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Abstract 5715: Epigenomic profiling identifies distinct neuroendocrine subtypes in lung cancer with neuroendocrine differentiation

Takashi Sato, Junko Hamamoto, Katsura Emoto, Takahiro Fukushima, Kai Sugihara, Masayuki Shirasawa, Yoshiro Nakahara, Satoshi Igawa, Yoshiki Murakumo, Takashi Kohno, Kouya Shiraishi, Hiroyuki Yasuda, Kenzo Soejima, Hideo Watanabe, Katsuhiko Naoki

Cancer Res (2022) 82 (12_Supplement): 5715.

DOI: https://doi.org/10.1158/1538-7445.AM2022-5715

Published: 15 June 2022

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Journal Articles

Upregulation of FGF9 in Lung Adenocarcinoma Transdifferentiation to Small Cell Lung Cancer

Cancer Res (2021) 81 (14): 3916–3929.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-4048

Published: 15 July 2021

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Includes: Supplementary data

Journal Articles

Abstract 4111: EGFR wild type allele amplification induces acquired resistance to mutation-specific EGFR tyrosine kinase inhibitors in non-small cell lung cancer cells

Keigo Kobayashi, Shigenari Nukaga, Hiroyuki Yasuda, Keita Masuzawa, Jyunko Hamamoto, Ichiro Kawada, Katsuhiko Naoki, Sachiyo Mimaki, Shingo Matsumoto, Koichi Goto, Katsuya Tsuchihara, Tomoko Betsuyaku, Kenzo Soejima

Cancer Res (2017) 77 (13_Supplement): 4111.

DOI: https://doi.org/10.1158/1538-7445.AM2017-4111

Published: 01 July 2017

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Abstract 2099: In vitro characterization of the effect of nazartinib against non-small cell lung cancer activating clinically relevant EGFR mutants

Keita Masuzawa, Hiroyuki Yasuda, Toshiyuki Hirano, Shigenari Nukaga, Hanako Hasegawa, Junko Hamamoto, Katsuhiko Naoki, Kenzo Soejima, Tomoko Betsuyaku

Cancer Res (2017) 77 (13_Supplement): 2099.

DOI: https://doi.org/10.1158/1538-7445.AM2017-2099

Published: 01 July 2017

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Journal Articles

Amplification of EGFR Wild-Type Alleles in Non–Small Cell Lung Cancer Cells Confers Acquired Resistance to Mutation-Selective EGFR Tyrosine Kinase Inhibitors

Shigenari Nukaga, Hiroyuki Yasuda, Katsuya Tsuchihara, Junko Hamamoto, Keita Masuzawa, Ichiro Kawada, Katsuhiko Naoki, Shingo Matsumoto, Sachiyo Mimaki, Shinnosuke Ikemura, Koichi Goto, Tomoko Betsuyaku, Kenzo Soejima

Cancer Res (2017) 77 (8): 2078–2089.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-2359

Published: 13 April 2017

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Includes: Supplementary data

Journal Articles

Abstract 4230: Visualizing the distribution of metabolites and the efficacy of BIBF1120 on metabolic status of lung cancer derived tumors by imaging mass-spectrometry (MS)

Daisuke Arai, Hiroyuki Yasuda, Kenzo Soejima, Shizuko Kagawa, Junko Hamamoto, Shigenari Nukaga, Katsuhiko Naoki, Katsura Emoto, Yuki Sugiura, Makoto Suematsu, Tomoko Betsuyaku

Cancer Res (2016) 76 (14_Supplement): 4230.

DOI: https://doi.org/10.1158/1538-7445.AM2016-4230

Published: 15 July 2016

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Journal Articles

Abstract 1365: Visualizing the effect of BIBF1120 in lung cancer cells by imaging-massspectrometry (MS)

Daisuke Arai, Kenzo Soejima, Hiroyuki Yasuda, Kota Ishioka, Shizuko Kagawa, Junko Hamamoto, Katsuhiko Naoki, Katsura Emoto, Yuki Sugiura, Makoto Suematsu, Tomoko Betsuyaku

Cancer Res (2015) 75 (15_Supplement): 1365.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1365

Published: 01 August 2015

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Journal Articles

Abstract 746: Activation of EGFR bypass signaling through TGFα overexpression induces acquired resistance to alectinib in ALK-translocated lung cancer cells

Tetsuo Tani, Hiroyuki Yasuda, Junko Hamamoto, Aoi Kuroda, Daisuke Arai, Kota Ishioka, Keiko Ohgino, Ichiro Kawada, Katsuhiko Naoki, Hayashi Yuichiro, Tomoko Betsuyaku, Kenzo Soejima

Cancer Res (2015) 75 (15_Supplement): 746.

