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Journal Articles

Abstract 2931: AXL-directed surface targeting approaches in recalcitrant pulmonary high-grade neuroendocrine carcinomas

Free
Kavya Ramkumar, C. Allison Stewart, Yan Yang, Bingnan Zhang, Qi Wang, Yuanxin Xi, Runsheng Wang, Alejandra G. Serrano, Luisa M. Solis Soto, Jing Wang, John V. Heymach, Carl M. Gay, Lauren A. Byers
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2931.
https://doi.org/10.1158/1538-7445.AM2025-2931
Published: 21 April 2025
View articletitled, Abstract 2931: AXL-directed surface targeting approaches in recalcitrant pulmonary high-grade neuroendocrine carcinomas
Journal Articles

Abstract 6158: STING-MAVS interaction as novel immune mechanism of DNA-PK-inhibitor in SCLC

Free
Caterina De Rosa, Luisa Amato, Concetta Tuccillo, Francesca Iommelli, Viviana De Rosa, Virginia Tirino, Federica Papaccio, Kavya Ramkumar, Qi Wang, Jing Wang, Alberto Servetto, Floriana Morgillo, Lauren Averett Byers, Fortunato Ciardiello, Carminia Maria Della Corte
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6158.
https://doi.org/10.1158/1538-7445.AM2025-6158
Published: 21 April 2025
View articletitled, Abstract 6158: STING-MAVS interaction as novel immune mechanism of DNA-PK-inhibitor in SCLC
Journal Articles

Abstract 2895: Efficacy of DNA-PK inhibitor as maintenance strategy after cisplatin induction in SCLC

Free
Luisa Amato, Caterina De Rosa, Concetta Tuccillo, Francesca Iommelli, Viviana De Rosa, Virginia Tirino, Federica Papaccio, Kavya Ramkumar, Qi Wang, Jing Wang, Alberto Servetto, Floriana Morgillo, Lauren Averett Byers, Fortunato Ciardiello, Carminia Maria Della Corte
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2895.
https://doi.org/10.1158/1538-7445.AM2025-2895
Published: 21 April 2025
View articletitled, Abstract 2895: Efficacy of DNA-PK inhibitor as maintenance strategy after cisplatin induction in SCLC
Journal Articles

Abstract 2928: Combination surface targeting strategies in relapsed small cell lung cancer (SCLC) to overcome intratumoral heterogeneity associated with treatment resistance

Free
C. Allison Stewart, Kavya Ramkumar, Runsheng Wang, Yan Yang, Bingnan Zhang, Yuanxin Xi, Lixia Diao, Qi Wang, Alberto Duarte, Ping Li, Azusa Tanimoto, Alejandra G. Serrano, Jody Vykoukal, Mukulika Bose, Loukia G. Karacosta, Luisa Solis Soto, Samir Hanash, Jing Wang, John V. Heymach, Lauren Averett Byers, Carl M. Gay
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2928.
https://doi.org/10.1158/1538-7445.AM2025-2928
Published: 21 April 2025
View articletitled, Abstract 2928: Combination surface targeting strategies in relapsed small cell lung cancer (SCLC) to overcome intratumoral heterogeneity associated with treatment resistance
Journal Articles

Abstract 6392: Activity of HER2-and TROP2- antibody drug conjugates (ADCs) in small cell lung cancer (SCLC) models with SLFN11 as a predictive biomarker

Free
Bingnan Zhang, Ali Ibrahim, C.Allison Stewart, Lixia Diao, Qi Wang, Li Shen, Yuann xi, Alejandra Serrano, Luisa M. Solis, Wei-Lien Wang, Kavya Ramkumar, Robert J. Cardnell, Runsheng Wang, Alberto Duarte, Jing Wang, Lauren A. Byers, Carl Gay
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6392.
https://doi.org/10.1158/1538-7445.AM2024-6392
Published: 22 March 2024
View articletitled, Abstract 6392: Activity of HER2-and TROP2- antibody drug conjugates (ADCs) in small cell lung cancer (SCLC) models with SLFN11 as a predictive biomarker
Journal Articles

