishra
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 89.
https://doi.org/10.1158/1538-7445.AM2021-89
Published: 01 July 2021
View articletitled, Abstract 89: A TGF-beta Pathway-SREBP1 axis controls liver diseases from nonalcoholic steatohepatitis to hepatocellular carcinoma
Journal Articles

Abstract 1984: Crosstalk between sirtuins and TGF-β signaling suppresses liver cancer

Xiyan Xiang, Sobia Zaidi, Shuyun Rao, Kazufumi Ohshiro, Zhanhuai Wang, Wilma Jogunoori, Chuxia Deng, Patricia Latham, Lopa Mishra
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1984.
https://doi.org/10.1158/1538-7445.AM2021-1984
Published: 01 July 2021
View articletitled, Abstract 1984: Crosstalk between sirtuins and TGF-β signaling suppresses liver cancer
Journal Articles

Abstract 4443: Targeting E3 ligase PJA1 via TGF-β pathway in hepatocellular carcinoma

Kazufumi Ohshiro, Jian Chen, Wilma Jogunoori, Chu-Xia Deng, Bibhuti Mishra, Shulin Li, Lopa Mishra
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4443.
https://doi.org/10.1158/1538-7445.AM2019-4443
Published: 01 July 2019
View articletitled, Abstract 4443: Targeting E3 ligase PJA1 via TGF-β pathway in hepatocellular carcinoma
Journal Articles

Abstract 3382: A pan-cancer analysis reveals high frequency genetic alterations in mediators of signaling by the TGF-β superfamily

Kazufumi Ohshiro, Sobia Zaidi, Anil Korkut, Jian Chen, Shuyun Rao, Shoujun Gu, Wilma Jogunoori, Bibhuti Mishra, Rehan Akbani, Lopa Mishra
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3382.
https://doi.org/10.1158/1538-7445.AM2019-3382
Published: 01 July 2019
View articletitled, Abstract 3382: A pan-cancer analysis reveals high frequency genetic alterations in mediators of signaling by the TGF-β superfamily
Journal Articles

Abstract 3413: A pan-cancer atlas of genomic, epigenomic and transcriptomic alterations in the TGF-β pathway

Anil Korkut, Sobia Zaidi, Rupa Kanchi, Ashton C. Berger, Gordon Robertson, Lawrence N. Kwong, Mike Datto, Jason Roszik, Shiyun Ling, Andre Schultz, Visweswaran Ravikumar, Ganiraju Manyam, Arvind Rao, Simon Shelley, Yuexin Liu, Zhenlin Ju, Donna Hansel, Guillermo de Velasco, Arjun Pennathur, Jesper B. Andersen, Colm J. O'Rourke, Kazufumi Ohshiro, Wilma Jogunoori, Nancy Gough, Shulin Li, Hatice Osmanbeyoglu, Andres Houseman, Shuyun Rao, Maciej Wiznerowicz, Jian Chen, Shoujun Gu, Wencai Ma, Jiexin Zhang, Pan Tong, Andrew D. Cherniack, Chuxia Deng, Linda Resar-Smith, Jaffer Ajani, The Cancer Genome Atlas Research Network, John N. Weinstein, Lopa Mishra, Rehan Akbani
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3413.
https://doi.org/10.1158/1538-7445.AM2018-3413
Published: 01 July 2018
View articletitled, Abstract 3413: A pan-cancer atlas of genomic, epigenomic and transcriptomic alterations in the TGF-β pathway
Journal Articles

Abstract 2226: TGF-β and CEACAMs regulated biomarkers detect early colorectal cancer

Sobia Zaidi, Anil Korkut, Wilma Jogunoori, Jian Chen, Shoujun Gu, Shuyun Rao, Kazufumi Ohshiro, Rehan Akbani, Chuxia Deng, Bibhuti Mishra, Lopa Mishra
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2226.
https://doi.org/10.1158/1538-7445.AM2018-2226
Published: 01 July 2018
View articletitled, Abstract 2226: TGF-β and CEACAMs regulated biomarkers detect early colorectal cancer
Journal Articles

Abstract 5459: Regulation of IGF2 by TGF-β signaling in liver cancers and stem cell homeostasis

Shuyun Rao, Sobia Zaidi, Kazufumi Ohshiro, Jian Chen, Shoujun Gu, Wilma Jogunoori, Jon White, Bibhuti Mishra, Shulin Li, Rehan Akbani, Lopa Mishra
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5459.
https://doi.org/10.1158/1538-7445.AM2018-5459
Published: 01 July 2018
View articletitled, Abstract 5459: Regulation of IGF2 by TGF-β signaling in liver cancers and stem cell homeostasis
Journal Articles

Abstract 5330: Targeting hepatocellular carcinoma through TGF-β pathway E3 ligases

Shuyun Rao, Heather Levin, Jian Chen, Rehan Akbani, Jon White, Wilma Jogunoori, Shoujun Gu, Kazufumi Ohshiro, Sobia Zaidi, Bibhuti Mishra, Asif Rashid, Shulin Li, Lopa Mishra
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5330.
https://doi.org/10.1158/1538-7445.AM2017-5330
Published: 01 July 2017
View articletitled, Abstract 5330: Targeting hepatocellular carcinoma through TGF-β pathway E3 ligases