DOI: https://doi.org/10.1158/1538-7445.AM2015-746

Published: 01 August 2015

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Journal Articles

Abstract 3006: Hyperoxia may be a treatment option for NSCLC

Junko Hamamoto, Hiroyuki Yasuda, Ichiro Nakachi, Michael G. Edwards, Masayoshi Miyawaki, Makoto Nishino, Aoi Kuroda, Tetsuo Tani, Daisuke Arai, Kota Ishioka, Ichiro Kawada, Katsuhiko Naoki, Tomoko Betsuyaku, Kenzo Soejima

Cancer Res (2015) 75 (15_Supplement): 3006.

DOI: https://doi.org/10.1158/1538-7445.AM2015-3006

Published: 01 August 2015

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Journal Articles

Abstract 3916: Oncogenic potential of FGF9 in lung cancer

Kota Ishioka, Kenzo Sejima, Hiroyuki Yasuda, Junko Hamamoto, Ahmed Hegab, Tetsuo Tani, Aoi Kuroda, Daisuke Arai, Keiko Ohgino, Takashi Sato, Terai Hideki, Ichiro Kawada, Katsuhiko Naoki, Yuichiro Hayashi, Tomoko Betsuyaku

Cancer Res (2015) 75 (15_Supplement): 3916.

DOI: https://doi.org/10.1158/1538-7445.AM2015-3916

Published: 01 August 2015

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Journal Articles

Abstract 4: ABT-263 is effective in a subset of non-small cell lung cancer cell lines

Aoi Kuroda, Keiko Ohgino, Hiroyuki Yasuda, Junko Hamamoto, Daisuke Arai, Kota Ishioka, Tetsuo Tani, Shigenari Nukaga, Ichiro Kawada, Katsuhiko Naoki, Kenzo Soejima, Tomoko Betsuyaku

Cancer Res (2015) 75 (15_Supplement): 4.

DOI: https://doi.org/10.1158/1538-7445.AM2015-4

Published: 01 August 2015

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Journal Articles

Abstract 414: Aberrant DNA methylation and expression of mRNA in EGFR-mutant lung cancer cell line with long-term exposure to gefitinib

Hideki Terai, Kenzo Soejima, Katsuhiko Naoki, Hiroyuki Yasuda, Takashi Sato, Daisuke Arai, Keiko Ohgino, Kota Ishioka, Aoi Kuroda, Tetsuo Tani, Ayano Ohashi, Makoto Nishino, Masayoshi Miyawaki, Junko Hamamoto, Tomoko Betsuyaku

Cancer Res (2014) 74 (19_Supplement): 414.

DOI: https://doi.org/10.1158/1538-7445.AM2014-414

Published: 01 October 2014

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Journal Articles

Abstract 5195: Claudin-1, a novel target of miR-375 in non-small cell lung cancer

Satoshi Yoda, Kenzo Soejima, Hiroyuki Yasuda, Takashi Sato, Daisuke Arai, Keiko Ohgino, Kota Ishioka, Tetsuo Tani, Ayano Oashi, Aoi Kuroda, Makoto Nishino, Masayoshi Miyawaki, Junko Hamamoto, Katsuhiko Naoki, Tomoko Betsuyaku

Cancer Res (2014) 74 (19_Supplement): 5195.

DOI: https://doi.org/10.1158/1538-7445.AM2014-5195

Published: 01 October 2014

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Journal Articles

Abstract 5257: FGF9 overexpression promotes tumorigenic potential of non-small cell lung cancer (NSCLC) cells, and is associated with poor prognosis in NSCLC patients.

Kota Ishioka, Kenzo Soejima, Hiroyuki Yasuda, Keiko Ohgino, Satoshi Yoda, Takashi Sato, Junko Hamamoto, Daisuke Arai, Tetsuo Tani, Aoi Kuroda, Katsuhiko Naoki, Tomoko Betsuyaku

Cancer Res (2013) 73 (8_Supplement): 5257.

DOI: https://doi.org/10.1158/1538-7445.AM2013-5257

Published: 15 April 2013

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Journal Articles

Abstract 5652: Activation of FGF2-FGFR1 pathway in EGFR-mutant lung cancer cell line with long-term gefitinib exposure.

Hideki Terai, Kenzo Soejima, Katsuhiko Naoki, Hiroyuki Yasuda, Ryosuke Satomi, Sohei Nakayama, Satoshi Yoda, Shinnosuke Ikemura, Takashi Sato, Kota Ishioka, Daisuke Arai, Keiko Ohgino, Tetsuo Tani, Aoi Kuroda, Junko Hamamoto, Tomoko Betsuyaku

Cancer Res (2013) 73 (8_Supplement): 5652.

DOI: https://doi.org/10.1158/1538-7445.AM2013-5652

Published: 15 April 2013

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Journal Articles

Abstract 4585: Expression of fibroblast growth factor-9 is associated with poor prognosis of resected non-small cell lung cancer patients

keiko ohgino, Kenzo Soejima, Daisuke Arai, Kota Ishioka, Takashi Sato, Hideki Terai, Shinnosuke Ikemura, Satoshi Yoda, Junko Hamamoto, Katsuhiko Naoki, Tomoko Betsuyaku

Cancer Res (2012) 72 (8_Supplement): 4585.