Abstract 6799: The impact of targeting TRAF2 and NCK-interacting protein kinase on anti-tumor effect and tumor immune environment in cMYC-high small cell lung cancer

Free
Azusa Tanimoto, Kavya Ramkumar, Allison Stewart, Bingnan Zhang, Robert Cardnell, Shen Li, Qi Wang, Jing Wang, Carl Gay, Lauren Averett Byers
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6799.
https://doi.org/10.1158/1538-7445.AM2024-6799
Published: 22 March 2024
View articletitled, Abstract 6799: The impact of targeting TRAF2 and NCK-interacting protein kinase on anti-tumor effect and tumor immune environment in cMYC-high small cell lung cancer
Journal Articles

Abstract 5864: YAP1 defines a highly plastic, persister cell population in small cell lung cancer (SCLC) following relapse

Free
C. Allison Stewart, Sarah M. Groves, Runsheng Wang, Kavya Ramkumar, Yuanxin Xi, Lixia Diao, Alejandra G. Serrano, Azusa Tanimoto, Ashley M. Victorian, Sayantan Bhattacharyya, Alexa J. Halliday, Neda Kalhor, Luisa Maren Soto, Pedro Filipe Da Rocha, Natalie Vokes, Loukia G. Karacosta, Jing Wang, John V. Heymach, Vito Quaranta, Bonnie Glisson, Lauren Averett Byers, Carl M. Gay
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5864.
https://doi.org/10.1158/1538-7445.AM2024-5864
Published: 22 March 2024
View articletitled, Abstract 5864: YAP1 defines a highly plastic, persister cell population in small cell lung cancer (SCLC) following relapse
Journal Articles

Abstract 3854: TNIK inhibition as a novel therapeutic in cMyc high/TTF1 low SCLC

Free
Azusa Tanimoto, Robert J. Cardnell, Benjamin B. Morris, Kavya Ramkumar, Shen Li, Qi Wang, Allison C. Stewart, Carl Michael Gay, Jing Wang, Lauren Averett Byers
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3854.
https://doi.org/10.1158/1538-7445.AM2023-3854
Published: 04 April 2023
View articletitled, Abstract 3854: TNIK inhibition as a novel therapeutic in cMyc high/TTF1 low SCLC
Journal Articles

Abstract 6206: Combined inhibition of AXL and ATR enhances replication stress, cell death and immune response in small cell lung cancer

Free
Kavya Ramkumar, C. Allison Stewart, Azusa Tanimoto, Qi Wang, Yuanxin Xi, Benjamin B. Morris, Runsheng Wang, Li Shen, Robert J. Cardnell, Jing Wang, Carl M. Gay, Lauren A. Byers
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6206.
https://doi.org/10.1158/1538-7445.AM2023-6206
Published: 04 April 2023
View articletitled, Abstract 6206: Combined inhibition of AXL and ATR enhances replication stress, cell death and immune response in small cell lung cancer
Journal Articles

Abstract 3196: Subtype-specific targeting of cell surfaceome with CAR T therapies in small cell lung cancer

Free
Bingnan Zhang, Yan Yang, C.Allison Stewart, Kavya Ramkumar, Runsheng Wang, Robert Cardnell, Lixia Diao, Qi Wang, Jing Wang, Lauren Byers, Carl Gay, John Heymach
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3196.
https://doi.org/10.1158/1538-7445.AM2023-3196
Published: 04 April 2023
View articletitled, Abstract 3196: Subtype-specific targeting of cell surfaceome with CAR T therapies in small cell lung cancer
Journal Articles

Abstract 4525: YAP1 in relapsed pulmonary high-grade neuroendocrine carcinomas (NEC) is associated with CDKN2A loss, intact RB1, EMT and therapeutic vulnerability to MEK1 and CDK4/6 inhibition