DOI: https://doi.org/10.1158/1538-7445.AM2012-4585

Published: 15 April 2012

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Journal Articles

Abstract 4956: Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma

Junko Hamamoto, Satoshi Yoda, Katsuhiko Naoki, Sohei Nakayama, Ryosuke Satomi, Hideki Terai, Shinnosuke Ikemura, Takashi Sato, Yuichiro Hayashi, Kenzo Soejima

Cancer Res (2011) 71 (8_Supplement): 4956.

DOI: https://doi.org/10.1158/1538-7445.AM2011-4956

Published: 15 April 2011

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Journal Articles

Abstract 5302: Overcoming cancer immune evasion in lung carcinoma using EGFR-TKI (Gefitinib)

Ryosuke Satomi, Katsuhiko Naoki, Tomonori Yaguchi, Hiroyuki Yasuda, Sohei Nakayama, Satoshi Yoda, Hideki Terai, Shinnosuke Ikemura, Takashi Sato, Kenzo Soejima, Akitoshi Ishizaka, Yutaka Kawakami

Cancer Res (2010) 70 (8_Supplement): 5302.

DOI: https://doi.org/10.1158/1538-7445.AM10-5302

Published: 15 April 2010

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Journal Articles

Enhanced growth inhibition of human NSCLC cell resistant to gefitinib (ZD1839) by a dual tyrosine kinase inhibitor of EGFR / VEGFR2 (AEE788) in combination with a mTOR inhibitor (RAD001).

Ichiro Nakachi, Katsuhiko Naoki, Kenzo Soejima, Ichiro Kawada, Hideo Watanabe, Hiroyuki Yasuda, Akitoshi Ishizaka

Cancer Res (2006) 66 (8_Supplement): 1193.

Published: 15 April 2006

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Journal Articles

Homozygous Deletions and Chromosome Amplifications in Human Lung Carcinomas Revealed by Single Nucleotide Polymorphism Array Analysis

Cancer Res (2005) 65 (13): 5561–5570.

DOI: https://doi.org/10.1158/0008-5472.CAN-04-4603

Published: 01 July 2005

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Includes: Supplementary data

NARROW

Abstract 5715: Epigenomic profiling identifies distinct neuroendocrine subtypes in lung cancer with neuroendocrine differentiation

Upregulation of FGF9 in Lung Adenocarcinoma Transdifferentiation to Small Cell Lung Cancer

Abstract 4111: EGFR wild type allele amplification induces acquired resistance to mutation-specific EGFR tyrosine kinase inhibitors in non-small cell lung cancer cells

Abstract 2099: In vitro characterization of the effect of nazartinib against non-small cell lung cancer activating clinically relevant EGFR mutants

Amplification of EGFR Wild-Type Alleles in Non–Small Cell Lung Cancer Cells Confers Acquired Resistance to Mutation-Selective EGFR Tyrosine Kinase Inhibitors

Abstract 4230: Visualizing the distribution of metabolites and the efficacy of BIBF1120 on metabolic status of lung cancer derived tumors by imaging mass-spectrometry (MS)

Abstract 1365: Visualizing the effect of BIBF1120 in lung cancer cells by imaging-massspectrometry (MS)

Abstract 746: Activation of EGFR bypass signaling through TGFα overexpression induces acquired resistance to alectinib in ALK-translocated lung cancer cells

Abstract 3006: Hyperoxia may be a treatment option for NSCLC

Abstract 3916: Oncogenic potential of FGF9 in lung cancer

Abstract 4: ABT-263 is effective in a subset of non-small cell lung cancer cell lines

Abstract 414: Aberrant DNA methylation and expression of mRNA in EGFR-mutant lung cancer cell line with long-term exposure to gefitinib

Abstract 5195: Claudin-1, a novel target of miR-375 in non-small cell lung cancer

Abstract 5257: FGF9 overexpression promotes tumorigenic potential of non-small cell lung cancer (NSCLC) cells, and is associated with poor prognosis in NSCLC patients.

Abstract 5652: Activation of FGF2-FGFR1 pathway in EGFR-mutant lung cancer cell line with long-term gefitinib exposure.

Abstract 4585: Expression of fibroblast growth factor-9 is associated with poor prognosis of resected non-small cell lung cancer patients

Abstract 4956: Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma

Abstract 5302: Overcoming cancer immune evasion in lung carcinoma using EGFR-TKI (Gefitinib)

Enhanced growth inhibition of human NSCLC cell resistant to gefitinib (ZD1839) by a dual tyrosine kinase inhibitor of EGFR / VEGFR2 (AEE788) in combination with a mTOR inhibitor (RAD001).

Homozygous Deletions and Chromosome Amplifications in Human Lung Carcinomas Revealed by Single Nucleotide Polymorphism Array Analysis

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