Free
C. Allison Stewart, Lixia Diao, Yuanxin Xi, Runsheng Wang, Kavya Ramkumar, B. Leticia Rodriguez, Benjamin B. Morris, Li Shen, Bingnan Zhang, Yan Yang, Azusa Tanimoto, Veronica Y. Novegil, Luisa M. Solis Soto, Pedro F. Simoes da Rocha, Natalie Vokes, Don L. Gibbons, Michael Frumovitz, Junya Fujimoto, Jing Wang, Bonnie Glisson, Lauren A. Byers, Carl M. Gay
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4525.
https://doi.org/10.1158/1538-7445.AM2023-4525
Published: 04 April 2023
View articletitled, Abstract 4525: YAP1 in relapsed pulmonary high-grade neuroendocrine carcinomas (NEC) is associated with CDKN2A loss, intact RB1, EMT and therapeutic vulnerability to MEK1 and CDK4/6 inhibition
Journal Articles

Abstract 2602: Combined inhibition of AXL and ATR enhances cell death and immune response in small cell lung cancer

Free
Kavya Ramkumar, Azusa Tanimoto, C. Allison Stewart, Qi Wang, Li Shen, Robert J. Cardnell, B. Leticia Rodriguez, Don L. Gibbons, Jing Wang, Carl M. Gay, Lauren A. Byers
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2602.
https://doi.org/10.1158/1538-7445.AM2022-2602
Published: 15 June 2022
View articletitled, Abstract 2602: Combined inhibition of AXL and ATR enhances cell death and immune response in small cell lung cancer
Journal Articles

Abstract 22: A novel, inflamed small cell lung cancer transcriptional subtype, SCLC-I, defines a subset of patients with distinct immunotherapy vulnerability

Free
Carl M. Gay, C. Allison Stewart, Lixia Diao, Barzin Y. Nabet, Junya Fujimoto, Luisa M. Solis, Wei Lu, Yuanxin Xi, Robert J. Cardnell, Natalie I. Vokes, Kavya Ramkumar, Stephen G. Swisher, Jack A. Roth, Bonnie S. Glisson, David S. Shames, Ignacio I. Wistuba, Jing Wang, John Minna, John V. Heymach, Lauren A. Byers
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 22.
https://doi.org/10.1158/1538-7445.AM2021-22
Published: 01 July 2021
View articletitled, Abstract 22: A novel, inflamed small cell lung cancer transcriptional subtype, SCLC-I, defines a subset of patients with distinct immunotherapy vulnerability
Journal Articles

The Hydroxyquinoline Analogue YUM70 Inhibits GRP78 to Induce ER Stress–Mediated Apoptosis in Pancreatic Cancer

Free
Soma Samanta, Suhui Yang, Bikash Debnath, Ding Xue, Yuting Kuang, Kavya Ramkumar, Amy S. Lee, Mats Ljungman, Nouri Neamati
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (7): 1883–1895.
https://doi.org/10.1158/0008-5472.CAN-20-1540
Published: 01 April 2021
View articletitled, The Hydroxyquinoline Analogue YUM70 Inhibits GRP78 to Induce ER Stress–Mediated Apoptosis in Pancreatic Cancer
Open the PDF for The Hydroxyquinoline Analogue YUM70 Inhibits GRP78 to Induce ER Stress–Mediated Apoptosis in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 276: Targeting AXL sensitizes non-small cell lung cancer to ATR inhibitors by enhancing replication stress

Free
Kavya Ramkumar, Pan Tong, You-Hong Fan, David Peng, John V. Heymach, Don L. Gibbons, Jing Wang, Lauren A. Byers
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 276.
https://doi.org/10.1158/1538-7445.AM2019-276
Published: 01 July 2019
View articletitled, Abstract 276: Targeting AXL sensitizes non-small cell lung cancer to ATR inhibitors by enhancing replication stress
Journal Articles

Abstract 5678: Design of GRP78 inhibitors as novel therapeutics for breast cancer.

Free
Kavya Ramkumar, Bikash Debnath, Amy S. Lee, Nouri Neamati
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5678.
https://doi.org/10.1158/1538-7445.AM2013-5678
Published: 15 April 2013
View articletitled, Abstract 5678: Design of GRP78 inhibitors as novel therapeutics for breast cancer.